[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"impulse-control-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:impulse-control-disorders":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100554381","bilateral-subthalamic-stimulation-in-pd-patients-with-impulse-control-disorders---stimpulsecontrol-100554381",false,"NCT06498349","Bilateral Subthalamic Stimulation in PD Patients With Impulse Control Disorders - STIMPulseControl","A Randomized Controlled Trial of Bilateral Subthalamic Stimulation in Patients With Parkinson's Disease and Impulse Control Disorders","Inclusion Criteria:\n\n1. Age at the time of enrollment: ≤ 70 years\n2. Diagnosis of PD according to MDS clinical diagnostic criteria\n3. Onset of first PD motor symptoms ≥ 4 years\n4. Moderate or severe impulse control disorder or related behavioral disorders according to Ardouin, with at least 1 score greater than or equal to 3 (or at least 2 scores greater than or equal to 2) on the Ardouin behaviour scale with the following items considered to reflect ICBDs or related behaviors: pathological gambling, hypersexuality, shopping, eating, hobbyism, punding and compulsive medication use\n5. MDS-UPDRS III improvement of ≥ 30% in the standardized levodopa test or classical Parkinsonian tremor at rest\n6. Adaptation of medical therapy has been attempted\n7. MoCA ≥ 24 in the meds on condition\n8. BDI-II score \\\u003C 20 in the meds on condition, or Patients with moderately severe depression with a BDI-II between 20 and 28 points, strict consideration must be made with the involvement of a psychiatrist. Patients must be willing and able to comply this.\n9. Patients able to understand the study requirements and the treatment procedures\n10. Written informed consent before any study-specific tests or procedures are performed\n\n    Exclusion Criteria:\n11. Surgical contraindications to undergo DBS operation\n12. Ongoing severe depression (BDI-II \\> 28)\n13. suicidal ideation (item 9 of BDI-II \\> 1)\n14. Dementia (MoCA \\\u003C 24) in the meds on condition\n15. Any prior movement disorder treatments that involved intracranial surgery\u002Fablation or intracranial device implantation\n16. Any other active implanted device that is likely to interfere with the implantation or functioning of the DBS system\n17. Simultaneous participation in another clinical trial targeting or potentially interfering with ICD\n18. Any history of recurrent seizures or haemorrhagic stroke\n19. Fertile women not using adequate contraceptive methods\n20. Any terminal illness with significantly reduced life expectancy which exclude DBS implantation according to standard clinical care\n21. A female who is breastfeeding or of child-bearing potential with a positive urine pregnancy test or not using adequate contraception\n22. Any impairment that would limit subject's ability to participate in the study and perform study procedures\n23. Have any significant medical condition that is likely to interfere with study procedures or likely to confound evaluation of study endpoints","ALL","18 Years","70 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","The focus of the study is on patients Parkinson's disease showing as well behavioral disorders that can be described as pathological and are summarized under the term impulse control disorder (ICD). Changes in behavior and also pathological disorders are a common side effect of treatment for Parkinson's disease. The goal of this academic study is to compare the effect of surgical (deep brain stimulation, DBS) treatment combined with a coordinated and adapted best medical treatment (BMT) to be compared with the effect of optimized best medical treatment (BMT) alone. The stimulation arm (DBS+BMT) as well as the medication arm (BMT only) will be monitored according to clinical routine. Participants will have to agree to be randomly assigned to either deep brain stimulation in combination with the best medical treatment (DBS group) or the best medical treatment alone (BMT group). Participants will have to come regularly according to clinical routine to the clinic and complete various questionaires and scales for the study.",[27,28],"Parkinson Disease","Impulse Control Disorders","RECRUITING","2025-12-30",{"date":32,"type":33},"2026-01-05","ACTUAL",{"date":35,"type":33},"2024-09-05",{"date":37,"type":21},"2028-07-15",{"name":39,"class":40},"University of Kiel","OTHER",12,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":66,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100587090","controlled-evaluation-of-an-exercise-program-for-overweight-adolescents-100587090","NCT06923865","Controlled Evaluation of an Exercise Program for Overweight Adolescents","Now! Project - a Controlled Evaluation of a Physical Activity Program for Adolescents With Overweight","Now!","Inclusion Criteria:\n\n* BMI above the 90th percentile for their age and gender (WHO reference table)\n* Deficits in movement motivation and motor skills\n* No health complaints or movement-restricting conditions\n* No health risks for maximal exertion\n* Ability to verbally communicate pain or discomfort\n* Unremarkable PAR-Q questionnaire\n* Signed parental consent form\n\nExclusion Criteria:\n\n* Acute or chronic illness\n* Inability to follow the study procedures (e.g., language barriers, psychological disorders)","12 Years","14 Years",{"count":53,"type":21},150,[24],"Physical activity decreases as young people get older, especially during the shift from early to late adolescence. Unfortunately, around 81% of school-aged children worldwide between the ages of 11 and 17 do not meet the recommendation of at least one hour of physical activity per day - and this is also true in Switzerland. Not being active enough, whether normal weight or overweight, can lead to long-term health problems and is a major factor in becoming overweight over time. This results in healthcare costs and negatively affects quality of life. Supporting physical activity in overweight youth requires well-rounded, thoughtful programs.\n\nThe investigators studying the impact of the movement programs now! and now!+ on the physical activity and health of young people. The goal is to look at both physical and mental changes equally.\n\nTaking part in this study involves minimal physical or mental risk for the participants. These small risks from the testing methods and activities are taken into account in how the program is explained and carried out.\n\nThe benefits for the participants - feeling healthier and fitter physically, and more confident and capable mentally - clearly outweigh any potential risks, thanks to the additional, guided, and personalized exercise program.\n\nThe participants take part in the now! and now!+ exercise programs run by the Basel-Stadt Sports Office and the DSBG. now! is a 90-minute group session with up to 14 young people, while now!+ is a 90-minute small-group session with 2 to 4 participants. Both programs take place once a week over a 12-month period and pause during school holidays (38 training weeks in total).\n\nEach session includes a warm-up, a strength or endurance training block, and a coordination phase. The program is modular and adapted to the physical and personal needs of each participant. This ensures that overweight adolescents are not overstrained and don't develop symptoms like pain, frustration, or lack of motivation (Behringer et al., 2011), while still allowing for a training stimulus that supports physical improvement.\n\nThe results of the evaluations are directly used to improve and further develop the exercise program. The overall project includes three rounds, each consisting of one year of training and three test sessions, each lasting about two hours. The now! and now!+ programs are held weekly for a total of 38 weeks per year, with breaks during school holidays.\n\nEach of the three test sessions includes the same set of assessments (see \"Study Intervention\") and follows a set order: The process begins with measuring body size and blood pressure, followed by a static retinal vessel analysis. After these medical checks, participants do a 5-minute warm-up on a stationary bike at a set resistance level. Then, strength tests are performed: knee extension on the IsoMed 2000, handgrip strength, and jump power on the Leonardo force plate. The endurance test using spiroergometry marks the end of the physical assessments.\n\nFinally, impulse control is tested, and participants complete a set of questionnaires. At the end of the session, each participant is given an actigraph (a small motion sensor worn on the body) to track their physical activity over the following seven days.",[57,58,59,60,61,28,62,63,64,65],"Adolescent","Pediatric Obesity","Exercise Therapy","Health Promotion","Program Evaluation","Quality of Life","Retinal Vessels","Strength Training Effects","Aerobic Capacity",[67,68,69,70,71],"Overweight adolescents","Youth physical activity","Motor performance in children","Impulse control and fitness","training in peer groups","NOT_YET_RECRUITING","2025-04-04",{"date":75,"type":33},"2025-04-11",{"date":77,"type":21},"2025-06-01",{"date":79,"type":21},"2029-12",{"name":81,"class":40},"University Hospital, Basel, Switzerland",1]