[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"indirect-restoration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:indirect-restoration":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100628771","clinical-performance-of-printed-hybrid-resin-in-indirect-restorations-100628771",false,"NCT07465978","Clinical Performance of Printed Hybrid Resin in Indirect Restorations","Clinical Behavior of 3D-Printed VarseoSmile TriniQ Resin Versus CAD\u002FCAM Cerasmart in Indirect Restorations for Endodontically Treated Teeth: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* Signed informed consent\n* Need to restore an endodontically treated molar with an indirect adhesive overlay\n* Physically and psychologically able to tolerate conventional restorative procedures\n* No high caries risk\n* No active periodontal disease\n* Natural antagonist tooth present\n* Need for full cuspal coverage restoration (overlay)\n* Remaining wall thickness \\\u003C3 mm in the endodontically treated tooth\n* Occlusal thickness of the restoration ≥1 mm\n* Willing and able to attend follow-up visits\n\nExclusion Criteria:\n\n* Poor oral hygiene\n* Uncontrolled parafunctional habits (e.g., bruxism)\n* High caries risk\n* Active periodontal disease\n* Active pulpal disease\n* Absence of natural antagonist tooth\n* Need for partial cuspal coverage restoration (inlay or onlay)\n* Insufficient interarch space for restoration\n* Teeth planned as abutments for removable or fixed prostheses\n* Known allergy to any materials used in the study","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This randomized clinical trial aims to evaluate the clinical performance of a 3D-printed hybrid resin (VarseoSmile TriniQ) used for indirect restorations in endodontically treated teeth, compared with a CAD\u002FCAM composite block (Cerasmart). In addition, two different luting protocols will be compared: a preheated microhybrid composite (Enamel Plus HRi) and a resin cement (RelyX Universal).\n\nSixty patients requiring restoration of an endodontically treated molar with an indirect adhesive overlay will be recruited at the University Dental Clinic of the Universitat Internacional de Catalunya (Barcelona, Spain). Participants will be randomly assigned to receive restorations fabricated either using the printed hybrid resin or the CAD\u002FCAM composite material. Each material group will be further divided according to the cementation technique used.\n\nAll restorations will be fabricated following a digital workflow that includes intraoral scanning, CAD design, and either additive manufacturing (3D printing) or subtractive milling. Adhesive luting procedures will be performed according to standardized clinical protocols.\n\nClinical evaluations will be performed at baseline, 3 months, 6 months, and 12 months, and annually thereafter. The clinical performance of the restorations will be assessed using modified United States Public Health Service (USPHS) criteria, including parameters such as marginal adaptation, contact points, color stability, wear, fracture occurrence, secondary caries, and patient comfort.\n\nThe results of this study will provide clinical evidence regarding the behavior of 3D-printed hybrid resin restorations and their potential use as an alternative to conventional CAD\u002FCAM composite materials for indirect restorations in endodontically treated teeth.",[26,27],"Endodontically Treated Teeth","Indirect Restoration",[29,30,31,32,33,34,35,36],"Indirect restoration","CAD-CAM dentistry","3D printing dentistry","Hybrid resin restoration","Overlay restoration","Digital dentistry","VarseoSmile TriniQ","cerasmart","RECRUITING","2026-03-11",{"date":40,"type":41},"2026-03-16","ACTUAL",{"date":43,"type":41},"2024-12-13",{"date":45,"type":20},"2027-06-01",{"name":47,"class":48},"Universitat Internacional de Catalunya","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":62,"conditions":63,"keywords":69,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":49},"100618255","graphene-reinforced-cadcam-restorations-for-mih-affected-molars-in-adolescents-a-prospective-clinical-study-100618255","NCT07329244","Graphene-Reinforced CAD\u002FCAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study","Clinical Evaluation of Graphene-Reinforced CAD\u002FCAM Indirect Restorations in Molars Affected by Molar-Incisor Hypomineralization (MIH) in Adolescents: A Clinical Study","Inclusion Criteria:\n\n* Adolescents aged 10-16 years.\n* Permanent molars with moderate or severe MIH (EAPD criteria).\n* Vital and restorable teeth.\n* Ability to attend follow-up visits.\n* Informed consent from guardian + assent from the minor.\n\nExclusion Criteria:\n\n* Fluorosis, amelogenesis imperfecta, or other enamel defects.\n* Severe bruxism not controlled.\n* Active extensive caries or irreversible pulpitis.\n* Systemic conditions affecting enamel or healing.\n* Hypersensitivity\u002Fallergy to materials\u002Fadhesives.\n* Use of analgesics\u002FAINEs \\\u003C24 h before baseline VAS.\n\n  * Orthodontic bands on the study molar.","10 Years","16 Years",{"count":60,"type":20},30,[23],"This study evaluates the clinical performance, marginal integrity, surface wear, color stability, and postoperative sensitivity of graphene-reinforced CAD\u002FCAM indirect restorations (inlays, onlays, overlays) in molars affected by moderate to severe Molar-Incisor Hypomineralization (MIH) in adolescents. A total of 30 patients aged 10-16 years will receive minimally invasive indirect restorations fabricated from a nano-reinforced graphene polymer (G-CAM®). Clinical outcomes will be assessed using FDI criteria, VAS sensitivity scores, patient satisfaction, and digital 3D scans over a 12-month follow-up. The study aims to determine clinical acceptability and safety compared with historical outcomes reported for composite and lithium-disilicate indirect restorations.",[64,65,66,67,68,27],"Tooth Demineralization","Tooth Sensitivity","Enamel Mineralization Disorders","Tooth Sensitivity After Composite Restorations","Tooth Eruption Disorder",[70,71,72,73,74,75],"molar-incisor hypomineralization","MIH","enamel defects","indirect restorations","minimally invasive dentistry","adhesive dentistry","NOT_YET_RECRUITING","2025-12-28",{"date":79,"type":41},"2026-01-09",{"date":81,"type":20},"2026-01-10",{"date":83,"type":20},"2027-01-11",{"name":47,"class":48}]