[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"immunotherapy-induced-pneumonitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:immunotherapy-induced-pneumonitis":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":5},"100568990","incentive-spirometry-to-improve-outcomes-in-lung-cancer-patients-undergoing-concurrent-chemotherapy-and-radiation-therapy-100568990",false,"NCT06688422","Incentive Spirometry to Improve Outcomes in Lung Cancer Patients Undergoing Concurrent Chemotherapy and Radiation Therapy","Incentive Spirometry for Respiratory Enhancement Pilot Clinical Trial in Lung Cancer Patients Undergoing Concurrent Chemotherapy and Radiation Therapy","INSPIRE-CRT","Inclusion Criteria:\n\n* Confirmed diagnosis of advanced non-small-cell lung cancer\n* Performance status (ECOG 0-1)\n* Eligible for concurrent chemotherapy and radiation\n* 18 years or older\n\nExclusion Criteria:\n\n* Previous lung or thoracic surgery\n* Enrollment in another pulmonary intervention trial\n* Home oxygen usage prior to enrolment\n* Radiological evidence of pleural effusion, pneumothorax, bullous emphysema, - or pneumonitis on staging imaging\n* Presence of active respiratory tract infection\n* Uncontrolled nausea and vomiting\n* Prior exposure to drugs such as amiodarone, bleomycin, or immunotherapy\n* Inability or unwillingness of individual to give written informed consent","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if using an incentive spirometer can reduce lung problems in people with advanced lung cancer who are receiving chemotherapy and radiation therapy. The main questions the study aims to answer are:\n\nDoes using an incentive spirometer lower the chances of developing lung inflammation (pneumonitis)? Does it improve overall survival and quality of life?\n\nParticipants will:\n\nUse an incentive spirometer, a device that helps with deep breathing, 10 times every hour while awake.\n\nContinue using the spirometer daily during treatment and for up to three months after treatment.\n\nComplete quality of life assessments at the start of the study and at 3, 6, and 12 months.\n\nResearchers will compare the results to see if the incentive spirometer helps reduce lung problems and improves participants\\' well-being during and after their cancer treatment.",[27,28,29,30,31],"Lung Cancer","Pneumonitis","Radiation-Induced Lung Injury","Immunotherapy-Induced Pneumonitis","Non-Small-Cell Lung Cancer (NSCLC)",[33,34,35,36,37,38,39,40,41,42],"Incentive Spirometry","Chemotherapy","Radiation Therapy","Quality of Life (QoL)","Respiratory Complications","Advanced Lung Cancer","Concurrent Chemoradiotherapy","Pulmonary Toxicity","Immunotherapy Maintenance","Lung Function","RECRUITING","2026-04-13",{"date":46,"type":47},"2026-04-15","ACTUAL",{"date":49,"type":47},"2024-12-01",{"date":51,"type":21},"2026-12",{"name":53,"class":54},"The Cooper Health System","OTHER"]