[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immune-development\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immune-development":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,74,97,117,134],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100587267","human-genes-and-microbiota-in-early-life-100587267",false,"NCT06926166","Human Genes and Microbiota in Early Life","Human Genes and Microbiota in Early Life (HuGME)","HuGME","Inclusion Criteria:\n\nPregnant women with \\\u003C 20 weeks of gestation Pregnant women intended to eventually deliver in Guangzhou Women and Children's medical center Permanent residengts of families intended to remain in Guangzhou with their child for ≥3 years\n\nExclusion Criteria:\n\nRefuses to have blood and stool samples stored at Born in Guangzhou cohort study Biobank.",true,"ALL",{"count":20,"type":21},20000,"ESTIMATED","OBSERVATIONAL","The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life and their interaction with the host on maternal-offspring health consequences in later life in the born in Guangzhou cohort study in China. Identification of the effect of microbiota in early life, as well as environmental factors and microbe-host interaction, will lead to a better understanding of disease pathogenesis and provide a foundation for targeted mechanistic investigation into the consequences of microbial-host crosstalk for long-term health. It also can result in new strategies to predict and prevent diseases in later life.",[25,26,27,28,29,30,31],"Host and Microbiome","Pregnancy Outcomes","Pregnancy Complications","Neurodevelopmental Disorders","Immune Development","Childhood Obesity","Type 2 Diabetes","RECRUITING","2025-04-07",{"date":35,"type":36},"2025-04-13","ACTUAL",{"date":38,"type":36},"2019-04-01",{"date":40,"type":21},"2038-12-31",{"name":42,"class":43},"Guangzhou Women and Children's Medical Center","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":17,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":73,"locationsCount":44},"100334345","maternal-grandmothers-in-the-born-in-guangzhou-cohort-study-100334345","NCT03633162","Maternal Grandmothers in the Born in Guangzhou Cohort Study","MGBIG","Inclusion Criteria:\n\n1. Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center\n2. Baseline information of maternal grandmother's daughter during pregnancy available\n\nExclusion Criteria:\n\n1. Significant cardiovascular abnormalities\n2. Intelligent obstacle, intellectual disabilities or gawkish condition","FEMALE","36 Years","100 Years",{"count":56,"type":21},5000,"The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of \"grandmother-mother-child\" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.",[59,29,30,25,60],"Hereditary Transmission","Neurodevelopment",[62,63,64,65,66],"Maternal Grandmother","Genes","Immune","Cohort","Child development","2024-09-27",{"date":69,"type":36},"2024-10-01",{"date":71,"type":36},"2018-05-21",{"date":40,"type":21},{"name":42,"class":43},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":96,"locationsCount":44},"100337045","preterm-birth-cohort-study-in-guangzhou-100337045","NCT03668327","Preterm Birth Cohort Study in Guangzhou","PBCSG","Inclusion Criteria:\n\n1. Born before 37 weeks of gestation\n2. Born in Guangzhou Women and Children's Medical Center\n3. Intended to remain in Guangzhou for more than 3 years\n\nExclusion Criteria:\n\n1. Multiple birth\n2. Stillbirth\n3. With major congenital abnormalities","18 Years",{"count":56,"type":21},"The Preterm Birth Cohort Study in Guangzhou (PBCSG) aims to explore the impact of genetic and environmental factors including life styles on preterm birth, to examine the interaction effect between these factors, and to follow up the short-term and long-term outcomes of preterm childrens.",[85,60,29,25],"Preterm Birth",[87,65,88,89],"Preterm","Early development","Child","2024-02-22",{"date":92,"type":36},"2024-02-26",{"date":94,"type":36},"2012-02-01",{"date":40,"type":21},{"name":42,"class":43},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":81,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":113,"startDateStruct":114,"completionDateStruct":115,"leadSponsor":116,"locationsCount":44},"100311188","twins-born-in-guangzhou-100311188","NCT03331133","Twins Born in Guangzhou","Twins Born in Guangzhou Cohort Study","2-BIG","Inclusion Criteria:\n\n1. Live twins delivered in Guangzhou Women and Children's Medical Center\n2. Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years\n3. Baseline information during pregnancy available",{"count":106,"type":21},1000,"The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.",[109,29,30,25,60],"Twin Diseases",[111,112,65],"Twin","Early Development",{"date":92,"type":36},{"date":94,"type":36},{"date":40,"type":21},{"name":42,"class":43},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":129,"startDateStruct":130,"completionDateStruct":131,"leadSponsor":133,"locationsCount":44},"100249529","the-born-in-guangzhou-cohort-study-bigcs-100249529","NCT02526901","The Born in Guangzhou Cohort Study (BIGCS)","BIGCS","Inclusion Criteria:\n\n* Pregnant women with \\\u003C20 weeks of gestation\n* Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center\n* Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years",{"count":125,"type":21},30000,"The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China. Data are collected regarding environmental, occupational and lifestyle exposures as well as health outcomes in later life. Biological samples including blood and tissue samples are also collected from the participants.",[128,26,60,29,30,25],"Intrauterine Hyperglycemia",{"date":92,"type":36},{"date":94,"type":4},{"date":132,"type":21},"2030-12-31",{"name":42,"class":43},{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":156,"leadSponsor":157,"locationsCount":44},"100403176","gdm-and-its-consequences-in-mothers-and-offsprings-100403176","NCT04529889","GDM and Its Consequences in Mothers and Offsprings","Gestational Diabetes Mellitus and Its Consequences in Mothers and Offsprings","GDMCMO","Inclusion Criteria:\n\n1. Pregnant women diagnosed with gestational diabetes mellitus\n2. Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center\n3. Permanent residents or families intended to remain in Guangzhou with their child for no less than 3 years\n\nExclusion Criteria:\n\n1. Women with pre-gestational diabetes mellitus\n2. Women with chronic hypertension or kidney disease",{"count":143,"type":21},7000,"Gestational diabetes mellitus (GDM) is one of the most common disorders which occured during pregnancy. GDM is not only associated with short-term maternal and fetal adverse outcomes, but also related to a wide range of long-term consequences for both mother and child. The GDM and Its Consequences for mothers and offsprings (GDMCMO) aims to establish a cohort to follow both maternal and offsprings'short-term and long-term outcomes, including fetal malformations including congenital heart diseases, birth weight, preterm birth, caesarean section delivery, body growth and neurodevelopment after birth, obesity, type 2 diabetes and impaired insulin sensitivity and secretion, lung health and allergic diseases later in life for offspring, as well as future type 2 diabetes and cardiovascular risk factors for mother after delivery. Biological samples including blood and tissue samples of mothers and children are also collected during pregnancy and after delivery.",[146,147,60,29,30,25],"Gestational Diabetes Mellitus","Pregnancy Outcome",[149,150,151,65],"Hyperglycaemia","Maternal health","Children","2023-09-11",{"date":154,"type":36},"2023-09-13",{"date":94,"type":36},{"date":40,"type":21},{"name":42,"class":43}]