[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"infection-prevention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:infection-prevention":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,50,75,104,144,176,201],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100632776","effect-of-virtual-reality-based-handwashing-education-on-knowledge-skills-and-emotional-indicators-in-preschool-children-100632776",false,"NCT07518082","Effect of Virtual Reality-Based Handwashing Education on Knowledge, Skills, and Emotional Indicators in Preschool Children","The Effect of Virtual Reality-Based Handwashing Education on Knowledge, Skills, and Emotional Indicators in Preschool Children: A Randomized Controlled Trial","VR-HAND","Inclusion Criteria:\n\n* Children aged 5-6 years\n* Enrolled in a preschool institution\n* Able to understand and follow instructions in Turkish\n* No physical, visual, auditory, or cognitive impairment that would prevent participation in the intervention\n* Willing to participate in the study\n* Written informed consent obtained from parents\n\nExclusion Criteria:\n\n* Children aged below 5 or above 6 years\n* Children with neurological, visual, auditory, or balance disorders that may interfere with virtual reality use\n* Children with orthopedic or motor impairments affecting handwashing ability\n* Children who have previously used virtual reality devices\n* Children whose parents do not provide consent\n* Children who experience discomfort, fear, or adverse reactions during the intervention",true,"ALL","5 Years","6 Years",{"count":22,"type":23},66,"ESTIMATED","INTERVENTIONAL",[26],"NA","A randomized controlled trial designed to evaluate the effects of virtual reality-based handwashing education on handwashing knowledge, skills, and emotional indicators in preschool children aged 5-6 years. The study will be conducted in a kindergarten setting in Istanbul, Turkey, with a total of 66 children who meet the inclusion criteria. Participants will be randomly assigned to one of three groups: a virtual reality-based education group, a traditional handwashing education group, or a control group receiving no intervention. Data will be collected using a sociodemographic information form, a handwashing knowledge form, a handwashing skill assessment form, and the Children's Emotional Indicators Scale. Outcomes will be assessed at baseline and 2 weeks after the intervention.",[29,30,31],"Hand Hygiene","Health Education","Infection Prevention",[33,34,35,36],"Virtual Reality","Preschool Children","Handwashing Education","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-05-18",{"date":40,"type":41},"2026-05-20","ACTUAL",{"date":43,"type":23},"2026-05-25",{"date":45,"type":23},"2026-12-01",{"name":47,"class":48},"Istanbul Arel University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100635000","biofilm-induced-antimicrobial-resistance-risk-eradication-in-critical-care-central-venous-catheters-100635000","NCT07546994","Biofilm-induced Antimicrobial Resistance RIsk ERadication in Critical Care Central Venous Catheters","BARRIER","Inclusion Criteria:\n\n* Central venous catheters (conventional central venous lines, dialysis catheters, PICC lines) showing positive microbiological culture taken from adult patients in the critical care units (intensive care units, post-operative intensive care units and post-resuscitation intensive care units)\n* Patient consent is free, informed, and non-opposition, provided after delivery of an information letter and oral explanation.\n\nExclusion Criteria:\n\n* None","18 Years",{"count":59,"type":23},150,"OBSERVATIONAL","Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs. The pathophysiology of these infections relies on the formation of a biofilm, an organized microbial structure that confers exceptional tolerance to anti-infectives and the immune system. However, data concerning the characteristics of the in vivo biofilm (kinetics, composition, endo- vs. extraluminal organization) on central venous catheters in intensive care patients are very limited, hindering the development of effective and targeted prevention strategies.\n\nThe main aim of this study is to quantify the density and describe the spatial distribution (extra- and intraluminal compartments) of the biofilm on infected or colonized central venous catheters, prospectively collected from patients in the critical care units.",[63,64,31],"Catheter-Related Infections","Biofilms","2026-04-16",{"date":67,"type":41},"2026-04-23",{"date":69,"type":23},"2026-04",{"date":71,"type":23},"2028-04",{"name":73,"class":48},"Centre Hospitalier Universitaire de Nīmes",2,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":24,"phases":85,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100614129","phase-4-antibiotic-prophylaxis-after-simple-tooth-extraction-in-immunosuppressed-patients-with-autoimmune-rheumatic-diseases-100614129","NCT07275580","Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases","Effectiveness of Short-Course Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases","PRO-EXOD","Inclusion Criteria:\n\n* Age ≥18 years\n* Confirmed diagnosis of an ARD: SLE, RA, JIA, AS, PsA, IIM, systemic vasculitis, primary Sjögren's syndrome, or SSc\n* Under immunosuppressive or biologic therapy ≥3 months\n* Indication for simple extraction of tooth with chronic odontogenic focus\n* Provided informed consent\n\nExclusion Criteria:\n\n* Individuals who do not agree to participate in the study will be excluded.\n* Patients who require more technically complex extractions, such as impacted or impacted third molars.\n* Patients with local and systemic changes that require more extensive antibiotic coverage, such as cases with clinical signs of acute infections, anticoagulated patients, heart patients, patients who have undergone radiotherapy or are undergoing treatment for neoplasms.\n* Patients allergic to amoxicillin.",{"count":84,"type":23},352,[86],"PHASE4","This randomized, double-blind, placebo-controlled clinical trial aims to evaluate whether single-dose amoxicillin prophylaxis administered prior to simple tooth extraction reduces postoperative infection rates in immunosuppressed patients with autoimmune rheumatic diseases (ARDs).\n\nAlthough antibiotic prophylaxis is not recommended for healthy individuals undergoing simple extractions, immunosuppressed ARD patients frequently receive antibiotics despite limited evidence supporting this practice.\n\nSecondary objectives include assessing infection severity, postoperative complications, and the impact of ARD diagnosis and immunosuppressive treatment on infection risk.",[89,90,31,91],"Autoimmune Rheumatic Diseases","Tooth Extraction","Antibiotic Prophylaxis",[89,90,31,93,94],"Amoxicillin","Antibiotic Stewardship","2026-04-14",{"date":97,"type":41},"2026-04-15",{"date":99,"type":23},"2026-06-01",{"date":101,"type":23},"2029-12-30",{"name":103,"class":48},"University of Sao Paulo General Hospital",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":24,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":143},"100515587","optimising-kangaroo-care-to-reduce-neonatal-severe-infectionsepsis-and-resistant-bacterial-colonisation-among-high-risk-infants-in-nicu-100515587","NCT05993442","Optimising Kangaroo Care to Reduce Neonatal Severe Infection\u002FSepsis and Resistant Bacterial Colonisation Among High-risk Infants in NICU.","Optimising Kangaroo Care to Reduce Neonatal Severe Infection\u002FSepsis and Resistant Bacterial Colonisation Among High-risk Infants in Neonatal Intensive Care: a Pragmatic, Multicentre, Parallel Cluster Randomised Hybrid Implementation-effectiveness Study.","NeoDeco","INCLUSION CRITERIA\n\n1\\. Site level\n\n1a. Neonatal unit that provide routinely cares for extremely premature infants (\\\u003C28 weeks' gestation).\n\n1b. Minimum capacity of 12 beds.\n\n1c. Access to a -70 to -80°C freezer for storage of research samples\n\n1d. Willing to implement optimised KC if allocated to the intervention group.\n\n1e. Willing to commit to offering the minimum expected target duration or an increase of 50% if neonatal unit is already offering \\>67% of the minimum expected target duration, if allocated to the intervention arm.\n\n1f. Prepared to implement NeoIPC surveillance.\n\n1. g. Adequate resources and expertise and approvals from relevant Research Ethics Committees, as appropriate.\n2. Infant level\n\n2a. All high-risk infants (born at \\\u003C32 weeks' gestation) admitted to participating neonatal units, regardless of complexity of care, anticipated hospitalisation duration, room type, or whether admitted directly after birth.\n\nEXCLUSION CRITERIA 1 Site level\n\n1. a. Participation in other research that could directly influence the study intervention or outcomes.\n2. a. Average StSC duration already exceeding 18 hours per day.\n3. a. Anticipated major changes in resistant bacterial colonisation pressure during the study\n\n2 Infant level 2a. No infant-level exclusion criteria for data collection. We exclude infants from individual data and sample collection if their parents or legal guardians do not provide written informed consent. These infants contribute to cluster-aggregated outcomes.","32 Weeks",{"count":114,"type":23},3080,[26],"NeoDeco is a pragmatic, multicenter, parallel-group, cluster-randomised hybrid effectiveness-implementation trial designed to evaluate the impact of implementing optimised Kangaroo Care (KC) at the unit level compared to standard care in high-technology neonatal units. The trial includes a baseline period, a wash-in phase, and a staggered randomisation approach. The primary focus of the NeoDeco study is on high-risk preterm infants born at less than 32 weeks' gestational age, a population particularly vulnerable to hospital-acquired infections and sepsis during their initial hospital stay. By investigating hospital-acquired infections specifically, the study targets the period during which optimised KC practices are likely to have the most significant impact.",[118,31],"Infection, Bacterial",[120,121,122,123,124,125,126,127,128,129,130,131],"Nosocomial Infection","Prevention","Cluster","Implementation science","Surveillance","Kangaroo Care","Skin to Skin Contact","Neonatal Intensive Care Unit","NICU","Neonatal severe infection","Resistant bacterial","Pre-term infants","RECRUITING","2026-03-20",{"date":135,"type":41},"2026-03-25",{"date":137,"type":41},"2024-05-28",{"date":139,"type":23},"2026-05",{"name":141,"class":142},"PENTA Foundation","NETWORK",24,{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":24,"phases":154,"briefSummary":155,"conditions":156,"keywords":161,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":175},"100602916","oral-care-layered-enhancement-for-improved-oral-hygiene-in-intensive-care-units-100602916","NCT07129733","Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units","Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units: A Stepped-Wedge Cluster Randomized Clinical Trial","ORACLE","Inclusion Criteria:\n\n* All patients who receive mechanical ventilation in the participating intensive care units\n\nExclusion Criteria:\n\n* Does not meet inclusion criteria",{"count":153,"type":23},4800,[26],"The goal of the ORACLE study is to evaluate the impact of implementing a standardized oral hygiene bundle on outcomes in critically ill, mechanically ventilated patients. The primary objective is to determine whether this bundle can increase the number of ventilator-free days compared to the standard of care.",[157,31,158,159,160],"Mechanical Ventilation","Oral Care","Oral Hygiene, Oral Health","VAP - Ventilator Associated Pneumonia",[162,163,164,165],"Oral care","Oral hygiene","critically ill","mechanical ventilation","2025-08-15",{"date":168,"type":41},"2025-08-19",{"date":170,"type":23},"2025-09-01",{"date":172,"type":23},"2026-11-30",{"name":174,"class":48},"Hospital do Coracao",6,{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":24,"phases":185,"briefSummary":186,"conditions":187,"keywords":189,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":199,"locationsCount":4},"100593098","effectiveness-evaluation-of-the-mosquito-free-campus-initiative-on-dengue-fever-prevention-and-control-a-cluster-randomized-controlled-trial-100593098","NCT07002021","Effectiveness Evaluation of the \"Mosquito-Free Campus\" Initiative on Dengue Fever Prevention and Control: A Cluster Randomized Controlled Trial","Inclusion Criteria:\n\n* Primary and middle school students within the age range of 6-15 years.\n* The primary and middle schools are located in Yuexiu District, Baiyun District of Guangzhou city or Nanhai District of Foshan City.\n* The schools have the necessary infrastructure, management level and resource allocation to participate in dengue fever prevention and control.\n* The schools agree to implement the intervention measures during the research period.\n* The schools are willing to provide baseline data and participate in subsequent assessments before the intervention is implemented.\n\nExclusion Criteria:\n\n* Unwilling to participate in the project.\n* Participants (students or staff members) are unable to participate in the intervention or withdraw from the study due to personal reasons.","15 Years",{"count":184,"type":23},3940,[26],"The goal of this cluster randomized controlled trial is to evaluate the effect of health education interventions on the score of the knowledge, attitudes, and practices (KAP) of dengue in in primary and middle school students in the city of Guangzhou and Foshan in China.\n\nIndividuals aged 6 to 15 years who are in grades 1-9 in primary schools in Guangzhou and Foshan will be enrolled. 20 primary schools will be randomly selected, with half designated as intervention group schools and the remaining half as control group schools. The intervention group will receive a health education intervention focused on dengue prevention every semester for 6 months, while the control group will continue with their routine school health education for 6 months.\n\nResearchers will compare the differences in the score of the KAP of dengue between the intervention and control groups after 6 months to see if health education can improve knowledge, attitudes and practices of dengue among primary and middle school students.",[188,31],"Dengue",[190,191,192],"health education","schools","China","2025-05-25",{"date":195,"type":41},"2025-06-03",{"date":197,"type":23},"2025-06-15",{"date":99,"type":23},{"name":200,"class":48},"Sun Yat-sen University",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":18,"minAge":207,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":24,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":49},"100589711","prophylactic-negative-pressure-wound-therapy-in-laparotomy-wounds-a-randomized-clinical-trial-100589711","NCT06957964","Prophylactic Negative Pressure Wound Therapy in Laparotomy Wounds: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients of age between 20 to 70 years, both genders\n* Undergoing laparotomy under general anaesthesia\n* ASA I-II\n\nExclusion Criteria:\n\n* Patients who did not complete the follow up instructions\n* Pregnant patients\n* Patients already undergone a relook laparotomy, if their abdomen is left open or if unable to adhere","20 Years","70 Years",{"count":210,"type":23},70,[26],"Total 70 participants meeting selection criteria will be enrolled in the study from operational theatre. They will be randomly divided in two groups by using lottery method. In group A, Negative Pressure Wound Therapy will be applied at end of procedure. In group B, no Negative Pressure Wound Therapy will be placed. They will be shifted to post-surgical wad for 72 hours and then will be discharged with prescription of standard antibiotics and will be followed-up in OPD for 30 days. If patient will develop surgical site wound infection, then it will be noted. If infection will not be cured with antibiotics course, then re-operation will be done. Patients complications will be managed as per hospital protocol. All this information will be recorded in proforma.",[214,31,215],"Wound","Negative Pressure Wound Therapy","2025-04-27",{"date":218,"type":41},"2025-05-06",{"date":220,"type":41},"2025-03-25",{"date":222,"type":23},"2025-06-25",{"name":224,"class":48},"Dr Hamail Khanum"]