[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immediate-implant-placement\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immediate-implant-placement":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,50,79,106,135,156,193,219,240,265,291],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100640017","autologous-demineralized-dentin-graft-with-or-without-melatonin-for-immediate-implant-osseointegration-100640017",false,"NCT07610876","Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration","Effect of Autologous Demineralized Dentin Graft With or Without Melatonin Gel on the Osseo Integration of Immediately Placed Implants: A Randomized Clinical Study","Inclusion Criteria:\n\n* Age above 20 years\n* Non-restorable maxillary premolar teeth\n* Candidates for immediate implant placement\n* Intact socket walls\n* Jumping gap \\>2 mm\n* Non-smokers or light smokers\n* No acute infection\n* Adequate bone for primary stability\n\nExclusion Criteria:\n\n* Heavy smokers\n* Bruxism or clenching\n* Uncontrolled systemic disease\n* Chemotherapy\u002Fradiotherapy\n* Immunocompromised patients",true,"ALL","20 Years",{"count":20,"type":21},16,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized clinical study aims to evaluate the effect of autologous demineralized dentin graft (ADDG) with or without melatonin gel on the osseointegration of immediately placed dental implants in the maxillary premolar region. Sixteen patients requiring extraction and immediate implant placement will be randomly allocated into two groups. Clinical and radiographic outcomes including implant stability, peri-implant probing depth, modified bleeding index, marginal bone loss, buccal bone thickness, and bone density will be evaluated over a 9-month follow-up period.",[27,28,29],"Dental Implants","Immediate Implant Placement","Osseointegration",[31,32,33,34,29,35,36],"Melatonin","Dentin graft","Immediate implant","ADDG","CBCT","Dental implant stability","RECRUITING","2026-05-20",{"date":40,"type":41},"2026-05-28","ACTUAL",{"date":43,"type":41},"2025-08-11",{"date":45,"type":21},"2026-11-10",{"name":47,"class":48},"Suez Canal University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100634398","factors-affecting-immediate-anterior-implants-esthetics-100634398","NCT07539168","Factors Affecting Immediate Anterior Implants Esthetics.","Factors Affecting Immediate Anterior Implants Esthetics . Clinical Retrospective Study","Inclusion Criteria:\n\n* flapless immediately placed implants in esthetic zone with 3 years follow up CBCT,\n* presence of immediate postoperative CBCT,\n* initial intact thick gingival biotype with at least 2 mm band of keratinized tissue\n* thin intact labial bone plate (\\\u003C 1mm) extending 7 mm apically assessed by CBCT with good apical bone\n* patients who had provided an informed consent.\n\nExclusion Criteria:\n\n* patients with medical conditions that would compromise the surgical procedures, uncontrolled diabetes mellitus, taking IV bis-phosphonates for treatment of osteoporosis\n* patients with active infection related at the site of implant and patients with untreated active periodontal diseases.","21 Years","55 Years",{"count":60,"type":21},500,"OBSERVATIONAL","This retrospective cohort study evaluates clinical, surgical, and prosthetic factors associated with early and mid-term outcomes of immediate implant placement in the anterior maxilla. The primary objective is to identify predictors of implant survival and complications (e.g., infection, soft-tissue dehiscence, esthetic failure) within 12 months following placement. Secondary objectives include assessment of peri-implant marginal bone loss, prosthetic complications, and esthetic outcomes (pink esthetic score).",[64,65,28],"Pink Esthetic Score","Implant Survival Rate",[67],"Immediate implant, esthetics, anterior maxilla","NOT_YET_RECRUITING","2026-04-17",{"date":71,"type":41},"2026-04-22",{"date":73,"type":21},"2026-06-01",{"date":75,"type":21},"2026-09-01",{"name":77,"class":78},"International Dental Contiuing Education","NETWORK",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":16,"sex":17,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":49},"100630815","evaluation-of-the-magnesium-shield-compared-to-dual-zone-grafting-approach-in-immediate-implant-site-management-100630815","NCT07492576","Evaluation of the Magnesium Shield Compared to Dual Zone Grafting Approach in Immediate Implant Site Management","Evaluation of the Magnesium Shield Compared to Dual Zone Grafting Approach in Immediate Implant Site Management: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* 18-60 years of age\n* Patients have hopeless maxillary teeth, a thin buccal plate of bone ≤1 mm and intact overlying soft tissue intact overlying soft tissues in aesthetic zone (EDS-2, Kan classification)\n* Periodontally healthy (good oral hygiene)\n* Medically controlled patient\n\nExclusion Criteria:\n\n* Smokers\n* patients with systemic diseases\n* history of chemotherapy or radiotherapy within the past 2 years.\n* Acute infection","18 Years","60 Years",{"count":89,"type":21},22,[24],"Will (GBR) by application of magnesium membrane with immediate implant will have more volume gain , higher pink esthetic score, and lower visual analogue scale than dual zone grafting technique? Several methods have been suggested for the preservation of post-extraction resorption and promoting an increase in the bone density with immediate implant placement. one of these techniques is the dual zone concept (DZ), atraumatic tooth extraction using peristomes and luxators, implant placement along with the bone grafting material applied to both the bone and tissue zones.\n\nThe aim of (DZ) is to augment the soft tissue using a bone graft to avoid mucosal recession after implant placement thus keeping the gingival contour providing optimal soft tissue aesthetic.\n\nThe use of magnesium membrane in combination with inorganic bovine bones will be placed between the membrane and immediate implant. This allows implant placement while simultaneously rehabilitating the entire socket, due to its unique material properties, a magnesium membrane is used to rebuild, support the buccal or oral walls in compromised sockets, and promotes cortical bone growth . Many techniques available for preserving the bone of the socket post-tooth extraction, but in comparison to the current materials and techniques used , magnesium membrane is completely resorbable and does not require second surgery to be removed; it is synthetic and therefore does not need to be sourced from an additional surgical. magnesium membrane is excellent in providing both esthetic and functional outcomes that meet patient expectations.\n\nThe procedure involves flapless approach in which atraumatic tooth extraction using peristomes and forceps will be performed to preserve the available alveolar bone. The implant site will be prepared, and the implant will be placed palatal and 3-4m.m apical to the free gingival margin (FGM). magnesium membrane will be placed between the soft tissue and thin buccal wall. The edges of the membrane will be shaped and flattened with sculptor to prevent perforation of the soft tissue, and a layer off inorganic bovine bone will be placed between the e buccal wall and implant. Then immediate provisional restoration will be constructed and placed to allow an ideal final crown mimicking the natural emergence profile.",[28],[94,95,96],"Magnesium shield ,","Immidate implant","dual zone concept with immediate implant.","2026-03-27",{"date":99,"type":41},"2026-04-01",{"date":101,"type":41},"2026-03-19",{"date":103,"type":21},"2027-01-29",{"name":105,"class":48},"British University In Egypt",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":49},"100627528","assessment-of-labial-plate-thickness-after-immediate-implant-placement-using-two-different-xenografts-in-the-esthetic-zone-100627528","NCT07449806","Assessment of Labial Plate Thickness After Immediate Implant Placement Using Two Different Xenografts in the Esthetic Zone","Assessment of Labial Plate Thickness After Immediate Implant Placement in Type II Extraction Sockets Using Two Different Xenografts in the Esthetic Zone: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with one or more non-restorable teeth or remaining roots without signs of acute infection in the maxillary anterior region.\n* Type II extraction sockets.\n* Sufficient bone (\\>3 mm) apically and palatally to allow for proper implant positioning with sufficient primary stability (≥ 30 N cm).\n* Good compliance.\n\nExclusion Criteria:\n\n* Teeth with current acute periapical infection.\n* Medically compromised patients.\n* Heavy smokers (smoking of more than 10 cigarettes per day ).\n* Alcohol or drug abuse.\n* Patients undergoing chemotherapy and radiotherapy.\n* Poor oral hygiene.\n* Vulnerable groups (pregnant females and decision- impaired individual).",{"count":114,"type":21},26,[24],"This randomized clinical trial aims to evaluate labial bone plate changes following immediate implant placement in Type II extraction sockets using two different xenograft materials and de-epithelialized free gingival graft in the esthetic zone . Patients requiring extraction and immediate implant placement will be randomly allocated into two groups according to the xenograft material used for defect grafting. Clinical and radiographic outcomes will be assessed to determine dimensional bone changes and implant success",[118,119,28],"Alveolar Bone Loss","Tooth Extraction Status Nos",[121,122,123,124,125],"immediate implant placement","type II extraction socket","esthetic zone.","xenograft","randomized controlled clinical trial","2026-03-04",{"date":128,"type":41},"2026-03-06",{"date":130,"type":41},"2025-09-05",{"date":132,"type":21},"2026-09-25",{"name":134,"class":48},"Basma Gamal Mohamed Ahmed",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":17,"minAge":86,"maxAge":4,"enrollmentInfo":142,"targetDuration":144,"studyType":61,"phases":4,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":49},"100565896","labial-bone-thickness-around-immediate-implants-in-the-esthetic-zone-following-a-novel-socket-evaluation-system-100565896","NCT06648135","Labial Bone Thickness Around Immediate Implants in the Esthetic Zone Following a Novel Socket Evaluation System","a Novel Socket Evaluation System and Its Impact on Bone Formed Labial to Bone Immediate Anterior Implants. A 1-year Clinical Trial.","Inclusion Criteria:\n\n* Immedaite implants in anterior maxilla\n* thick gingival phenotype\n* intact but thin labial plate of bone (≤1mm)\n* sufficient apical bone to attain implant primary stability (a minimum of 35 Ncm insertion torque)\n\nExclusion Criteria:\n\n* smokers\n* pregnant women\n* patients with systemic disease\n* patients with parafunctional habits such as bruxism or clenching,\n* infected socket\n* periapical pathosis\n* history of radiotherapy or chemotherapy within the past 2 years.",{"count":143,"type":21},25,"5 Months","The anterior maxilla is a particularly challenging area for immediate implant placement due to its thin buccal bone walls. These walls are more susceptible to resorption after tooth extraction, which can lead to significant bone loss and inadequate support for an implant. However, Different socket dimension may affect the amount of bone formed labial to the implant, regardless of the garfting procedure.",[28],"2026-01-27",{"date":149,"type":41},"2026-01-28",{"date":151,"type":21},"2026-03-01",{"date":153,"type":21},"2026-07-01",{"name":155,"class":48},"Misr International University",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":17,"minAge":86,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":166,"briefSummary":167,"conditions":168,"keywords":174,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":49},"100601274","osseodensification-efficacy-on-molar-septum-expansion-in-immediate-molar-implant-placement-100601274","NCT07108361","\"Osseodensification Efficacy on Molar Septum Expansion in Immediate Molar Implant Placement","\"Osseodensification Efficacy on Molar Septum Expansion in Immediate Molar Implant Placement: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients requiring placement in the posterior region.\n\n  * ASA I and II patients who can undergo immediate implant placement and restorative procedures.\n  * Both males and females.\n  * Patient's age: 18-50 years old.\n  * Patients who can come for the follow-up visit.\n  * Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Pregnancy.\n\n  * Smoking\n  * Patients with previously failed dental implants at the implant placement site.\n  * Patients with active infections.\n  * Other medical conditions that might affect the osseointegration of dental implants, such as diabetes, cardiovascular disease, hypertension, and osteoporosis","50 Years",{"count":165,"type":21},80,[24],"The ideal positioning of immediate implants in molar extraction sockets often requires the osteotomy to be in the interradicular septum, which can be challenging in some cases, with traditional site preparation techniques. Also, the alveolar ridge undergoes various remodeling processes following tooth extraction, resulting in hard and soft tissue loss which complicates prosthodontic rehabilitation. Immediate implant placement help preserve the alveolar ridge dimensions and buccal ridge contour. While osseodensification has shown promise in enhancing primary stability and bone microarchitecture, its clinical and microstructural effects in molar extraction sockets remain underexplored. Although there is ample documentation of information on the temperature that is generated during preparation of implant sites, there are no studies available in the literature comparing conventional drilling and osseodensification techniques; therefore, the present investigation was aimed at analyzing the efficacy of osseodensification compared to conventional drilling in terms of bone dimensions preservation , changes in bone architecture during implant site preparation and heat generation to define which technique can be safely applied to achieve the necessary implant primary stability without damaging the surrounding bone.\n\nAim of the study:\n\nIs to compare the molar septum dimensions using osseodensification expansion versus the conventional drilling protocol and to assess the role of jumping gap grafting in preservation of the alveolar ridge dimensions and buccal ridge contour in addition to Evaluation of the effect of osseodensification on the bony micro-architecture and heat generation",[169,170,171,172,173,28],"Implant Osseointegration","Implant Osteotomy","Implant Placement","Implant Primary Stability","Molar Extraction Socket",[175,176,177,178,179,180,181,182,183,184],"non restorable tooth","molar extraction","multirooted teeth","extraction socket","immediate Implant placement","Osseodensification","ex-vivo","RCT","Jumping gap","Grafting","2025-08-06",{"date":43,"type":41},{"date":188,"type":21},"2025-09",{"date":190,"type":21},"2028-09",{"name":192,"class":48},"Ain Shams University",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":16,"sex":17,"minAge":86,"maxAge":200,"enrollmentInfo":201,"targetDuration":4,"studyType":22,"phases":203,"briefSummary":204,"conditions":205,"keywords":206,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":49},"100582418","effect-of-albumin-platelet-rich-fibrin-or-leucocyte--platelet-rich-fibrin-on-immediate-implant-100582418","NCT06863051","Effect of Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant","Clinical and Radiographic Evaluation of Xenograft With Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant Placement in Mandibular Molar Extraction Sites: Randomized Clinical Trial.","1. Inclusion criteria\n\n   * The presence of non-restorable mandibular molar.\n   * Patient 18-45 years old\n   * Intact buccal and lingual walls\n   * Good oral hygiene.\n   * Prescence of sufficient restorative space.\n   * Jumping gap more than 2 mm.\n2. Exclusion criteria\n\n   * Proximity of anatomical structures\n   * Acute localized infection (suppuration at the surgical field)\n   * Patients on chemotherapy or radiotherapy.\n   * Patients who have systemic disorders (diseases) {diabetes mellitus, autoimmune disease, …etc},\n   * Pregnant patients.\n   * Smoking and Alcohols.\n   * Presence of periapical pathology affecting the neighboring teeth.","45 Years",{"count":202,"type":21},20,[24],"The objective of this study will be to compare between Immediate Implant grafted with xenograft and Alb-PRF gel versus xenograft with L-PRF.",[28],[207,208,209],"Implant","PRF","Albumin","2025-07-30",{"date":212,"type":41},"2025-08-01",{"date":214,"type":21},"2025-08-20",{"date":216,"type":21},"2027-02-10",{"name":218,"class":48},"Kafrelsheikh University",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":16,"sex":17,"minAge":86,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":22,"phases":226,"briefSummary":228,"conditions":229,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":49},"100593192","phase-1-effectiveness-of-topical-application-of-melatonin-on-bone-density-and-implant-stability-in-immediate-implantation-100593192","NCT07003243","Effectiveness of Topical Application of Melatonin On Bone Density and Implant Stability In Immediate Implantation","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Presence of single-rooted non-restorable anterior or premolar teeth indicated for extraction.\n* Jumping gap ≥ 2 mm as measured clinically or radiographically.\n* Apical bone ≥ 2 mm beyond the socket on radiographs.\n* Good general health with no contraindications for oral surgery.\n* Patient willing to undergo immediate implant placement.\n* Ability and willingness to return for follow-up visits.\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* Presence of active periodontal disease or acute infection at the surgical site.\n* Patients with systemic conditions that could compromise healing (e.g., uncontrolled diabetes, immune compromise).\n* History of bisphosphonate therapy.\n* Head and neck irradiation.\n* Pregnancy or lactation.\n* Heavy smokers (≥20 cigarettes\u002Fday).\n* -Bruxism or parafunctional habits.\n* Inability to comply with study protocol or follow-up schedule.",{"count":143,"type":21},[227],"PHASE1","Dental implants have revolutionized the replacement of missing teeth, offering predictable and long-lasting rehabilitation for both fully and partially edentulous patients. Since Brånemark's landmark work in 1969, which defined osseointegration as \"a direct structural and functional connection between ordered living bone and the surface of a load-bearing implant\" (Brånemark et al., 1969), implantology has become an integral part of restorative dentistry.\n\nTraditionally, implant therapy followed a delayed protocol requiring a healing period of up to six months after extraction to allow complete soft and hard tissue regeneration before implant placement (Adell et al., 1981). This approach was based on the belief that mature bone is essential for achieving osseointegration. However, subsequent research demonstrated that immediate placement of implants into fresh extraction sockets can also lead to successful osseointegration without compromising outcomes (Araujo et al., 2005).\n\nImmediate implant placement, defined as placing an implant at the time of tooth extraction, has gained popularity due to its clinical benefits. These include a reduction in surgical sessions, shortened overall treatment time, preservation of the alveolar ridge, especially the buccal plate, and superior soft tissue esthetics (Van Der Weijden et al., 2009). However, these advantages are contingent upon achieving primary implant stability and proper case selection. A biological challenge that often arises in such cases is the presence of a \"jumping gap\" - a void between the implant surface and the socket wall - which may require the use of bone grafts or regenerative materials to facilitate bone fill and stability.\n\nIn recent years, research has explored various biologically active molecules and growth factors to enhance bone healing and implant integration, especially in immediate placement protocols. These include bone morphogenetic proteins (BMPs), platelet-rich plasma (PRP), and platelet-derived growth factors. Among these, melatonin has emerged as a promising agent due to its multifaceted biological activity (Zechner et al., 2003).\n\nMelatonin (N-acetyl-5-methoxytryptamine) is an endogenously produced neurohormone primarily secreted by the pineal gland. While best known for regulating circadian rhythms, melatonin also possesses strong antioxidant, anti-inflammatory, and bone-promoting properties. It enhances osteoblast proliferation, stimulates collagen matrix formation, and inhibits osteoclast-mediated bone resorption. These effects make melatonin a potential therapeutic agent for improving bone density and implant stability.\n\nTopical application of melatonin at implant sites has shown encouraging results in experimental models, demonstrating improved bone-to-implant contact, accelerated bone regeneration, and enhanced mechanical stability. These findings suggest a potential role for melatonin in immediate implant protocols, where rapid healing and early osseointegration are critical for clinical success.\n\nGiven the biological potential of melatonin, the present study aims to evaluate the effectiveness of topical application of melatonin on bone density and implant stability in immediate implantation cases through a randomized controlled clinical trial.",[28,230],"Melatonin Production","2025-05-25",{"date":233,"type":41},"2025-06-04",{"date":235,"type":21},"2025-05-26",{"date":237,"type":21},"2026-05",{"name":239,"class":48},"University of Baghdad",{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":22,"phases":249,"briefSummary":250,"conditions":251,"keywords":252,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":4},"100532035","immediate-implant-placement-utilizing-vestibular-flap-versus-single-flap-approach-with-bone-graft-100532035","NCT06207565","Immediate Implant Placement Utilizing Vestibular Flap Versus Single Flap Approach With Bone Graft","Clinical and Radiographic Evaluation of Immediate Implant Placement Utilizing Vestibular Flap Versus Single Flap Approach With Bone Graft in Anterior Maxilla: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients who have one non-restorable maxillary anterior (Canine to Canine region) with sound adjacent teeth.\n* Intact thick biotype gingival tissue with at least 2mm band of keratinized tissue.\n* Buccal bone thickness less than 1mm assessed in CBCT with good apical bone for implant primary stability.\n* Good oral hygiene\n* Patient accepts to provide an informed consent.\n\nExclusion Criteria:\n\n* Smokers\n* Pregnant and lactating females.\n* Medically compromised patients.\n* Patients with active infection related at the site of implant\u002Fbone graft placement.\n* Patients with untreated active periodontal diseases.\n* Patients with parafunctional habits.",{"count":248,"type":21},34,[24],"Due to the evolution of esthetic implant dentistry and tissue regeneration (hard and soft tissue), flap design plays a crucial role in the maintenance and regeneration of the marginal soft tissue and interdental papillae around dental implants. The present study aims to compare soft and hard tissue changes following immediate implant placement with ridge augmentation using the vestibular flap versus single flap approach.",[28],[253,254,255,256],"Immediate implant placement","Anterior Maxilla","Vestibular flap","single flap approach","2025-04-15",{"date":259,"type":41},"2025-04-18",{"date":261,"type":21},"2025-09-01",{"date":263,"type":21},"2026-08-01",{"name":155,"class":48},{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":16,"sex":17,"minAge":86,"maxAge":87,"enrollmentInfo":272,"targetDuration":4,"studyType":22,"phases":274,"briefSummary":275,"conditions":276,"keywords":277,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":49},"100580827","immediate-implant-placement-using-xenograft-mixed-with-vitamin-d-versus-hyaluronic-acid-100580827","NCT06842368","Immediate Implant Placement Using Xenograft Mixed with Vitamin D Versus Hyaluronic Acid.","Immediate Implant Placement Using Xenograft As Space Filling Material Mixed with Vitamin D Versus Hyaluronic Acid in Posterior Mandible Region: a Randomized Controlled Clinical Trial.","Inclusion Criteria:\n\nAge: 18-60.\n\n* Systemically healthy patients indicated for single or multiple immediate implants in posterior teeth region.\n* Absence of any peri-apical pathosis.\n* Patients with intact buccal plate of bone.\n* Patients with adequate bone volume for the dental implant procedure.\n* Patient with good oral hygrine\n\nExclusion Criteria:\n\n* Heavy Smokers.\n* Systemic disease that may affect the final outcome of the surgical procedure.\n* No or poor patient's compliance.\n* Patients with psychological problems.\n* Pathology at the site of intervention.\n* Patient with vit d deficiency",{"count":273,"type":21},24,[24],"Immediate implant placement using xenograft as space filling material mixed with vitamin D versus hyaluronic acid in posterior mandible region This study aims to evaluate implant stability and density after placement of immediate implant and Xenograft mixed with Hyaluronic acid or Vitamin D at posterior mandible region",[28],[278,279,280,281],"Hyaluronic acid","Vitamin D","Xenograft","Immediate Implant","2025-02-19",{"date":284,"type":41},"2025-02-24",{"date":286,"type":41},"2025-02-02",{"date":288,"type":21},"2025-10-30",{"name":290,"class":48},"Cairo University",{"id":292,"slug":293,"hasResults":11,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":17,"minAge":86,"maxAge":163,"enrollmentInfo":298,"targetDuration":4,"studyType":22,"phases":299,"briefSummary":300,"conditions":301,"keywords":302,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":49},"100578325","evaluation-of-doxycycline-nanoparticle-with-gelatin-sponge-on-immediate-implant-in-esthetic-region-100578325","NCT06809829","Evaluation of Doxycycline Nanoparticle With Gelatin Sponge on Immediate Implant in Esthetic Region","Clinical and Radiographic Evaluation of Doxycycline and Doxycycline Loaded Nanoparticles With Gelatin Sponge on Immediate Implant Placement in Esthetic Zone: A Randomized Clinical Trial","Inclusion Criteria:\n\n* The presence of non-restorable single-rooted maxillary centrals, canines or premolars.\n* Sufficient bone volume.\n* Good oral hygiene.\n* The remaining space between the socket and the fixture equals or more than 2mm at the coronal third of the socket.\n* Sufficient bone width (≥ 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).\n\nExclusion Criteria:\n\n* Insufficient bone volume.\n* Active infection.\n* Patients on chemotherapy or radiotherapy.\n* Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, …etc},\n* Pregnant patients,\n* Patients with bone diseases\n* Presence of periapical pathology affecting the neighbouring teeth.\n* Smokers.",{"count":20,"type":21},[24],"The goal of this clinical trial is to Evaluate the effect of Doxycycline nanoparticles along with gelatin sponge in immediate implant cases in esthetic zone. The main question it aims to answer is:\n\nDoes the application of doxycycline nanoparticles with gelatin sponge improve the clinical and radiographic outcomes of immediate implant cases in esthetic zone?\n\nResearchers will compare eight patients undergoing immediate implant placement with the buccal gap filled with doxycycline loaded gelatin nanoparticles along with gelatin sponge (group A) with eight patients undergoing immediate implant placement with the buccal gap filled with doxycycline along with gelatin sponge (group B). to see if the doxycycline loaded nanoparticles will improve the clinical and radiographic outcomes of the immediate implant .\n\nParticipants will \\[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\\].",[28],[28,303,304,305],"Nanoparticles","Doxycycline","Gelatin Sponge","2025-02-04",{"date":308,"type":41},"2025-02-05",{"date":310,"type":21},"2025-02",{"date":312,"type":21},"2027-02",{"name":218,"class":48}]