[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"idiopathic-scoliosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:idiopathic-scoliosis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,53,80,114,138,163,184,204,228,251,270,289,314,333,357,384,409,431,458,482,510],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100444723","advanced-spinal-innovations-with-robotics-and-enabling-technology-registry-100444723",false,"NCT05071144","Advanced SPinal Innovations With Robotics and Enabling Technology Registry","ASPIRE","Inclusion Criteria:\n\n* Diagnosis of a spine deformity\n* Scheduled for surgery using robotics and navigation and\u002For patient-specific rods\n* Up to and including 21 years of age\n* Speak and read English or Spanish\n\nExclusion Criteria:\n\n• None",true,"ALL","0 Years","21 Years",{"count":21,"type":22},700,"ESTIMATED","5 Years","OBSERVATIONAL","Creation of a pediatric robotic spine surgery registry will allow for data collection and analysis on the coupled use of robotics and navigation, as well as patient-specific rods in pediatric spine deformity surgery across participating study institutions. Eventually, an educational and informative framework for this technology will be established.",[27,28,29,30,31,32],"Spine Deformity","Idiopathic Scoliosis","Adolescent Idiopathic Scoliosis","Spondylolisthesis","Congenital Scoliosis","Neuromuscular Scoliosis",[34,35,36,37,38,39],"Pediatric","Spine","Surgery","Registry","Robotic","Navigation","RECRUITING","2026-06-18",{"date":43,"type":44},"2026-06-22","ACTUAL",{"date":46,"type":44},"2021-12-13",{"date":48,"type":22},"2031-12",{"name":50,"class":51},"Boston Children's Hospital","OTHER",10,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":79},"100460909","post-market-clinical-follow-up-study-on-the-safety-and-performance-of-ennovate-complex-100460909","NCT05281757","Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Complex","Multicenter Post Market Clinical Follow-Up (PMCF) Study on the Safety and Performance of Ennovate® Complex - A Prospective Study on Scoliosis Patients","COSINE","Inclusion Criteria:\n\n* Informed consent in the documentation of clinical and radiological results of patients who are minimum 18 years old\n* Informed consent in the documentation of clinical and radiological results of patients AND legal representative (parent) for patients who are younger than 18\n* Patient's indication according to IFU\n* Patient is not pregnant\n\nExclusion Criteria:\n\n* Patient's clear unability or unwillingness to participate in follow-up examinations",{"count":62,"type":22},200,"Multicenter, multinational Post-Market Clinical Follow-Up (PMCF) study on the safety and performance of Ennovate® Complex - A prospective, pure data collection of all Ennovate® scoliosis patients in selected centers (not interventional, multicentric)",[65,66,31,32,28],"Hyperkyphosis","Hyperlordosis",[68],"upper-thoracic spine","2026-06-01",{"date":71,"type":44},"2026-06-02",{"date":73,"type":44},"2022-02-18",{"date":75,"type":22},"2028-10",{"name":77,"class":78},"Aesculap AG","INDUSTRY",2,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":97,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":108,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100638326","a-study-to-evaluate-a-new-semi-rigid-brace-the-resilient-brace-by-thinks-works-as-a-way-to-limit-curve-worsening-in-kids-with-idiopathic-scoliosis-100638326","NCT07574632","A Study to Evaluate a New Semi-rigid Brace, the RESILIENT Brace by Thinks Works, as a Way to Limit Curve Worsening in Kids With Idiopathic Scoliosis.","The RESILIENT Scoliosis Brace System Clinical Trial (RESILIENT)","RESILIENT","Inclusion Criteria:\n\n* Diagnosis of Idiopathic Scoliosis (IS)\n* Age of 9 - 16 years when brace treatment is prescribed\n* Primary right apex main thoracic scoliosis curve with an apex of T6 or lower\n* Cobb angle, as measured on a standing PA spine x-ray, 20 degrees or larger and 30 degrees or less, obtained no more than 6 weeks prior to trial enrollment.\n* Sanders Skeletal Maturity Score of 1-5\n* No prior brace treatment or surgery for scoliosis\n* Patient \\& guardian select the RESILIENT brace for treatment\n* The guardian must confirm that there is cellular connectivity at the place(s) where the patient lives\n\nExclusion Criteria:\n\n* Scoliosis other than idiopathic scoliosis: e.g. Neuromuscular, Congenital, or Syndrome Related\n* Age less than 9 years or older than 16 years\n* Sanders Skeletal Maturity Score of 6 or greater\n* Primary Left apex thoracic scoliosis\n* Primary lumbar scoliosis\n* Primary Right Thoracic curve with an apex above T6\n* Inability to remove and apply the brace independently\n* Inability to respond to written and verbal questions\n* Patient \\& Guardian select traditional TLSO for treatment\n* Guardian confirms there is no cellular connectivity at the place(s) where the patient lives","9 Years","16 Years",{"count":91,"type":22},30,"INTERVENTIONAL",[94],"NA","The goal of this clinical trial is to learn if the RESILIENT Scoliosis Brace System works to treat children with idiopathic scoliosis. It will also learn about the safety, comfort, and usability of the brace. The main questions it aims to answer are:\n\n* Can the RESILIENT brace prevent the spinal curve from progressing beyond 35 degrees during growth?\n* How much does the brace correct the curve when it is first worn (in-brace correction)?\n* How well do participants follow the prescribed brace wear time and force levels?\n* How does wearing the brace affect quality of life and daily activities?\n\nResearchers will study a single group of participants using the RESILIENT brace and evaluate outcomes over time using standard clinical assessments, including X-rays and patient-reported questionnaires.\n\nParticipants will:\n\n* Be fitted with the RESILIENT brace and instructed on how to use it\n* Wear the brace daily according to physician recommendations throughout their growth period\n* Attend clinic visits at approximately 4-6 weeks after starting treatment and then about every 6 months for follow-up evaluations\n* Undergo standard-of-care spine X-rays to monitor curve progression\n* Complete questionnaires about their quality of life and experience with the brace\n* Have brace wear time and applied forces monitored using sensors embedded in the device\n\nParticipants will be followed from the start of brace treatment until they are done growing and have completed treatment.",[28],[98,99,100,101,102,103,104,105],"scoliosis","brace","idiopathic scoliosis","flexible brace","semi-rigid brace","adolescent idiopathic scoliosis","AIS","IS","2026-05-28",{"date":69,"type":44},{"date":106,"type":44},{"date":110,"type":22},"2029-08",{"name":112,"class":78},"Thinks Works, PBC",1,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":16,"sex":17,"minAge":122,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":92,"phases":126,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":113},"100620390","characterization-of-visual-perception-impairments-in-patients-with-idiopathic-scoliosis-100620390","NCT07356999","Characterization of Visual Perception Impairments in Patients With Idiopathic Scoliosis","Characterization of Visual Perception Alterations in Patients With Idiopathic Scoliosis: Towards a Theory of Perceptual Imbalance","EYAIS","Inclusion Criteria:\n\nGroup Scoliosis:\n\n* Girls or boys aged 11 to 18 inclusive.\n* Patients with progressive idiopathic scoliosis\n* Candidates for either orthopedic (brace) or surgical (arthrodesis correction) treatment for which a pre-therapeutic multimodal assessment is planned.\n\nControl group:\n\n\\- Girls or boys aged 11 to 18 inclusive.\n\nExclusion Criteria:\n\nThe following individuals will not be included:\n\n* Individuals with another musculoskeletal disorder.\n* Individuals with a neurosensory disorder that may affect the balance of the trunk or lower limbs.\n* Individuals with uncorrected visual perception disorders (visual check within 12 months prior to the examination).\n* Lack of consent from the subject.\n* Lack of consent from legal representatives.\n* Failure to understand the instructions for performing the tests.\n\nIn addition, for the control group:\n\n\\- Suffering from scoliosis","11 Years","18 Years",{"count":125,"type":22},70,[94],"Scoliosis is more than just a curve in the spine; it is a complex, 3D twisting of the backbone. While it can be caused by birth defects or tumors, the most common type-idiopathic scoliosis-appears in healthy teenagers for no clearly known reason.\n\nThe Theory of Balance Researchers believe that scoliosis might actually be caused by a \"glitch\" in how the body stays upright. Instead of the spine curving on its own, the curve might be the body's way of compensating for a poor sense of balance.\n\nTo stay balanced, the human brain relies on three main \"inputs\":\n\n1. The Vestibular System: Located in the inner ear (detects movement).\n2. Proprioception: The body's \"inner map\" (sensing where your limbs are).\n3. Vision: Seeing the world around you to stay oriented.\n\nThe Goal of the Study Even though humans rely heavily on their eyes to stay balanced, the role of vision in scoliosis has not been studied very much.\n\nThis experiment aims to test the hypothesis that teenagers with scoliosis have trouble processing visual information to maintain their posture. By using advanced motion analysis, researchers want to see if a \"misunderstanding\" of visual cues is contributing to the spinal deformity.",[28],"2026-05-22",{"date":131,"type":44},"2026-05-26",{"date":133,"type":44},"2026-04-21",{"date":135,"type":22},"2027-09-01",{"name":137,"class":51},"Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":145,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":92,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":113},"100625597","effect-of-bright-light-therapy-on-idiopathic-scoliosis-100625597","NCT07424703","Effect of Bright Light Therapy on Idiopathic Scoliosis","Effect of Morning Bright Light Therapy on the Onset and Progression of Idiopathic Scoliosis: A Prospective, Single-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age between 10 and 15 years.\n2. Classified as evening chronotype based on the reduced Horne-Östberg Morningness-Eveningness Questionnaire (rMEQ), defined as a score \\\u003C 12.\n3. Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.\n4. Skeletally immature (Risser sign 0-3) with a major Cobb angle \\\u003C 40 degrees at baseline.\n5. Written informed consent\u002Fassent provided by the participant and legal guardian.\n6. Willing and able to comply with the study protocol, including device use and scheduled follow-ups.\n\nExclusion Criteria:\n\n1. Plans to relocate outside the study area within the next 24 months.\n2. Use of medications that may interfere with circadian rhythm within the past 3 months (e.g., lithium, exogenous melatonin, melatonergic antidepressants).\n3. Trans-meridian travel across at least two time zones within the past 3 months or anticipated during the study period.\n4. Presence of any eye disease (e.g., glaucoma, retinal disease, macular degeneration) that could be exacerbated by or interfere with light therapy.\n5. Clinically diagnosed sleep disorder (e.g., narcolepsy, restless legs syndrome) or prominent medical condition known to interfere with sleep continuity and quality (e.g., moderate-to-severe eczema).\n6. Severe chronic health conditions that could confound study outcomes, including but not limited to:\n\n   * Known syndromic, neuromuscular, or congenital musculoskeletal causes of scoliosis.\n   * History of spine surgery or significant spinal trauma.\n   * Spinal tumor.\n   * Leg length discrepancy \\> 20 mm.\n   * Other severe chronic diseases (e.g., poorly controlled diabetes, chronic liver or renal disease, malabsorption syndromes).\n   * Severe obesity (body mass index z-score ≥ 3).","10 Years","15 Years",{"count":148,"type":22},120,[94],"This trial aims to investigate whether morning bright light therapy can reduce the progression rate of idiopathic scoliosis in children and potentially prevent its de novo development.",[28,152,153],"Eveningness","Delayed Sleep Phase","2026-05-14",{"date":156,"type":44},"2026-05-19",{"date":158,"type":44},"2025-09-01",{"date":160,"type":22},"2028-09-01",{"name":162,"class":51},"Second Affiliated Hospital of Wenzhou Medical University",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":170,"maxAge":146,"enrollmentInfo":171,"targetDuration":4,"studyType":92,"phases":173,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":113},"100618774","effect-of-vitamin-a-supplementation-on-idiopathic-scoliosis-100618774","NCT07335991","Effect of Vitamin A Supplementation on Idiopathic Scoliosis","Effect of Vitamin A Supplementation on the Onset and Progression of Idiopathic Scoliosis: A Prospective, Single-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age between 6 and 15 years.\n2. Biochemically confirmed vitamin A deficiency (serum retinol \\\u003C 0.20 mg\u002FL) or insufficiency (serum retinol 0.20-0.29 mg\u002FL).\n3. Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.\n4. Skeletally immature (Risser sign 0-3) with a major Cobb angle \\\u003C 40 degrees at baseline.\n5. Written informed consent\u002Fassent provided by the participant and legal guardian.\n\nExclusion Criteria:\n\n1. Unwillingness or inability to comply with all study procedures and follow-up visits.\n2. Plans to relocate outside the study area within the next 24 months.\n3. Previous high-dose vitamin A supplementation therapy within the past 12 months.\n4. Clinical signs of severe vitamin A deficiency syndrome (e.g., xerophthalmia, Bitot's spots).\n5. Serum vitamin A level \\> 0.70 mg\u002FL (to avoid risk of hypervitaminosis A).\n6. Severe chronic health conditions that could confound study outcomes, including but not limited to:\n\n   * Known syndromic, neuromuscular, or congenital musculoskeletal causes of scoliosis.\n   * History of spine surgery or significant spinal trauma.\n   * Spinal tumor.\n   * Leg length discrepancy \\> 20 mm.\n   * Other severe chronic diseases (e.g., poorly controlled diabetes, chronic liver or renal disease, malabsorption syndromes).\n   * Severe obesity (body mass index z-score ≥ 3).","6 Years",{"count":172,"type":22},140,[94],"This study aims to investigate whether vitamin A supplementation can influence spinal curve magnitude in idiopathic scoliosis children and potentially prevent its de novo development.",[176,28],"Vitamin A Deficiency",{"date":178,"type":44},"2026-05-15",{"date":180,"type":44},"2025-05-13",{"date":182,"type":22},"2028-06-01",{"name":162,"class":51},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":170,"maxAge":146,"enrollmentInfo":191,"targetDuration":4,"studyType":92,"phases":193,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":198,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":113},"100618527","effect-of-adenotonsillectomy-on-spinal-curve-magnitude-in-children-with-sleep-disordered-breathing-100618527","NCT07332780","Effect of Adenotonsillectomy on Spinal Curve Magnitude in Children With Sleep-Disordered Breathing","A Randomized Controlled Study of Adenotonsillectomy on Spinal Curve Magnitude in Children With Mild Sleep-Disordered Breathing","Inclusion Criteria:\n\n1. Age between 6 and 15 years.\n2. Diagnosed with mild SDB, defined as: Obstructive Apnea-Hypopnea Index (OAHI) ≤5 events\u002Fhour on a laboratory-based PSG performed within the past 6 months, AND parental report of habitual obstructive breathing symptoms (e.g., snoring, mouth-breathing, witnessed apneas) occurring \\>3 nights per week on average.\n3. Tonsillar hypertrophy grade ≥2 (on a scale of 0-4) and deemed an appropriate candidate for AT upon ENT evaluation (i.e., no absolute contraindications such as submucous cleft palate).\n4. Has undergone radiographic screening for idiopathic scoliosis at the first clinic visit.\n5. Skeletally immature (Risser sign 0-3) with spinal Cobb angle \\\u003C 40 degrees.\n6. Informed consent\u002Fassent provided by the participant and guardian.\n\nExclusion Criteria:\n\n1. Unwillingness or inability to comply with study procedures.\n2. Plans to relocate outside the study area within 24 months.\n3. Previous tonsillectomy or adenoidectomy.\n4. Recurrent tonsillitis meeting guideline criteria for immediate AT.\n5. Severe OSA (OAHI \\>10 or as per clinician judgment) or significant hypoxemia requiring immediate CPAP therapy.\n6. Severe chronic conditions that could confound outcomes, including but not limited to:\n\n   * Known syndromic, neuromuscular, or congenital musculoskeletal causes of scoliosis.\n   * History of spine surgery or significant spinal injury.\n   * Spinal tumor.\n   * Leg length discrepancy \\>20 mm.\n   * Severe cardiopulmonary disease (e.g., cystic fibrosis, congenital heart disease).\n   * Significant cardiac arrhythmia noted on PSG.\n   * Bleeding disorders, Sickle Cell Disease.\n   * Uncontrolled diabetes, narcolepsy, or asthma.\n   * Known genetic, craniofacial, neurological, or psychiatric conditions likely to affect the airway or study participation.\n   * Severe obesity (BMI z-score ≥ 3).",{"count":192,"type":22},160,[94],"This study aims to determine the effect of adenotonsillectomy (AT) surgery on the progression of spinal curvature in children with mild sleep-disordered breathing (SDB) and concurrent scoliosis, as well as its potential role in preventing the de novo development of scoliosis in children with SDB.",[196,28,197],"Sleep-disordered Breathing (SDB)","Obstructive Sleep Apnea (OSA)",{"date":178,"type":44},{"date":200,"type":44},"2025-07-11",{"date":202,"type":22},"2028-07-31",{"name":162,"class":51},{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":213,"conditions":214,"keywords":215,"overallStatus":218,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":227},"100637974","a-retrospective-review-outcomes-of-the-reflect-system-for-idiopathic-scoliosis-100637974","NCT07589023","A Retrospective Review: Outcomes of the REFLECT™ System for Idiopathic Scoliosis","A Retrospective Review of Clinical and Radiographic Outcomes Following the Use of the REFLECT™ Scoliosis Correction System in the Treatment of Idiopathic Scoliosis","Inclusion Criteria:\n\nSubjects must meet all of the following criteria to be included in the study:\n\n1. Requires surgical treatment to obtain and maintain correction of idiopathic scoliosis\n2. Skeletally immature\n3. Major Cobb angle of 30° and 65°\n4. Bone structure adequate to safely accommodate screw fixation\n5. Failed bracing treatment and\u002For intolerant to brace wear\n6. Treated with the REFLECT™ Scoliosis Correction System, using single or dual REFLECT cord(s) per curve\n7. Availability of medical and radiographic records evaluating the product under study preoperatively through a minimum of 12 months postoperative\n\nExclusion Criteria:\n\nPatients were excluded from the study if they met any of the following conditions:\n\n1. Presence of any systemic infection, local infection, or skin compromise at the surgical site\n2. Prior spinal surgery at the level(s) to be treated\n3. Known poor bone quality, defined as a T-score of -1.5 or less\n4. Any other medical or surgical condition which would preclude the potential benefit of spinal surgery, such as coagulation disorders, allergies to the implant materials, or patient unwillingness or inability to cooperate with postoperative care instructions",{"count":212,"type":22},100,"This study reviews medical records of children and adolescents treated for idiopathic scoliosis (a sideways curve of the spine with no known cause) using the REFLECT™ Scoliosis Correction System.",[28],[98,100,216,217],"spinal curve","REFLECT System","NOT_YET_RECRUITING","2026-05-11",{"date":178,"type":44},{"date":222,"type":22},"2026-06-15",{"date":224,"type":22},"2027-07-31",{"name":226,"class":78},"Globus Medical Inc",3,{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":17,"minAge":145,"maxAge":123,"enrollmentInfo":236,"targetDuration":4,"studyType":92,"phases":238,"briefSummary":240,"conditions":241,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":79},"100564232","phase-3-evaluation-of-analgesia-for-spine-fusion-elective-surgery-in-children-100564232","NCT06626503","Evaluation of Analgesia for Spine Fusion Elective Surgery in Children","Prospective Randomized Evaluation of Analgesia for Spine Fusion Elective Surgery in Children (PRECISE Spine Trial)","PRECISE","Inclusion Criteria:\n\n1. Age 10 - \\\u003C 18 years\n2. American Society of Anesthesiologists (ASA) Physical Status 1 or 2\n3. Undergoing PSF for idiopathic scoliosis\n4. Participant or legal guardian can speak and read English or Spanish\n\nExclusion Criteria:\n\n1. Pregnant patients\n2. Methadone allergy\n3. Preoperative prolonged QTc more than 460 msec (-30 days to 0 day)\n4. Subjects undergoing concomitant treatment with known cytochrome P450 inhibitors included in methadone labeling (i.e. macrolides (e.g. erythromycin), azole-antifungal agents (e.g. ketoconazole, voriconazole), protease inhibitors (e.g. ritonavir), fluconazole, SSRIs (e.g. sertraline, fluvoxamine)\n5. Preoperative opioid use within 30 days before surgery\n6. History of severe sleep apnea, defined as a prior sleep study demonstrating an apnea-hypopnea index (AHI) greater than 10.\n7. Significant liver, kidney, neurological disease, developmental delay, or any other co-existing medical condition per discretion of the clinical investigator",{"count":237,"type":22},500,[239],"PHASE3","The multicenter PRECISE Analgesia (Prospective Randomized Evaluation of Analgesia for Idiopathic Scoliosis Spine Fusion Elective Surgery in Children) trials will a) implement and investigate the efficacy and safety of multidose methadone-based standardized enhanced recovery after surgery (ERAS) protocol, and b) develop personalized ERAS protocols including precision methadone and oxycodone dosing and c) personalized analgesia for the safe and effective opioid-sparing management of surgical pain after posterior spine fusion (PSF) in children.",[28],"2026-04-29",{"date":244,"type":44},"2026-05-05",{"date":246,"type":44},"2025-10-30",{"date":248,"type":22},"2029-08-31",{"name":250,"class":51},"Senthil Sadhasivam",{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":11,"sex":17,"minAge":170,"maxAge":146,"enrollmentInfo":258,"targetDuration":4,"studyType":92,"phases":259,"briefSummary":260,"conditions":261,"keywords":4,"overallStatus":218,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":113},"100628812","effect-of-bifidobacterium-breve-supplementation-on-the-onset-and-progression-of-idiopathic-scoliosis-100628812","NCT07466511","Effect of Bifidobacterium Breve Supplementation on the Onset and Progression of Idiopathic Scoliosis","Effect of Bifidobacterium Breve Supplementation on the Onset and Progression of Idiopathic Scoliosis: A Prospective, Single-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 6 to 15 years\n\nDiagnosed with idiopathic scoliosis based on clinical evaluation and radiographic examination at the first clinic visit\n\nSkeletally immature, defined as Risser sign 0 to 3\n\nMajor Cobb angle \\\u003C 40 degrees at baseline\n\nWritten informed consent provided by the participant or legal guardian\n\nAble and willing to comply with study procedures\n\nExclusion Criteria:\n\n* Plans to relocate within the next 24 months\n\nUse of antibiotics, probiotics, hormones, immunosuppressants, or other nutritional supplements known to affect gut microbiota within the past 3 months or during the study period without investigator approval\n\nKnown allergy, sensitivity, or intolerance to the investigational product or its ingredients\n\nCurrent or prior significant gastrointestinal disease requiring medication, or history of gastrointestinal surgery\n\nSevere gastrointestinal symptoms such as persistent heartburn or indigestion\n\nMusculoskeletal, neurodevelopmental, syndromic, or other conditions that may account for the spinal deformity\n\nHistory of spine surgery or major spinal injury\n\nSpinal tumor or malignant disease involving the spine\n\nLeg length discrepancy \\> 20 mm\n\nSevere chronic diseases that could interfere with study participation or outcome assessment, including but not limited to diabetes, narcolepsy, or poorly controlled asthma\n\nSevere obesity, defined as BMI z-score ≥ 3",{"count":212,"type":22},[94],"Researchers hypothesized that Bifidobacterium breve Supplement could reduce the progression rate of idiopathic scoliosis in children and potentially prevent the occurrence of new cases of scoliosis.",[28],"2026-03-09",{"date":264,"type":44},"2026-03-12",{"date":266,"type":22},"2027-01-01",{"date":268,"type":22},"2030-12-31",{"name":162,"class":51},{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":4,"eligibilityCriteria":276,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":277,"targetDuration":4,"studyType":92,"phases":278,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":79},"100539051","reflect-scoliosis-system-post-approval-study-100539051","NCT06298812","REFLECT Scoliosis System Post Approval Study","A Prospective, Single-Arm, Multi-Center, Registry Post-Approval Study of Growth Modulation in the Treatment of Idiopathic Scoliosis With the REFLECT™ Scoliosis Correction System","Inclusion Criteria:\n\n* Diagnosis of progressive idiopathic scoliosis\n* Preoperative major Cobb angle 30°-65°\n* Preoperative flexibility to ≤30° on side bending radiograph (left or right)\n* Skeletally immature at the time of surgery with Risser sign \\\u003C5 or Sanders score \\\u003C8\n* Osseous structure dimensionally adequate to accommodate screw fixation, as determined by radiographic imaging\n* Failed or intolerant to bracing\n* Signed informed consent and\u002For assent forms specific to this study\n\nExclusion Criteria:\n\n* Prior spinal surgery at the level(s) to be treated\n* Documented poor bone quality, defined as a T-score of -1.5 or less\n* Presence of any systemic infection, local infection, or skin compromise at the surgical site\n* Any medical or surgical condition which would preclude the potential benefit of spinal surgery, such as coagulation disorders, allergies to the implant materials, and patient's unwillingness or inability to cooperate with post-operative care instructions\n* Unwillingness, inability, or living situation (e.g. custody arrangements, homelessness, detention) that would preclude ability to return to the study site for follow-up visits as described in protocol and Informed Consent\n* Active participation in a drug or device study that is more than minimal risk such that participation would confound the measurements of the present study",{"count":212,"type":22},[94],"The purpose of this multi-center, prospective, single-arm registry Post-Approval Study (PAS) is to evaluate the radiographic and clinical outcomes of 100 patients with idiopathic scoliosis treated with the REFLECT™ Scoliosis Correction System, as a condition of HDE approval",[28],"2026-02-11",{"date":283,"type":44},"2026-02-13",{"date":285,"type":44},"2024-04-08",{"date":287,"type":22},"2032-03-31",{"name":226,"class":78},{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":105,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":17,"minAge":145,"maxAge":123,"enrollmentInfo":296,"targetDuration":4,"studyType":92,"phases":298,"briefSummary":299,"conditions":300,"keywords":301,"overallStatus":218,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":4},"100624742","implementation-of-specific-tailored-exercises-program-versus-exergaming-exercises-on-cobb-angle-in-the-treatment-of-adolescent-idiopathic-scoliosis-100624742","NCT07413588","Implementation of Specific Tailored Exercises Program Versus Exergaming Exercises on Cobb Angle in the Treatment of Adolescent Idiopathic Scoliosis.","Implementation of Specific Tailored Exercises Program Versus Exergaming Exercises on Cobb Angle in the Treatment of Adolescent Idiopathic Scoliosis: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Thoracic spine region with C-shaped scoliosis\n* Individuals aged 10-18 years\n* Cobb's angle from 10 to 25 degrees\n* Both genders (male and female)\n* Adolescent idiopathic scoliosis\n\nExclusion Criteria:\n\n* Mental health disorders\n* Neuromuscular or rheumatic diseases\n* A history of spinal surgery\n* Patients been prescribed brace treatment\n* Leg length discrepancy",{"count":297,"type":22},54,[94],"this study will be conducted to investigate the difference between specific tailored exercise program and exergaming exercises on Cobb's angle, angle of trunk rotation, pulmonary function and quality of the life in adolescent idiopathic scoliosis.",[28],[302,303,304,29],"Tailored Exercises Program","Exergaming Exercises","Cobb Angle","2026-02-09",{"date":307,"type":44},"2026-02-17",{"date":309,"type":22},"2026-02-10",{"date":311,"type":22},"2026-12-10",{"name":313,"class":51},"Cairo University",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":17,"minAge":321,"maxAge":123,"enrollmentInfo":322,"targetDuration":4,"studyType":92,"phases":323,"briefSummary":324,"conditions":325,"keywords":4,"overallStatus":218,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":332,"locationsCount":113},"100621159","three-dimensional-correction-methods-for-idiopathic-scoliosis-in-adolescent-100621159","NCT07366996","Three-Dimensional Correction Methods for Idiopathic Scoliosis in Adolescent","Three-Dimensional Correction Methods for Idiopathic Scoliosis in Adolescent: Comparative Study","Inclusion Criteria:\n\n* Teenagers diagnosed with typical idiopathic scoliosis.\n* Teenagers aged 13 to 18 years\n* Both genders will be included.\n* Participants with a Cobb angle ranging from 10° to 25°, as determined by radiographic analysis.\n* Participants with Risser sign of 2 to 3, indicating incomplete skeletal maturity.\n* Participants must be able to understand and follow instructions, ensuring effective participation in the treatment protocol.\n\nExclusion Criteria:\n\n* Adolescents with significant visual or auditory impairments that could interfere with the ability to participate in or benefit from the rehabilitation programs.\n* Adolescents with cognitive, mental, or psychological disorders that hinder understanding or following the instructions necessary for the treatment protocol.\n* Adolescents who have previously undergone spinal surgery or any surgical interventions related to scoliosis or other spinal conditions.\n* Adolescents with non-idiopathic scoliosis or scoliosis secondary to other underlying conditions (e.g., neuromuscular, congenital, or syndromic scoliosis).\n* Adolescents with fixed spinal deformities that are not amenable to correction through non-surgical 3D approach.\n* Adolescents with concurrent musculoskeletal conditions that could interfere with the treatment or assessment of scoliosis (e.g., significant hip or knee deformities).\n* Adolescents currently participating in other clinical trials or receiving treatments that might confound the study results.","13 Years",{"count":91,"type":22},[94],"This study aims to compare the effectiveness of \"Schroth method\" and \"Scientific Exercise Approach to Scoliosis\" for correcting idiopathic scoliosis in adolescents.",[28],"2026-01-17",{"date":328,"type":44},"2026-01-26",{"date":330,"type":22},"2026-02-01",{"date":178,"type":22},{"name":313,"class":51},{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":4,"eligibilityCriteria":339,"healthyVolunteers":11,"sex":17,"minAge":123,"maxAge":4,"enrollmentInfo":340,"targetDuration":4,"studyType":92,"phases":342,"briefSummary":343,"conditions":344,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":113},"100579122","analgesic-efficacy-of-multiple-mid-transverse-process-to-pleura-mtp-block-and-pca-in-idiopathic-scoliosis-patients-undergoing-posterior-spinal-fusion-100579122","NCT06820190","Analgesic Efficacy of Multiple Mid-Transverse Process to Pleura (MTP) Block and PCA in Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion","Comparison of Analgesic Efficacy of Multiple Mid-Transverse Process to Pleura (MTP) Block and PCA in Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n* Idiopathic scoliosis patients undergoing posterior spinal fusion surgery.\n\nExclusion Criteria:\n\n* Patients with pre-existing infection at block site.\n* Known allergy to study drugs.\n* Coagulation disorder.\n* History of psychiatric illness.\n* Pre-existing neurological deficits.\n* Patient with morbid obesity (body mass index \\>40 kg\u002Fm2).\n* Presence of any pre-operative pain or history of chronic pain.\n* History of regular analgesic.",{"count":341,"type":22},40,[94],"This study aims to compare the analgesic efficacy of multiple mid-transverse process to pleura (MTP) block and PCA in idiopathic scoliosis patients undergoing posterior spinal fusion surgery.",[345,346,28,347],"Multiple Mid-Transverse Process to Pleura","PCA","Posterior Spinal Fusion","2026-01-06",{"date":350,"type":44},"2026-01-07",{"date":352,"type":44},"2025-02-12",{"date":354,"type":22},"2026-12-01",{"name":356,"class":51},"Tanta University",{"id":358,"slug":359,"hasResults":11,"nctId":360,"briefTitle":361,"officialTitle":361,"acronym":362,"eligibilityCriteria":363,"healthyVolunteers":11,"sex":17,"minAge":122,"maxAge":364,"enrollmentInfo":365,"targetDuration":4,"studyType":92,"phases":367,"briefSummary":368,"conditions":369,"keywords":370,"overallStatus":218,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":381,"locationsCount":383},"100585887","multicentric-evaluation-of-enhanced-recovery-after-surgery-protocol-in-adolescent-idiopathic-scoliosis-surgery-100585887","NCT06908213","Multicentric Evaluation of Enhanced Recovery After Surgery Protocol in Adolescent Idiopathic Scoliosis Surgery","EMRACSIA","Inclusion Criteria:\n\n* Adolescents between 11 and 17 years old\n* Adolescent idiopathic scoliosis diagnosis\n* Posterior vertebral fusion surgery indicated to treat the patient\n* Informed consent signed by both parents \u002F legal guardians\n\nExclusion Criteria:\n\n* Comorbidities that might influence the duration of hospitalization (e.g. respiratory failure, diabetes…)\n* Previous spine surgery\n* Patient not benefiting from an health insurance plan\n* Pregnant, parturient or breastfeeding woman\n* Patient benefiting of psychiatric care\n* Patient subject to a legal protection measure (guardianship, curatorship)","17 Years",{"count":366,"type":22},316,[94],"Adolescent idiopathic scoliosis is a deformation of the spine affecting 2 to 4% of under 18 years old population. This can have severe physical or psychological impact during adulthood. The deformation causes mechanical constraints resulting in early osteoarthritis, which results in adulthood disability.\n\nThere is also an impact on the respiratory function in most severe cases of idiopathic scoliosis. Adolescents affected by a scoliosis with an angle of 40° of more undergo a surgery called posterior fusion during adolescence to limit these impacts.\n\nIn France, more than 1000 adolescent patients undergo a surgery called posterior spinal fusion for their severe scoliosis.\n\nThis aims to straighten the spine by bone grafting all the vertebras included in the scoliosis. Two metal rods are implanted to favour osteosynthesis of the straight spine.\n\nThis intervention suffer of a bad image and worries the patients and their parents, as it needs metal implants near the spinal cord.\n\nThe worry comes from the most severe complication that may happen exceptionally following this surgery, which is a definitive paraplegia. The scar is quite large and the surgery reduces the mobility of a part of the spine. The intervention produces a quite large haemorrhage, which leads to a diminution in haemoglobin level, resulting in a fatigue during the following weeks.\n\nOn the following days, the patient will need a specific protocol of pain management including morphine-based and anti-inflammatory drugs.\n\nThis intervention will often require a 5 to 7 days hospitalization with a 1 to 2 month convalescence period at home or in rehabilitation centre.\n\nThis intervention is performed on adolescent patients without comorbidities. Moreover, the surgical approach is not profound passing between the para-vertebral muscles with no close large blood vessels or major organs. The pain is caused by correction tensions and the access to the vertebras during the surgery.\n\nSurgical techniques have considerably evolved allowing shorter interventions and to reduce the loss of blood.\n\nThe association between morphine-based treatments and grade I analgesics enables an effective pain management.\n\nThis intervention appears to perfectly suit to an enhanced recovery after surgery procedure (ERAS).\n\nERAS is a set of procedure meant to enhance its tolerance and to reduce its morbidity and the hospitalization duration after surgery and the recovery duration.\n\nERAS is well developed in adult patients undergoing surgery, it is also well described in paediatric patient especially on adolescent scoliosis surgeries.\n\nAs the pain is well controlled during the hospitalization as well when the patient get back home, there are very few obstacles to an ERAS procedure in this indication for a patient without comorbidities.\n\nNumerous articles report experiences of medical staff with ERAS protocols.\n\nGenerally, the set of measures includes:\n\n* Before surgery: Providing information and therapeutic patient education, iron supplementation, physiotherapy, skin disinfection, digestive preparation against constipation\n* During surgery: recuperations of blood cells to limit blood loss, use of modern tools to facilitate the positioning of pedicle screws, surgery performed by 2 surgeons\n* After surgery: Pain management until stopping of analgesics by patient and maintenance of a link between the patient at home and the hospital staff after end of hospitalization The articles published about ERAS reports a favourable experience of such protocols with an efficient pain management, reduced hospitalization durations without increasing morbidity or re-hospitalizations. However, no studies have studied and proved by a robust scientific method the benefits of ERAS in adolescent scoliosis.\n\nNo studies evaluate the patients' quality of life or follow the patient for more than 6 months after surgery (limiting the assessment of long term complications e.g. infectious complications).\n\nThe link between hospital staff and the patient after his return back home is not described as well.\n\nThis research project aims to confirm with a robust scientific approach that ERAS protocols in idiopathic scoliosis in adolescents allow to reduce the duration of hospitalization compared to standard of care procedures while improving quality of life after surgery.",[28],[371,372,373],"Idiopathic scoliosis","adolescents","Enhanced recovery after surgery","2025-03-26",{"date":376,"type":44},"2025-04-03",{"date":378,"type":22},"2025-05-01",{"date":380,"type":22},"2029-04-01",{"name":382,"class":51},"Hospices Civils de Lyon",11,{"id":385,"slug":386,"hasResults":11,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":4,"eligibilityCriteria":390,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":146,"enrollmentInfo":391,"targetDuration":4,"studyType":92,"phases":393,"briefSummary":394,"conditions":395,"keywords":396,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":405,"leadSponsor":407,"locationsCount":79},"100449892","scoliosis-specific-exercises-for-mild-idiopathic-scoliosis-100449892","NCT05138393","Scoliosis-specific Exercises for Mild Idiopathic Scoliosis","PREventing Mild Idiopathic SCOliosis PROgression (PREMISCOPRO): a Randomized Controlled Trial Comparing Scoliosis-specific Exercises to Observation in Mild Idiopathic Scoliosis","Inclusion Criteria:\n\n* Cobb 15-24 degrees\n* Skeletally immature, Sanders score of 4 or less and Risser \\\u003C 2.\n* No menarche for females\n* Aged 9-15 years\n* Apex of the primary curve at T7 or caudal\n\nExclusion Criteria:\n\n* Non-idiopathic scoliosis (i.e. neuromuscular, syndromic or congenital scoliosis)\n* No previous surgical or brace treatment for scoliosis",{"count":392,"type":22},90,[94],"Idiopathic scoliosis is the most common spinal deformity in children and adolescents with an estimated prevalence of 3%. About one tenth of the children with scoliosis develop a deformity that requires treatment with brace or surgery with the current treatment protocol. In Sweden, mild scoliosis curves not requiring treatment, but at risk for progression during childhood, are only observed until skeletal maturity without active treatment. If progression occurs and treatment is required, standard treatment consists of bracing 20 hours or more per day. Scoliosis-specific exercises have been reported to be a possible treatment modality in terms of halting progression in mild scoliosis, but the findings are not generally accepted.",[28],[371,397,398,399,400],"Randomized controlled trial","Exercise","Rehabilitation","Self-correction","2025-02-20",{"date":403,"type":44},"2025-02-21",{"date":73,"type":44},{"date":406,"type":22},"2037-11-30",{"name":408,"class":51},"Karolinska Institutet",{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":415,"eligibilityCriteria":416,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":364,"enrollmentInfo":417,"targetDuration":4,"studyType":92,"phases":419,"briefSummary":420,"conditions":421,"keywords":422,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":425,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":79},"100424326","brace-treatment-for-idiopathic-scoliosis-preventing-idiopathic-scoliosis-progression-100424326","NCT04805437","Brace Treatment for Idiopathic Scoliosis; PReventing Idiopathic SCOliosis PROgression","3D Designed Boston Brace Versus Standard Boston Brace in Halting Progression in Idiopathic Scoliosis: a Randomized Controlled Trial","PRISCOPRO","Inclusion Criteria:\n\n* Cobb 25-40 degrees\n* Skeletally immature, Sanders score of 6 or less and Risser 2 or less.\n* Menarche status maximum one year in females\n* Aged 9-17 years\n* No previous brace treatment or surgery for scoliosis\n* Apex of the primary curve at T7 or caudal\n\nExclusion Criteria:\n\n* Non-idiopathic scoliosis (i.e. neuromuscular, syndromic or congenital scoliosis)\n* Previous spine surgery",{"count":418,"type":22},170,[94],"Idiopathic scoliosis is the most common spinal deformity in children and adolescents with an estimated prevalence of 3%. About one tenth of the children with scoliosis develop a deformity that requires treatment with brace or surgery with the current treatment protocol. When brace treatment for scoliosis is indicated, standard treatment consists of bracing 20 hours or more per day. Outcomes of brace treatment depend to a large extent on wearing time and since many adolescents feel uncomfortable in the brace, it is of importance to combine efficacy and comfortability of the brace.",[28],[371,397,423,424],"Brace","Orthosis",{"date":403,"type":44},{"date":427,"type":44},"2021-04-30",{"date":429,"type":22},"2037-04",{"name":408,"class":51},{"id":432,"slug":433,"hasResults":11,"nctId":434,"briefTitle":435,"officialTitle":435,"acronym":4,"eligibilityCriteria":436,"healthyVolunteers":16,"sex":17,"minAge":437,"maxAge":438,"enrollmentInfo":439,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":441,"conditions":442,"keywords":443,"overallStatus":218,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":4},"100575877","implementation-of-momentum-spinetm-a-new-3d-imaging-software-for-idiopathic-scoliosis-100575877","NCT06777992","Implementation of Momentum SpineTM: a New 3D Imaging Software for Idiopathic Scoliosis","Inclusion Criteria:\n\n* Children aged between 8 and 14 with a confirmed radiographic diagnosis of Idiopathic Scoliosis who have not undergone spinal nor thoracic surgery.\n\nExclusion Criteria:\n\n* Patients who may be pregnant. Patients with the existence of a second deformity, or any other neuromuscular condition.","8 Years","14 Years",{"count":440,"type":22},142,"Brief Summary\n\nThe goal of this clinical trial is to evaluate the implementation of Momentum Spine™, a new 3D imaging software designed to improve the monitoring and management of idiopathic scoliosis in children aged 8-14 years. Idiopathic scoliosis affects 1-3% of the pediatric population and is currently monitored through hospital visits with radiographic imaging every 4-6 months, which exposes patients to cumulative radiation over time. This study explores whether Momentum Spine™ can provide a safer, more accessible alternative by enabling at-home monitoring using clinical photographs taken on smartphones.\n\nThe primary questions this study seeks to answer are:\n\nCan Momentum Spine™ accurately predict scoliosis progression, including Cobb angle changes, compared to standard radiographic assessments? Can the use of Momentum Spine™ reduce the number of X-rays required and improve the timing of clinical follow-ups? Does the use of Momentum Spine™ affect patient satisfaction, healthcare utilization, and overall quality of life? This study is a prospective, two-arm randomized controlled trial conducted at CHU Sainte-Justine. Participants will be divided into two groups: the control group will receive standard care, which involves regular clinical visits and radiographic evaluations; the intervention group will use Momentum Spine™ at home, alongside standard care.\n\nIntervention Details\n\nParticipants in the intervention group will:\n\nUse the Momentum Spine™ application to capture 3D images of their torso at home every two months. These images will be processed by Momentum Spine™ algorithms to assess curve progression.\n\nParticipants will receive notifications and guidance on performing scans at home, supported by the study team to ensure accuracy.\n\nThe primary outcomes include clinical measures such as changes in Cobb angle at 1 and 2 years, curve progression of more than 5 degrees, whether the main curve reaches 45 degrees, and the need for surgical referral. Secondary outcomes focus on the accuracy, sensitivity, and specificity of Momentum Spine™, as well as patient-reported measures such as health-related quality of life and satisfaction with care, users' acceptability of the software, healthcare services utilization and pathway costs.\n\nThis study also aims to address key challenges in scoliosis care, including reducing radiation exposure, improving follow-up timing to align with growth spurts, and providing equitable access to care for families who may live far from specialty clinics. By validating the performance of Momentum Spine™, this trial has the potential to transform scoliosis management, ensuring safer and more effective care pathways.",[27,28],[371,444,445,446,447,448],"Screening","Spine deformity","Progression","Non-invasive 3D scans","Pediatrics","2025-01-10",{"date":451,"type":44},"2025-01-16",{"date":453,"type":22},"2025-03",{"date":455,"type":22},"2028-12",{"name":457,"class":51},"St. Justine's Hospital",{"id":459,"slug":460,"hasResults":11,"nctId":461,"briefTitle":462,"officialTitle":463,"acronym":4,"eligibilityCriteria":464,"healthyVolunteers":11,"sex":17,"minAge":438,"maxAge":4,"enrollmentInfo":465,"targetDuration":4,"studyType":92,"phases":466,"briefSummary":467,"conditions":468,"keywords":471,"overallStatus":218,"whyStopped":4,"lastUpdateSubmitDate":473,"lastUpdatePostDateStruct":474,"startDateStruct":476,"completionDateStruct":478,"leadSponsor":480,"locationsCount":113},"100572037","erector-spinae-plane-block-vs-patient-controlled-analgesia-in-correction-surgery-for-idiopathic-scoliosis-100572037","NCT06728046","Erector Spinae Plane Block v.s Patient Controlled Analgesia in Correction Surgery for Idiopathic Scoliosis","Analgesic Effects of Ultrasound-Guided Erector Spinae Plane Block v.s Patient Controlled Analgesia in Correction Surgery for Idiopathic Scoliosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 14 years or older, regardless of gender.\n* Scheduled for scoliosis correction surgery.\n* Signed informed consent from the participant or their legal guardian.\n\nExclusion Criteria:\n\n* Allergy to local anesthetics such as ropivacaine.\n* Family history of malignant hyperthermia.\n* Severe systemic diseases affecting the heart, lungs, liver, or kidneys.\n* Neurological or psychiatric disorders.\n* Communication difficulties, such as hearing impairment or speech disorders.\n* Concurrent participation in other clinical studies.\n* Other conditions deemed unsuitable for participation by the investigators.",{"count":341,"type":22},[94],"Scoliosis correction surgery involves extensive surgical wounds, intense intraoperative stimulation, and severe postoperative pain, often necessitating the use of potent opioids. However, there is a critical clinical need for effective pain management strategies that both ensure sufficient analgesia and minimize opioid-related adverse effects. The Erector Spinae Plane Block (ESPB) has shown promise as an effective analgesic technique, but its application in scoliosis correction surgery has not been reported.We hypothesize that ESPB provides superior postoperative analgesia compared to patient-controlled intravenous analgesia (PCA) pumps. Specifically, ESPB is expected to significantly reduce postoperative pain scores, decrease perioperative opioid consumption, and mitigate opioid-related side effects.\n\nThis study is a randomized controlled trial involving 40 participants undergoing scoliosis correction surgery, randomized into two groups: the ESPB group and the PCA group. The primary outcome measure is the resting pain score at 2 hours postoperatively, which will be used to evaluate the efficacy of ESPB. Secondary outcomes include perioperative opioid consumption and the incidence of opioid-related adverse effects. The study aims to provide evidence for ESPB as an innovative and effective method for postoperative analgesia in scoliosis correction surgery.",[28,469,470],"Erector Spinae Plane Block","Patient Controlled Analgesia",[469,470,472],"Idiopathic Scoliosis Correction Surgery","2024-12-06",{"date":475,"type":44},"2024-12-11",{"date":477,"type":22},"2025-01-01",{"date":479,"type":22},"2027-05-31",{"name":481,"class":51},"West China Hospital",{"id":483,"slug":484,"hasResults":11,"nctId":485,"briefTitle":486,"officialTitle":486,"acronym":4,"eligibilityCriteria":487,"healthyVolunteers":11,"sex":17,"minAge":321,"maxAge":488,"enrollmentInfo":489,"targetDuration":4,"studyType":92,"phases":490,"briefSummary":491,"conditions":492,"keywords":495,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":506,"leadSponsor":508,"locationsCount":113},"100528458","precision-medicine-for-nociception-sngception-and-proprioception-100528458","NCT06161038","Precision Medicine for Nociception, Sngception and Proprioception.","Inclusion Criteria:\n\n1.Cohort A:\n\n(1) Age between 20-100 years old. (2) VAS\\>=30 or VAS\\>=30 at 4 kg pressure (3) Diagnosed as myofascial pain syndrome patients and willing to receive treatment (including LLLT, therapeutic ultrasound, and local dextrose injection therapy) 2. Cohort B:\n\n1. Age between 13-65 years old.\n2. Diagnosed as idiopathic scoliosis The diagnosis of scoliosis was confirmed by antero-posterior plain Xray with Cobbs angle larger than 10 degrees.\n\nExclusion Criteria:\n\n1.Cohort A: Those having active infection, malignancy, and hematological diseases were excluded. The patients had received local injection at upper trapezius within 6 months are also excluded.\n\n2.Cohort B:\n\n1. Those having active infection, malignancy, and hematological diseases were excluded.\n2. Those having specific etiologies of scoliosis, including congenital scoliosis due to malformation or faulty segmentation of the vertebrae and neuromuscular scoliosis due to muscular imbalance, syndromic scoliosis or degenerative scoliosis.\n3. Pregnancy.","100 Years",{"count":192,"type":22},[94],"Precision medicine is defined as \"an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person\" by the Precision Medicine Initiative.\n\nPatients have different response to different treatment modalities, and sore\u002Fpain medicine is no exception. In our experience, low-level laser (LLL), ultrasound, and prolotherapy can reduce sore \u002Fpain through different genetic pathway. Whether the therapeutic effect is controlled by the genetic variants of those sore \u002Fpain related genes or not, is still in debate. The aims of this study are (1) To set up next generation sequencing (NGS)-based approach to find genetic variants which can determine the response of sng\u002Fpain treatment modalities and the phenotype of idiopathic scoliosis. (2) To find possible metabolomics and proteomic markers of sng\u002Fpain. (3) To determine the algorithm of precision medicine for sng\u002Fpain control via the genetic markers.\n\nInvestigators will recruit 80 myofascial pain participant and 80 idiopathic scoliosis participant from Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Bei-Hu Branch in 2023 and 2025. The myofascial pain participant participants will receive LLL, ultrasound, and prolotherapy, and the therapeutic effect will be recorded. The clinical trial will evaluate the Sng \u002F pain (VAS) and muscle tone of the idiopathic scoliosis participant. The blood and urine samples from the first, the second, and the third visits will be analyzed by next generation sequencing, and mass spectrometry to find the possible biomarker in 2024 and 2025. Investigators expect to develop the individualized treatment plan by means of these biomarkers. Hopefully, the results will be widely applied in the field of sore \u002Fpain medicine.",[399,493,494,28],"Pain, Shoulder","Pain, Chronic",[496,497,498,499,500],"Sng \u002F Pain","Precision medicine","Next generation sequencing","Proprioception","Prolotherapy","2024-10-17",{"date":503,"type":44},"2024-10-21",{"date":505,"type":44},"2023-10-01",{"date":507,"type":22},"2025-12-31",{"name":509,"class":51},"National Taiwan University Hospital",{"id":511,"slug":512,"hasResults":11,"nctId":513,"briefTitle":514,"officialTitle":515,"acronym":4,"eligibilityCriteria":516,"healthyVolunteers":11,"sex":17,"minAge":123,"maxAge":517,"enrollmentInfo":518,"targetDuration":4,"studyType":92,"phases":519,"briefSummary":520,"conditions":521,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":529,"leadSponsor":530,"locationsCount":113},"100559362","a-suggested-rehabilitation-protocol-for-the-treatment-of-c-shape-scoliosis-100559362","NCT06563141","A Suggested Rehabilitation Protocol for the Treatment of C-shape Scoliosis","A Suggested Rehabilitation Protocol for the Treatment of C-shape Scoliosis: a Randomized Control Trial","Inclusion Criteria:\n\n1. Adult individuals aged 18 to 30 years (after complete ossification and before the start of the ageing process and joint changes) as mentioned in studies.\n2. Thoracolumbar scoliosis with Cobb angle between 10 to 30 degrees because a curve below 10 degrees has no effect and above 30 is indicated for surgery.\n\nExclusion Criteria:\n\n1. History of orthopaedic surgeries.\n2. History of road traffic accidents (RTA).\n3. Myopathy.\n4. True leg length discrepancy.\n5. Neuropathy.\n6. Mental disorders.\n7. Bone tumor.\n8. Heart disease or circulatory problems.\n9. Early osteoporosis.","30 Years",{"count":125,"type":22},[94],"This study aims to compare the effectiveness of mechanical traction and 3D apical vertebral mobilization and active exercises on Cobb's angle, spinal ROM, and function in patients with C-shaped scoliosis.",[28,522,399,523],"Scoliosis Idiopathic","C-shape","2024-08-17",{"date":526,"type":44},"2024-08-20",{"date":528,"type":44},"2024-07-01",{"date":378,"type":22},{"name":313,"class":51}]