[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"implant-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:implant-failure":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100599007","effect-of-bone-augmentation-simultaneous-to-implant-removal-on-the-prognosis-of-reimplantation-at-the-same-site-100599007",false,"NCT07078890","Effect of Bone Augmentation Simultaneous to Implant Removal on the Prognosis of Reimplantation at the Same Site","Inclusion Criteria:\n\n* 1\\. Age greater than 18 years 2. Implant failure requiring removal 3. Plan to reimplant in the same site 4. Periodontal health, or stabilized periodontitis after treatment\n\nExclusion Criteria:\n\n* 1\\. Uncontrolled metabolic diseases 2. Taking medications that have an effect on bone metabolism 3. The implant has detached at the time of consultation 4. Do not consent to reimplant in the same site 5. Unwillingness to participate in the follow-up of this study 6. Other conditions that do not qualify for implant therapy","ALL","18 Years","90 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim of this study was to investigate the effect of bone augmentation simultaneous to implant removal on the prognosis of reimplantation at the same sites, providing recommendations for management strategies after failed implant removal.",[26,27,28],"Implant Failure","Bone Augmentation","Prognosis","RECRUITING","2025-07-13",{"date":32,"type":33},"2025-07-22","ACTUAL",{"date":35,"type":33},"2025-03-12",{"date":37,"type":20},"2027-08",{"name":39,"class":40},"The Dental Hospital of Zhejiang University School of Medicine","OTHER",3,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100595403","phase-1-use-of-biocompatible-thermoplastic-impregnated-with-vancomycin-as-a-temporary-orthopedic-spacer-100595403","NCT07031999","Use of Biocompatible Thermoplastic Impregnated With Vancomycin as a Temporary Orthopedic Spacer","ORTOPLA","Inclusion Criteria:\n\n* Age:\n\nPatients aged 18 years or older.\n\nGender:\n\nIndividuals of all genders are eligible for participation.\n\nIndication for Prosthesis Replacement:\n\nPatients with an active infection related to a hip, knee, or shoulder prosthesis who require implant removal due to infection and placement of an antibiotic-loaded spacer.\n\nInformed Consent:\n\nPatients or their legal guardians must have signed the Informed Consent Form (ICF), authorizing their participation in the study.\n\nActive Infection:\n\nPatients must present with clinical signs of active periprosthetic infection, such as pain, fever, or purulent discharge at the implant site.\n\nWillingness for Follow-Up:\n\nPatients must be willing to attend outpatient follow-up visits and undergo clinical evaluations over a 6-month postoperative period.\n\nExclusion Criteria:\n\n* Inactive Infection:\n\nPatients without signs of active prosthetic infection (i.e., no fistula, purulent discharge, or erythema).\n\nPregnancy or Lactation:\n\nPregnant or breastfeeding women.\n\nSeverely Compromised Immunosuppression:\n\nPatients with conditions that significantly impair the immune system, including:\n\nSolid organ or hematopoietic stem cell transplantation.\n\nUntreated HIV infection or CD4 count \\\u003C 350 cells\u002Fmm³.\n\nProlonged use of immunosuppressive therapy (e.g., corticosteroids at doses equivalent to \\>0.5 mg\u002Fkg\u002Fday of prednisone for more than 3 weeks).\n\nClinically Incompatible Conditions:\n\nPatients with severe or unstable medical conditions that may compromise procedural safety or the ability to adhere to study follow-up.\n\nInability to Attend Postoperative Follow-Up:\n\nPatients unable to comply with postoperative follow-up visits or telephone consultations due to mobility restrictions or lack of access.",{"count":50,"type":20},30,[52,53],"PHASE1","PHASE2","With the progressive aging of the population and the rising number of individuals with degenerative diseases, there has been an increasing indication for joint replacement arthroplasties as a treatment for osteoarthritis in major joints. Knee, hip, and shoulder prostheses have become effective treatment options for joint degeneration, aiming to restore motor function, improve mobility, and relieve pain. In this context, infection remains a major concern, as it can lead to implant removal and the need to replace it with a temporary implant (articular spacer) combined with local antibiotic delivery and systemic antimicrobial therapy-both essential for the complete resolution of the infectious condition.\n\nPolylactic acid (PLA) is a biocompatible and biodegradable polymer that can be used in 3D printing technologies to develop customized implants and temporary spacers for the treatment of periprosthetic and bone infections, in addition to its potential application in bone reconstruction. The development of such products through reverse engineering, combined with advanced imaging techniques and specialized computational systems, enables the creation of patient-specific implant models, thus optimizing the recovery process.\n\nTherefore, this research project proposes the development and application of a polymer with suitable antimicrobial activity, based on reverse engineering and 3D printing technologies, for the design of orthopedic prostheses and implants. This study aims to address treatment needs in Brazil, where the cost of bone substitutes and articular spacers remains high, especially in orthopedic reconstruction, and where public healthcare systems face challenges in providing adequate and affordable solutions.\n\nIn this sense, the development of customized, biocompatible, low-cost, and antimicrobial implants may have a significant impact on both patient outcomes and the public health system. This technology is innovative, as it will bring a novel category of medical product to the national market with potential for global reach, thereby representing a substantial advancement in the healthcare field.",[26,56],"Infection",[58,59],"PLA","prosthesis","NOT_YET_RECRUITING","2025-06-19",{"date":63,"type":33},"2025-06-22",{"date":65,"type":20},"2026-06-01",{"date":67,"type":20},"2028-12-01",{"name":69,"class":40},"Hospital Universitario Evangelico de Curitiba"]