[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immunologic-paralysis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immunologic-paralysis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100396964","immune-homeostasis-in-sepsis-and-septic-shock-100396964",false,"NCT04448951","Immune Homeostasis in Sepsis and Septic Shock","Immune Homeostasis in Patients With Sepsis and Septic Shock: a Single Center Observational Study","IMHOTEP","Inclusion Criteria:\n\n* sepsis\u002Fseptic shock (SEPSIS-3)\n* age ≥18\n* informed consent\n* inclusion within first 24hrs after development\u002Fdiagnosis of septic shock\n\nExclusion Criteria:\n\n* disagreement of the patient or legal representative with the entry into the study\n* patients with primary or secondary immunodeficiency\n* presence of active haematological malignancy or an active non-haematological malignancy",true,"ALL","18 Years",{"count":21,"type":22},200,"ESTIMATED","90 Days","OBSERVATIONAL","Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.",[27,28,29,30],"Sepsis","Immunologic Paralysis","Immunologic Suppression","Immune Deficiency",[32,33,34,35,36,37,38],"sepsis","septic shock","immune response","immunoparalysis","transcriptomics","flow-cytometry","immunomodulation","RECRUITING","2024-08-20",{"date":42,"type":43},"2024-08-21","ACTUAL",{"date":45,"type":43},"2020-09-01",{"date":47,"type":22},"2027-12-31",{"name":49,"class":50},"Charles University, Czech Republic","OTHER"]