[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inflammatory-biomarkers\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inflammatory-biomarkers":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,70,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100563308","frailty-hip-fractures-and-inflammatory-biomarkers-100563308",false,"NCT06614478","Frailty, Hip Fractures and Inflammatory Biomarkers","Frailty in Hip Fracture Patients Treated With Surgery; the Role of Simple Inflammatory Biomarkers. An Observational Study","Inclusion Criteria:\n\n* age \\>65 years, ASA PS I-III, non- institutionalized, able to communicate patients\n\nExclusion Criteria:\n\n* Patients with severe cognitive dysfunction, those treated conservatively, those with pathological fractures and patients who refused to participate","ALL","65 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.",[24,25,26],"Frailty","Hip Fracture","Inflammatory Biomarkers","RECRUITING","2026-05-03",{"date":30,"type":31},"2026-05-05","ACTUAL",{"date":33,"type":31},"2023-04-01",{"date":35,"type":20},"2027-04-12",{"name":37,"class":38},"University of Thessaly","OTHER",2,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":69},"100617812","inflammatory-biomarkers-and-postoperative-delirium-in-pediatric-circumcision-100617812","NCT07323485","Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision","Effect of Preoperative Inflammatory Biomarkers on Postoperative Delirium in Children Undergoing Circumcision","Inclusion Criteria:\n\n* Children aged 2-12 years.\n* Patients scheduled to undergo elective circumcision under general anesthesia.\n* Patients classified as ASA physical status I-II.\n* Patients whose parents or legal guardians provide written informed consent, and whose age-appropriate verbal assent is obtained from the child.\n* Patients in whom anesthesia and surgical procedures are performed according to standard institutional protocols throughout the study period.\n\nExclusion Criteria:\n\n* Children with a history of neurological or psychiatric disorders (e.g., epilepsy, developmental delay, autism spectrum disorder, anxiety disorders).\n* Patients classified as ASA physical status III-IV.\n* Patients with incomplete preoperative laboratory data or with hematological or hormonal disorders that may affect inflammatory parameters.\n* Patients who develop excessive sedation after premedication or whose preoperative assessment cannot be completed.\n* Patients with protocol deviations during surgery or anesthesia (e.g., additional medications, prolonged surgical duration, or changes in procedure due to complications).\n* Patients whose parents or legal guardians do not provide consent or who decline participation.",true,"MALE","2 Years","12 Years",{"count":52,"type":20},140,"Postoperative delirium may occur in children after general anesthesia, even following short procedures such as circumcision. Preoperative systemic inflammation has been associated with postoperative delirium in adults, but data in pediatric patients are limited. This prospective observational study aims to evaluate the association between preoperative inflammatory biomarkers and postoperative delirium in children aged 2-12 years undergoing elective circumcision under general anesthesia. Inflammatory biomarkers derived from routine complete blood count parameters, including NLR, PLR, MLR, SII, and SIRI, will be analyzed. Postoperative delirium will be assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale in the post-anesthesia care unit. The relationship between inflammatory biomarkers and delirium development and severity will be evaluated. This study seeks to identify simple preoperative markers that may help predict postoperative delirium risk in pediatric patients.",[55,56,26],"Postoperative Delirium","Pediatric Anesthesia",[58,56,26,55],"Circumcision","2026-02-18",{"date":61,"type":31},"2026-02-20",{"date":63,"type":31},"2026-01-18",{"date":65,"type":20},"2026-07-25",{"name":67,"class":68},"Ankara Etlik City Hospital","OTHER_GOV",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":92,"leadSponsor":94,"locationsCount":69},"100604326","inflammatory-biomarkers-as-predictors-of-ponv-following-pediatric-orchiopexy-100604326","NCT07148063","Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy","Association of Preoperative Inflammatory Biomarkers With Postoperative Nausea and Vomiting in Children Undergoing Orchiopexy","Inclusion Criteria:\n\n* Patients aged between 1 and 8 years\n* Patients with ASA physical status I-II\n* Patients scheduled for elective orchiopexy\n* Obtained written informed consent from parents\u002Fguardians\n\nExclusion Criteria:\n\n* Patients younger than 1 year or older than 8 years\n* Patients with ASA physical status III or higher\n* Presence of acute infection signs\n* History of previous nausea or vomiting","1 Year","8 Years",{"count":80,"type":20},170,"Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV).\n\nRecent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators.\n\nThis prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.",[56,83,26],"Postoperative Nausea and Vomiting (PONV)",[85,86,83,87],"Pediatric anesthesia","Orchiopexy","Inflammatory biomarkers","2025-09-08",{"date":90,"type":31},"2025-09-09",{"date":88,"type":31},{"date":93,"type":20},"2026-03-27",{"name":95,"class":68},"Diskapi Yildirim Beyazit Education and Research Hospital",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":108,"phases":109,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":4},"100596495","effects-os-physiotherapeutic-rehabilitation-on-function-autonomic-and-inflammatory-in-patients-with-long-covid-100596495","NCT07046208","Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid","Effects os Physiotherapeutic Rehabilitation on Cardiovascular Autonomic Modulation and Biomarkers Inflammatory and Cardiac Conditions in Patients With Long Covid","LongCovidRehab","Inclusion Criteria:\n\n* both sexes\n* aged 20 and 59 years\n* clinical evaluation and undergoing clinical follow-up of Post COVID-19.\n* least one persistent COVID-19-related symptom.\n\nExclusion Criteria:\n\n* incomplete data.\n* presence of a pacemaker\n* use of antihypertensive drugs that alter HRV\n* persistent pulmonary alterations\n* persistent desaturation\n* anaemia or presence of reinfection.","20 Years","59 Years",{"count":107,"type":20},58,"INTERVENTIONAL",[110],"NA","Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems. Objectives: This study aims to evaluate the effects of a physiotherapeutic rehabilitation protocol on cardiovascular autonomic modulation and on inflammatory and cardiac biomarkers in patients with Long COVID. Methodology: This is a controlled clinical trial, carried out in a cardiorespiratory rehabilitation outpatient clinic, involving individuals with a clinical diagnosis of Long COVID undergoing a protocol of 20 aerobic, anaerobic and respiratory rehabilitation sessions. Heart rate variability (HRV) variables will be analyzed using linear and non-linear methods, in addition to serum levels of CKMB, LDH, ferritin and C-reactive protein. Expected results: Rehabilitation is expected to provide an improvement in autonomic function and a reduction in inflammatory and cardiac markers, contributing to the understanding of the pathophysiological mechanisms of Long COVID and helping to propose evidence-based therapeutic strategies.",[113,114,115,26],"Long COVID","Heart Rate Variability (HRV)","Cardiac Biomarkers","NOT_YET_RECRUITING","2025-06-29",{"date":119,"type":31},"2025-07-01",{"date":121,"type":20},"2025-08-11",{"date":123,"type":20},"2026-09-30",{"name":125,"class":38},"Universidade do Estado do Pará"]