[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ileus-postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ileus-postoperative":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,77,98,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100639650","oral-lactulose-for-gastrointestinal-recovery-after-complex-appendectomy-100639650",false,"NCT07589465","Oral Lactulose for Gastrointestinal Recovery After Complex Appendectomy","Oral Lactulose for Postoperative Gastrointestinal Recovery After Complex Appendectomy: A Prospective Triple-Blind Placebo-Controlled Single-Center Randomized Trial","Inclusion Criteria:\n\n* 1.Age ≥18 years.2.Complicated appendicitis confirmed by SAS2.0 score, intraoperative findings, or pathology.3.Undergoing appendectomy (open or laparoscopic).4.Able to provide informed consent and comply with follow-up.\n\nExclusion Criteria:\n\n* 1.Preoperative intestinal obstruction, IBD, or intestinal tumor.2.Planned postoperative fasting \\>48 hours.3.Hypersensitivity to lactulose or placebo.4.Severe organ dysfunction (ASA ≥IV).5.Pregnancy or lactation.6.Cognitive or psychiatric disorder impairing follow-up.","ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a prospective, triple-blind, placebo-controlled, single-center randomized clinical trial to evaluate the efficacy and safety of early oral lactulose for promoting postoperative gastrointestinal functional recovery in patients undergoing appendectomy for complicated appendicitis. Eligible patients aged ≥18 years with complicated appendicitis confirmed by preoperative SAS 2.0 score, intraoperative findings, or postoperative pathology will be randomly assigned 1:1 to receive oral lactulose or placebo on postoperative day 1 and day 2. The primary outcome is time to GI-2 (time from surgery to the later of first defecation or first tolerance of solid food). Secondary outcomes include time to first flatus, defecation rate within 72 hours, postoperative nausea and vomiting, length of hospital stay, medical costs, postoperative complications, and lactulose-related adverse events. A total of 150 patients will be enrolled. This study aims to provide high-level evidence for optimizing postoperative management in patients with complicated appendicitis.",[26,27,28],"Ileus Postoperative","Gastrointestinal Function","Complicated Appendicitis","RECRUITING","2026-06-20",{"date":32,"type":33},"2026-06-25","ACTUAL",{"date":35,"type":20},"2026-06-21",{"date":37,"type":20},"2029-06-30",{"name":39,"class":40},"Nanchong Central Hospital","OTHER_GOV",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100631119","the-acure-trial-acupuncture-for-colorectal-recovery-100631119","NCT07496528","The ACURE Trial: Acupuncture for Colorectal Recovery","Acupuncture for Colorectal sUrgery Recovery Enhancement: A Randomized Controlled Trial Evaluating Gastrointestinal Functional Recovery After Minimally Invasive Resection","ACURE","Inclusion Criteria:\n\n* Histologically confirmed colorectal cancer requiring scheduled curative-intent resection.\n* Age between 18 and 79 years, inclusive.\n* Ability to understand the study protocol and provide written informed consent.\n* American Society of Anesthesiologists (ASA) physical status classification of I, II, or III.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women.\n* History of major abdominal surgery within the past 4 weeks.\n* Receipt of chemotherapy or radiotherapy within the past 6 months.\n* History of organ transplantation with rejection episodes within the past 30 days.\n* Presence of active infection (e.g., tuberculosis, sepsis, peritonitis).\n* Positive for hepatitis B, hepatitis C, or HIV with an uncontrolled viral load.\n* Severe malnutrition, defined as a Nutritional Risk Screening (NRS 2002) score ≥ 3.\n* History of total colectomy or requirement for ileorectal anastomosis.\n* Requirement for multivisceral resection due to tumor invasion.\n* Scheduled for prophylactic stoma creation.\n* Moderate to severe cognitive impairment, epilepsy, or uncontrolled neurological disorders.\n* Active psychiatric illness (e.g., bipolar disorder, schizophrenia) that may interfere with study compliance.\n* Severe cardiopulmonary insufficiency (e.g., New York Heart Association \\[NYHA\\] class IV heart failure or requirement for long-term oxygen therapy).\n* Presence of open wounds, skin infections, or known allergies at or near the designated acupuncture sites.\n\nHistory of adverse reactions to acupuncture, including syncope (fainting) or needle phobia.\n\nParticipation in another clinical trial within the past 6 months.\n\nAnticipated inability to complete the study protocol due to physical, psychological, or logistical reasons.","80 Years",{"count":52,"type":20},240,[23],"Purpose:\n\nThe goal of this clinical trial is to evaluate whether electroacupuncture (EA) can accelerate the recovery of bowel function in patients undergoing minimally invasive surgery for colorectal cancer.\n\nMain Questions to be Answered:\n\nDoes electroacupuncture reduce the time to the first bowel movement after surgery compared to standard care or a \"sham\" (placebo) treatment?\n\nCan electroacupuncture improve overall gastrointestinal tolerance and reduce postoperative discomfort?\n\nStudy Design:\n\nParticipants will be randomly assigned to one of three groups:\n\nElectroacupuncture Group: Receives active electrical stimulation at specific acupuncture points.\n\nSham Acupuncture Group: Receives superficial needling at non-treatment points with no electrical current to serve as a placebo.\n\nStandard Care Group: Receives standard hospital recovery protocols (ERAS) without acupuncture.\n\nAll treatments will consist of four 30-minute sessions: one before surgery and three on the days following the procedure. Researchers will compare the three groups to see if the electroacupuncture group experiences a faster return of digestive function.",[56,26,57,58],"Colorectal Neoplasms","Postoperative Complication","Gastrointestinal Motility",[60,61,62,63,64,65],"electroacupuncture","acupuncture therapy","colorectal cancer","enhanced recovery after surgery","minimally invasive surgery","postoperative ileus","NOT_YET_RECRUITING","2026-03-31",{"date":69,"type":33},"2026-04-06",{"date":71,"type":20},"2026-04-01",{"date":73,"type":20},"2029-05-31",{"name":75,"class":76},"Chang Gung Memorial Hospital","OTHER",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":84,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":41},"100524383","effect-of-lollipop-on-postoperative-gastrointestinal-recovery-in-children-100524383","NCT06108011","Effect of Lollipop on Postoperative Gastrointestinal Recovery in Children","Effect of Lollipop on Postoperative Gastrointestinal Recovery in Children: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Patients receiving major abdominal surgery (e.g.appendicectomy, choledochal cyst surgery, bowel resection etc)\n\nExclusion Criteria:\n\n* Patients with neurological conditions that preclude sucking\u002Fswallowing.\n* Patients under sedation and\u002For mechanical ventilation and\u002For ionotropic support in the post operative period.\n* Patients with known food allergy or allergy to food coloring agents",{"count":85,"type":20},50,[23],"Postoperative ileus is common in children. There are various method to prevent postoperative ileus. In this study, the investigators will explore the role of sucking lollipop after operation on the recovery of gastrointestinal function in children.",[26],"2024-12-05",{"date":91,"type":33},"2024-12-11",{"date":93,"type":33},"2023-12-01",{"date":95,"type":20},"2025-06",{"name":97,"class":76},"The University of Hong Kong",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":106,"minAge":17,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":21,"phases":110,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":126},"100510180","phase-2-preventing-gastrointestinal-disturbance-in-patients-after-longitudinal-laparotomy-100510180","NCT05923086","Preventing Gastrointestinal Disturbance in Patients After Longitudinal Laparotomy.","A Multi-center, Randomized, Double Blind, Placebo-controlled, Phase 2 Study to Investigate the Efficacy of ORE-001 in Preventing Gastrointestinal Disturbance\u002F Intolerance in Patients After Longitudinal Laparotomy","ORE001PIIPOI","Inclusion Criteria:\n\n1. Patient must be able to understand the requirements of the study and give written informed consent prior to study start.\n2. Female patients aged between 18 and 75 years (both inclusive).\n3. Gynecologic surgery performed completely by longitudinal laparotomy.\n4. Patient with ECOG Performance status up to 1.\n5. Patient is highly likely to comply with the protocol and complete the study.\n6. Patient agrees to be scheduled for peridural catheter (PDC).\n\nExclusion Criteria:\n\n1. Patient has a history of gastrectomy, total colectomy, stoma creation, short bowel syndrome.\n2. Patient has pre-operative ileus.\n3. Patient is taking opioid analgesics longer than two post-operative days, exceeding a dosing of 35 mg morphine equivalent per day.\n4. Chemotherapy treatment within 10 days after longitudinal surgery.\n5. Smoking during the hospital stay.\n6. Any contraindication as per summary of product characteristic for the usage of local anesthetics for PDC.\n7. History of uncontrolled (at the discretion of the Investigator) cardiovascular, renal and\u002For hepatic failure.\n8. History of severe allergic or anaphylactic reactions, especially to local anesthetics.\n9. Clinically significant (at the discretion of the Investigator) deviation from the normal laboratory values.\n10. Clinically significant (at the discretion of the Investigator) abnormal ECG.\n11. Intake of any class 1B antiarrhythmic drugs if used for antiarrhythmic purpose (e.g., Lidocaine, Mexiletine, Phenytoin) and of any class 3 antiarrhythmic drugs - Kalium channel blockers (e.g., Amiodarone, Dronedarone, Sotalol, Ibutilide, Dofetilide, Bretylium).\n12. Significant (at the discretion of the Investigator) symptomatic, viral, bacterial (including upper respiratory infection), or fungal (non-cutaneous) infection (especially with need of antibiotic treatment) within the past 2 weeks prior to study medication administration.\n13. Experimental agent within 30 days or ten half-lives, whichever is longer, prior to study medication administration.\n14. Pregnancy or planning to become pregnant during the study.\n15. Any other condition, which in the opinion of the Investigator precludes the patient's participation in the study.\n16. Patients with close affiliation with the Investigator or persons working at the respective study sites or patients who are an employee of the Sponsor.","FEMALE","75 Years",{"count":109,"type":20},126,[111],"PHASE2","This is a multi-center, randomized, double blind, placebo-controlled, phase 2 pilot efficacy study.",[26],[115],"local anesthetic","2024-10-01",{"date":118,"type":33},"2024-10-03",{"date":120,"type":33},"2024-01-11",{"date":122,"type":20},"2025-12-31",{"name":124,"class":125},"Orexa BV","INDUSTRY",3,{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":16,"minAge":135,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":21,"phases":139,"briefSummary":140,"conditions":141,"keywords":145,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":41},"100551141","time-to-return-of-bowel-function-following-perioperative-probiotics-in-colorectal-cancer-surgery-100551141","NCT06456229","Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery","Time to Return of Bowel Function Following Perioperative Probiotics in Colorectal Cancer Surgery (PICCS-1)","PICCS-1","Inclusion Criteria:\n\n1. undergoing elective colorectal cancer surgery in which an oncologic resection is planned\n2. age between 21 and 99 years at the time of consent\n3. willing to consider oral nutritional supplementation\n4. on an early recovery after surgery (ERAS) pathway\n5. able to provide informed consent\n\nExclusion Criteria:\n\n1. patients with known contraindications to probiotic use\n2. patients undergoing emergency surgery\n3. taking any other form of probiotics\n4. taking oral antibiotics within 7 days of commencement of study\n5. vulnerable patients including pregnant patients, inmates, and those who are cognitively impaired and therefore are not able to provide informed consent.","21 Years","99 Years",{"count":138,"type":20},162,[23],"There is pre-existing evidence that probiotics could be useful in the improvement of ileus rates. One metaanalysis of 30 studies demonstrated a reduction in the prevalence of post-operative ileus as determined by time to flatus, time to defecation, as well as postoperative abdominal distension (PMID:37373843). More broadly in gastrointestinal surgery, a meta-analysis of 21 randomised controlled trials similarly affirmed the speedier recovery of gastrointestinal function after surgery when probiotics were administered (PMID: 35231076). In spite of these advantages, the routine use of probiotics perioperatively for colorectal cancer surgery is not performed in Singapore. We therefore seek to perform a trial to investigate whether probiotic administration perioperatively may reduce post operative ileus rates.",[142,26,143,144],"Colorectal Cancer","Flatus","Diet, Healthy",[62,146,147,148,149,150,151,152],"colorectal surgery","nutritional supplementation","probiotics","time to bowel movement","time to flatus","length of stay","complications","2024-06-11",{"date":155,"type":33},"2024-06-13",{"date":157,"type":20},"2024-07-01",{"date":159,"type":20},"2025-05-01",{"name":161,"class":76},"National University Hospital, Singapore"]