[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ileus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ileus":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100600625","rectus-sheath-catheters-following-midline-laparotomy-100600625",false,"NCT07099924","Rectus Sheath Catheters Following Midline Laparotomy","Bilateral Rectus Sheath Catheters Following Midline Laparotomy. A Randomized, Placebo-controlled Trial","Inclusion Criteria:\n\n* Median laparotomy\n* Age over 18 years\n* Informed consent has been obtained\n\nExclusion Criteria:\n\n* Local signs of inflammation\n* known allergy to local anesthetics used\n* chronic pain syndrome\n* drug addiction\n* post-operative ventilation that cannot be completed on the day of surgery\n* lack of consent or cooperation\n* pregnancy\n* participation in another medical study\n* sepsis","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC. The target structures are the anterior cutaneous branches of the spinal nerves Th7-Th12. RSC can be used in particular if thoracic epidurals are contraindicated (compromised coagulation), technically unfeasible or refused by the patient.\n\nThe study investigates placebo-controlled weather RSC have a significant additional analgesic effect in a multimodal analgesic concept. Primary outcome parameters are the maximum pain score, the Quality-of-Recovery-15-Score (QoR-15GE) and the opioid consumption (morphine equivalents) in the first 72h postoperatively.",[26,27,28],"Acute Abdomen","Ileus","Colorectal Carcinoma",[30,31,32,33],"postoperative analgesia","rectus sheath catheter","ultrasound","midline laparotomy","NOT_YET_RECRUITING","2025-07-30",{"date":37,"type":38},"2025-08-01","ACTUAL",{"date":40,"type":20},"2025-07",{"date":42,"type":20},"2027-09",{"name":44,"class":45},"Asklepios Kliniken Hamburg GmbH","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":65,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100586637","study-of-treatment-with-intensified-omeprazole-treatment-to-prevent-high-output-stoma-1-100586637","NCT06917963","Study of Treatment With Intensified Omeprazole Treatment to Prevent High Output Stoma 1","Study of Treatment With Intensified Omeprazole Treatment to Prevent High Output Stoma 1: a Randomized, Non-blinded, Controlled Trial","STOP-HOS-1","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for elective or emergency surgery requiring end or loop ileostomy formation\n* Able and willing to provide written informed consent\n* No contraindications to omeprazole use\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Known hypersensitivity or allergy to proton pump inhibitors (including omeprazole)\n* Conditions preventing accurate measurement of daily ileostomy output",{"count":56,"type":20},80,[23],"The goal of this clinical trial is to evaluate if intensified omeprazole therapy can reduce high-output stoma (HOS) in adults undergoing ileostomy formation surgery. The main objectives of the study are:\n\n* To assess if intensified omeprazole treatment significantly reduces mean daily ileostomy output (ml\u002F24h) during the first three postoperative days compared to standard omeprazole treatment.\n* To evaluate the proportion of patients meeting the criteria for high-output stoma (HOS ≥1400 ml\u002Fday) on consecutive postoperative days.\n* To measure the time required for stabilization of ileostomy output (\\\u003C1400 ml\u002Fday maintained for three consecutive days).\n* To determine the incidence of dehydration-related complications, specifically electrolyte disturbances (hyponatremia, hypokalemia).\n* To compare the length of initial hospital stay, frequency of rehospitalizations within 30 days post-discharge, and total length of hospital stay (including rehospitalizations).\n\nResearchers will compare 10 days intensified omeprazole treatment (loading dose of 80 mg IV followed by 40 mg IV twice daily) with standard treatment (40 mg IV once daily) to determine the effectiveness of intensified dosing in reducing ileostomy output and improving postoperative outcomes.\n\nParticipants will:\n\n* Receive either standard or intensified intravenous omeprazole during their hospitalization and after discharge for 10 days combined.\n* Undergo daily measurements of ileostomy output.\n* Have routine laboratory assessments of electrolyte levels.\n* Participate in follow-up assessments up to 30 days post-discharge, conducted either through outpatient visits or telephone consultations.",[60,61,62,63,27,64],"Stoma - Ileostomy","High Output Stoma","Colon Cancer","IBD (Inflammatory Bowel Disease)","Omeprazole",[66,67,68,69,70,71,72],"stoma","ileostomy","high output stoma","omeprazole","ipp","colon cancer","ibd","RECRUITING","2025-07-28",{"date":76,"type":38},"2025-07-31",{"date":78,"type":38},"2025-04-10",{"date":80,"type":20},"2027-07",{"name":82,"class":45},"Medical University of Gdansk",2,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":95,"conditions":96,"keywords":102,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":46},"100578786","prevention-of-postoperative-hernias-in-emergency-surgery-100578786","NCT06815822","Prevention of Postoperative Hernias in Emergency Surgery","PROPHECY","Inclusion criteria:\n\n* Patient age \\> 18 years.\n* Emergency or urgent surgery.\n* Specific surgical indications (acute appendicitis, acute cholecystitis, incarcerated hernia, gastrointestinal perforation, and obstruction).\n\nExclusion criteria:\n\n* Lack of patient consent.\n* Open abdomen technique applied.","100 Years",{"count":93,"type":20},500,"OBSERVATIONAL","The aim of this observational study is to understand the risk factors and incidence of postoperative hernias among patients undergoing emergency surgery. The main question it aims to answer is:\n\nWhat is the incidence of postoperative hernias in this group of patients?\n\nA brief telephone interview will be conducted with participants who will be included in this study one year after the surgery. If the presence of a postoperative hernia is suspected, the patient will be invited to a follow-up visit to the surgical clinic, where the diagnosis will be confirmed by imaging tests.",[97,98,99,27,100,101],"Incarcerated Hernia","Appendicitis Acute","Cholecystitis, Acute","Perforated Gastro-duodenal Ulcers","Perforated Bowel",[103,104,105,106,107,108],"postoperative hernia","trocar site hernia","parastomal hernia","incisional hernia","outcomes","emergency surgery","2025-06-12",{"date":111,"type":38},"2025-06-15",{"date":113,"type":38},"2025-06-01",{"date":115,"type":20},"2026-12-31",{"name":117,"class":45},"Jan Kochanowski University"]