[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immunoparalysis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immunoparalysis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100635328","innate-immune-immunoparalysis-and-ventilator-associated-pneumonia-in-critically-ill-elderly-patients-100635328",false,"NCT07551258","Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients","Intensity and Duration of Innate Immune System Immunoparalysis in the Pathophysiology of Ventilator-Associated Pneumonia in Mechanically Ventilated Elderly Patients","IMP-VM","Inclusion Criteria:\n\n* ≥18 years\n* Mechanical ventilation expected \\>48h\n* Intubation between 24h pre- and 48h post- ICU admission\n* Informed consent\n\nExclusion Criteria:\n\n* Known severe immunosuppression, including primary immunodeficiency disorders, advanced HIV infection (AIDS), active hematological malignancy under treatment, recent chemotherapy or immunosuppressive therapy\n* High dose steroids at immunosuppressive doses\n* Active autoimmune disease\n* Pregnancy\n* End-of-life situation",true,"ALL","18 Years",{"count":21,"type":22},170,"ESTIMATED","90 Days","OBSERVATIONAL","This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients. Immunoparalysis will be assessed through monocyte HLA-DR expression and ex vivo lipopolysaccharide (LPS)-stimulated TNF-α production.\n\nThe study will include three cohorts: elderly patients (≥65 years), younger adults (\\\u003C65 years), and healthy controls. The primary objective is to determine whether the presence, duration, intensity, and trend of immunoparalysis are associated with the incidence of VAP and other ICU-acquired infections. Secondary objectives include characterization of immunoparalysis dynamics, comparison of measurement methods, and evaluation of clinical outcomes.",[27,28,29],"Intubated ICU Patients","Ventilator Associated Pneumonia ( VAP)","Immunoparalysis",[31,32,33,34,35],"invasive mechanical ventilation","LPS stimulation","HLA-DR","innate immunity","ICU-acquired infections","RECRUITING","2026-05-17",{"date":39,"type":40},"2026-05-19","ACTUAL",{"date":42,"type":22},"2026-05-01",{"date":44,"type":22},"2028-07-31",{"name":46,"class":47},"Hospital Universitari de Bellvitge","OTHER"]