[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"idiopathic-normal-pressure-hydrocephalus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:idiopathic-normal-pressure-hydrocephalus":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100439121","multi-omics-research-of-idopathic-normal-pressure-hydrocephalus-inph-100439121",false,"NCT04998175","Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)","Multi-omics Research of Prognostic Factors of Ventriculoperitoneal Shunt for Idopathic Normal Pressure Hydrocephalus","Inclusion Criteria:\n\n* Age ≥ 60 years;\n* Diagnosis of iNPH based on clinical assessment\n* Participant is able to give written informed consent\n\nExclusion Criteria:\n\n* Combining AD and Parkinson's disease and other nervous system diseases\n* Participant is not medically available for shunt surgery\n* Secondary NPH","ALL","60 Years","90 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research",[27],"Idiopathic Normal Pressure Hydrocephalus",[27,29,30,31,32],"Prognostic factor","Ventriculoperitoneal shunt","Cerebrospinal fluid","Proteomics","RECRUITING","2026-04-21",{"date":36,"type":37},"2026-04-24","ACTUAL",{"date":39,"type":37},"2020-09-15",{"date":41,"type":21},"2026-12-30",{"name":43,"class":44},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100625838","integrated-multimodal-assessment-to-optimize-diagnosis-and-surgical-selection-in-idiopathic-normal-pressure-hydrocephalus-100625838","NCT07427836","Integrated Multimodal Assessment to Optimize Diagnosis and Surgical Selection in Idiopathic Normal Pressure Hydrocephalus","Integrated Multimodal Approach for Diagnostic Optimization and Surgical Candidate Selection in Idiopathic Normal Pressure Hydrocephalus: The Role of CSF Biomarkers, Cognitive-Motor Assessment, and Neuroimaging","NPH-OPTIMIZE","Inclusion Criteria:\n\n* Age 60 years or older.\n* Patients with suspected idiopathic normal pressure hydrocephalus referred to the institutional diagnostic, therapeutic, and care pathway.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent.","85 Years",{"count":56,"type":21},116,"OBSERVATIONAL","Idiopathic normal pressure hydrocephalus (iNPH) is a neurological condition that can cause walking difficulties, cognitive impairment, and urinary incontinence. Although iNPH can be treated with cerebrospinal fluid (CSF) shunt surgery, diagnosis is often challenging because its symptoms and brain imaging findings may overlap with those of other neurodegenerative disorders, such as Alzheimer's disease or vascular parkinsonism. As a result, some patients may experience delayed diagnosis or may not be referred for potentially beneficial surgical treatment.\n\nThis observational study aims to evaluate whether combining different types of clinical information can improve the diagnosis of iNPH and help identify patients who are more likely to benefit from surgery. The study integrates cognitive testing, motor performance assessment, CSF biomarker analysis, and brain magnetic resonance imaging.\n\nPatients aged over 60 years with suspected iNPH who are evaluated within a standardized diagnostic care pathway will be included. Cognitive and motor performance will be assessed before and after a cerebrospinal fluid tap test, which is part of routine clinical practice. Results will be compared between patients who receive a confirmed diagnosis of iNPH and undergo CSF shunt surgery and patients who receive an alternative diagnosis and do not undergo surgical treatment.\n\nThe results of this study may help improve diagnostic accuracy, reduce false-negative test results, and support better clinical decision-making in patients with suspected idiopathic normal pressure hydrocephalus.",[27],[61,62,63,64],"Cognition","CSF biomarkers","CSF tap test","Gait assessment","2026-02-16",{"date":67,"type":37},"2026-02-23",{"date":69,"type":21},"2026-02-11",{"date":71,"type":21},"2035-01",{"name":73,"class":44},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico",2,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":16,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":87,"studyType":57,"phases":4,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":45},"100549032","clinical-outcome-in-patients-with-inph-100549032","NCT06428734","Clinical Outcome in Patients With INPH","Phenotypes, Biomarkers and Pathophysiology in INPH","Inclusion Criteria:\n\n* patients who was diagnosed as idiopathic normal pressure hydrocephalus\n\nExclusion Criteria:\n\n* patient received surgical treatment or interventional treatment before patient is pregnant patient unable to complete follow-up patient with other types of hydrocephalus other nervous system diseases",true,"18 Years","80 Years",{"count":86,"type":21},200,"2 Years","The aim of this study is to determine the clinical spectrum and natural progression of idiopathic normal pressure hydrocephalus （iNPH ) and related disorders in a prospective single center study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the etiology and molecular mechanisms of these diseases.",[90,27,91,92,93],"Hydrocephalus","CSF","Glympathic System","Omic",[90,27],"2024-05-20",{"date":97,"type":37},"2024-05-24",{"date":99,"type":21},"2024-05-15",{"date":101,"type":21},"2027-05",{"name":103,"class":44},"Xuanwu Hospital, Beijing"]