[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inflammasomes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inflammasomes":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100616971","association-of-periodontal-status-and-smoking-with-salivary-inflammasome-markers-100616971",false,"NCT07312552","Association of Periodontal Status and Smoking With Salivary Inflammasome Markers","The Impact of Periodontal Status and Smoking on Salivary Inflammasome Levels: A Cross-Sectional Study","Inclusion Criteria:\n\n* systemically healthy,\n* clinical diagnosis of periodontitis,\n* clinical diagnosis of periodontal health\n\nExclusion Criteria:\n\n* history of regular use of systemic antibiotics, anti-inflammatory, or antioxidant drugs (previous 6 months);\n* nonsurgical periodontal treatment (previous 6 months);\n* surgical periodontal treatment (previous 12 months);\n* presence of \\\u003C20 teeth;\n* current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy);\n* diabetes diagnosis; rheumatoid arthritis diagnosis; and pregnancy, lactating, or excessive alcohol consumption.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},116,"ESTIMATED","1 Day","OBSERVATIONAL","The aim of this study is to evaluate the relationship between periodontal status and salivary levels of the inflammasomes NOD-like receptor family, pyrin domain containing 3 (NLRP-3), NOD-like receptor family, pyrin domain containing 6 (NLRP-6), NOD-like receptor family, pyrin domain containing 12 (NLRP-12), NOD-like receptor family, CARD domain containing 5 (NLRC-5), interleukin-1 beta (IL-1β) and interleukin-10 (IL-10). Furthermore, this study aims to investigate whether the salivary levels of these inflammasomes may serve as potential diagnostic biomarkers for distinguishing individuals with periodontitis from those without. In addition, the potential role of smoking in modulating the relationship between periodontal status and salivary inflammasome levels will also be explored.",[27,28,29,30,31],"Periodontitis","Periodontal Disease","Periodontal Health","Smoking","Inflammasomes","RECRUITING","2026-01-17",{"date":35,"type":36},"2026-01-21","ACTUAL",{"date":38,"type":36},"2025-12-23",{"date":40,"type":22},"2026-07",{"name":42,"class":43},"Uskudar University","OTHER"]