[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inguinal-hernia-bilateral\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inguinal-hernia-bilateral":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,58,85,113],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100643499","phase-1-reversing-inguinal-hernia-trial-the-evaluation-of-sex-hormones-to-reverse-inguinal-hernias-in-males-100643499",false,"NCT07604272","Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males","Reversing InGuinal Hernia Trial (RIGHT Trial): The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males","RIGHT","Inclusion Criteria:\n\n* Male sex\n* Age ≥ 50 years at time of enrollment\n* Symptomatic unilateral inguinal hernia confirmed on physical examination\n* Hernia visible \u002F confirmed on groin ultrasound\n* Non-recurrent inguinal hernia (primary hernia only)\n* Willing and able to provide written informed consent\n* Able and willing to comply with all protocol-required visits, laboratory assessments, imaging, and follow-up\n* Willing to use contraception and avoid fathering a child during study participation and for 12 months after last dose\n* Willing to be counseled regarding vitamin D and calcium supplementation Bone safety mitigation measure per PIND response.\n\nExclusion Criteria:\n\nHernia Characteristics\n\n* Scrotal hernia (any)\n* Bilateral inguinal hernia\n* Recurrent inguinal hernia (prior repair at same site)\n\nRenal \\& Hepatic\n\n* Clinically significant renal dysfunction judged by investigator to increase study risk\n* Clinically significant hepatic dysfunction at baseline\n\nHematologic\n\n■ Clinically significant baseline hematologic abnormality (including elevated hematocrit or polycythemia)\n\nUrologic \u002F Prostate\n\n* Symptomatic benign prostatic hyperplasia (BPH) requiring active medical or procedural treatment\n* Clinically significant untreated prostate disease\n\nSkeletal \u002F Bone\n\n* Baseline osteoporosis (T-score ≤ -2.5 on DEXA at any site)\n* Recent fragility fracture (within prior 12 months or as judged by investigator)\n* Other clinically significant skeletal vulnerability judged to increase risk from estrogen suppression\n\nImmunosuppression ■ Active immunosuppression (e.g., systemic corticosteroids, biologic agents, post-transplant regimens)\n\nPsychiatric\n\n■ Unstable or uncontrolled psychiatric illness that, in the investigator's judgment, would interfere with safe study participation\n\nReproductive \u002F Fertility ■ Actively pursuing fertility or planning conception during study participation\n\nPrior \u002F Concomitant Therapy\n\n* Current use of androgen replacement therapy, exogenous estrogen, or other endocrine-active agents that would confound study interpretation\n* Prior or current use of aromatase inhibitor or selective estrogen receptor modulator \u002F degrader within 6 months of enrollment\n\nGeneral\n\n■ Any other clinically significant medical condition, laboratory abnormality, or circumstance that, in the investigator's judgment, would place the participant at unacceptable risk or compromise study integrity","MALE","50 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","This is a prospective, single-center, three-arm Phase 1 safety and feasibility trial evaluating anti-estrogen therapy in men age 50 years and older with symptomatic unilateral inguinal hernias. Participants will be randomized to receive fulvestrant 250 mg intramuscularly, fulvestrant 500 mg intramuscularly, or letrozole 5 mg orally for 6 months. The study will evaluate safety, tolerability, feasibility, hormone changes, hernia size, patient-reported outcomes, bone density, and imaging-based hernia classification.",[27,28,29,30],"Inguinal Hernia Unilateral","Inguinal Hernia Bilateral","Inguinal Hernia Without Obstruction or Gangrene","Inguinal Hernia, Without Mention of Obstruction or Gangrene",[32,33,34,35,36,37,38,39,40,41,42,43,44],"inguinal hernia","hernia","fulvestrant","letrozole","anti-estrogen therapy","aromatase inhibitor","estrogen receptor","ESR1","male inguinal hernia","hormonal therapy","fibrosis","hernia prevention","hernia regression","RECRUITING","2026-06-24",{"date":48,"type":49},"2026-06-26","ACTUAL",{"date":51,"type":21},"2026-07-01",{"date":53,"type":21},"2028-06",{"name":55,"class":56},"Northwestern University","OTHER",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":66,"minAge":67,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":22,"phases":70,"briefSummary":72,"conditions":73,"keywords":74,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":79,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":57},"100628432","watchful-waiting-versus-immediate-repair-for-occult-contralateral-inguinal-hernias-100628432","NCT07461558","Watchful Waiting Versus Immediate Repair for Occult Contralateral Inguinal Hernias.","WATCH IT TRIAL WAtchful Waiting Versus immediaTe Repair for Occult Contralateral Hernias Found During MIS Inguinal Hernia Repair Trial.","WATCH IT","Inclusion Criteria:\n\n* Male or female patients ≥18 years old\n* Symptomatic unilateral inguinal hernia\n* Occult contralateral hernia identified intraoperatively\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Prior contralateral inguinal hernia repair\n* Symptomatic, bilateral inguinal hernias confirmed on physical exam\n* Contraindications to general anesthesia or surgery\n* Urgent or emergent presentations\n* Adults unable to consent\n* Pregnant patients","ALL","18 Years",{"count":69,"type":21},380,[71],"NA","This study will compare two ways of managing a small, hidden hernia that can sometimes be found during minimally invasive surgery to repair a hernia on one side of the groin. Occasionally while fixing the known hernia, the surgeon discovers a small hernia on the other side that has not caused any symptoms. Surgeons do not agree on the best way to handle these hernias. Some believe it should be repaired right away during the same operation to prevent it from getting bigger or from causing symptoms later, which could require another surgery. Others believe it is better to leave it alone since it is not causing problems and groin hernia surgery carries risks including long-term pain.\n\nThis study will randomly assign patients, if a hidden hernia is found during surgery, to either having it repaired immediately or to have it monitored over time. Patients will be followed up at 30 days, 1 year and 2 years following surgery. The researchers will compare recovery and quality of life between the two groups. For those in the monitoring group, the study will also track whether the hidden hernia causes symptoms or eventually needs surgery. The goal is to determine whether repairing the hidden hernia right away is as safe and effective as watching and waiting, so doctors and patients can make more informed decisions in the future.",[28,27],[75,76,77,78],"Occult inguinal hernia","Asymptomatic inguinal hernia","Minimally invasive inguinal hernia repair","Transabdominal preperitoneal inguinal hernia repair",{"date":48,"type":49},{"date":81,"type":49},"2026-04-01",{"date":83,"type":21},"2029-04",{"name":55,"class":56},{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":66,"minAge":67,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":22,"phases":95,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":57},"100615198","bilateral-vs-unilateral-inguinal-hernia-repairs-with-an-asymptomatic-inguinal-hernia-in-bilateral-hernias-100615198","NCT07289490","Bilateral vs Unilateral Inguinal Hernia Repairs With an Asymptomatic Inguinal Hernia in Bilateral Hernias","A Register-based Randomized Controlled Multicenter Trial of Laparo-endoscopic Bilateral Inguinal Hernia Repairs With an Asymptomatic Contralateral Hernia","BILAP HERNIA","Inclusion Criteria:\n\n* Elective laparo-endoscopic surgery of bilateral primary inguinal hernia\n* Both men and women\n* above and 18 years old\n* One of the hernias is asymptomatic\n* Surgical center that perform \\> 50 laparo-endoscopic groin hernia repairs per year.\n\nExclusion Criteria:\n\n* Recurrent groin hernias (earlier repair in the groin)\n* Femoral hernias (both symptomatic and asymptomatic)\n* Combined femoral groin hernias\n* Detected femoral hernia during surgery (they will be recommended to be operated with a bilateral repair)\n* Another operative procedure at the same time\n* A history of open lower abdominal surgery (except appendectomy) like prostate surgery\n* ASA fitness grade \\> 3\n* Patients that cannot undergo general anesthesia\n* Pregnancy\n* Age \\\u003C 18 years\n* Infected wounds\n* Emergency operation (incarcerated hernia)\n* Inability to fill in questionnaires due to language barriers or condition as Alzheimer's",{"count":94,"type":21},2200,[71],"Groin hernia repair is one of the most common surgical procedures, with around 20 million performed annually worldwide. In Sweden, over 16,000 groin hernia operations are registered each year in the Swedish Hernia Register (SHR), which has maintained 98% data completeness and validation over the past 30 years. The SHR, with currently over 400,000 recorded operations, has significantly improved the quality of hernia surgery both in Sweden and internationally. Two key outcomes that can affect a patient's quality of life after groin hernia repair are recurrence and chronic pain, both of which are tracked by the SHR and serve as quality indicators for hernia surgery in Sweden. The management of asymptomatic contralateral inguinal hernias in patients with bilateral hernias has been a topic of debate in recent decades. Most bilateral hernias are now treated laparoscopically, and this trend is growing. However, despite the prevalence of bilateral and asymptomatic contralateral hernias, there is no consensus on the optimal timing for repairing the asymptomatic side. This multicenter, register-based randomized controlled trial, using the highly validated Swedish Hernia Register, aims to investigate outcomes for asymptomatic contralateral inguinal hernias in patients with bilateral hernias.Investigate the differences in the outcome of chronic pain (patient reported outcome measure with pain questionnaire), reoperation, peri - and postoperative complications and patient satisfaction between laparo-endoscopic bilateral inguinal hernia repair with an asymptomatic contralateral groin hernia versus a laparo-endoscopic unilateral inguinal hernia repair without repairing the asymptomatic contralateral groin hernia in bilateral inguinal hernias in adults. Additionally, to study the prevalence of future elective and emergency hernia repair of the unrepaired asymptomatic contralateral inguinal hernia.The chronic pain, reoperation, peri - and postoperative complications and patient satisfaction is hypothesized to be equal between bilateral inguinal hernia repairs with an asymptomatic contralateral inguinal hernia compared to unilateral symptomatic inguinal hernia repairs",[28],[99,100,101,102],"Bilateral inguinal hernia","chronic pain","recurrence","asymptomatic contralateral inguinal hernia","NOT_YET_RECRUITING","2025-12-14",{"date":106,"type":49},"2025-12-17",{"date":108,"type":21},"2026-08-18",{"date":110,"type":21},"2036-12-31",{"name":112,"class":56},"Karolinska Institutet",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":120,"sex":66,"minAge":67,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":57},"100541434","incidence-of-regurgitation-in-patients-undergoing-intubation-in-semi-fowler-vs-supine-position-100541434","NCT06329817","Incidence of Regurgitation in Patients Undergoing Intubation in Semi-fowler v\u002Fs Supine Position","Incidence of Regurgitation in Patients Undergoing Intubation in Semi-fowler v\u002Fs Supine Position in a Tertiary Care Hospital","Inclusion Criteria:\n\n* Adults 18-60 years of age\n* Must be able to talk\n\nExclusion Criteria:\n\n* patients less than 18 years of age or above 60,\n* Pregnant women\n* Handicapped individuals\n* patients with intestinal obstruction",true,"60 Years",{"count":123,"type":21},100,[71],"One of the most dreaded complication of general anaesthesia is aspiration of gastric contents after induction of general anaesthesia.Many endeavours and measures have been practiced to reduce the incidence of aspiration pneumonia.One such method is to intubate the patient in semi-fowler or supine posture.My study is aimed to find out safe and best position between these two after induction of general anaesthesia to prevent aspiration pneumonia.",[28],"2024-09-17",{"date":129,"type":49},"2024-09-19",{"date":131,"type":49},"2024-03-16",{"date":133,"type":21},"2025-09",{"name":135,"class":56},"Pak Emirates Military Hospital"]