[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"induction-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:induction-anesthesia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100612024","ketamine-lidocaine-versus-ketamine-fentanyl-for-induction-of-anesthesia-in-patients-with-left-ventricular-systolic-dysfunction-undergoing-elective-coronary-artery-bypass-100612024",false,"NCT07248202","Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass","A Comparison Between the Effect of Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia on Cerebral Perfusion Guided by Near Infra-red Spectroscopy in Patients With Coronary Artery Disease and Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass Graft Surgery: (A Randomized Controlled Study)","Inclusion Criteria:\n\n* patients with coronary artery disease\n* with moderate to severe left ventricular dysfunction (ejection fraction \\\u003C 40%),\n* scheduled for elective CABG surgery\n\nExclusion Criteria:\n\n* associated chronic stroke, TIA , carotid occlusive disease( due to abnormal vasomotor activity), patients with known neurological impairment (cerebral infarction , dementia ), significant carotid artery stenosis ,\n* valvular heart disease,\n* persistent arrhythmias,\n* congestive cardiac failure,\n* on mechanical ventilation,\n* intra-aortic balloon pump,\n* emergency surgery,\n* and those with known allergy to any of the study's drugs,\n* severe systemic non-cardiac disease and\n* patients with baseline NIRS reading \\\u003C 60%\n* Patients with dementia or visual or auditory impairment","ALL","21 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study compares ketamine\u002Ffentanyl versus ketamine\u002Flidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better preserves cerebral oxygenation.",[26,27,28,29,30,31,32],"Coronary Artery Disease (CAD)","Left Ventricular (LV) Systolic Dysfunction","Induction Anesthesia","Coronary Bypass Graft Surgery","Ketamine","Fentanyl","Lidocaine","RECRUITING","2026-03-15",{"date":36,"type":37},"2026-03-17","ACTUAL",{"date":39,"type":37},"2025-12-01",{"date":41,"type":20},"2026-07",{"name":43,"class":44},"Cairo University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":45},"100593935","early-phase-1-relationship-between-remimazolam-and-etomidate-in-induction-of-general-anesthesia-100593935","NCT07012902","Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia","The Interaction Between Remimazolam and Etomidate During Induction of General Anesthesia Was Studied by Isoradiometric Analysis","Inclusion Criteria:\n\n1. Both sexes\n2. aged 18-60 yr\n3. ASA physical status I-II\n4. BIM: 18-28kg\u002Fm²\n\nExclusion Criteria:\n\n1. allergic to remimazolam and etomidate\n2. in pregnancy or lactation\n3. serious cardiovascular diseases, long-term alcoholism\n4. used sedative drugs or opioids within 24 hours\n5. severe mental illness and myasthenia gravis -","18 Years","60 Years",{"count":56,"type":20},125,[58],"EARLY_PHASE1","In modern anesthesia practice, anesthesiologists often need to choose a combination of multiple drugs according to the specific conditions and surgical needs of patients, which can not only achieve more fine anesthesia management, but also improve perioperative safety and patient comfort. In clinical practice, anesthesiologists will use etomidate combined with a small dose of remimazolam for anesthesia induction to obtain more stable hemodynamics, prevent intraoperative awareness, and relieve anxiety.However, what is the best dose ratio of etomidate combined with remimazolam, the current literature does not give clear indicators.",[28,61],"Drug Interactions",[63,64,65],"Isoradiation analysis","etomidate","remimazolam","NOT_YET_RECRUITING","2025-06-08",{"date":69,"type":37},"2025-06-10",{"date":71,"type":20},"2025-06-12",{"date":73,"type":20},"2025-07-19",{"name":75,"class":44},"Second Hospital of Shanxi Medical University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":87,"conditions":88,"keywords":94,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":45},"100583690","high-flow-nasal-oxygen-for-preoxygenation-in-emergency-surgery-patients-with-full-stomachs-100583690","NCT06879600","High-Flow Nasal Oxygen for Preoxygenation in Emergency Surgery Patients With Full Stomachs","Research on Pre-Anesthetic Blood Oxygenation Effect of High-Flow Nasal Oxygen for Emergency Surgery Patients With Full Stomachs","HFNC","Inclusion Criteria:\n\n* Emergency surgical patients at risk of gastric fullness requiring endotracheal intubation.\n* Patients aged 18 years or older.\n* Health status classified as ASA I or II.\n* Mallampati classification I or II.\n\nExclusion Criteria:\n\n* Patients with a predicted difficult airway, facial deformities, or an inability to achieve a proper mask seal.\n* Patients with respiratory diseases.\n* Pregnant patients.\n* Patients allergic to anesthesia or resuscitation drugs.\n* Patients who do not consent to participate in the study.",{"count":85,"type":20},200,[23],"Patients with full stomachs face a high risk of regurgitation and aspiration under general anesthesia. To minimize the time between the loss of airway protective reflexes and successful tracheal intubation, rapid sequence induction intubation is commonly used. However, these patients are particularly vulnerable to hypoxemia during anesthesia induction, especially in emergency cases. Pre-oxygenation before induction is crucial for ensuring patient safety during apnea.\n\nHigh-flow nasal oxygen (HFNO) therapy, which consists of an air\u002Foxygen blender, an active humidifier, and a single heated circuit, has recently gained widespread use in intensive care units (ICUs) for managing hypoxemic respiratory failure. HFNC can deliver a constant fraction of inspired oxygen (FiO₂) from 0.21 to 1.0 at high flow rates (up to 60 L\u002Fmin or higher). Its advantages include generating continuous positive airway pressure, reducing anatomical dead space, improving ventilation-perfusion matching, enhancing mucociliary clearance, and decreasing the work of breathing.\n\nGiven these benefits, HFNO has the potential to improve pre-oxygenation before and during anesthesia induction in emergency surgery patients with full stomachs.",[89,90,91,28,92,93],"High-flow Nasal Cannula","Oxygenation","General Anesthesia","Emergency Surgery Patients","Full Stomach",[95,96,97,92,98],"High-flow nasal cannula","oxygenation","Induction anesthesia","full stomach","2025-03-10",{"date":101,"type":37},"2025-03-17",{"date":103,"type":37},"2023-07-19",{"date":105,"type":20},"2026-12-31",{"name":107,"class":44},"Nguyen Dang Thu"]