[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inactivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inactivity":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,76,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100564015","phase-2-a-mobile-intervention-to-reduce-pain-and-improve-health-iii-100564015",false,"NCT06623669","A Mobile Intervention to Reduce Pain and Improve Health-III","MORPH-III","Inclusion Criteria:\n\n* Aged 65+ years\n* Body mass index of 30-45 kg\u002Fm2 or \\>45 kg\u002Fm2 with physician's approval\n* No loss or gain of more than 5% body mass in previous 6 months\n* Presence of knee or hip osteoarthritis as ascertained via the Roux questionnaire\n* Independently living\n* Low active (i.e., not participating in regular resistance training and\u002For \\>20 mins\u002Fday of aerobic exercise on more than 2 days\u002Fweek in past 3 months as ascertained via a modified CHAMPS questionnaire)\n* Have no contraindication for safe and optimal participation in exercise based on EASY screening (pertaining to chest pain and discomfort during physical activity, dizziness or light headedness, or frequent falls and use of assistive devices)\n* Not currently using a weight loss medication (medications for diabetes management are permitted if weight stable)\n* Approved for participation by medical director\n* Willing to provide informed consent and agree to all study procedures and assessments.\n\nExclusion Criteria:\n\n* Reside in skilled nursing facility, rehab or assisted living environment\n* History of pharmacologic treatment for a psychiatric disorder other than depression\u002Fanxiety within past year\n* Current untreated and\u002For unstable clinical depression or anxiety (Patient Health Questionnaire (PHQ-9) \\>15)\n* Hospitalization for psychiatric event within past year prior to screening\n* History of mild cognitive impairment or dementia\n* Cognitive impairment (\\\u003C32) on Modified Telephone Interview for Cognitive Status survey (TICS-M)\n* Hearing or visual impairment that would preclude use of the videoconferencing software\n* Severe arthritis or other musculoskeletal disorder that is a contraindication for safe walking\n* Presently undergoing treatment for orthopedic fracture\n* Currently using a weight loss medication (medications for diabetes management are permitted if weight stable)\n* Contraindication based on EASY screening (pertaining to chest pain and discomfort during physical activity, dizziness or light headedness, or frequent falls and use of assistive devices) without physician approval\n* Joint replacement or other orthopedic surgery in past 6 months\n* Joint replacement or other orthopedic surgery planned in next 18 months\n* Have a diagnosis of uncontrolled hypertension; current or recent past (within 1 year) severe symptomatic heart disease, uncontrolled angina, stroke, chronic respiratory disease other than asthma or COPD, any disease requiring oxygen use, neurological or hematological disease; cancer requiring current treatment, except non-melanoma skin cancers; kidney failure requiring dialysis; have a Katz ADL disability; or engage in heavy alcohol use \\>14 drinks\u002Fweek.\n* Current participation in other research study with a prospective intervention\n* Unable\u002Funwilling to commit to study protocol, including random assignment and use of technology tools\n* Unable\u002Funwilling to attend three virtual testing appointments","ALL","65 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","The experience of chronic pain powerfully and negatively affects quality of life and functional independence in aging. Unfortunately, while as many as three in four older adults experience chronic pain, few have access to effective non-pharmacological pain management strategies. Participating in regular physical activity, avoiding sustained sitting, and maintaining a healthy weight are important and interrelated lifestyle inputs to chronic pain, and socially rich behavioral interventions informed by contemporary theories of behavior change appear important for engaging in activity and healthy eating in the long term. Our group has demonstrated in a series of Stage I trials that a group-mediated behavioral intervention combining dietary behavior change and a physical activity program focused on moving often throughout the day contributes to meaningful weight loss, and lasting weight maintenance, with pilot data suggesting this may contribute to improved pain, physical function, and health-related quality of life among older adults with chronic pain. As these were NIH Stage I trials, there are several important gaps to be addressed in the present trial: (1) both studies of chronic pain recruited small samples and were 12 weeks in duration, limiting our ability to establish efficacy and the durability of changes to activity, HRQOL, and pain outcomes; (2) participants included anyone with chronic pain, regardless of pain type, a likely contributor to heterogeneous pain intensity and interference findings; and (3) the investigators have yet to examine behavioral maintenance.\n\nThe overarching goal of the proposed Stage II \"mobile intervention to reduce pain and improve health-III (MORPH-III)\" is to establish the efficacy of the intervention for enhancing physical activity via steps (primary), and for reducing pain interference and body weight while enhancing physical function (secondary) among older adults with chronic knee or hip osteoarthritic (OA) pain. The investigators will recruit 200 older adults with knee or hip osteoarthritic pain to engage in a 6-month remotely delivered intervention comprising weekly group or individual intervention meetings plus brief individual goal-setting coaching calls. This will be followed by a 12-month no-contact maintenance period, where participants will attempt to sustain behavioral goals on their own.\n\nThe Specific Aims are:\n\nSpecific Aim 1: To examine the impact of MORPH on ActivPAL-assessed daily steps relative to an enhanced usual care control. Hypotheses: MORPH will significantly increase steps relative to control at month 6.\n\nSpecific Aim 2: To examine the impact of MORPH on pain interference, change in body weight, and physical function relative to the enhanced usual care control. Hypotheses: MORPH will result in significant reductions in pain interference and body weight and improvement in physical function relative to control at month 6.\n\nExploratory Aims: Aim 1: To investigate the impact of the MORPH intervention on steps, weight change, pain interference, and physical function at month 18. Aim 2: If the MORPH intervention results in reduced pain interference at 6 and\u002For 18 months, the investigators will examine the extent to which 6-month change in steps, weight, pain self-efficacy, and catastrophizing mediate change in interference at 6 and\u002For 18 months.",[26,27,28,29],"Chronic Pain","Osteoarthritis","Obesity and Overweight","Inactivity",[31,32,33,34,35],"Digital health","Randomized Trial","Physical Activity","Weight Loss","Aging","RECRUITING","2026-02-18",{"date":39,"type":40},"2026-02-20","ACTUAL",{"date":42,"type":40},"2025-08-14",{"date":44,"type":20},"2029-08-31",{"name":46,"class":47},"Wake Forest University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100624562","exercise-approaches-and-physical-activity-level-in-inactive-adults-100624562","NCT07411248","Exercise Approaches and Physical Activity Level in Inactive Adults","Effects of Different Exercise Approaches on Physical Activity Level and Health Outcomes in Inactive Adults","Inclusion Criteria:\n\n* Taking fewer than 5,000 steps per day and classified as physically inactive according to the International Physical Activity Questionnaire-Short Form (\\\u003C600 MET-min\u002Fweek)\n* Residing in Istanbul\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Diagnosis of end-stage congestive heart failure\n* Presence of malignant or unstable arrhythmia\n* Lack of adequate infrastructure to participate in technology-based physical activity programs\n* Presence of mental dysfunction\n* Presence of acute musculoskeletal injury\n* Pregnancy\n* Answering \"YES\" to any item on the Physical Activity Readiness Questionnaire (PAR-Q)",true,"18 Years","35 Years",{"count":60,"type":20},30,[62],"NA","This randomized, controlled, single-blind study aims to compare the effects of different exercise approaches on physical activity level and health-related outcomes in inactive adults. Thirty inactive individuals aged 18-35 years will be randomly assigned to supervised face-to-face group exercise, mobile application-based exercise, or video-based home exercise. Exercise programs will be performed three days per week for eight weeks and will include aerobic, strengthening, and flexibility exercises.",[65,29,66],"Healthy Participants","Exercise Training","2026-02-11",{"date":69,"type":40},"2026-02-13",{"date":71,"type":40},"2025-01-06",{"date":73,"type":20},"2026-03-02",{"name":75,"class":47},"Biruni University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":56,"sex":16,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":4,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":48},"100594870","the-link-between-physical-activity-and-brain-health-in-healthy-adults-100594870","NCT07025070","The Link Between Physical Activity and Brain Health in Healthy Adults","The Link Between Strength and Endurance Training and Brain Health in Healthy Adults: A Comparative Study of Former Professional Athletes and Sedentary Individuals","MINA","Inclusion Criteria:\n\n* Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days\u002Fweek of moderate-vigorous intensity).\n* Group B: sedentary individuals, (i.e., perform \\\u003C150 min of moderate intensity exercise per week or IPAQ score\\\u003C600 MET min\u002Fweek).\n* In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations.\n* Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition\n\nExclusion Criteria:\n\n* Medical conditions that have a high risk of associated cognitive symptoms.\n* Severe head injury with loss of consciousness within the previous 5 years.\n* Alcoholism (\\>3 alcoholic drinks per day).\n* Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics.\n* Hearing or visual impairment that would preclude testing\n* History of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease).\n* Incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor).\n* Presence of severe systemic disease (e.g., cancer under treatment).\n* Consumption of anabolic substances.\n* Problems understanding spoken or written Spanish.\n* Those with pacemakers or metallic implants that may interfere with the MRI.","40 Years","75 Years",{"count":87,"type":20},60,"OBSERVATIONAL","The goal of this observational study is to investigate the cross-sectional relationship between physical activity and brain health from a multiscale approach (neuropsychology, neuroimaging, peripheral biomarkers and genetics) in former athletes and sedentary individuals. The main question it aims to answer is:\n\nDo former athletes have better brain structure than sedentary people? Evaluating the differences in neurodegenerative processes between competitive training and sedentary and inactivity.",[91,29,92],"Alzheimer Disease","Preventive Therapy",[94],"physical activity","2025-06-09",{"date":97,"type":40},"2025-06-17",{"date":99,"type":40},"2024-11-25",{"date":101,"type":20},"2026-09",{"name":103,"class":47},"Technical University of Madrid",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":56,"sex":111,"minAge":57,"maxAge":17,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":48},"100581286","improving-physical-activity-participation-in-latinas-with-mindfulness-100581286","NCT06848335","Improving Physical Activity Participation in Latinas With Mindfulness","Seamos Activas","Inclusion Criteria:\n\n* Female\n* Generally healthy (If asthma, controlled high blood pressure and\u002For controlled type II diabetes, may be able to participate with physician consent)\n* Sedentary (defined as participating in MVPA for 60 minutes or less per week and engaging in muscle-strengthening exercise on less than 2 days per week)\n* Hispanic or Latina (self-identified)\n* Must be able to read and write in Spanish fluently\n* 18 - 65 years of age\n* Planning on living in the area for the next 18 months\n* Own a cell phone capable of sending and receiving text messages\n* Required to have reliable access to the Internet via a computer or mobile device\n* Must be able to receive materials in the mail, either at your own home or at a mailbox\n\nExclusion Criteria:\n\n* BMI greater than 45\n* Not able to walk continuously for 30 minutes\u002Flimited ability to complete daily activity or ability to exercise\n* Exercise is against advice of doctor\n* Inability to walk independently\n* Current or planned pregnancy in the next 12 months\n* Heart disease\u002Ftreatment\n* Heart murmur\n* Angina\u002Fchest pain or Angina\u002Fchest pain with exertion\n* Palpitations\n* Stroke\u002FTransient Ischemic Attacks\n* Peripheral Vascular Disease\n* Diabetes that requires insulin\n* Non-insulin dependent diabetes without physician approval to participate\n* Chronic infectious disease- HIV, Hepatitis C but does not have doctor approval\n* Chronic liver disease\n* Cystic Fibrosis\n* Abnormal EKG on last EKG performed\n* Emphysema, Chronic bronchitis, Chronic Obstructive Pulmonary Disease\n* Seizure in past year\n* Surgery in past year on heart, lung, joint, orthopedic surgery\n* Surgery pending in next year on lung, joint, orthopedic surgery\n* Unusual\u002Fconcerning shortness of breath\n* Asthma (may be able to participate with physician consent)\n* High blood pressure\u002Fhigh blood pressure medication (may be able to participate with physician consent)\n* Use of Beta Blockers or medicines not approved by doctor.\n* Abnormal Medical Stress Test in the last 12 months\n* Musculoskeletal problems\n* Fainting\u002Fdizziness more than 3 times in past year OR which interferes with daily activities OR causes loss of balance\n* Cancer treatment in past 3 months\n* Hospitalized for psychiatric disorder in past 3 years or suicidal\n* Participation in prior Seamos Activas II study or participant in other research study about exercise currently or within the last 6 months ago","FEMALE",{"count":113,"type":20},258,[62],"In this study, the investigators are exploring how a mindfulness-based physical activity program can help improve exercise habits and overall health among 258 inactive Latina women aged 18 to 65. The study will be conducted entirely remotely over and 18 month period. During the first 6 months, all participants will receive an exercise program that has previously been tested by our research team. After 6 months, the investigators will check if participants are meeting the recommended exercise guidelines of at least 150 minutes\u002Fweek of at least moderate intensity activity. Participants who meet the guidelines will continue with the successful exercise program for another 6 months. For participants who do not meet the guidelines (are exercising less than 150 minutes\u002Fweek), they will receive one of two enhanced programs, which will be randomly assigned. One program offers additional physical activity support, and the other incorporates stress management through mindfulness techniques. For all participants, over 18 months, the investigators will track physical activity levels, stress, and heart health indicators.",[29,117,118],"Inactivity\u002FLow Levels of Exercise","Inactivity, Physical",[33,120,121,122,123,124],"Latinas","Spanish-Language","Text-Message","Exercise","Mindfulness","2025-04-23",{"date":127,"type":40},"2025-04-25",{"date":129,"type":40},"2025-03-21",{"date":131,"type":20},"2029-07-31",{"name":133,"class":47},"Bess Marcus"]