[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inoca-ischemia-with-non-obstructive-coronary-artery-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inoca-ischemia-with-non-obstructive-coronary-artery-disease":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100643138","advanced-invasive-diagnosis-strategy-for-post-pci-patients-with-stable-coronary-syndromes-undergoing-coronary-angiography-100643138",false,"NCT07638137","Advanced Invasive Diagnosis Strategy for Post-PCI Patients With Stable Coronary Syndromes Undergoing Coronary Angiography","Advanced Invasive Diagnosis Strategy for Post-PCI Patients With Stable Coronary Syndromes Undergoing Coronary Angiography: the AID Post-PCI Angina Study","Inclusion Criteria:\n\n* Patients with a history of previous percutaneous coronary intervention (PCI) with drug eluting stent (DES), bare metallic stent (BMS), or drug coated balloon (DCB) due to acute coronary syndrome or chronic coronary syndrome, who presented with angina or documented myocardial ischemia by non-invasive testing and are referred for invasive coronary angiography.\n\nExclusion Criteria:\n\n* Acute myocardial infarction (ST-segment elevation myocardial infarction \\[STEMI\\] and non-ST-segment elevation myocardial infarction \\[NSTEMI\\]).\n* Age \\\u003C 18 years old.\n* Pregnancy.\n* Severe left ventricle systolic dysfunction (left ventricular ejection fraction ≤30 %).\n* Congestive heart failure with reduced ejection fraction.\n* Concomitant severe valvular heart disease.\n* Severely decreased renal function (glomerular filtration rate \\\u003C 30 mL\u002Fmin\u002F1.73 m2).\n* Significant epicardial coronary artery disease unable to be treated by PCI.\n* Previous coronary artery bypass grafting (CABG).\n* Presence of any anatomic features precluding intracoronary instrumentation with pressure guidewires.\n* Contraindications to the administration of adenosine or acetylcholine.","ALL","18 Years",{"count":19,"type":20},246,"ESTIMATED","12 Months","OBSERVATIONAL","AID Post-PCI Angina is as an observational, prospective, single-cohort, multicenter study designed to investigate the causes and origins of post-PCI angina by using the advance invasive diagnosis (AID) strategy combining with angiography derived physiology (ADP) in an all-comers population of patients with post-PCI angina referred for invasive coronary angiography. An all-comers population of patients with a history of previous percutaneous coronary intervention (PCI), who presented with angina or documented myocardial ischemia by non-invasive testing and are referred for invasive coronary angiography (ICA) will be enrolled. ICA will be performed with the application of the structure AID strategy to evaluate both obstructive and non-obstructive cause of myocardial ischemia. Then, angiography derived physiological assessment of epicardial coronary artery using functional coronary angiography in each vessel will be performed in both index procedure and the previous procedure in all patients. By combining information obtained from both procedures, the causes and origins of post-PCI angina will be made. Treatment will be decided by the operators according to the result. Patients will complete the Seattle Angina Questionnaire (SAQ) at baseline and at 1, 6, and 12 months after the procedure. The main hypothesis of this study states that, in patients with post-PCI angina referred to ICA, the application of the structured AID strategy combining with angiography derived physiology (ADP) will lead to a high diagnostic yield in identifying the origins of obstructive disease and causes of post-PCI angina.",[25,26,27,28],"Angina (Stable)","Percutaneous Coronary Intervention (PCI)","INOCA (Ischemia With Non Obstructive Coronary Artery Disease)","Chronic Coronary Syndrome",[30,31,28],"Angina","Percutaneous Coronary Intervention","RECRUITING","2026-06-04",{"date":35,"type":36},"2026-06-10","ACTUAL",{"date":38,"type":36},"2025-03-12",{"date":40,"type":20},"2028-03-30",{"name":42,"class":43},"Fundacion Investigacion Interhospitalaria Cardiovascular","OTHER",5,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100585018","analysis-of-coronary-reactivity-testing-with-and-without-intracoronary-nitrate-testing-100585018","NCT06896903","Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing","CRT-NITRO","Inclusion Criteria:\n\n1. Aged 18 or older\n2. Patient being evaluated for ANOCA or INOCA\n3. Clinical suspicion for angina\n4. Patient should be able to comply with the protocol.\n5. Provide written informed consent before study participation.\n\nExclusion Criteria:\n\n1. Existing coronary artery disease\n2. Previous percutaneous interventions within the coronaries\n3. Current use (within 48 hours) of long-acting nitrate therapies\n4. Current use (within 48 hours) of PDE-5 inhibitors (sildenafil, tadalafil)\n5. Any other condition or co-morbidity which, in the opinion of the investigator or operator, may pose a significant hazard to the subject if he or she is enrolled in the study.\n6. Children below 18 years, prisoners, pregnant people and patients who are unable to provide consent are excluded.",{"count":53,"type":20},50,"INTERVENTIONAL",[56],"NA","This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary nitroglycerine.",[59,27],"ANOCA - Angina With Non-obstructive Coronary Arteries",[61,62],"Coronary Reactivity Testing","Intracoronary Nitroglycerine","2026-04-30",{"date":65,"type":36},"2026-05-05",{"date":67,"type":36},"2025-05-21",{"date":69,"type":20},"2027-06-01",{"name":71,"class":43},"Baylor Research Institute",1]