[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"induction-of-labor-affected-fetus--newborn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:induction-of-labor-affected-fetus--newborn":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,69,95],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100541065","castor-oil-ingestion-and-balloon-catheter-for-labor-induction-in-nulliparous-100541065",false,"NCT06325007","Castor Oil Ingestion and Balloon Catheter for Labor Induction in Nulliparous","The Effect of Combining Single Balloon Catheter With Castor Oil Ingestion for Cervical Ripening on Time to Delivery Among Nulliparous Women.","Inclusion Criteria:\n\n* Women above 18 years old\n* Sign an informed consent\n* Term pregnancy (\\>37 weeks)\n* Viable fetus\n* Singleton\n* Vertex presentation\n* Intact membranes\n* Cervix with Bishop score ≤6\n\nExclusion Criteria:\n\n* Previous cesarean delivery\n* Major fetal malformations\n* Contraindication to spontaneous vaginal delivery\n* Amniotic fluid index \\>25cm\n* Chorioamnionitis at admission\n* Placental abruption\n* Previous prostaglandin use for induction of labor\n* A low-lying placenta (up to 2 cm from the internal os)\n* Carriers of hepatitis B or C or human immunodeficiency viruses\n* Women with a history of allergy to latex.\n* Women with a history of allergy to castor oil",true,"FEMALE","18 Years","60 Years",{"count":21,"type":22},142,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this randomized controlled trial is to examine the efficacy of combining castor oil ingestion with extra-amniotic single balloon catheter for cervical ripening on time from induction to delivery in nulliparous women.\n\nThe main question it aims to answer are:\n\nDoes the addition of the use of castor oil to extra-amniotic single balloon reduce the time until birth? Does the addition of the castor oil affect other perinatal outcomes during childbirth? Are the side effects of the castor tolerated by the mothers? Participants will be randomly divided into 2 groups: the study group will drink a mixture of 60 ml of castor oil mixed with 140 ml of orange juice. Thirty minutes later, an extra-amniotic single balloon catheter will be inserted above the internal cervical os and filled with 60 mL of normal saline. In the control group, a foley catheter will be inserted into cervical canal without ingestion of castor oil.",[28],"Induction of Labor Affected Fetus \u002F Newborn","RECRUITING","2026-04-07",{"date":32,"type":33},"2026-04-13","ACTUAL",{"date":35,"type":33},"2024-04-11",{"date":37,"type":22},"2026-12-31",{"name":39,"class":40},"Holy Family Hospital, Nazareth, Israel","OTHER",2,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100445392","phase-4-the-stimulation-to-induce-mothers-study-100445392","NCT05079841","The Stimulation To Induce Mothers Study","The Stimulation To Induce Mothers (STIM) Study: A Parallel Group Randomized Controlled Trial","STIM","Inclusion Criteria:\n\n* Nulliparous\n* Gestational age 36 0\u002F7 weeks and greater at enrollment\n* Singleton gestation\n* Planned to undergo initiation of exogenous oxytocin infusion by their maternity care provider\n* Spontaneous rupture of membranes or if membranes intact, modified Bishop score ≥5 and cervix dilated \\\u003C6 cm within one hour of enrollment\n* Ability to give informed consent\n\nExclusion Criteria:\n\n* Unable to understand English or Spanish\n* Prior use of exogenous oxytocin or attempt at nipple stimulation during the current pregnancy\n* Presence of tachysystole (defined as more than 5 contractions in 10 minutes averaged over 30 minutes), recurrent variable or late fetal decelerations, and bradycardia in the prior 30 minutes before enrollment\n* Non-vertex presenting fetus at time of enrollment\n* Planned for cesarean delivery or contraindication to labor by institutional policy (e.g., placenta previa, vasa previa, active genital herpes infection, previous transmural myomectomy)\n* Multi-fetal gestation (e.g., twins, triplets, and higher-order multiples)\n* Intrauterine fetal death\n* Major fetal anomaly suspected prenatally (defined as a fetal anomaly with anticipated neonatal intensive care unit admission)\n* Suspected alloimmunization (given the increased likelihood for anticipated neonatal intensive care unit admission)\n* Known severe fetal growth restriction (estimated fetal weight \\\u003C3rd percentile) or abnormal umbilical artery Doppler studies (given the increased likelihood for anticipated neonatal intensive care unit admission)\n* HIV infection (nipple stimulation is not encouraged given the recommendation for these mothers not to breastfeed)\n* Participation in another interventional study that influences management of labor and delivery or perinatal morbidity or mortality\n* History of mastectomy or other contraindication to use of electronic breast pump\n* Known allergic reactions to components of the electronic breast pump or to synthetic oxytocin intravenous solution\n* Significantly impaired consciousness or executive function (e.g., intubated or sedated)",{"count":51,"type":22},988,[53],"PHASE4","The investigators propose a parallel group randomized clinical trial of intrapartum nipple stimulation versus exogenous oxytocin infusion for nulliparous women undergoing induction of labor near term. The central hypothesis is that intrapartum nipple stimulation to induce labor increases spontaneous vaginal delivery, improves patient-centered outcomes such as childbirth satisfaction, labor agentry, and pain scores, and reduces adverse neonatal and maternal outcomes in nulliparous women. The investigators will pursue the following specific aims: 1) Assess the effectiveness of intrapartum nipple stimulation on the rate of spontaneous vaginal delivery in nulliparous women, 2) Breastfeeding as the sole source of nutrition at time of maternal hospital discharge (Primary Aims); 3) Maximal percent newborn weight loss during the birth hospitalization within 72 hours of life, 4) Determine the effect of intrapartum nipple stimulation on the rate of adverse maternal and neonatal outcomes, 5) Determine the impact of intrapartum nipple stimulation on patient-centered outcomes and 6) In a sub-cohort of women who are enrolled in the trial, investigators will measure the change in oxytocin concentration from baseline to time at which patient achieves a regular contraction pattern.",[56,57,28,58],"Oxytocin","Labor Pain","Physiologic Effects of Drugs","2026-03-19",{"date":61,"type":33},"2026-03-24",{"date":63,"type":33},"2021-11-15",{"date":65,"type":22},"2029-03",{"name":67,"class":40},"Yale University",3,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":77,"targetDuration":4,"studyType":23,"phases":79,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":94},"100497649","cervical-ripening-as-an-outpatient-method-using-the-foley-comfort-100497649","NCT05759988","Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)","Cervical Ripening as an Outpatient Method Using the Foley: a Randomized Trial","COMFORT","Inclusion Criteria\n\n* Eligible for induction of labor\n* Live singleton gestation ≥37 weeks and \\\u003C42 weeks\n* Nulliparous, ≥18 years of age with no previous deliveries \\>20 weeks\n* Cephalic presentation\n* Intact membranes\n* Bishop score ≤8 and cervical dilation \\\u003C3 cm\n* English or Spanish speaking (Able to read\u002Funderstand consent and instructions)\n* Have reliable transportation to get back to the hospital and have a self-reported safe residence to go home to with the Foley catheter\n\nExclusion Criteria\n\n* Known oligohydramnios (DVP \\\u003C2cm)\n* Known moderate-severe polyhydramnios (AFI ≥30 at time of delivery)\n* Concern regarding fetal status during antenatal testing: At provider discretion, but includes fetal decelerations, biophysical profile ≤6\u002F10\n* Vaginal bleeding or concern for\u002Fknown abruption prior to Foley placement\n* Chorioamnionitis\n* Any fetal growth restriction\n* Preeclampsia with severe features\n* Severe chronic hypertension\n* Type 1 diabetes or poorly controlled pre-gestational diabetes\n* Sickle cell disease\n* Major fetal anomaly\n* Women on therapeutic anticoagulation\n* Decreased fetal movement\n* HIV Positive (rationale: HIV positive patients require an IV medication at the start of labor induction which cannot be given as an outpatient. There is universal testing of HIV in the 3rd trimester to verify this exclusion criteria)\n* Maternal cardiac disease requiring telemetry monitoring throughout induction\u002Flabor course",{"count":78,"type":22},2300,[25],"A multicenter pragmatic randomized trial of nulliparous women undergoing a term (≥37 weeks) induction of labor wherein the provider intends to use a Foley catheter for cervical ripening. The investigators will be comparing outpatient cervical ripening with a Foley catheter to routine inpatient cervical ripening (Foley +\u002F- other method). With this trial, the investigators aim to test our central hypothesis that outpatient Foley will decrease the primary Cesarean Delivery (CD) rate and risk of maternal\u002Fneonatal morbidity compared with inpatient cervical ripening.",[28],[83,84],"Foley balloon catheter","Outpatient cervical ripening","2026-01-29",{"date":87,"type":33},"2026-02-02",{"date":89,"type":33},"2023-04-13",{"date":91,"type":22},"2027-06-30",{"name":93,"class":40},"University of Pennsylvania",6,{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":23,"phases":105,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":118},"100544965","the-impact-of-a-customized-informative-video-prior-to-induction-of-labor-on-anxiety-relieve-100544965","NCT06375746","The Impact of a Customized Informative Video Prior to Induction of Labor on Anxiety Relieve.","The Impact of a Customized Informative Video Prior to Induction of Labor on Anxiety Relieve - a Randomized Controlled Trial","Inclusion Criteria:\n\n* Pregnant women, aged 18-45, undergoing medical IOL at term.\n* Unfavorable cervix (BISHOP score \\\u003C6).\n* Cervical ripening with either prostaglandin E2 (PGE2) tablets or extra-amniotic balloon (EAB).\n* Provided consent to participate in the study.\n* No language barrier preventing completion of the questionnaire.\n\nExclusion Criteria:\n\n* Sensitivity to PGE2.\n* Preterm labor.\n* Premature rupture of membranes.\n* Stillbirth.\n* Elective pregnancy termination.","45 Years",{"count":104,"type":22},180,[25],"To determine whether watching a personalized video prior to medically indicated labor induction among term parturients reduces anxiety levels according to the STAI questionnaire, compared to a standard counselling.",[28],"2024-07-28",{"date":110,"type":33},"2024-07-30",{"date":112,"type":33},"2024-05-01",{"date":114,"type":22},"2024-08-31",{"name":116,"class":117},"Wolfson Medical Center","OTHER_GOV",1]