[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"incarceration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:incarceration":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,92,117,153,183],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100583775","phase-4-injectable-buprenorphine-in-prison-a-preference-trial-100583775",false,"NCT06880718","Injectable Buprenorphine in Prison: A Preference Trial","Injectable Buprenorphine During Transition Out of Prison: A Partially Randomized Preference Pilot Trial","Inclusion Criteria:\n\n1. be at least 18 years of age and incarcerated in the RIDOC facility,\n2. be currently diagnosed with OUD and enrolled in the RIDOC MOUD program,\n3. have an expected release date within 120 days of study enrollment,\n4. have an interest in XR-B and\n5. be English speaking\n\nExclusion Criteria:\n\n1. individuals who are pregnant or planning conception,\n2. diagnosed with a severe or acute medical or psychiatric disability preventing safe study participation or making follow-up unlikely,\n3. have a release date within 21 days of initiation, or\n4. have previously had an allergy to buprenorphine. Post-enrollment exclusion will include individuals if there is a change in release date beyond the 120 days and therefore no longer meet original inclusion criteria. These individuals would return to usual MOUD care.","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this pilot trial is to compare two branded extended-release buprenorphine (XR-B) formulations (Sublocade vs. Brixadi) to explore how they improve treatment retention after release from prison among incarcerated individuals with opioid use disorder (OUD) who are transitioning back into the community.\n\nThe main question it aims to answer are:\n\nHow do Sublocade and Brixadi compare in terms of feasibility, acceptability, and effectiveness? Does giving people a choice of medication affect how well they stay in treatment?\n\nUsing a partially randomized preference trial approach, there will be a comparison between participants who choose their XR-B formulation to those who are randomly assigned to see if patient preference influences treatment outcomes. The trial is a hybrid implementation-effectiveness trial.\n\nParticipants will:\n\n* Choose which medication they prefer or be randomly assigned if they don't have a preference.\n* Receive monthly injections of either Sublocade or Brixadi before and after release from prison.\n* Complete surveys and clinical assessments on treatment experience and acceptability.\n* Be monitored for treatment retention, opioid use, and adverse events for six months post-release.\n\nResearchers will compare the two treatments to see which one works better for people leaving prison and if allowing people to choose their treatment improves results.",[26,27,28,29],"Opioid Use Disorder","Incarceration","Medications for Opioid Use Disorder","Buprenorphine",[31,32,33,34,35,36],"opioid use disorder","incarceration","prison","long-acting injectable","buprenorphine","XR-B","RECRUITING","2026-05-13",{"date":40,"type":41},"2026-05-15","ACTUAL",{"date":43,"type":41},"2026-02-18",{"date":45,"type":20},"2027-06",{"name":47,"class":48},"Lifespan","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100635861","systematic-examination-of-health-inequalities-documentation-patterns-and-determinants-100635861","NCT07558187","Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants","Assessment of Lifestyle Parameters and Biomarkers of Biochemistry and Physiology to Address Health Inequalities: An Exploratory Cohort Study","CHANCE","Inclusion Criteria:\n\n* Adults (\\>18 years of age)\n* All healthy individuals who reside in rural and urban areas\n* All patients with non-communicable diseases who reside in rural and urban areas\n* Patients with opioid use disorders under medication for addiction treatment with methadone and buprenorphine\n* Individuals incarcerated in correctional facilities\n\nExclusion Criteria:\n\n* Minors (\\\u003C18 years of age)\n* Individuals with communicable diseases",true,{"count":60,"type":20},2000,"OBSERVATIONAL","The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident. Indeed, the low-income residents in several European countries, including Greece, had limited access to the healthcare system for several reasons. In addition, vulnerable populations, with patients suffering from opioid use disorders and incarcerated individuals being among them, do not have the same chances regarding health services, compared to the general population. According to the World Health Organization, physical activity is a key non-pharmaceutical intervention for both prevention of chronic non-communicable diseases and address of social health inequalities. Thus, this study will focus on specific population groups of the Region of Thessaly, Greece, who have limited access to healthcare services. It aims, primarily, to the assessment of demographic characteristics (i.e., body mass index, alcohol consumption, smoking, educational level etc), which are fundamental parameters for the assessment of health inequalities. Secondly, quality of life, physical activity levels and biomarkers in the level of Biochemistry (i.e., blood oxidative stress and inflammation) and Physiology (i.e., cardiorespiratory fitness, body composition) will be collected a well. All data will be integrated into an interactive digital platform that will be accessible by any putative stakeholder in the area of health system or administration. Based on scientifically robust data and evidence-based findings, the research team of the project will draft recommendations and guidelines that will be communicated to all stakeholders. To that end, the problem of limited access to health system that the examined populations face, will be highlighted and targeted actions and policies are expected to be adopted by local (i.e., in the province of Thessaly) and national (i.e., Greek) authorities. In this respect, non-pharmaceutical interventions and guidelines will be proposed towards the trajectory of holistically approaching the issue of health inequalities.",[64,65,27,66],"Non-communicable Diseases (NCD)","Addiction to Opioids","Opioid-use Disorders",[68,69,70,71,72,73,74,75,76,77,78,79,80,81],"Health inequalities","Physical activity\u002Fexercise","Demographics","Quality of life","Heroin craving","Oxidative stress","Antioxidants","Resting energy expenditure","Body composition","Alcohol","Body mass index","Smoking","Cardiorespiratory fitness","Opioid use disorders","2026-04-22",{"date":84,"type":41},"2026-04-30",{"date":86,"type":41},"2026-03-10",{"date":88,"type":20},"2028-12",{"name":90,"class":48},"University of Thessaly",5,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":21,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":4},"100613345","cash-transfers-for-reentry-100613345","NCT07265375","Cash Transfers for Reentry","Inclusion criteria:\n\n* Aged 18 or older\n* Exiting Nebraska state prisons during the study enrollment period\n\nExclusion criteria:\n\n\\- Conviction of a sex crime or homicide",{"count":99,"type":20},450,[101],"NA","Investigators will execute a mixed methods randomized controlled trial to determine the impacts of cash transfers of $1,000 per month for one month followed by $750 for eleven months. Investigators will measure the impacts of the cash transfers on physical and mental health, housing stability, healthcare utilization, financial stability, and interactions with the criminal legal system.",[104,27],"Poverty",[106,32,107],"cash transfer","recidivism","NOT_YET_RECRUITING","2026-04-16",{"date":82,"type":41},{"date":112,"type":20},"2026-06",{"date":114,"type":20},"2029-12-15",{"name":116,"class":48},"University of Pennsylvania",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":58,"sex":124,"minAge":17,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":21,"phases":128,"briefSummary":129,"conditions":130,"keywords":136,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":152},"100626311","california-meps-hub-100626311","NCT07433985","California MEPS Hub","California Hub for HIV\u002FSTI\u002FSUD Prevention Research With Reentry Populations","Inclusion Criteria:\n\nRCT Participants\n\n* Assigned male at birth\n* Ages 18 - 59\n* Was released from incarceration in the previous 12 months (incarceration is defined as a stay in jail, prison, or detention centers for over 24 hours)\n* Reports an SUD diagnosis or seeking SUD services at any time in the 24 months prior to enrollment\n* During the 24 months prior to enrollment, either:\n\n  1. Reports intercourse with a person assigned male at birth\n  2. Reports injection drug use\n* Has not received an HIV diagnosis (based on self-report)\n* Possesses a smartphone or plans to obtain one\n* Plans to reside within designated jurisdictions (counties) for the 9 months following enrollment\n\nCBO and agency staff participating in implementation surveys or interviews\n\n* \\>=18 years of age\n* Employed at a study site or otherwise involved with intervention implementation and\u002For maintenance OR works at an agency in the counties where the study is taking place (Los Angeles, Riverside, San Bernardino, and Alameda counties, California).\n* Willing to provide informed consent for participation.\n\nExclusion Criteria:\n\nRCT Participants:\n\n* Does not have a smart phone and is not willing to obtain one\n* Is not able to speak and understand English\n* Has insufficient reading skills to operate a mobile application on a cell phone\n\nCBO participating in implementation interviews\n\n\\- n\u002Fa","MALE","59 Years",{"count":127,"type":20},318,[101],"The California Hub for HIV\u002FSUD Prevention Research with Reentry Populations addresses the question: \"Can the evidence-based MEPS intervention be adapted and implemented at a range of organizations to effectively serve a wider range of clients?\"\n\nThe Mobile Enhanced Prevention Support (MEPS) intervention was originally implemented in Los Angeles County and was proven successful in promoting biomedical HIV prevention (PrEP) uptake and preventative screenings in people who used drugs who recently left incarceration. MEPS is an evidence-based intervention for people with substance use disorders (SUD) that incorporates a client-centered planning session, including trained peer mentors, service utilization incentives, and a mobile application (GeoPass).\n\nThe study includes a randomized controlled trial (RCT) across three community partners located in Riverside and Alameda Counties. At least 300 people will be enrolled in these three counties; the first 200 will be randomized to either receive the intervention or usual care, with the final 100 all receiving the intervention. The primary implementation outcome for the study involves using an implementation science framework and assessment tools to examine MEPS's implementation. Key outcomes include how well the implementation strategies used support intervention enrollment and retention, integration with existing services in each partnering community agency, and perceived intervention acceptability, feasibility, appropriateness, and maintenance at 6- and 12-months. The primary effectiveness outcome for the study is an increase in HIV testing, PrEP uptake and adherence, and SUD service utilization at 6 months and 12 months in the MEPS compared to the usual care group. Secondary effectiveness outcomes include frequency of service use for SUDs, hepatitis C virus testing, and linkage to care for those who test positive for HIV or hepatitis C.",[131,132,133,27,134,135],"HIV Prevention","Sexually Transmitted Infections (STI)","Preexposure Prophylaxis (PrEP)","Hepatitis C Virus (HCV)","Substance Use Disorder (SUD)",[137,138,139,140,141,142],"implementation science","contingency management","mobile health technology (mHealth)","community based participatory research","type 3 hybrid implementation effectiveness trial","randomized controlled trial","2026-04-01",{"date":145,"type":41},"2026-04-03",{"date":147,"type":41},"2025-12-01",{"date":149,"type":20},"2029-07-31",{"name":151,"class":48},"University of California, Los Angeles",3,{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":21,"phases":163,"briefSummary":164,"conditions":165,"keywords":169,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":49},"100589366","phase-4-implementing-low-barrier-hcv-treatment-in-a-jail-setting-100589366","NCT06953479","Implementing Low-Barrier HCV Treatment in a Jail Setting","MINMON-J: An Effectiveness Implementation Pilot Study Evaluating a Low-barrier Hepatitis C Treatment Model in a Jail Setting","MINMON-J","Inclusion Criteria:\n\n* Incarcerated individual at RIDOC\n* Age ≥ 18 years\n* Awaiting trial (i.e., not sentenced)\n* English speaking\n* Diagnosis of active HCV (HCV RNA \\>1000 IU\u002FmL within 90 days prior to study entry)\n* Treatment-naïve for current HCV infection\n* No cirrhosis (FIB-4 Score \\\u003C3.25 within 90 days prior to study entry)\n* Self-report of injection drug use\n* Ability and willingness to be contacted after jail release\n* Verbal commitment to continue medication after discharge\n* Desire to receive Sofosbuvir\u002FVelpatasvir (Epclusa)\n\nExclusion Criteria:\n\n* Cirrhosis (FIB-4 Score \\>3.25 within 90 days prior to study entry and\u002For clinical signs of cirrhosis)\n* Positive for Hepatitis B surface antigen\n* Actively pregnant or breastfeeding\n* Known allergy\u002Fsensitivity to study drug components\n* Acute or serious illness requiring hospitalization at enrollment\n* Documented severe persistent mental illness (SPMI) by RIDOC\n* Any clinical history of hepatic decompensation (e.g., ascites, SBP, HE, HRS, variceal bleeding)\n* HIV-positive with active or acute AIDS-defining opportunistic infection within 90 days",{"count":162,"type":20},40,[23],"The goal of this clinical trial is to learn whether a low-barrier treatment program can help people with hepatitis C virus (HCV) who are in jail start and complete treatment more easily. This study focuses on adults at the Rhode Island Department of Corrections who have active HCV and are awaiting trial.\n\nThe study asks:\n\n* Can a simplified, low-barrier HCV treatment program work in a jail setting?\n* Do participants finish treatment and get cured using this approach?\n\nAll participants will receive a 12-week course of the HCV medication sofosbuvir\u002Fvelpatasvir (Epclusa). If they are released before completing treatment, they will take the remaining doses with them. Community Health Workers (CHWs) will help support participants after release, including reminding them to take medications and helping them get follow-up lab work.\n\nResearchers will measure:\n\n* Whether participants are cured of HCV\n* Whether the treatment approach is easy to use (feasible), acceptable, and followed correctly (fidelity)\n* Whether the program could be used in other jails or expanded in the future\n\nThis study may help bring HCV treatment to more people in jail, reduce community spread of the virus, and support national goals to eliminate HCV.",[166,27,167,168],"HEPATITIS C (HCV)","Injection Drug Use","Implementation Science",[170,32,171,172,173,174,137],"hepatitis c","jail","injection drug use","minimal monitoring","MINMON","2026-02-26",{"date":177,"type":41},"2026-02-27",{"date":179,"type":41},"2025-06-11",{"date":181,"type":20},"2027-08",{"name":47,"class":48},{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":58,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":21,"phases":193,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":49},"100586749","hotspot-study-implement-and-evaluate-the-prep-pre-exposure-prophylaxis-implementation-strategy-100586749","NCT06919419","HOTSPOT Study: Implement and Evaluate the PrEP (Pre-exposure Prophylaxis) Implementation Strategy","The HOTSPOT Study Hybrid Implementation-effectiveness Study to Optimize HIV Testing and PrEP in a Southern Jail","Hotspot","Inclusion Criteria:\n\n* 18 years of age or older\n* Incarcerated in Dallas County Jail\n\nExclusion Criteria:\n\n* Severe medical or psychiatric disability making participation unsafe\n* Unable to provide consent\n* Not remaining in the local area after release from custody",{"count":192,"type":20},3600,[101],"The goal of this study is to measure the implementation and effectiveness of a multicomponent strategy for PrEP for people who are incarcerated at the Dallas County Jail. Specifically, based on a patients risk score on an electronic medical record HIV prediction model, referrals from providers and\u002For patient self-referrals, a PrEP patient navigator will meet with individuals at the jail to discuss HIV risk, offer HIV\u002FSTI testing if not yet completed and offer education around PrEP with referrals to community-based PrEP providers.",[196,197,27],"PrEP","HIV","2026-02-06",{"date":200,"type":41},"2026-02-10",{"date":202,"type":41},"2025-03-01",{"date":204,"type":20},"2027-08-31",{"name":206,"class":48},"University of Texas Southwestern Medical Center"]