[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"infection-surgical-site\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:infection-surgical-site":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100559720","phase-4-prevention-of-infections-in-cardiac-surgery-pics-a-cluster-randomized-factorial-cross-over-trial-100559720",false,"NCT06567808","Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial","PICS","Inclusion Criteria:\n\nAdult patients (≥18 years of age) undergoing open-heart surgery (i.e. sternotomy, including minimally-invasive surgical techniques through mini-sternotomies)\n\nExclusion Criteria:\n\n1. On systemic antibiotics or with an active bacterial infection at the time of surgery\n2. Previously enrolled in this trial\n3. Known to be colonized with methicillin-resistant staphylococcus aureus (MRSA). Where it is unethical to not administer glycopeptides.\n4. Beta-lactam or vancomycin allergy precluding the use of cefazolin or vancomycin, respectively\n5. Participation in other studies that may interfere with this trial.\n6. Patients undergoing cardiac transplant","ALL","18 Years",{"count":19,"type":20},38000,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this pragmatic, multi-centre factorial cluster randomized cross-over trial is to assess the efficacy of a combination of cefazolin plus vancomycin compared to cefazolin monotherapy, as well as a comparison of short versus long-term prophylaxis with four study arms: 1) cefazolin short-term, 2) cefazolin long-term, 3) cefazolin plus vancomycin short-term and 4) cefazolin plus vancomycin long-term.",[26],"Infection, Surgical Site","NOT_YET_RECRUITING","2026-03-10",{"date":30,"type":31},"2026-03-12","ACTUAL",{"date":33,"type":20},"2026-03-01",{"date":35,"type":20},"2028-07-30",{"name":37,"class":38},"Hamilton Health Sciences Corporation","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":49,"briefSummary":50,"conditions":51,"keywords":58,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100554892","phase-4-powdered-intrawound-vancomycin-in-open-fractures-trial-100554892","NCT06504992","Powdered Intrawound Vancomycin in Open Fractures Trial","Powdered Intrawound Vancomycin in Open Fractures: a Randomized Controlled Trial","PIVOT","Inclusion Criteria:\n\n* 18 years or older at time of surgery\n* Patients with an open fracture classified as Gustilo Type I to IIIc in the clavicle, humerus, radius, ulna, metacarpals, upper extremity phalanges (fingers), femur, tibia, fibula and metatarsals and lower extremity phalanges (toes).\n* Open fracture treated operatively with plate(s) and screw(s) hardware fixation and intramedullary fixation (IM nail).\n* Able to attend standard of care follow up for six months post-operatively\n\nExclusion Criteria:\n\n* Patients with known vancomycin allergy, drug administration reaction, or other sensitivities to vancomycin.\n* Patients who have already had definitive fracture fixation before enrollment in the study\n* Patients with open fracture already infected at time of enrollment\n* Patients with current positive blood cultures (bacteremia) at time of enrollment (current, meaning they have not received treatment and now have negative most-recent blood cultures).\n* Patients who have other forms of local antibiotics that are left in place at the end of the definitive fixation surgery (e.g., antibiotic loaded cement or polymethyl methacrylate (PMMA) beads)\n* Patients who do not speak English\n* Patients who are currently pregnant\n* Patients who are unable to provide consent and do not have a substitute decision maker able to provide consent\n* Patients who will have severe difficulty with follow up",{"count":48,"type":20},350,[23],"The purpose of this randomized control trial is to compare the rate of post-operative infection in patients with open fractures in upper or lower extremity long bones randomized to receive intra-operative intrawound topical vancomycin powder on their open fractures in addition to the current best practice of intravenous antibiotics with irrigation and debridement compared to intravenous antibiotics with irrigation and debridement alone during definitive operative fixation of the fracture.",[52,53,26,54,55,56,57],"Open Fracture","Trauma","Fractures, Open","Wound Infection","Fractures, Bone","Post-Operative Wound Infection",[59,60,61,62,63],"open fracture","vancomycin","infection","trauma","intrawound","2024-09-17",{"date":66,"type":31},"2024-09-19",{"date":68,"type":20},"2024-11-01",{"date":70,"type":20},"2029-09-01",{"name":72,"class":38},"University of Manitoba",1]