[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"infant-body-composition-and-metabolism\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:infant-body-composition-and-metabolism":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":40,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":65},"100628121","breastmilk-and-the-link-to-overweightobesity-and-maternal-diet-in-the-mother-breastmilk-child-triad-100628121",false,"NCT07457515","Breastmilk and the Link to Overweight\u002FObesity and Maternal Diet in the Mother-breastmilk-child Triad","Analysis of the Transmission of Overweight\u002FObesity in the Mother-breastmilk-child Triad in Relation to Maternal Cardiometabolic Status and Diet","BLOOM-Triad","Inclusion Criteria:\n\nfor mother:\n\n* at least 19 years,\n* plan of exclusively or predominantly breastfeeding for 6 months,\n* consent to a sampling of biological material and participate in all planned procedures (for both mother and infant),\n* willingness to finish the follow-up,\n* well-understanding of the Polish language (for non-Polish nationalities); for infants:\n* 1 month or less,\n* clinically healthy,\n* none or one formula feeding per day\n\nExclusion Criteria:\n\nfor mother:\n\n* type 1 or 2 diabetes diagnosed before pregnancy,\n* uncontrolled thyroid disease,\n* breastfeeding more than 1 child or being a milk donor,\n* tobacco\u002Falcohol use during pregnancy or currently,\n* inability to express a sufficient amount of milk; for infants:\n* congenital disease,\n* birth from a multiple pregnancy,\n* preterm birth (\\\u003C37 Hbd).",true,"FEMALE","19 Years",{"count":21,"type":22},165,"ESTIMATED","OBSERVATIONAL","The prospective 5-month follow-up study will involve 150 mother-infant dyads grouped based on maternal baseline BMI category (normal weight, overweight, obesity). The investigators plan 3 study visits (1, 3, and 6 months postpartum) with analysis the following parameters and outcomes:\n\n1. maternal anthropometry and body composition;\n2. maternal dietary intake and dietary patterns (with results of biomarker-based validation);\n3. maternal status of lipophilic antioxidants, selected vitamins, and fatty acids profile that may be related to adipose tissue metabolism, inflammation, and cardiometabolic status;\n4. maternal metabolomics, adipokines, insulin, selected biomarkers of inflammation, altered glucose metabolism, and oxidation;\n5. breastmilk composition assessed by systemic approach (macronutrients, fatty acids profile, lipophilic antioxidants, adipokines, hormones, immunological profile, and preliminary lipidomic analysis in part of the study group);\n6. infant growth trajectory, body composition, urine metabolomics, and biomarkers of oxidative stress.\n\nAdditionally, maternal and infant stool, buccal swabs, and human milk samples will be banked for further microbiome analysis studies.",[26,27,28,29,30,31,32,33,34,35,36,37,38,39],"Body Weight","Obesity & Overweight","Human Milk\u002FBreastfeeding","Body Composition","Maternal Cardiometabolic Health","Growth & Development","Metabolomic Profile","Infant Body Composition and Metabolism","Carotenoid Status","Fatty Acid Status","Immunologic Markers","Adipokines","Inflammation Biomarkers","Vitamin E",[41,42,43,44,37,45,46,47,48,49,50,51,52],"Lactation","Body composition","Infant development","Diet","Carotenoids","Fatty acids","Metabolomics","Inflammation","Oxidative stress","Overweight","Obesity","Tocopherols","NOT_YET_RECRUITING","2026-03-02",{"date":56,"type":57},"2026-03-09","ACTUAL",{"date":59,"type":22},"2026-02",{"date":61,"type":22},"2029-09",{"name":63,"class":64},"Warsaw University of Life Sciences","OTHER",4,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":17,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":79,"conditions":80,"keywords":86,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":105},"100600324","studying-phenotypic-risks-for-obesity-and-underlying-traits-in-young-infants-100600324","NCT07096011","Studying Phenotypic Risks for Obesity and Underlying Traits in Young Infants","Studying Phenotypic Risks for Obesity and Underlying Traits in Young Infants: A Pilot Study","SPROUT","Inclusion Criteria:\n\n* Aged 2 weeks to less than 17 weeks at screening\n* Being fed human milk as a primary source of food\n* Be willing to consume one meal of infant formula\n* Be willing to complete a DXA measurement\n\nExclusion Criteria:\n\n* Unable to complete the screening visit and two clinic visits within 14 days\n* Born with health conditions that would render procedures unsafe\n* Born earlier than 35 days and 0 weeks gestation\n* Eating supplemental foods\n* Physician diagnosed feeding difficulties that may require a special type of nipple for bottle feeding","ALL","2 Weeks","16 Weeks",{"count":78,"type":22},40,"The purpose of this research study is to understand how infants metabolize different meals and to develop clinical tools which identify infants as having two different phenotypes. The phenotypes are the 1) metabolic \"thriftiness\" and 2) the metabolic flexibility.",[33,81,82,83,84,85],"Metabolism","Energy Expenditure","Infant Formula","Human Milk, Breast Milk","Metabolic Flexibility",[87,88,89,90,91,92,93,94],"infant","metabolism","energy expenditure","infant formula","breast milk","human milk","thrifty phenotype","metabolic flexibility","RECRUITING","2025-08-21",{"date":98,"type":57},"2025-08-22",{"date":100,"type":57},"2025-07-28",{"date":102,"type":22},"2027-05",{"name":104,"class":64},"Pennington Biomedical Research Center",1]