[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"impacted-mandibular-third-molar\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:impacted-mandibular-third-molar":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,81,113],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100608186","the-effect-of-different-flap-closure-techniques-on-postoperative-morbidity-in-impacted-third-molar-surgery-100608186",false,"NCT07198282","The Effect of Different Flap Closure Techniques on Postoperative Morbidity in Impacted Third Molar Surgery","The Effect of Different Flap Closure Techniques on Postoperative Morbidity: A Randomized Controlled Trial for Impacted Third Molar Surgery","GMC02","Inclusion Criteria:\n\n* Patients aged 18-40 years.\n* Patients with no systemic diseases (ASA I).\n* Patients with impacted mandibular third molars indicated for extraction, with bone and\u002For mucosal retention, in similar positions (Pell \\& Gregory Class 2, Position B; Winter classification vertical or mesioangular).\n\nExclusion Criteria:\n\n* Patients classified as ASA II, III, or IV.\n* Known allergy to anesthetic solutions.\n* Allergy to acrylate.\n* Pregnant or breastfeeding women.\n* Individuals with tobacco use ≥10 cigarettes\u002Fday.\n* Alcohol users.\n* Patients using antiplatelet agents.\n* Patients using anticoagulants.\n* Patients with coagulation disorders.\n* Patients with immunosuppressive diseases or receiving immunosuppressive therapy.\n\nPatients with acute pain or local infection at the surgical site.","ALL","18 Years","40 Years",{"count":21,"type":22},148,"ESTIMATED","INTERVENTIONAL",[25],"NA","1\\. ABSTRACT This study is a randomized controlled trial comparing the clinical efficacy and safety of four different flap closure techniques in reducing postoperative morbidity (pain, swelling, trismus, wound healing) and improving patient quality of life (GOHAI) following impacted mandibular third molar extraction. The methods include conventional suturing, sutureless technique, surgical drain, and cyanoacrylate tissue adhesive, which are commonly used in oral surgery practice. The study aims to scientifically evaluate the effects of each method on patients and to determine the most appropriate clinical approach.",[28,29,30],"Impacted Mandibular Third Molar","Postoperative Morbidity","Oral Surgery",[32,33,34,35,36],"Impacted third molar","Flap closure techniques","Cyanoacrylate","Sutureless technique","Surgical drain","RECRUITING","2026-06-08",{"date":40,"type":41},"2026-06-09","ACTUAL",{"date":43,"type":41},"2026-05-08",{"date":45,"type":22},"2026-08-30",{"name":47,"class":48},"Recep Tayyip Erdogan University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100635613","phase-4-effect-of-preoperative-submucosal-dexamethasone-on-postoperative-discomfort-after-mandibular-third-molar-surgery-100635613","NCT07554963","\"Effect of Preoperative Submucosal Dexamethasone on Postoperative Discomfort After Mandibular Third Molar Surgery\"","Effect of Preoperative 4 mg Submucosal Dexamethasone on Postoperative Discomfort After Impacted Mandibular Third Molar Surgery: A Randomized Controlled Trial","DEXA-M3M","Inclusion Criteria:\n\n* Adults aged 18 to 55 years\n* Patients requiring surgical extraction of impacted mandibular third molars\n* Patients willing to provide informed consent\n\nExclusion Criteria:\n\n* Patients with systemic diseases\n* Patients with periodontal disease\n* Pregnant or lactating women\n* Patients who have used antibiotics or anti-inflammatory drugs within the past 7 days\n* Patients with known hypersensitivity to dexamethasone","55 Years",{"count":60,"type":22},268,[62],"PHASE4","This study aims to determine whether giving a single dose of dexamethasone before surgery can reduce pain and difficulty in opening the mouth after removal of an impacted lower wisdom tooth. Pain and limited mouth opening are common problems after this procedure and can affect eating, speaking, and daily activities.\n\nA total of 268 patients aged 18 to 55 years who require surgical removal of an impacted mandibular third molar will be included. Participants will be randomly assigned to one of two groups. One group will receive a 4 mg dexamethasone injection under the gum before surgery, while the other group will not receive this medication. All patients will undergo the same surgical procedure and receive standard postoperative care.\n\nPain will be measured using a visual analogue scale, and mouth opening will be assessed using a standard measuring method. These outcomes will be recorded on the second and seventh days after surgery.\n\nThe results of this study will help determine whether preoperative dexamethasone is an effective and simple method to reduce postoperative discomfort and improve recovery after third molar surgery.",[28,65,66],"Postoperative Pain","Trismus",[68,69,70,65],"Dexamethasone","Third Molar Surgery","Impacted Tooth","NOT_YET_RECRUITING","2026-04-27",{"date":74,"type":41},"2026-05-01",{"date":74,"type":22},{"date":77,"type":22},"2026-10-01",{"name":79,"class":80},"Hayat Abad Medical Complex, Peshawar","OTHER_GOV",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100627214","cyanoacrylate-adhesive-in-impacted-mandibular-third-molars-surgery-100627214","NCT07445724","Cyanoacrylate Adhesive in Impacted Mandibular Third Molars Surgery","Evaluation of Soft Tissue Healing and Microbiological Status in Patients Undergoing Surgical Extraction of Impacted Mandibular Third Molars Using Cyanoacrylate Adhesive","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Patients presenting with bilateral mandibular third molars indicated for extraction, with the same level of surgical difficulty according to the Pell-Gregory classification, and an angulation difference between the two teeth not exceeding 15° according to the Winter classification on panoramic radiographs.\n* No use of local or systemic antibiotics within 2 weeks prior to surgery.\n* Absence of serious systemic diseases such as coagulation disorders or uncontrolled diabetes, and no acute infection at the extraction site.\n* Patients who agree to participate in the study after receiving clear explanation and counseling.\n\nExclusion Criteria:\n\n* Patients who are uncooperative in providing necessary information or who decline to continue participation in the study.\n* A difference in surgical duration between the two sides exceeding 12 minutes, or the occurrence of intraoperative complications.\n* Patients with known hypersensitivity or allergy to any materials used in the study, such as lidocaine local anesthetic, cyanoacrylate adhesive, or suture materials.",{"count":89,"type":22},23,[25],"The goal of this randomized clinical trial is to evaluate whether cyanoacrylate tissue adhesive can improve postoperative outcomes compared with conventional silk sutures in patients undergoing surgical removal of impacted mandibular third molars.\n\nThe main questions it aims to answer is: Is there a difference in wound healing support, soft-tissue conditions, and microbiological outcomes at the surgical site of impacted mandibular third molar extraction between closure with conventional sutures and cyanoacrylate tissue adhesive? Researchers will compare cyanoacrylate tissue adhesive with conventional silk sutures to determine whether the adhesive provides superior postoperative recovery and periodontal outcomes.\n\nParticipants will:\n\n* Undergo surgical extraction of an impacted mandibular third molar.\n* Receive wound closure using either cyanoacrylate tissue adhesive or conventional silk sutures.\n* Be followed postoperatively for assessment of pain, swelling, trismus, soft-tissue healing, and periodontal measurements at specified time points.",[28],[94,95,96,97,98,99,100,101,102,103],"impacted mandibular third molar","Cyanoacrylate tissue adhesive","Silk suture","Wound closure","Postoperative pain","Soft-tissue healing","Periodontal healing","Oral microbiota","Randomized controlled trial","Oral surgery","2026-02-25",{"date":106,"type":41},"2026-03-03",{"date":108,"type":22},"2026-03",{"date":110,"type":22},"2026-12",{"name":112,"class":48},"University of Medicine and Pharmacy at Ho Chi Minh City",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":120,"sex":17,"minAge":18,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":125,"conditions":126,"keywords":128,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":49},"100622649","wound-healing-and-bacterial-adherence-with-triclosan-coated-sutures-after-mandibular-impacted-third-molar-surgery-100622649","NCT07386366","Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery","Evaluation of Soft Tissue Healing and Antibacterial Effectiveness of Triclosan-Coated Polyglactin 910 Sutures After Impacted Mandibular Third Molar Surgery: A Randomized Double-Blind Split-Mouth Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 35 years.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Presence of two symmetric impacted mandibular third molars with the same level of difficulty according to the Pell-Gregory and Winter classification; the difference in angulation between the two third molars is no more than 15 degrees.\n* No use of topical or systemic antibiotics for at least 4 weeks before surgery.\n* Able and willing to provide written informed consent.\n* No active infection associated with the mandibular third molar at the time of enrollment.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding.\n* Allergy to local anesthetic (2% lidocaine with 1:100,000 epinephrine) or any medications used in the study.\n* Radiographic findings suggestive of a tumor or cyst associated with the impacted mandibular third molar.\n* Participant withdraws consent or does not agree to continue participation.\n* Unable to attend scheduled follow-up visits.\n* Difference in surgical extraction time between the two procedures is 12 minutes or more.\n* Suture loss\u002Floosening before completion of the final assessment time point.",true,"35 Years",{"count":123,"type":22},14,[25],"The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the stitches after lower impacted wisdom tooth surgery in adults aged 18 to 35 years.\n\nThe main questions it aims to answer are:\n\n1. Does triclosan-coated polyglactin 910 suture lead to better soft-tissue wound healing than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?\n2. Does triclosan-coated polyglactin 910 suture result in a lower oral bacterial load adhered to the suture material than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?\n\nParticipants will:\n\n* Have surgery to remove two similar lower impacted wisdom teeth (one on each side)\n* Receive triclosan-coated stitches on one side and standard stitches on the other side, with the side assignment chosen at random\n* Return for follow-up visits on day three, day five, and day seven after surgery for healing checks, simple ratings of pain and swelling, and collection of a small stitch sample for bacterial testing.",[28,127],"Postoperative Wound Healing",[129,130,131,132,103,133,134,135],"Triclosan-coated suture","Polyglactin 910","Impacted third molar surgery","Mandibular third molar","Postoperative wound healing","Bacterial adhesion","Antibacterial suture","2026-01-27",{"date":138,"type":41},"2026-02-04",{"date":140,"type":41},"2025-10-07",{"date":142,"type":22},"2026-07",{"name":112,"class":48}]