[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"infectionpost-surg-procedure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:infectionpost-surg-procedure":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100477013","sarcopenia-in-colorectal-cancer-patients-intervention-study-100477013",false,"NCT05491434","Sarcopenia in Colorectal Cancer Patients, Intervention Study","Intervention, Non-randomized Controlled, Non-masked and Comparative Study of Presurgical Conditioning in Colorectal Cancer Patients Who Present With Sarcopenia","Inclusion Criteria:\n\n* Age ≥ 70 years old,\n* Colon adenocarcinoma without synchronous metàstasis,\n* No urgent surgery,\n* ECOG performance status ≤ 2,\n* no pregnancy or lactation,\n* signature of the informed consent,\n* ability to comply with the study indications.\n\nExclusion Criteria:\n\n* rectal càncer,\n* Concomitant neoplastic disease in the last 5 years\n* medical or mental condition of the patient that compromises the authorization of informed consent,\n* Concomitant uncontrolled or stable medical condition,\n* Clinically significant heart disease (congestive heart failure, symptomatic coronary disease)\n* Refusal to participate in the study.","ALL","70 Years",{"count":19,"type":20},370,"ESTIMATED","INTERVENTIONAL",[23],"NA","The sarcopenia is a new concept for evaluating the functional status of patients, introduced during the last 20 years. This is defined as the relationship between the deterioration of muscle mass and the decrease in strength, the metabolic rate, the aerobic capacity and subsequently the evaluation of the functional status. The sarcopenia has been estimated to affect 5% to 13% of people aged between 60 and 70 years, increasing from 11% to 50% in those aged 80 years and older. In a study by Lieffers et al. of a total of 234 patients with colorectal cancer, with a mean age of 63 years according to the values observed by Prado et al., the prevalence of sarcopenia would be around 39%, being able to reach up to 60% in patients with chronic diseases.\n\nThe goal of this study is to compare the cumulative incidence of post-surgical complications due to infection at 30 days between the group of patients without sarcopenia and the group of patients with sarcopenia with an intervention based on a nutritional supplement + physical exercise.",[26,27,28],"Sarcopenia","Postoperative Complications","Infection;Post Surg Procedure",[26,30,31,32,33],"Colon cancer","Postoperative complications","Inmunologic status","L3 CT image","RECRUITING","2025-05-15",{"date":37,"type":38},"2025-05-20","ACTUAL",{"date":40,"type":38},"2020-12-01",{"date":42,"type":20},"2026-01-31",{"name":44,"class":45},"Hospital Universitari de Bellvitge","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":46},"100494480","post-splenectomy-infections-after-surgery-for-peritoneal-malignancies-opsi-100494480","NCT05718726","Post Splenectomy Infections After Surgery for Peritoneal Malignancies (OPSI)","Overwhelming Post-Splenectomy Infections (OPSI) After Cytoreductive Surgery and Hyperthemic Intraperitoneal Chemotherapy: a Prospective Observational Study","OPSI","Inclusion Criteria:\n\n\\- Patients aged \\>18 and \\\u003C80 years Patients capable of providing informed consent Patients who have a splenectomy in conjunction with complete cytoreductive surgery (CRS) for any pathology\n\nExclusion Criteria:\n\n\\- Patients who are \\\u003C18 and \\>80 Patients who do not provide informed consent Patients on immunosuppression therapy","18 Years","79 Years",{"count":58,"type":20},300,"OBSERVATIONAL","The spleen is involved in maintaining immunity and plays an important role in the elimination of encapsulated bacteria and parasites. Patients who undergo splenectomy in conjunction with complete CRS for peritoneal malignancy are at risk of overwhelming post-splenectomy infections post-operatively. These patients are therefore administered vaccinations to lower the risk of infections but as they do not completely eliminate the risk, patients are also prescribed prophylactic antibiotics without clear evidence that they are useful in preventing OPSI. The use of prophylactic antibiotics is not without risk with potential short and long-term risks including resistance, interaction with other medication, clostridium difficile infections, fungal infections, other changes to the microbiome and cost. This study will investigate the incidence of OPSI post splenectomy and assess compliance with prophylactic antibiotics. This is an observational study where consented patients will be telephoned at fixed time points which are 1,6,12 weekly and 6 monthly for a period of five years post-operatively. As part of routine care patients will be telephoned by the clinical nurse specialist at weeks 1,6 and 12. In addition to this the research nurse will telephone the patient 6 monthly for a period of 5 years and complete a questionnaire. The research nurse will complete the questionnaire during each telephone call and this should not take more than 20 minutes. At the start of the telephone call, consent will be confirmed each time and the research nurse will check that the patient is still happy to participate before going ahead.",[28,62],"Peritoneal Cancer","2024-11-25",{"date":65,"type":38},"2024-11-27",{"date":67,"type":38},"2021-03-25",{"date":69,"type":20},"2031-02-01",{"name":71,"class":45},"Hampshire Hospitals NHS Foundation Trust"]