[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immunologic-deficiency-syndromes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immunologic-deficiency-syndromes":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100265520","genetic-study-of-immunodeficiency-search-for-new-genetic-causes-for-primary-immunodeficiencies-100265520",false,"NCT02735824","Genetic Study of Immunodeficiency: Search for New Genetic Causes for Primary Immunodeficiencies","GSI","Inclusion Criteria:\n\n* Patients: Pediatric patients (in\u002Foutpatient or referred) with suspected or confirmed Inborn Errors of Immunity.\n* Relatives: Healthy or affected biological relatives of enrolled patients.\n* Controls: Healthy volunteers with no history of chronic immunological, inflammatory, or infectious disease.\n* Consent: Ability to provide signed informed consent (or guardian consent).",true,"ALL",{"count":19,"type":20},500,"ESTIMATED","OBSERVATIONAL","Individuals with suspected primary immunodeficiency will be studied and the results compared with healthy controls. Primary immunodeficiency may manifest as recurrent, severe or unusual infections as well as signs and symptoms of immune dysregulation such as autoimmunity or lymphoproliferation.",[24,25],"Immunologic Deficiency Syndromes","Primary Immune Deficiency (PID)","RECRUITING","2026-05-11",{"date":29,"type":30},"2026-05-14","ACTUAL",{"date":32,"type":30},"2016-02",{"date":34,"type":20},"2027-12",{"name":36,"class":37},"University Children's Hospital, Zurich","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":38},"100349861","sequential-transplantation-of-ucbscs-and-islet-cells-in-children-and-adolescents-with-monogenic-immunodeficiency-t1dm-100349861","NCT03835312","Sequential Transplantation of UCBSCs and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency T1DM","Sequential Transplantation of Umbilical Cord Blood Stem Cells and Islet Cells in Children and Adolescents With Monogenic Immunodeficiency Type 1 Diabetes Mellitus","Inclusion Criteria:\n\n1.Type 1 diabetes mellitus children with genetic immunodeficiency\n\n1. Meet the diagnostic criteria of type 1 diabetes mellitus: clinical manifestations of typical diabetes mellitus include polyphagia, polyuria, weight loss, or diabetic ketoacidosis, confirmed by blood sugar level, islet function and autoimmune antibody.\n2. Existence of extrapancreatic organ damage: (1) inflammatory bowel disease, (2) impairment of renal function, (3) repeated infection of mouth, skin, anus or whole body, (4) immune hepatitis, (5) persistent chronic immune iridocyclitis, (6) immune adrenalinitis leading to adrenocortical dysfunction, (7) pituitary inflammation leading to hypophysis, (8) rheumatoid disease, (9) immune vasculitis, (10) systemic lupus erythematosus, (11) other organs besides thyroid function damage. Suffering from one or more of above diseases. Recurrence after receiving regular clinical treatment, including symptomatic treatment of organ protective drugs.\n3. Gene mutation was found according to gene diagnosis: gene mutation was found by gene sequencing. Literature searches at home and abroad confirmed that the defect of the gene resulted in autoimmune or immune dysfunction, resulting in multiple organ dysfunction and poor prognosis.\n\nExclusion Criteria:\n\n1. Mature and effective treatment methods are available.\n2. HIV, HBV and HCV were positive.\n3. A the active period of infection.\n4. At the active stage of malignant tumors.\n5. Combination of other fatal diseases.\n6. Existence of mental and psychological diseases.","18 Years",{"count":48,"type":20},50,"INTERVENTIONAL",[51],"NA","This study evaluates the efficacy of sequential transplantation of umbilical cord blood stem cells and islet cells in children with monogenic immunodeficiency type 1 diabetes mellitus. Umbilical cord blood stem cell transplantation will be performed first. Children with stable immune reconstruction will than receive islet cell transplantation.",[54,24],"Diabetes Mellitus, Type 1",[56,57],"Islets of Langerhans Transplantation","Cord Blood Stem Cell Transplantation","2026-03-15",{"date":60,"type":30},"2026-03-17",{"date":62,"type":30},"2019-02-20",{"date":64,"type":20},"2030-12-31",{"name":66,"class":37},"Children's Hospital of Fudan University"]