[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immunologic-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immunologic-disease":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100499667","patients-pregnant-women-with-or-without-primary-antiphospholipid-antibody-syndrome-100499667",false,"NCT05786235","Patients Pregnant Women With or Without Primary Antiphospholipid Antibody Syndrome","Inclusion Criteria:\n\n* Group 1\n\n  1. Pregnant patients between the ages of 18 and 45 years.\n  2. Diagnosis of primary APS, according to international classification criteria.\n* Group 2\n\n  1. Pregnant patients between the ages of 18 and 45 years.\n  2. Patients with at least one previous full-term pregnancy.\n  3. No diagnosis of APS, according to international classification criteria.\n\nExclusion Criteria:\n\n* Group 1\n\n  1. PMA pregnancies.\n  2. Known chronic pathology in gestational period such as chronic essential hypertension, neurological pathology\n  3. Previous thrombotic event\n  4. Chronic renal failure not related to AD\n  5. Previous history of oncology\n* Group 2\n\n  1. Pregnancy by PMA.\n  2. Previous history of polyabortion and\u002For late pregnancy complications.\n  3. Known chronic pathology in gestational period such as chronic essential hypertension, neurological pathology\n  4. Previous thrombotic event\n  5. Previous history of oncology",true,"FEMALE","18 Years","45 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","The purpose of the study is to evaluate the ability of placental angiogenesis markers to predict the risk of PE in pregnancy in women with primary APS.\n\nTo construct reference intervals of placental angiogenesis markers specific to women affected by primary APS in pregnancy by measuring the levels of sFlt-1and PlGF in serum maternal serum and their sFlt-1\u002FPlGF ratio during the trimesters of gestation (I TM, II TM and III TM).\n\nFor this aim the study will involve recruiting two groups of subjects, one will be cases and one will be controls.",[25,26,27,28,29,30],"Preeclampsia","Immunologic Disease","Antiphospholipid Antibody Syndrome Primary","Pregnancy Complications","Pregnancy, High Risk","Rheumatic Diseases","RECRUITING","2025-06-17",{"date":34,"type":35},"2025-06-18","ACTUAL",{"date":37,"type":35},"2022-12-06",{"date":39,"type":21},"2026-06-06",{"name":41,"class":42},"IRCCS San Raffaele","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":57,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":43},"100501284","medically-assisted-fertilization-techniques-in-systemic-immunoreumatologic-diseases-100501284","NCT05807256","Medically Assisted Fertilization Techniques in Systemic Immunoreumatologic Diseases","Assessment of Maternal-fetal Outcome in Pregnancy From Medically Assisted Fertilization Techniques in Women With Systemic Immunoreumatologic Diseases","Inclusion Criteria:\n\n* Patients diagnosed with systemic immunoreumatologic disease such as SLE, APS, RA, SpA, SclS, SS, PM-DM, vasculitis\n* patients who have performed one or more PMAs between January 2000 and April 2021\n* patients who had their last follow-up by February 2022\n\nExclusion Criteria:\n\n* Patients diagnosed with only one organ autoimmunity (e.g., diabetes mellitus I, thyroiditis of Hashimoto's, celiac disease or chronic inflammatory bowel disease in the absence of systemic disease associated);\n* patients with severe renal failure, significant pulmonary hypertension or cardiomyopathy severe.","50 Years",{"count":53,"type":21},500,"Systemic rheumatological diseases often occur in young women of childbearing age and can therefore impact fertility. There are diseases, such as arthritis, which present no contraindication to assisted reproductive techniques (ARTs), because there is no influence on the disease itself if the disease activity at conception is stable. On the other hand, patients suffering from connective tissue diseases, primarily Systemic Lupus Erythematosus (SLE) and patients suffering from primary or SLE-related Anti-Phospholipid Antibody Syndrome (APS), deserve more targeted therapies both in the context of ARTs and in the ensuing pregnancy.\n\nTo evaluate the response to ARTs in patients with systemic rheumatological diseases, both in terms of reactivation of the underlying pathology and in terms of ARTs outcome.",[30,56,29,28,26],"Fertility Disorders",{"date":34,"type":35},{"date":59,"type":35},"2022-05-04",{"date":61,"type":21},"2025-11-30",{"name":41,"class":42}]