[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immunologic-activity-alteration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immunologic-activity-alteration":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100357008","restoration-of-microbiota-in-neonates-100357008",false,"NCT03928431","Restoration of Microbiota in Neonates","Restoration of Microbiota in Neonates - a Randomized Controlled Trial","RoMaNs","Inclusion Criteria:\n\n* Infants of healthy mothers with uncomplicated pregnancies at term, mothers of any ethnic or social background that can speak, read, and understand Swedish to the extent that they can consent in Swedish. An additional inclusion criterion for mothers in the CS groups is vaginal pH ≤ 4 at the time of birth.\n\nExclusion Criteria:\n\n* Infants of mothers with pre-eclampsia or complicated pregnancies, mothers \\\u003C18 years or \\>40 years of age, genital herpes simplex, genital warts, HIV, Hepatitis B or complications during delivery, infants delivered prior to 37 weeks of gestation. Additional exclusion criteria for mothers in the CS group: Mothers positive to Group B Streptococcus, Group A Streptococcus, bacterial vaginosis, vaginal pH \\> 4 at the time of birth. Mothers with fecal samples positive for Salmonella, Shigella, Campylobacter or Yersinia.","ALL","5 Minutes","15 Minutes",{"count":21,"type":22},300,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of the study is to examine the effect of exposure of cesarean section (CS) delivered neonates to a natural condition of birth, i.e. to the microbiota of the birth canal, on the acquisition of microbial genes during development of the microbiome at multiple body sites, immune system maturation and allergy risk in childhood",[28,29,30],"Atopic Dermatitis","Atopic Asthma","Immunologic Activity Alteration",[32,33,34,35,36],"microbiota","cesarean section","vaginal delivery","allergy","immunological programming","RECRUITING","2025-06-26",{"date":40,"type":41},"2025-07-01","ACTUAL",{"date":43,"type":41},"2019-01-01",{"date":45,"type":22},"2028-12-31",{"name":47,"class":48},"Karolinska Institutet","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":5},"100560706","the-role-of-a-mycobacterium-growth-inhibition-assay-to-quantify-host-immune-control-of-m-tuberculosis-100560706","NCT06580639","The Role of a Mycobacterium Growth Inhibition Assay to Quantify Host Immune Control of M. Tuberculosis","The Role of a Mycobacterium Growth Inhibition Assay to Quantify Host Immune Control of M. Tuberculosis From Healthy Blood Donors and Patients With Latent or Active Tuberculosis.","MGIA","Inclusion Criteria: Healthy blood donors or subjects who will get vaccinated.\n\nExclusion Criteria:Known HIV infection, not Swedish citizen, chronic liver och kidney disease,immunosuppression from treatment or disease.",true,"18 Years",{"count":61,"type":22},280,"OBSERVATIONAL","The goal of this observational study is to learn about how the blood leucocytes from patients with and without exposure or disease from tuberculosis (TB) are able to kill live mycobacteria (M. tuberculosis). The main question it aims to answer is:\n\nIs intracellular growth suppression of M. tuberculosis in peripheral blood mononuclear cells variable among healthy blood donors and higher than in patients with latent TB compared to active TB?",[65,30],"Tuberculosis","2024-08-28",{"date":68,"type":41},"2024-08-30",{"date":70,"type":41},"2020-08-01",{"date":72,"type":22},"2025-12-01",{"name":74,"class":75},"Linkoeping University","OTHER_GOV"]