[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inflammaging\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inflammaging":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100638771","agewise-unravelling-the-gut-hormone-axis-in-womens-ageing-100638771",false,"NCT07614542","AGEWISE: Unravelling the Gut-Hormone Axis in Women's Ageing","Inclusion Criteria:\n\n* Female sex\n* Aged 40 to 64 years\n* Resident in mainland Portugal or the islands\n* Able and willing to provide written informed consent\n* Willing to provide stool and blood samples and complete three questionnaires\n\nExclusion Criteria:\n\n* Age below 40 years or 65 years and older\n* Inability to give informed consent\n* Refusal to provide stool or blood samples or complete questionnaires\n* Pregnancy\n* Diagnosed gastrointestinal disorders (including inflammatory bowel disease, Crohn's disease, ulcerative colitis, irritable bowel syndrome, chronic diarrhoea of unknown cause, or recurrent Clostridioides difficile infection)\n* Active oncological disease","FEMALE","40 Years","64 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","AGEWISE is an observational study that aims to understand how changes in gut microbiome are related to hormonal changes during women's ageing, particularly across the different stages of menopause. The study will include healthy women aged 40 to 64 years living in Portugal, who will provide stool and blood samples and complete questionnaires about their health, lifestyle, diet, and menopausal symptoms. Researchers will study the gut microbiome together with hormone levels and markers of inflammation to better understand how menopause affects long-term health and to support the development of improved prevention strategies for women.",[24,25,26,27,28],"Menopause","Gut Microbiome","Hormonal Changes","Chronic Low-Grade Inflammation","Inflammaging",[30,31,32,33,34],"microbiome","biomarkers","metagenomics","menopausal transition","women's health","RECRUITING","2026-05-22",{"date":38,"type":39},"2026-05-29","ACTUAL",{"date":41,"type":39},"2025-06-02",{"date":43,"type":20},"2036-12",{"name":45,"class":46},"Gulbenkian Institute for Molecular Medicine","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":47},"100623383","resveratrol-effects-on-inflammatory-biomarkers-and-cardiometabolic-parameters-100623383","NCT07395921","Resveratrol Effects on Inflammatory Biomarkers and Cardiometabolic Parameters.","Effects of Resveratrol Supplementation on Inflammatory Biomarkers and Cardiometabolic Parameters in Community-dwelling Adults. (RESINCA-trial)","RESINCA","Inclusion Criteria:\n\n* Comunnity-dwelling persons.\n* Any ethnicity.\n* With willingness to consume the bar daily during the intervention period.\n\nExclusion Criteria:\n\n* Allergy\u002Fintolerance to ingredients in the bar.\n* Pregnancy or breastfeeding.\n* Use of antioxidant\u002Fpolymeroid supplements in the last 4 weeks.\n* Unstable chronic diseases (e.g., severe liver failure, advanced kidney failure, active cancer).\n* Persons in treatments that strongly interfere with polyphenol metabolism (e.g., antibiotics, anti-inflammatories, corticosteroids, anti-allergy medication).\n* Persons with metal prosthesis.\n* Persons undergoing or waiting for metabolic bariatric surgery.\n* Persons with scheduled digestive surgery within the next 8 weeks\n* Persons in recent treatments for hypertension (less than 3 month).\n* Participation in another clinical trial.",true,"ALL","18 Years","65 Years",{"count":61,"type":20},75,"INTERVENTIONAL",[64],"NA","This study aims to evaluate the effect of the supplementation of grape pomace bars enriched in resveratrol on inflammatory biomarkers and cardiometabolic parameters in community-dwelling adults",[67,68,69,70,28],"Inflammation Biomarkers","Cardiometabolic Health Indicators","Antioxidant Status, Inflammation","Antioxidant Capabilities",[72,73,74,75,76,77],"Resveratrol","inflammation","inflammaging","antioxidant","cardiometabolic health","nutritional intervention","NOT_YET_RECRUITING","2026-05-18",{"date":81,"type":39},"2026-05-19",{"date":83,"type":20},"2026-06-01",{"date":85,"type":20},"2026-12-01",{"name":87,"class":88},"Center for Research and Innovation Viña Concha y Toro","INDUSTRY",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":97,"targetDuration":99,"studyType":21,"phases":4,"briefSummary":100,"conditions":101,"keywords":108,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":47},"100621576","macrophagemonocyte-driven-inflammation-and-anesthetic-sensitivity-in-aging-100621576","NCT07372417","Macrophage\u002FMonocyte Driven Inflammation and Anesthetic Sensitivity in Aging","Role of Macrophage\u002FMonocyte Mediated Inflammatory Response in Diminished Anesthetic Requirements During Aging","MACRO-AGE","Inclusion Criteria:\n\n* Age between 18-30 years or over 60 years old\n* Scheduled for abdominal surgery\n* General anesthesia planned with or without spinal anesthesia\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Chemotherapy or systemic corticosteroid use within the past 2 weeks.\n* Pregnancy.\n* Active sepsis or systemic infection.\n* Emergency surgery.\n* Requirement of ketamine or dexmedetomidine during the first hour of anesthesia.\n* History or diagnosis of: stroke with persistent neurological deficit, dementia, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, central nervous system autoimmune disorders, systemic autoimmune diseases, or infectious diseases of the central nervous system.\n* Current treatment with immunomodulatory medications.\n* Psychiatric disorders with psychotic features.\n* Use of psychoactive or psychotropic recreational drugs within the week prior to surgery.",{"count":98,"type":20},60,"1 Day","The goal of this observational study is to determine whether macrophage\u002Fmonocyte mediated inflammatory signaling contributes to reduced anesthetic requirements in older adults undergoing major abdominal surgery. The main questions it aims to answer are:\n\n* Is there a difference in anesthetic dosing requirements (minimum effective dose) between young and older patients undergoing major abdominal surgery?\n* How do electroencephalographic (EEG) signatures under anesthesia correlate with age and systemic inflammatory markers?\n* Is there an association between age, levels of circulating inflammatory cytokines, and monocyte\u002Fmacrophage phenotypes with anesthetic requirements?\n\nIf there is a comparison group: Researchers will compare older adult patients undergoing major abdominal surgery to younger adult patients undergoing major abdominal surgery to see if macrophage\u002Fmonocyte-mediated inflammatory signaling influences anesthetic sensitivity and the risk of postoperative neurocognitive complications in the older population.\n\nParticipants will:\n\n* Receive general anesthesia for major abdominal surgery, with continuous recording of anesthetic dose requirements.\n* Undergo electroencephalographic (EEG) monitoring during the anesthetic period.\n* Provide blood samples for the measurement of circulating inflammatory cytokines and the assessment of monocyte phenotypes.\n* Provide peritoneal tissue samples (collected during surgery) to evaluate tissue macrophage populations.\n* Provide cerebrospinal fluid (CSF) samples to assess biomarkers of blood-brain barrier permeability.",[102,103,104,105,106,67,28,107],"Aging","Inflammation","Blood-Brain Barrier Permeability","Anesthesia Brain Monitor","Anesthesia Depth Monitoring","Monocyte",[102,103,109,110,111,112,113,114,115],"General Anesthesia","Anesthetic Sensitivity","Cytokines","Alpha Oscillations","Blood Brain Barrier","Monocyte phenotype","macrophage phenotype","2026-01-19",{"date":118,"type":39},"2026-01-28",{"date":120,"type":20},"2026-01-25",{"date":122,"type":20},"2027-06-15",{"name":124,"class":46},"University of Chile"]