[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"idiopathic-intracranial-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:idiopathic-intracranial-hypertension":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100581941","disease-biosignatures-in-alsftd-spectrum-new-impactful-biological-perspectives-beyond-clinical-approaches-100581941",false,"NCT06856850","Disease Biosignatures in ALS\u002FFTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches","SPECTRALS","Inclusion Criteria:\n\n* Clinical criteria for ALS (Brooks et al., 2000; de Carvalho M., 2008), FTD (GornoTempini et al., 2011; Rascovsky et al., 2011)\n\nExclusion Criteria:\n\n* na","ALL","18 Years",{"count":19,"type":20},230,"ESTIMATED","OBSERVATIONAL","Diagnosis of ALS\u002FFTD disease spectrum is challenging because it largely relies on clinical symptoms. Identifying novel biomarkers is essential for a paradigm shift towards a more precise biological-based diagnosis. To achieve this aim, having access to proper specimens and analytical methods is crucial. Our team of experts in neurology, biology, chemistry, physics, and AI will explore ALS\u002FFTD from novel perspectives using transcriptomics, proteomics, genomics and other innovative approaches to analyzing easily accessible tissues. The seed amplification assay (SAA) will be also exploited to detect pathological TDP-43. This project aims to create disease fingerprints useful for patient stratification and monitoring of disease progression, and to evaluate the therapeutic efficacy in clinical trials, thus overcoming the limits of clinical interpretation. Discovering new biomarkers and cellular pathways will improve the diagnosis and treatment of these devastating diseases.",[24,25,26,27,28,29],"ALS (Amyotrophic Lateral Sclerosis)","FTD","Neuropathic","Psychiatric Disorders","Idiopathic Intracranial Hypertension","Frontotemporal Dementia (FTD)",[31,32,33,34,35,36,37,38,39],"Amyotrophic lateral sclerosis","frontotemporal dementia","microbiota","miRNA","protein-NMR","TDP-43","endocytic disfunction","seed amplification assay","peripheral biomarker","RECRUITING","2026-03-25",{"date":43,"type":44},"2026-03-30","ACTUAL",{"date":46,"type":44},"2025-02-27",{"date":48,"type":20},"2026-08",{"name":50,"class":51},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","OTHER",4,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100581825","prospective-ocular-imaging-for-intracranial-pressure-evaluation-100581825","NCT06855342","Prospective Ocular Imaging for Intracranial Pressure Evaluation","POICCP","Healthy controls:\n\nInclusion Criteria:\n\n1. Aged ≥18 years\n2. Presumed normal ICP undergoing routine mydriatic ophthalmology OCT scans.\n\nExclusion Criteria:\n\n1. Significant media opacity restricting acquisition of retinal vein imaging and video capture in both eyes.\n2. Current or previous evidence of glaucoma, glaucoma suspect, family history of glaucoma in a 1st degree relative, or non-glaucoma related optic neuropathy in both eyes.\n3. Retinal vein or artery occlusions in both eyes (branch or central).\n4. Active or history of proliferative diabetic retinopathy, or diabetic papillitis in both eyes.\n5. Symptoms and\u002For signs that, in the opinion of the investigator, indicate possible raised intracranial pressure.\n6. Current or previous history of disorders affecting intracranial pressure including, but not limited to, idiopathic intracranial hypertension, hydrocephalus, epilepsy, intracranial bleeds, space occupying lesions or tumours, traumatic brain injury, central nervous system inflammatory or infectious disorders, congenital neuro-cranial disorders, neurosurgical or interventional procedures. Radiologically-confirmed ischaemic stroke is permissible, provided the patient did not develop a subsequent haemorrhagic stroke or require neurosurgical intervention.\n7. Current or recent (6 months) history of medication use affecting intracranial pressure including steroids, vitamin A analogues, tetracyclines, recombinant growth hormone, lithium, nitrofurantoin, nalidixic acid, sulfenazone, cyclosporine, amiodarone.\n8. Bed-bound patients.\n9. Patients who, in the opinion of the investigator, would be unwilling or unable to provide written informed consent, or undergo the testing procedures as described in the protocol.\n\nPatients due to undergo lumbar puncture or intracranial pressure bolt monitoring:\n\nInclusion:\n\n1. Aged ≥18 years.\n2. Patients due to undergo lumbar puncture with measurement of Opening and Closing CSF pressures\n3. Patients due to undergo continuous ICP monitoring\n\nExclusion:\n\n2\\. Current or previous evidence of glaucoma or glaucoma suspect in both eyes.\n\n3\\. Retinal vein or artery occlusions in both eyes (branch or central).\n\n4\\. Bed-bound patients.\n\n5\\. Patients who, in the opinion of the investigator, would be unwilling or unable to provide written informed consent, or undergo the testing procedures as described in the protocol.",true,{"count":62,"type":20},160,"This is a prospectively recruiting, database development study collecting images and videos of the spontaneous venous pulsation at the back of people's eyes - this is a pulse one can see on examination of the back of the eye, originating from the blood vessels around the nerve that connects the eye to the brain (the optic nerve), and is present in most people who have normal pressure around the brain. However, in people with raised pressure in the brain, this pulse disappears as the pressure rises. Many things can cause the pressure around the brain to increase, including tumours, swellings and trauma. The investigators want to test if high-quality images and videos of this pulse, taken using both hand-held and larger, fixed-platform machines, can be used to train a software tool to automatically detect this pulse. The investigators want to collect these images and videos in 2 groups of patients: those with no known or suspected brain pressure problems, and those who are suspected to have raised pressure and\u002For are due to undergo measurement of the pressure around the brain, called lumbar punctures or intracranial pressure bolt monitoring. These tests to check the pressure around the brain are invasive - they involve inserting needles in the back or directly into the brain to measure the pressure, and carry risks. The value of these two groups of people will be to help train the software to reasonably say whether a pulse is present or absent and, hopefully, estimate what the pressure around the brain may be without the need for an invasive test.",[28,65,66],"Intracranial Pressure Increase","Spontaneous Venous Pulsations",[66,68],"Optic disc videography","2025-08-01",{"date":71,"type":44},"2025-08-03",{"date":73,"type":44},"2025-01-10",{"date":75,"type":20},"2025-11-30",{"name":77,"class":51},"King's College Hospital NHS Trust",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":60,"sex":16,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":78},"100558043","ocular-perfusion-in-patients-with-idiopathic-intracranial-hypertension-100558043","NCT06545981","Ocular Perfusion in Patients With Idiopathic Intracranial Hypertension","Inclusion criteria for patients with idiopathic intracranial hypertension\n\n* Men and Women aged ≥ 18 years\n* Signed informed consent\n* Newly diagnosed idiopathic intracranial hypertension or relapse of idiopathic intracranial hypertension\n* Non-Smokers\n\nInclusion criteria for healthy age- and sex-matched control subjects\n\n* Men and Women aged ≥ 18 years\n* Signed informed consent\n* Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant\n* Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant\n* Non-Smokers\n\nExclusion criteria for patients with idiopathic intracranial hypertension and healthy age- and sex-matched control subjects:\n\n* Blood donation in the three weeks preceding the study\n* Symptoms of a clinically relevant illness in the three weeks preceding the study\n* Ocular inflammation or infection within the last 3 months\n* History or family history of epilepsy\n* Diabetes mellitus type 1 or type 2\n* History or known presence of other cerebral vascular diseases (e.g.: arteriovenous malformation, aneurysm, major artery stenosis or occlusion)\n* History or known presence of intracranial infections (e.g.: meningitis)\n* History or known presence of other neurological diseases (e.g.: brain tumor, hydrocephalus, degenerative diseases)\n* Patients receiving corticosteroids or immunosuppressant therapy\n* Pregnant or breast-feeding women\n* Women of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception","90 Years",{"count":87,"type":20},48,"The proposed study aims to evaluate optic nerve head blood flow and microcirculation in patients with idiopathic intracranial hypertension. For this purpose, optic nerve head blood flow will be examined in patients with IIH before and after therapy and additionally compared with healthy age- and sex-matched control subjects. In addition, other parameters will be measured, in particular retinal blood flow, retinal oxygen saturation and retinal neurovascular coupling.",[28],"2024-08-29",{"date":92,"type":44},"2024-08-30",{"date":94,"type":44},"2024-05-28",{"date":96,"type":20},"2026-08-31",{"name":98,"class":51},"Medical University of Vienna"]