[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"idiopathic-normal-pressure-hydrocephalus-inph\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:idiopathic-normal-pressure-hydrocephalus-inph":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,74,99,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100614925","transcranial-ultrasound-assessment-of-cerebral-pulsatility-in-shunt-decision-making-for-suspected-idiopathic-normal-pressure-hydrocephalus-a-prospective-cohort-study-100614925",false,"NCT07285928","Transcranial Ultrasound Assessment of Cerebral Pulsatility in Shunt Decision-making for Suspected Idiopathic Normal Pressure Hydrocephalus: a Prospective Cohort Study","Contribution of Cerebral Pulsatility Assessment by Transcranial Ultrasound to the Decision-making for Cerebrospinal Fluid Shunting in Patients With Suspected Idiopathic Normal Pressure Hydrocephalus: a Prospective Cohort Study","HYDROPULSE","Inclusion Criteria:\n\n* Adult\n* Suspected iNPH (= at least 1\u002F3 of the triad symptoms + ventriculomegaly on brain imaging)\n* Hospitalised at Tours University Hospital for 'hydrocephalus assessment'\n* Patient who has provided written and signed consent\n\nNon-inclusion criteria\n\n* Individuals who objected to data processing\n* Walking assessment by the physiotherapy team impossible AND cognitive assessment by the speech therapy team impossible\n\nExclusion criteria\n\n* Patients already fitted with a CSF shunting system (VPS)\n* Suspicion of obstructive hydrocephalus (aqueduct stenosis, tumour, etc.)\n* Patients under legal protection (guardianship, curatorship, judicial protection).","ALL","18 Years",{"count":20,"type":21},110,"ESTIMATED","OBSERVATIONAL","This will be a single-center, prospective, analytical cohort study. All included patients will undergo transcranial ultrasound (TPI) with measurement of cerebral pulsatility parameters prior to subtractive lumbar puncture during hospitalization in the neurosurgery department, followed by a second ultrasound assessment either at one year after surgery for operated patients, or at one year after the initial ultrasound assessment for non-operated patients. This ultrasound evaluation will be integrated into the routine work-up, which is already systematically performed in cases of suspected idiopathic normal pressure hydrocephalus (iNPH).\n\nThe neurosurgical team's decision to perform cerebrospinal fluid (CSF) shunting will be made blinded to the ultrasound measurements and based solely on the standard clinical protocol.\n\nThe primary objective of the study is to demonstrate that the mean amplitude of cerebral pulsatility (MeanBTP) prior to subtractive lumbar puncture is significantly higher in patients who show clinical improvement 12 months after CSF shunting compared with those who do not, with a type I error risk (alpha) of 0.05.\"",[25,26],"Brain Pulsatility","Idiopathic Normal Pressure Hydrocephalus (INPH)",[28,29,30],"transcranial ultrasound","cerebral pulsatility","idiopathic normal pressure hydrocephalus (iNPH),","NOT_YET_RECRUITING","2026-04-29",{"date":34,"type":35},"2026-04-30","ACTUAL",{"date":37,"type":21},"2026-05",{"date":39,"type":21},"2029-05",{"name":41,"class":42},"University Hospital, Tours","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":55,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":43},"100622622","etiology-phenotype-outcome-pathway-study-on-freezing-of-gait-fog-100622622","NCT07386015","Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)","FREEZE-Path Cohort: Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)","Inclusion Criteria:\n\n1. Age 30-85 years\n2. Presence of freezing of gait or non-freezing gait or balance impairment\n3. Diagnosis of Parkinson's disease or related parkinsonian disorders according to established international criteria (including PD, PSP, MSA, DLB, CBD, vascular parkinsonism, or idiopathic normal pressure hydrocephalus)\n4. Ability to complete gait and balance assessment tasks independently or with assistance\n5. Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n1. Severe dementia (Mini-Mental State Examination score \\\u003C 10)\n2. Severe psychiatric disorders interfering with study participation\n3. Severe cardiopulmonary, musculoskeletal, or other medical conditions significantly affecting gait safety\n4. Stroke, fracture, or other major medical events within the past 3 months\n5. Inability to comply with follow-up procedures\n6. Refusal of video or speech data collection","30 Years","85 Years",{"count":54,"type":21},700,"36 Months","This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related neurological conditions.The purpose of this registry is to collect long-term clinical information from patients with freezing of gait or gait and balance problems, and to explore how different causes of FOG are related to symptoms, walking patterns, falls, disease progression, and outcomes over time. The study will include participants with Parkinson's disease and other conditions associated with freezing of gait.Participants will receive standard medical care as determined by their treating physicians. No experimental drugs or study-related treatments will be assigned as part of this registry. Clinical information will be collected during routine visits and follow-up assessments, including questionnaires, walking and balance evaluations, video recordings, and other commonly used clinical tests.The information collected in this study may help improve the understanding of freezing of gait, support better risk assessment for falls, and guide future research and clinical management strategies for patients with gait and balance disorders.",[58,59,60,61,26],"Freezing of Gait","Parkinson's Disease","Parkinsonism","Vascular Parkinsonism",[58,59,63],"parkinsonism","RECRUITING","2026-03-08",{"date":67,"type":35},"2026-03-10",{"date":69,"type":35},"2026-02-28",{"date":71,"type":21},"2030-11-30",{"name":73,"class":42},"Tianjin Huanhu Hospital",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":82,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":43},"100627349","phase-4-functional-outcomes-after-lumbopenitoneal-shunt-placement-under-local-anesthesia-for-patients-with-idiopathic-normal-pressure-hydrocephalus-flourish-trial-100627349","NCT07447479","Functional Outcomes After LumbOpenitoneal Shunt Placement UndeR Local Anesthesia for Patients With Idiopathic Normal preSsure Hydrocephalus (FLOURISH) Trial","Functional Outcomes After Lumbopenitoneal Shunt Placement Under Local Anesthesia for Patients With Idiopathic Normal Pressure Hydrocephalus Trial","FLOURISH","Inclusion Criteria:\n\n* Probable iNPH patients\n* Age 60 years or older at the time of the tap test\n* Patients capable of performing the Timed Up and Go test\n* Patients assignable within 2 weeks (14 days) of obtaining RCT consent\n* Patients capable of undergoing shunt surgery within 1 month (30 days) of assignment\n* Patients capable of follow-up at the assigned facility or referring facility for 12 months after assignment\n* Patients for whom informed consent was obtained\n\nExclusion Criteria:\n\n* Patients deemed unsuitable for lumbar-abdominal shunt surgery due to advanced degeneration of the lumbar spine and spinal canal, etc.\n* Patients deemed unsuitable for abdominal shunt surgery due to a history of multiple open abdominal surgeries, a history of severe intra-abdominal infection, etc.\n* Other patients deemed unsuitable by the attending physician","60 Years",{"count":84,"type":21},196,"INTERVENTIONAL",[87],"PHASE4","This study is a prospective observational registry study that enrolls all patients aged 60 years or older suspected of having idiopathic normal pressure hydrocephalus based on the Third Edition of the Guidelines for the Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus. From the cohort registered, patients judged to be candidates for surgery based on the 3rd Edition of the Guidelines for the Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus. These patients will be randomized 1:1 to undergo either ventriculoperitoneal shunt surgery under general anesthesia or lumbar peritoneal shunt surgery under local anesthesia. A randomized clinical trial would attest the non-inferiority of lumbar peritoneal shunt surgery under local anesthesia compared to ventriculoperitoneal shunt surgery under general anesthesia regarding the improvement in timed up-and-go test scores at 3 months post-surgery relative to pre-surgery levels.",[26],"2026-02-26",{"date":92,"type":35},"2026-03-03",{"date":94,"type":21},"2026-04-01",{"date":96,"type":21},"2031-03-31",{"name":98,"class":42},"Institute for Clinical Effectiveness, Japan",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":106,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":85,"phases":109,"briefSummary":111,"conditions":112,"keywords":113,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":43},"100553604","endoscopic-third-ventriculostomy-vs-ventriculoperitoneal-shunt-in-idiopathic-normal-pressure-hydrocephalus-endovest-100553604","NCT06488248","Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)","Endoscopic Third Ventriculostomy Compared to Ventriculoperitoneal Shunt as Treatment for Idiopathic Normal Pressure Hydrocephalus (ENDOVEST): A Randomized Trial","Inclusion Criteria:\n\n* \\>40 years of age\n* Symptom duration ≥3 months, \\\u003C24 months\n* No antecedent head trauma, ICH, meningitis, or other cause of secondary hydrocephalus\n* MUST show gait\u002Fbalance disturbance, PLUS cognition impairment AND\u002FOR urinary dysfunction.\n* Ventricular enlargement (Evans Index \\> 0.3) not attributable to cerebral atrophy or congenital enlargement\n* No macroscopic obstruction to cerebrospinal fluid (CSF) flow Spinal Tap-Test\n* Opening pressure (on lateral decubitus): \\\u003C24cmH2O\n* Clinical improvement in at least one of the main symptoms after 40-50ml withdrawal of CSF\n\nExclusion Criteria:\n\n* ≤40 years of age\n* No informed consent\n* Other neurologic, psychiatric or general medical condition which is sufficient to explain the presenting symptoms.\n* Previous cranial neurosurgical interventions\n* Other associated dementia syndromes\n* Incapacity to walk\n* Pregnancy and breastfeeding women","40 Years",{"count":108,"type":21},150,[110],"NA","The aim of this single-center, two-arm, open-labeled, randomized controlled clinical study is to compare two surgical interventions, endoscopic third ventriculostomy and ventriculoperitoneal shunt, in treating idiopathic normal pressure hydrocephalus in terms of clinical improvement.",[26],[114,115,116,117],"Surgical treatment","Neurosurgery","Endoscopic third ventriculostomy (ETV)","Ventriculoperitoneal shunt (VPS)","2025-01-31",{"date":120,"type":35},"2025-02-03",{"date":122,"type":35},"2025-01-17",{"date":124,"type":21},"2028-07-01",{"name":126,"class":42},"University Hospital, Basel, Switzerland",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":82,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":85,"phases":137,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":43},"100552891","the-pilot-study-of-medical-device-neuclare-for-patients-with-idiopathic-normal-pressure-hydrocephalus-inph-100552891","NCT06478979","The Pilot Study of Medical Device-Neuclare for Patients With Idiopathic Normal Pressure Hydrocephalus (iNPH)","A Prospective, Single-arm, Open-label, Non-randomized Exploratory Clinical Trial to Verify the Efficacy and Safety of Gait and Cognitive Improvement in Patients With Idiopathic Normal Pressure Hydrocephalus (iNPH) Using the Neuclare Physical Device for Medical Use","Inclusion Criteria:\n\n* Adults aged 60 to 90, regardless of gender\n* Individuals exhibiting gait disturbances along with at least one of the following symptoms: cognitive impairment or urinary incontinence\n* Evans' index \\> 0.3)\n* When the symptoms in 2) and 3) cannot be fully explained by other neurological or non-neurological diseases\n* Diagnosis of INPH based on the Investigator's clinical judgement based on criteria as described in the INPH Guidelines\n\nExclusion Criteria:\n\n* Patient with pathological lesions in the brain identified by MRI\n* A person who is confirmed to have organic brain lesions (e.g., cerebral edema, cerebral hemorrhage, cerebral infarction, cerebrovascular malformation, brain tumor, etc.) on a brain MRI.\n* Patients with metabolic disorders such as thyroid dysfunction, hyperglycemia, hypoglycemia, liver or kidney dysfunction, and long-term use of drugs that will cause cognitive decline (e.g., anticholinergic drugs)\n* History of psychiatric disorder other than the inclusion criteria.\n* A person with a severe history of cancer\u002Ftuberculosis\n* A person who has contact dermatitis or sensitive skin abnormalities\n* Patients with a high fever of 40 degrees Celsius or higher based on eardrum body temperature\n* A person whose bleeding is identified due to a common procedure or surgery that may affect vital signs\n* A person who is unable to perform MRI tests\n* A person with an allergic reaction to MRI contrast agents such as Definity or Gadovist.\n* Other cases where the investigator judged that it is difficult to participate in the study\n* Patient with behavioral and psychological symptoms of dementia (BPSD) that make cooperation in the clinical trial difficult\n* Patients with severe cognitive impairment, defined as an MMSE score of 17 or below\n* Patients who have undergone shunt surgery in the past year\n* Patients with a history of uncontrolled thyroid, liver, or kidney dysfunction\n* Patients taking medications that affect gait, cognition, or urinary tract function and who have had a change in medication regimen within the past 3 months.\n* Patients who have undergone a cerebrospinal fluid drainage test within the past 1 month.","90 Years",{"count":136,"type":21},20,[110],"This clinical trial aims to explore the effectiveness and safety of gait improvemen of Neuclare, a science medical device, for patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) Through methods such as Timed Up \\& Go Test (TUG), 10m gait , iNPH grading scale), etc, gait improvement before and after using Neuclare will be evaluated.",[140],"Idiopathic Normal Pressure Hydrocephalus (iNPH)","2024-12-26",{"date":143,"type":35},"2024-12-30",{"date":145,"type":35},"2024-07-22",{"date":147,"type":21},"2026-01-01",{"name":149,"class":150},"Deepsonbio","INDUSTRY"]