[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immediate-dental-implant-placement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immediate-dental-implant-placement":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,47,87,111,135,165,186,214,239,269,299,322],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100629380","supracrestal-socket-shield-technique-in-anterior-maxilla-a-case-series-100629380",false,"NCT07473921","Supracrestal Socket Shield Technique in Anterior Maxilla. A Case Series","Supracrestal Socket Shield Technique in Anterior Maxilla. A Case Report.","Inclusion Criteria:\n\n* Patients who have a single bounded non-restorable maxillary anterior tooth with opposing natural dentition with no periapical pathosis.\n* Adults above the age of 21.\n* Good oral hygiene.\n* Patient accepts to provide informed consent.\n* Thin intact labial plate of bone (1 mm or less), assessed by CBCT.\n* Intact gingival tissue with at least 2 mm keratinized tissue.\n* Teeth with intact labial root surfaces.\n* Minimum of 3-4 mm of apical bone for primary stability\n\nExclusion Criteria: • Smokers.\n\n* Pregnant and lactating females.\n* Medically compromised patients.\n* Patients with untreated active periodontal diseases.\n* Patients with active infection related to the implant site",true,"ALL","21 Years","55 Years",{"count":21,"type":22},5,"ESTIMATED","INTERVENTIONAL",[25],"NA","Post-extraction labio-palatal ridge collapse is a significant challenge in restorative and implant dentistry particularly in anterior maxilla. Following tooth extraction, marked dimensional alveolar ridge changes occur. The buccal plate of bone in the anterior zone is primarily composed of bundle bone, a tooth dependent structure that derives its blood supply from the periodontal ligament (PDL). The PDL loss after tooth extraction results in rapid resorption of the bundle bone, leading to horizontal and vertical ridge reduction (Araújo and Lindhe, 2005, Schropp et al., 2003). Studies have shown that 50% of ridge width reduction occurs within 12 months, with two thirds of this reduction occurring within the first 3 months (Schropp et al., 2003). Moreover, the labial plate thickness in the anterior maxilla is frequently thinner than 1 mm in the majority of cases (Huynh-Ba et al., 2010). The high incidence of mid-facial recession and soft tissue volume loss is attributed to those biological events.\n\nAlthough IIP has become increasingly popular due to its short treatment time, it doesn't prevent physiological remodeling associated with bundle bone resorption (Araújo and Lindhe, 2005). Consequently, soft tissue collapse and midfacial recession remain common complications, especially in thin periodontal phenotypes (Chappuis et al., 2013, Cosyn et al., 2012). In order to overcome the inevitable consequences of tooth extraction, a variety of ridge preservation techniques were proposed in the literature including; flapless implant placement, bone grafting, soft tissue augmentation procedures, immediate provisionalization, a more palatal orientation of the implant in the socket and the socket shield technique.",[28,29],"Immediate Dental Implant Placement","Anterior Maxilla",[31,32,33],"Esthetic zone","immediate implant placement","socket shield","NOT_YET_RECRUITING","2026-06-29",{"date":37,"type":38},"2026-07-01","ACTUAL",{"date":40,"type":22},"2026-09-01",{"date":42,"type":22},"2027-11-01",{"name":44,"class":45},"International Dental Contiuing Education","NETWORK",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":86},"100641124","do-immediate-digital-workflows-increase-patient-value-100641124","NCT07656597","Do Immediate Digital Workflows Increase Patient Value?","Do Immediate Digital Workflows Increase Patient Value? A Patient-Reported Outcome Measure-Based Randomized Controlled Trial Comparing Immediate Versus Delayed Digital Posterior Implant Workflows","ITI PROM RCT","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Indication for single implant therapy in a posterior premolar or molar extraction site.\n* Good oral hygiene with FMPS ≤20%.\n* Controlled periodontitis according to protocol definition.\n* At least one natural tooth adjacent to the implant site and presence of an antagonist tooth.\n* Ability to comply with study procedures and provide written informed consent.\n* Adequate bone volume for immediate or delayed placement.\n* Extraction site suitable for centrally positioned, prosthetically driven implant placement using straight prosthetic components.\n* Ability to achieve 3-4 mm circumferential implant engagement in native bone along the planned implant axis while maintaining safety distance from vital structures.\n* For molar sites, septal bone classified as Smith \\& Tarnow Type A or Type B, including cases requiring closed sinus floor elevation.\n* Post-extraction socket presenting as a contained or partially contained defect with at least three relatively intact socket walls and no individual socket wall vertical defect \\>5 mm.\n* No facial soft-tissue dehiscence or mucogingival defect associated with buccal bone dehiscence.\n\nExclusion Criteria:\n\n* • Known or suspected poor compliance, alcohol abuse, or substance abuse.\n\n  * Systemic or local contraindications to implant surgery.\n  * History of head\u002Fneck radiotherapy or recent malignancy within 5 years.\n  * Use of medications affecting bone metabolism.\n  * Bisphosphonate use within the past 5 years.\n  * Uncontrolled periodontal disease.\n  * Heavy smoking (\\>10 cigarettes\u002Fday).\n  * Pregnancy or lactation.\n  * Teeth with periapical lesions \\>5 mm in greatest diameter, or sockets demonstrating a large cortical perforation \\>5 mm in greatest dimension on CBCT.","18 Years",{"count":57,"type":22},50,[25],"This two-center randomized controlled trial will evaluate whether an immediate digital posterior implant workflow provides greater patient-defined value than a delayed digital workflow in adults requiring single posterior implant rehabilitation. Participants will be randomized 1:1 to immediate implant placement at the time of tooth extraction or to delayed implant placement after approximately 16 weeks of healing following extraction and ridge preservation as indicated. The primary endpoint is oral health-related quality of life assessed longitudinally using the OHIP-14 questionnaire and analyzed as the model-based mean score averaged across the active treatment phase from baseline through definitive crown delivery. Secondary outcomes include workflow-related patient experience, chairside time, number of visits, postoperative pain, buccal contour changes based on intraoral scan-derived volumetric analysis, radiographic marginal bone level changes, implant survival, clinical peri-implant parameters, technical complications, esthetic outcomes, accuracy of guided implant placement, and clinician-reported workflow outcomes.",[61,62,28,63,64,65,66],"Dental Implant","Implant Therapy","Delayed Implant","Guided Surgery Accuracy","Patient-Reported Outcomes (PRO)","Single Tooth Dental Implant",[61,32,68,69,70,71,72,73,74,75],"delayed implant placement","digital workflow","guided surgery","patient-reported outcomes","OHIP-14","posterior implant rehabilitation","chairside time","volumetric analysis","2026-06-15",{"date":78,"type":38},"2026-06-18",{"date":80,"type":22},"2026-08-03",{"date":82,"type":22},"2028-10-31",{"name":84,"class":85},"Heinrich-Heine University, Duesseldorf","OTHER",2,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":46},"100638724","influence-of-alveolar-bone-drilling-and-anatomical-position-on-integration-100638724","NCT07589140","Influence of Alveolar Bone Drilling and Anatomical Position on Integration","Influence of Alveolar Bone Drilling and Anatomical Position on the Primary Stability, Osseointegration and Functioning of Immediately Placed Dental Implants","Inclusion Criteria:\n\n* ≥ 18 years old.\n* healthy patients without medical contraindications for dental implantation surgery.\n* removable and non-molar teeth indicated for extraction in both jaws\n* healthy soft tissues (bleeding on probing \\\u003C 20%, plaque index \\\u003C 25%);\n* intact alveolar bone walls post-extraction\n* signed informed consent form and permission to use the obtained data for research purposes.\n\nExclusion Criteria:\n\n* Smokers (≥ 10 cigarettes per day);\n* history of uncontrolled periodontitis;\n* uncontrolled diabetes\u002Falcoholism;\n* use of drugs that may affect healing;\n* persons who, due to health status, cannot be considered capable of reasonably assessing their interests;",{"count":95,"type":22},124,[25],"The goal of this clinical trial is to learn if alveolar bone drilling and anatomical position of an immediately placed dental implant has influence on the primary stability, osseointegration and function. It aims to answer these questions:\n\n* Does absence of alveolar drilling before implant placement give the same result as traditional osteotomy with apical drilling?\n* Is palatinal root position of implant as succesful as central position?\n\nResearchers will compare crestal bone levels and primary stability of the implant after insertion in the groups. Subjects will be assigned to groups, acoording to clinical situation. Study groups:\n\n1. Dental implants will be placed in the extraction socket with an apical osteotomy.\n2. Dental implants will be placed in the extraction socket without performing an osteotomy.\n3. Dental implants will be placed in the centre of the extracted maxillary molar socket.\n4. Dental implants will be placed into the palatal root socket of the extracted maxillary molar.",[61,99,28],"Bone Grafting",[101],"dental implant","2026-06-01",{"date":104,"type":38},"2026-06-03",{"date":106,"type":22},"2026-07",{"date":108,"type":22},"2028-05",{"name":110,"class":85},"Lithuanian University of Health Sciences",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":124,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":4},"100638608","influence-of-the-primary-stability-and-temporary-prosthetics-100638608","NCT07585539","Influence of the Primary Stability and Temporary Prosthetics","Influence of the Primary Stability and Temporary Prosthetics of a Placed Dental Implant on Implant Osseointegration and Further Function When Performing Immediate Implantation in the Posterior Tooth Regions.",{"count":118,"type":22},90,[25],"The goal of this clinical trial is to to determine how different primary implant stability and loading management affect implant osseointegration and further function after one year. The main questions it aims to answer are: is primary stability of inserted implant needed for implant integration? Does primary stability and restoration mode of the implant influence marginal bone stability of that implant? Researchers will compare crestal bone levels and primary stability of the implant after insertion in 3 groups. Subjects will be assigned to groups, acoording to primary stability developed during insertion of the implant. Study groups - (1) If stability is low (5-10 N\u002Fcm), Megagen BlueDiamond implants will be inserted, and a temporary prosthesis will not be placed; the implant will be sutured; (2) If stability is moderate (15-35 N\u002Fcm), Megagen BlueDiamond implants will be inserted, and a custom plastic gingiva-forming healing abutment will be placed; (3) If stability is high (40 N\u002Fcm and higher), Megagen BlueDiamond implants will be inserted, and a temporary plastic crown will be placed. Primary outcome of the study will be implant integration, secondary ourtcomes - implant insertion depth during insertion and after osseointegration, marginal bone stability after prosthesis delivery and after one year, determination of the PES (pink esthetic score) index after prosthesis delivery and after 1 year, determination of the ISQ value after implant insertion and after osseointegration, changes in gingival volume around the implants after 1 year, determination of the Plaque Index (PI) after prosthesis delivery and after 1 year, determination of the Probing Pocket Depth (PPD) after prosthesis delivery and after 1 year, determination of the Bleeding on Probing (BOP) index after prosthesis delivery and after 1 year.",[28,122,123],"Immediate Dental Implant Loading","Marginal Bone Levels",[125],"Dental implant","2026-05-09",{"date":128,"type":38},"2026-05-13",{"date":130,"type":22},"2026-05-07",{"date":132,"type":22},"2028-01-05",{"name":134,"class":85},"Tomas Linkevicius",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":152,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":46},"100632964","immediate-implant-placement-using-socket-shield-with-cgf-100632964","NCT07520526","Immediate Implant Placement Using Socket Shield With CGF","Clinical and Radiographic Evaluation of Concentrated Growth Factors With Simultaneous Immediate Implant Placement in Socket Shield Technique","CGF","Inclusion Criteria:\n\n* Age ≥18 years old. (Younis, W., \\& El-Rashidy, A. 2020).\n* Both male and female patients.\n* Maxillary, anterior and premolar segment.\n\nExclusion Criteria:\n\n* A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera.",{"count":144,"type":22},7,[25],"This prospective case series study aims to clinically and radiographically evaluate the effectiveness of the socket shield technique combined with concentrated growth factors (CGF) in immediate implant placement in the esthetic zone. Outcomes will include crestal bone level changes assessed by CBCT and implant stability measured using Osstell.",[148,149,28,150,151],"Socket Shield Technique","Concentrated Growth Factors","Alveolar Bone Preservation","Alveolar Bone Loss",[153,154,155],"Socket shield technique","immediate implants","concentrated growth factor","2026-04-08",{"date":158,"type":38},"2026-04-13",{"date":160,"type":22},"2026-04-01",{"date":162,"type":22},"2026-12-30",{"name":164,"class":85},"Cairo University",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":141,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":23,"phases":173,"briefSummary":174,"conditions":175,"keywords":178,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":181,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":185,"locationsCount":46},"100632963","socket-shield-technique-with-cgf-and-xenograft-for-immediate-implants-100632963","NCT07520513","Socket Shield Technique With CGF and Xenograft for Immediate Implants","Clinical and Radiographic Evaluation of Bone Grafting Using Concentrated Growth Factors and Xenograft With Simultaneous Immediate Implant Placement in Socket Shield Technique","Inclusion criteria:\n\n* Age ≥18 years old. (Younis, W., \\& El-Rashidy, A. 2020).\n* Both male and female patients.\n* Maxillary, anterior and premolar segments.\n\nExclusion Criteria:\n\n* A medical history that contraindicates oral surgical treatment such as (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous bisphosphonates).\n* Presence of active or untreated periodontal disease.\n* Vertical root fractures involving the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorption.\n* Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera.",{"count":144,"type":22},[25],"This prospective case series aims to evaluate the clinical and radiographic outcomes of immediate implant placement using the socket shield technique combined with concentrated growth factors (CGF) and xenograft in the esthetic zone. The study will assess crestal bone level changes and implant stability over a 6-month follow-up period.",[151,148,176,28,149,177,150],"Bone Resorption","Xenograft",[154,179,180,177],"socket shield technique","Concentrated growth factor",{"date":158,"type":38},{"date":183,"type":22},"2026-04-05",{"date":162,"type":22},{"name":164,"class":85},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":141,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":202,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":46},"100632529","clinical-and-radiographic-evaluation-of-cgf-and-alloplastic-grafting-in-participants-undergoing-the-socket-shield-technique-for-immediate-anterior-maxillary-implant-placement-this-study-assesses-bone-healing-and-stability-when-managing-the-crestal-gap-in-the-esthetic-zone-100632529","NCT07514871","Clinical and Radiographic Evaluation of CGF and Alloplastic Grafting in Participants Undergoing the Socket Shield Technique for Immediate Anterior Maxillary Implant Placement. This Study Assesses Bone Healing and Stability When Managing the Crestal Gap in the Esthetic Zone.","Clinical and Radiographic Evaluation of Bone Grafting Using CGF and Alloplastic Graft With Simultaneous Immediate Implant Placement in Socket Shield Technique (Case Series Study).","Inclusion Criteria:\n\n* Participants must be 18 years of age or older.\n* Both male and female patients.\n* Maxillary, anterior and premolar segments.\n\nExclusion Criteria:\n\n* A medical history that contraindicates oral surgical treatment (uncontrolled\u002Funtreated diabetes mellitus, immuno-compromised status, radio\u002Fchemotherapy of the oral and maxillofacial region, treatment with oral and\u002For intravenous amino-bisphosponates).\n* Untreated periodontal disease.\n* Vertical root fractures on the buccal aspect.\n* Tooth \u002Fteeth with horizontal fractures below bone level.\n* Tooth \u002Fteeth with external or internal resorptions.\n* Patients with any oral destructive habits such as smoking, chewing tobacco, bruxism, etcetera.",{"count":144,"type":22},[25],"The goal of this clinical trial is to evaluate the clinical and radiographic effectiveness of the socket shield technique combined with concentrated growth factor (CGF) and alloplastic graft in promoting bone healing and achieving successful immediate implant placement in the esthetic zone.\n\nThis prospective case series involves both male and female participants aged 18 years or older who require immediate implant placement in the maxillary anterior segments. The main questions it aims to answer are :\n\nDoes the combined use of CGF and alloplastic grafting materials with the socket shield technique improve crestal bone levels as measured by CBCT?\n\nHow does this intervention affect secondary outcomes such as primary implant stability measured via the Osstell implant stability quotient?\n\nParticipants will: Undergo a socket shield procedure (partial extraction therapy) where the labial root fragment is retained to preserve the buccal bone. Provide a blood sample for the preparation of autologous CGF. Receive simultaneous immediate implant placement. Have a \"sticky bone\" mixture of CGF and alloplastic graft packed into the jumping gap around the implant. Attend follow-up appointments for clinical assessments and CBCT imaging at 2 weeks and 6 months post-operatively.",[197,198,148,199,28,200,201],"Alveolar Ridge Resorption","Bone Loss in the Esthetic Zone","Partial Extraction Therapy","Bone Regeneration Using Concentrated Growth Factor","Alloplastic Bone Grafting",[148,199,203,204,205],"Concentrated Growth Factor (CGF)","Alloplastic Bone Graft","Sticky Bone","2026-03-31",{"date":208,"type":38},"2026-04-07",{"date":210,"type":22},"2026-04-25",{"date":212,"type":22},"2026-11-01",{"name":164,"class":85},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":222,"phases":4,"briefSummary":223,"conditions":224,"keywords":227,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":237,"locationsCount":46},"100625820","immediate-implant-placement-and-immediate-restoration-with-prefabricated-provisionals-100625820","NCT07427602","Immediate Implant Placement and Immediate Restoration With Prefabricated Provisionals","Immediate Implant Placement and Immediate Restoration With Prefabricated Provisionals: A Retrospective Case Series Study","Inclusion Criteria:\n\n* The patient is 18 years or older;\n\n  * The implant region is an incisor (central or lateral), cuspid or first bicuspid in the maxilla; the adjacent teeth are natural teeth;\n  * Patient is treated with an immediate implant and an immediate prefabricated provisional restoration;\n  * The definitive restoration is at least one year in function\n\nExclusion Criteria:\n\n* Reference intraoral radiograph not available in the medical record",{"count":57,"type":22},"OBSERVATIONAL","* Background\n* There is a growing tendency to place a provisional restoration immediately following implant placement. Clinical advantages are shortening of treatment duration and soft tissue guiding during healing resulting in better esthetic outcomes. Provisional restorations can be made either chair-side or in the dental laboratory after implant placement. Nowadays, digital planning makes it possible to fabricate the provisional restoration before implant surgery. The advantage of this technique is that the treatment procedure of placement of the provisional restoration immediately after implant placement is much less time consuming for the patient and due to its machined polished character possibly beneficial for soft tissues.\n* Main research question The aim of this retrospective case series study, with full digital workflow, is to evaluate single tooth implant treatment after immediate implant placement in the maxillary aesthetic region, with respect to registration of possible complications during the time of placement and evaluation of the prefabricated provisional registration and evaluation of clinical and radiographical performance and aesthetic outcome with the definitive restoration after at least 1 year in function.\n* Design (including population, confounders\u002Foutcomes) The study design is a retrospective, single-arm observational study for evaluation of 50 patients with a failing tooth in the maxillary aesthetic region, which were treated with an implant-supported provisional and definitive restoration by means of a digital workflow. Outcomes: registration of possible complications during the time of placement and evaluation of the provisional registration and evaluation of clinical and radiographical performance and aesthetic outcome with the definitive restoration.\n* Expected results Satisfying results for patients and professionals (VAS-scores and PES\u002FWES-scores).",[225,28,226],"Dental Implants, Single-tooth","Crown",[228,229,230],"Immediate implant placement","Maxillary esthetic region","Prefabricated provisional","2026-02-20",{"date":233,"type":38},"2026-02-23",{"date":235,"type":22},"2026-03-01",{"date":212,"type":22},{"name":238,"class":85},"University Medical Center Groningen",{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":17,"minAge":247,"maxAge":4,"enrollmentInfo":248,"targetDuration":4,"studyType":23,"phases":250,"briefSummary":251,"conditions":252,"keywords":256,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":265,"leadSponsor":267,"locationsCount":4},"100624888","immediate-implants-in-front-teeth-with-bone-loss-regeneration-and-temporary-crown-in-a-randomized-clinical-study-100624888","NCT07415486","Immediate Implants in Front Teeth With Bone Loss: Regeneration and Temporary Crown in a Randomized Clinical Study","Immediate Implant Placement in Buccal Dehiscence Aesthetic Sites With Simultaneous Regeneration and Immediate Provisionalization: a Controlled Randomized Clinical.","GBR \u002F RCT","Inclusion Criteria:\n\n* • Adult patients with ⩾ 25 years of age.\n\n  * Ability to understand all the study procedures and to comply with them along the entire study period. Ability and willingness to give written informed consent.\n  * Periodontal health in an intact or reduced periodontium (2017 World Workshop in Periodontal and Peri-implant Diseases and Conditions) (G. Caton et al., 2018).\n  * Good level of oral hygiene (Plaque Index \\\u003C 20%) (Löe, 1967).\n  * Failing tooth in the anterior area of the maxillary arch (incisors, canines and premolars).\n  * Bone availability for a prosthetically driven single-unit immediate implant.\n  * A peri-implant BBD with a minimum vertical dimension height (VDH) of 3mm, detected by means of a CT imaging.\n  * Presence of adjacent teeth.\n  * Presence of antagonist teeth.\n  * Keratinized mucosa of at least 2mm on the buccal aspect of the tooth to be extracted.\n\nExclusion Criteria:\n\n* Smokers ⩾ 10 cigarettes per day.\n\n  * Pregnant women or lactating females.\n  * Acute periapical infection.\n  * Presence of buccal\u002Fpalatal and\u002For interproximal gingival recession in the target tooth.\n  * Any systemic disease or medication that contraindicates implant treatment or could influence the outcome of the therapy (i.e., non-controlled diabetes mellitus, osteoporosis, radiotherapy, bisphosphonate medication, ...).\n  * Long-term non-steroidal anti-inflammatory drug therapy (⩾ 3 months).\n  * Lack of primary manual stability of the implant during installation.","25 Years",{"count":249,"type":22},24,[25],"This clinical trial investigates the biological and clinical outcomes of immediate implant placement in aesthetic areas presenting with buccal bone dehiscence. Traditionally, these defects are treated with a bone graft and covered using a collagen membrane; however, there is ongoing debate about whether the membrane is necessary for optimal regeneration. This study proposes the use of a connective tissue graft instead of a collagen membrane, aiming to improve soft tissue volume and aesthetics without compromising bone healing.\n\nThe objective of the study is to evaluate whether the use of an autogenous connective tissue graft in combination with a deproteinized bovine bone mineral with collagen (DBBM-C) achieves results that are not inferior to the conventional protocol that uses DBBM-C and a collagen membrane. The main outcome variable is the vertical buccal bone gain measured after twelve months of healing.\n\nThe study design is a randomized controlled clinical trial including twenty-four patients divided equally into two groups. Each participant will attend eight follow-up visits over twelve months. After atraumatic tooth extraction, immediate implants (BLC, Straumann) will be placed using a prosthetically guided protocol. Buccal dehiscence will be measured intraoperatively, and a partial-thickness tunnel flap will be prepared to allow soft tissue adaptation and graft placement.\n\nIn the control group, the defect will be filled with DBBM-C and covered with a collagen membrane stabilized with horizontal mattress sutures. In the test group, the defect will receive DBBM-C covered by a connective tissue graft harvested from the palate and fixed in a similar manner. When primary stability is equal to or greater than 35 N\u002Fcm, an immediate screw-retained provisional crown will be delivered; if stability is lower, a customized healing abutment or Maryland-type provisional will be used instead.\n\nAfter three months, digital impressions will be taken to fabricate the definitive zirconia restoration. All restorative steps will be performed by experienced clinicians using a standardized digital workflow. Patients will follow routine postoperative care instructions, including soft diet and restricted brushing in the surgical area for one week.\n\nThe main benefits of this study include advancing the understanding of regeneration strategies for buccal bone dehiscence and improving clinical decision-making in immediate implant protocols. Participants are also expected to benefit from implant-supported rehabilitation, functional restoration, and aesthetic improvement. The potential risks are minimal and limited to typical surgical complications such as discomfort, swelling, or minor infection, which will be managed following established clinical protocols.\n\nIf a patient declines participation, conventional implant treatment will be offered, or alternative prosthetic options such as fixed or removable restorations will be provided. Any intra- or postoperative complications during the study will be treated promptly and documented according to institutional standards.\n\nThe biomaterials used include BLC Straumann implants, Bio-Oss Collagen (DBBM-C), Bio-Gide collagen membranes, and appropriate suture materials. Procedures will employ standard periodontal and tunneling instruments, as well as a digital intraoral scanner for accurate prosthetic fabrication.\n\nStatistical analysis will involve descriptive and inferential methods. The Kolmogorov-Smirnov test will assess normality, and mixed ANOVA models will evaluate differences between groups and across time points. Covariate adjustment will be performed using ANCOVA when necessary, and intra- and inter-examiner reliability will be tested with the intraclass correlation coefficient. The level of statistical significance will be set at 0.05.\n\nThe expected outcome is that the use of an autogenous connective tissue graft will demonstrate bone regeneration results equivalent to those obtained with a collagen membrane, while potentially improving soft tissue thickness and aesthetic integration. This finding would support the clinical use of soft tissue grafts as an alternative to collagen membranes in immediate implant placement within aesthetic regions showing buccal dehiscence.\n\nAll study procedures follow the principles of the Declaration of Helsinki and ethical standards for human clinical research. Participants will receive detailed information about the study protocol and will sign informed consent before inclusion.\n\nIn summary, this study aims to determine whether a connective tissue graft can safely replace a collagen membrane in the management of buccal dehiscence during immediate implant placement, offering comparable regenerative outcomes with possible superior soft tissue aesthetics.",[28,253,254,255],"Connective Tissue Graft","Connective Tissue Graft Harvesting","Soft Tissue Management in Subcrestal Dental Implants",[257,258,32,259,260],"Connective tissue graft","volumen changes in vestibular plate","emergence profile","immediate aesthetic crown","2026-02-12",{"date":263,"type":38},"2026-02-17",{"date":160,"type":22},{"date":266,"type":22},"2029-07-01",{"name":268,"class":85},"Universitat Internacional de Catalunya",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":275,"eligibilityCriteria":276,"healthyVolunteers":11,"sex":17,"minAge":277,"maxAge":19,"enrollmentInfo":278,"targetDuration":4,"studyType":23,"phases":280,"briefSummary":281,"conditions":282,"keywords":285,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":4},"100623034","thymoquinone-around-immediate-implant-100623034","NCT07391384","Thymoquinone Around Immediate Implant","Evaluation of the Effect of Thymoquinone Hydrogel With Bone Graft in Comparison to Bone Graft Only Around Immediate Implant (Randomized Controlled Clinical Trials)","Thymoquinone","Inclusion Criteria:\n\n* 1- Patients ages more than 18 years old, Participants were chosen according to specific eligibility criteria, requiring them to be healthy individuals classified as ASA I by the American Society of Anesthesiologists.\n\n  2- Patients requiring extraction of posterior teeth with consequent immediate implant placement.\n\n  3- Indications for extraction included: non restorable teeth (posterior teeth), untreatable caries, endodontic failures, remaining roots, vertical fracture of the roots.\n\n  4- Natural teeth adjacent to the tooth to be extracted will required to have complete occlusal surfaces and be free from infections..\n\n  5\\. Patients will selected with a thick soft tissue phenotype and a minimum keratinized tissue width (KTW) of 2 mm.\n\nExclusion Criteria:\n\n* Pathologies or drugs that alter tissue integration with dental implants. 2- Head and neck radiation therapy. 3- Renal disease, bleeding disorders and anticoagulant therapy. 4- Pregnant females. 5- Patients with severe para-functional habits and unfavorable occlusion 6- Smokers. 7- Malaligned teeth and teeth with acute periapical pathosis.","20 Years",{"count":279,"type":22},44,[25],"use of Thymoquinone hydrogel with bone graft in comparison to bone graft only around immediate implant-this hydrogel fill the jumping zone in comparison to using hydrogel bone graft only to increase primary stability and enhance osseointegration",[28,283,284],"Jumping Gap","Primary Stability of the Implants",[286,287,288,289],"immediate implant","thymoquinone","hydrogel","bone graft","2026-01-29",{"date":292,"type":38},"2026-02-05",{"date":294,"type":22},"2026-01-21",{"date":296,"type":22},"2026-04-11",{"name":298,"class":85},"shaimaa hamdy",{"id":300,"slug":301,"hasResults":11,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":4,"eligibilityCriteria":305,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":306,"enrollmentInfo":307,"targetDuration":4,"studyType":23,"phases":309,"briefSummary":310,"conditions":311,"keywords":312,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":46},"100616266","flapless-immediate-implant-placement-with-socket-shield-technique-versus-connective-tissue-graft-in-anterior-maxilla-100616266","NCT07303374","Flapless Immediate Implant Placement With Socket Shield Technique Versus Connective Tissue Graft in Anterior Maxilla","Supra-Implant Complex Stability Following Flapless Immediate Implant Placement With Socket Shield Technique Versus Connective Tissue Graft in Anterior Maxilla 1-Year Randomized Clinical Trial","Inclusion Criteria:\n\n* Initial intact thick gingival biotype\n* 2 mm band of keratinized tissue,\n* Thin intact labial bone plate (\\\u003C 1mm)\n* Good apical bone for primary stability\n* Patients who had provided an informed consent.\n\nExclusion Criteria:\n\n* Immediate implants with bone grafts or guided bone regeneration procedures\n* Uncontrolled diabetes mellitus\n* Patients taking IV bisphosphonates for treatment of osteoporosis\n* Patients with active infection related at the site of implant\n* Patients with untreated active periodontal diseases.","50 Years",{"count":308,"type":22},28,[25],"The present study aims to compare the dimensional stability of the supra-implant complex following flapless immediate implant placement using two socket management approaches: the connective tissue graft and the socket shield technique. Three-dimensional volumetric analysis and cone-beam computed tomography (CBCT) will be employed to assess and quantify changes in soft and hard tissue thickness and height surrounding the implant site.",[28,253,148],[313,257],"Socket Shield","2025-12-18",{"date":316,"type":38},"2025-12-24",{"date":318,"type":22},"2026-02",{"date":320,"type":22},"2027-05",{"name":44,"class":45},{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":328,"eligibilityCriteria":329,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":330,"enrollmentInfo":331,"targetDuration":4,"studyType":23,"phases":333,"briefSummary":334,"conditions":335,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":343,"locationsCount":345},"100601842","vestibular-versus-trapezoid-flap-in-immediate-implants-100601842","NCT07115758","Vestibular Versus Trapezoid Flap in Immediate Implants","The Impact of Vestibular Versus Trapezoidal Flap Design on Immediate Implants : a Randomized Clinical Trial","VST","Inclusion Criteria:\n\n* Patients having a hopeless maxillary tooth in the esthetic region missing coronal tooth structure, type II socket (deficient labial plate of bone and intact overlying soft tissues), adequate palatal bone, ≥ 3 mm apical bone to engage the immediately placed implants, thereby achieving optimum primary stability (a minimum of 30 Ncm insertion torque) following tooth extraction.\n\nExclusion Criteria:\n\n* Smokers, pregnant women, patients with systemic diseases, and history of chemotherapy or radiotherapy within the past 2 years.","99 Years",{"count":332,"type":22},32,[25],"The vestibular socket therapy was introduced by Elaskary et al that allowed immediate implant placement and total socket rehabilitation at the same time in class 2 compromised sockets , that showed supreme esthetic and functional predictability over 1,2,3 years of follow up, and showed minimal or no post restorative mid facial recession . The Vestibular socket therapy (VST) entails socket augmentation through a minimally invasive vestibular access incision to allow the delivery of the grafting components thus bypass the deleterious effect of the classic mucoperiosteal flap reflection as well as the deleterious effect of the delay approach, regardless of the degree of socket compromise \\[6-8\\].",[28,336],"Defect in Alveolar Ridge","2025-08-04",{"date":339,"type":38},"2025-08-11",{"date":341,"type":22},"2025-08-15",{"date":235,"type":22},{"name":344,"class":85},"British University In Egypt",3]