[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immobilization\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immobilization":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,83,113],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100639538","cross-education-of-skill-and-strength-in-healthy-people-subjected-to-an-upper-limb-disuse-model-100639538",false,"NCT07615062","Cross-education of Skill and Strength in Healthy People Subjected to an Upper-limb Disuse Model","Cross-education of Skill and Strength Through Contralateral Manual Dexterity Training in Healthy Young Adults Subjected to an Upper-limb Disuse Model: A Randomized Controlled Trial.","IMMO-CROSS","Inclusion Criteria:\n\n* Individuals will be eligible for inclusion if they are right-handed adults aged 18 to 35 years with a body mass index (BMI) between 18.5 and 30 kg\u002Fm².\n* Individuals must be classified as physically inactive, defined as not meeting the World Health Organization criteria of at least 150 minutes of moderate-intensity physical activity or 75 minutes of vigorous-intensity physical activity per week.\n\nExclusion Criteria:\n\n* Individuals who have engaged in physical training (e.g., any form of strength or aerobic exercise) or specific manual dexterity training within the past 6 months. - Individuals who regularly participate in artistic, occupational, or sporting activities requiring high levels of manual dexterity (e.g., musicians, gamers, craftspeople).\n* Individuals with a history of orthopedic or traumatic injuries affecting either upper extremity. Individuals with pathologies or conditions that preclude safe training (e.g., uncontrolled hypertension, or visual, auditory, or cognitive impairments \\[for example, dyscalculia\\]).\n* Individuals currently using nutritional supplements or medications that interfere with the regulation of skeletal muscle mass and strength (e.g., whey protein, creatine) or the central nervous system (e.g., antidepressants, anxiolytics, hypnotics).",true,"ALL","18 Years","35 Years",{"count":22,"type":23},34,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized controlled trial aims to compare manual dexterity and strength between a group undergoing a contralateral manual dexterity training program and a no-intervention control group in healthy, physically inactive individuals subjected to an induced upper-limb disuse model.",[29,30],"Disuse Atrophy","Immobilization",[32,30,33,34],"Cross-education","contralateral training","interlimb transfer","NOT_YET_RECRUITING","2026-05-22",{"date":38,"type":39},"2026-05-29","ACTUAL",{"date":41,"type":23},"2026-05-25",{"date":43,"type":23},"2027-01-30",{"name":45,"class":46},"Universidad Catolica de Temuco","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":19,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100640472","bed-rest-with-a-short-cervix-on-preterm-birth-100640472","NCT07577388","Bed Rest With a Short Cervix on Preterm Birth","BEWISE - Bed Rest With a Short Cervix on Preterm Birth","BEWISE","Pregnant women with gestational age 20+0 to 33+6\n\n* Cervical length \\\u003C 25 mm in singleton pregnancies and \\\u003C 30 mm in multiple pregnancies\n* Above 18 years of age\n* Reads and understands Danish or English","FEMALE",{"count":58,"type":23},6000,[26],"Maternal AR has long been used to prevent PTB. However, definitions of AR vary widely, ranging from complete bed rest to partial limitation of physical activity for one or more hours daily.\n\nThe use of maternal AR to prevent preterm birth is largely based on observational evidence linking strenuous physical activity to an increased risk of preterm birth, and the assumption that reduced activity may decrease myometrial activity. However, the existing evidence on the clinical effects of AR remains limited and has not demonstrated a reduction in preterm birth or a delay in deliv-ery. In contrast, some studies suggest a potential increase in preterm birth following AR and instead significant adverse maternal and fetal effects.\n\nThe overall aim of this study is to compare gestational age at birth in women with a short cervix who are prescribed AR compared with women with a short cervix who are not prescribed AR (NAR).\n\nThe primary hypothesis is that NAR is non-inferior to AR in prolonging pregnancy in women with a short cervix.\n\nSecondary hypotheses are that, compared with AR, NAR is associated with higher level of physical activity, lower risk of maternal depression, and reduced risk of loss of maternal bone mineral density.\n\nThrough the BEWISE study, we wish to implement a change in the Danish national clinical practice regarding AR from recommending AR in risk groups (current practice) to no longer recommending AR as part as routine care (new practice). We will evaluate this change in clinical practice by prospectively collecting data from women both before and after implementation of the new recommendation. The transition from AR to NAR will be implemented sequentially in each Danish region using a randomised stepped-wedge (SW) cluster design, with each region constituting a cluster. The order in which regions transition is determined by randomisation. Each region will adopt the new recommendation at 3-month intervals, resulting in full national transition from AR to NAR within 12 months Eligible participants are pregnant women in gestational age 20+0 to 33+6 and cervical length \\\u003C 25 mm in singleton pregnancies and \\\u003C 30 mm in multiple pregnancies. Participants must be above 18 years of age and be able to read and understand Danish or English. There are no exclusion criteria.\n\nThe primary outcome is gestational age in days (continuous).",[62,63,64,65,30,66,67,68,69,70,71,72,73],"Preterm Birth","Cervical Insufficiency","Bed Rest","Pregnancy Complications","Depression, Postpartum","Pregnancy Outcome","Infant, Premature","Uterine Cervical Incompetence","Premature Birth","Obstetric Labor, Premature","Physical Activity","Bone Density","2026-05-03",{"date":76,"type":39},"2026-05-11",{"date":78,"type":23},"2026-05-01",{"date":80,"type":23},"2029-05-01",{"name":82,"class":46},"Julie Glavind",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":18,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":24,"phases":94,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100625144","infant-massage-for-lymphedema-and-comfort-in-preterm-newborns-100625144","NCT07418814","Infant Massage for Lymphedema and Comfort in Preterm Newborns","The Effectiveness of Infant Massage in Reducing Immobilization-Related Lymphedema Symptoms and Increasing Comfort in Preterm Newborns","Inclusion Criteria:\n\nTo ensure a homogenous and clinically stable sample, infants meeting the following criteria will be recruited:\n\n* Clinical diagnosis of lymphedema.\n* Hemodynamic and clinical stability.\n* No current or recent (within 24 hours) administration of analgesic or sedative medications that could mask comfort assessments.\n* Intact skin integrity with no contraindications for topical massage.\n* Absence of congenital heart disease or neurological disorders (antenatal or postnatal diagnosis).\n* No immediate requirement for endotracheal aspiration.\n* Requirement for only non-invasive respiratory support (e.g., nCPAP).\n* Provision of written informed consent by the legal guardians (parents).\n\nExclusion Criteria:\n\nInfants will be excluded if they present with:\n\n* Major congenital anomalies.\n* Severe respiratory, cardiac, or neurological instability during the study period.\n* Any acute medical contraindication identified by the attending neonatologist.","28 Weeks","37 Weeks",{"count":93,"type":23},40,[26],"This randomized controlled trial investigates the effectiveness of infant massage in reducing symptoms of immobilization-related lymphedema and improving comfort in preterm newborns hospitalized in the Neonatal Intensive Care Unit (NICU). Preterm infants frequently develop lymphedema due to their immature circulatory systems and prolonged lack of movement.\n\nThe study compares two groups of infants: one receiving standard care and another receiving a daily 15-minute massage therapy session for 14 consecutive days in addition to standard care. Researchers will evaluate the impact of the massage by measuring the circumference of the infants' wrists, elbows, ankles, and knees to assess fluid reduction. Additionally, the infants' comfort levels will be assessed using the Premature Infant Comfort Scale (PICS). The goal is to determine if massage can serve as a safe, non-invasive method to manage lymphedema and reduce distress in this vulnerable population.",[97,70,98,30],"Lymphedema","Edema",[100,101,97,102,103,30],"Infant Massage","Preterm Infant","Neonatal Comfort","Massage Therapy","2026-02-11",{"date":106,"type":39},"2026-02-18",{"date":108,"type":23},"2026-04-01",{"date":110,"type":23},"2027-04-01",{"name":112,"class":46},"Erzurum Technical University",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":24,"phases":124,"briefSummary":125,"conditions":126,"keywords":130,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":4},"100562278","achilles-tendon-rupture---intervention-with-electrical-stimulation-100562278","NCT06601088","Achilles Tendon Rupture - Intervention With Electrical Stimulation","Acute Achilles Tendon Rupture - Intervention With Neuromuscular Electrical Stimulation","C-NMES-ATR","Inclusion Criteria:\n\n* Diagnosed with acute unilateral Achilles tendon rupture\n* Included within 10 days after injury.\n\nExclusion Criteria:\n\n* Inability to give consent to participate,\n* ongoing treatment with anticoagulants,\n* known allergy to contrast agents,\n* planned follow-up at another hospital,\n* inability to follow instructions,\n* known renal failure,\n* heart failure with pitting edema,\n* thrombophlebitis,\n* thromboembolic disease within the last 3 months,\n* previous surgery of the tendon,\n* known malignancy,\n* hemophilia,\n* pregnancy,\n* treatment with high doses of acetylsalicylic acid.","75 Years",{"count":123,"type":23},220,[26],"Acute Achilles tendon rupture (ATR) is an injury that is commonly associated with complications, such as blood clotting, muscle loss and tendon lengthening, all of which affect the long-term outcome and return to sports. These complication are related to the treatment of ATR with lower leg immobilization in a boot.\n\nThe investigators aim to demonstrate that an intervention with calf neuromuscular electrical stimulation (C-NMES) during leg immobilization after ATR can 1) reduce blood clots, 2) lower the degree of muscle loss, 3) decrease tendon lengthening and 4) improve long-term outcome.",[127,30,128,129],"Achilles Tendon Ruptures","Venous Thromboembolism (VTE)","Muscle Atrophy",[131,132],"neuromuscular electrical stimulation","duplex ultrasound","2024-09-15",{"date":135,"type":39},"2024-09-19",{"date":137,"type":23},"2025-01-15",{"date":139,"type":23},"2026-12-30",{"name":141,"class":46},"Karolinska University Hospital"]