[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inspiratory-effort\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inspiratory-effort":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100608309","assessment-of-respiratory-drive-and-inspiratory-effort-across-pressure-support-levels-in-patients-after-major-abdominal-surgery-100608309",false,"NCT07199881","Assessment of Respiratory Drive and Inspiratory Effort Across Pressure Support Levels in Patients After Major Abdominal Surgery","Inclusion Criteria:\n\n* Adult patients (≥18 years) admitted to the surgical ICU\n* Recent major abdominal surgery (intra-peritoneal operation without primary thoracic involvement, including luminal resection and\u002For resection of a gastrointestinal solid organ) requiring postoperative ICU care\n* Receiving invasive mechanical ventilation in pressure support ventilation (PSV) mode at the time of enrollment\n* Duration of invasive mechanical ventilation \\>48 hours\n* Clinically stable, with no plan for extubation within 6 hours of study enrollment, defined by all of the following: Respiratory rate \\\u003C35 breaths\u002Fmin, SpO₂ ≥90%, Heart rate \\\u003C140 bpm, No visible accessory muscle use, Hemodynamically stable without escalation of vasopressor support during the past hour, Able to tolerate short-term adjustments in PSV level as per protocol\n\nExclusion Criteria:\n\n* Known neuromuscular disease affecting respiratory muscle function\n* Hemodynamic instability requiring escalation of vasopressor support\n* Severe hypoxemic respiratory failure requiring Positive End-Expiratory Pressure (PEEP) \\>10 cmH₂O or FiO₂ \\>60%\n* Deep sedation (Richmond Agitation-Sedation Scale \\[RASS\\] score \\\u003C -3) or ongoing neuromuscular blockade\n* History of chronic obstructive pulmonary disease (COPD) or other obstructive lung disease","ALL","18 Years",{"count":18,"type":19},40,"ESTIMATED","INTERVENTIONAL",[22],"NA","This physiological observational study will assess respiratory drive and inspiratory effort across varying levels of pressure support ventilation (PSV) in adult surgical ICU (SICU) patients after major abdominal surgery. By using non-invasive bedside indices (airway occlusion pressure at 100 ms after the onset of inspiration \\[P0.1\\], maximum negative occlusion pressure \\[Pocc\\], and pressure muscle index \\[PMI\\]), we aim to quantify how patients adapt to changes in ventilatory support and determine patterns of under- and over-assistance. Findings may inform optimal titration of PSV to reduce complications and improve clinical outcomes.",[25,26,27],"Inspiratory Effort","Mechanical Ventilation","Major Abdominal Surgeries",[29,30,31,32,33],"Pressure support ventilation","respiratory drive","inspiratory effort","mechanical ventilation","Major Abdominal Surgery","RECRUITING","2025-11-15",{"date":37,"type":38},"2025-11-18","ACTUAL",{"date":40,"type":38},"2025-10-31",{"date":42,"type":19},"2027-09-30",{"name":44,"class":45},"Mahidol University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":20,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":68,"leadSponsor":70,"locationsCount":46},"100590712","use-of-nasal-pressure-to-assess-inspiratory-effort-under-different-oxygen-treatments-100590712","NCT06970990","Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments","Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments: a Prospective Physiological Study","Inclusion Criteria:\n\n1. No mechanical ventilation required,Able to tolerate oxygen therapy via nasal cannula, standard face mask, or nasal high-flow oxygen therapy;\n2. Respiratory stability:Capable of spontaneous breathing with effective cough for secretion clearance.Oxygen saturation (SpO₂) \\> 90% or PaO₂\u002FFiO₂ ≥ 150 mmHg when receiving nasal cannula oxygen at 3 L\u002Fmin;\n3. Hemodynamic stability:Heart rate (HR) ≤ 120 bpm;Systolic blood pressure (SBP) 90-150 mmHg;No vasoactive medications OR norepinephrine dosage \\\u003C 0.1-0.2 μg\u002Fkg·min (or equivalent doses of other vasoactive agents);\n4. Metabolic stability;\n5. Compliance with medical instructions.Able to follow prescribed tasks.Esophageal pressure monitoring catheter already in place;\n6. Patient or legal guardian agrees to participate and has signed the informed consent form.\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years;\n2. Pregnancy;\n3. Hemodynamic instability:Mean arterial pressure (MAP) \\\u003C 60 mmHg.Heart rate (HR) \\> 120 bpm or \\\u003C 60 bpm;\n4. Respiratory instability:Respiratory rate (RR) \\> 35 bpm.Oxygen saturation (SpO₂) \\\u003C 90%;\n5. Neuromuscular diseases or phrenic nerve injury;\n6. Recent trauma or surgery involving the trachea, esophagus, neck, or chest.Contraindications to esophageal catheter placement or inability to monitor esophageal pressure;\n7. Nasal obstruction or anatomical abnormalities:Complete nasal obstruction.Severe anatomical abnormalities (e.g., severe septal deviation, nasal polyps, or tumors) preventing catheter placement or compromising ventilation;\n8. High-risk craniofacial conditions:Severe facial trauma or skull base fracture with risk of catheter misplacement into the intracranial space.Active epistaxis or incomplete healing after nasal surgery;\n9. Bleeding risk:Severe coagulopathy.Esophageal\u002Fgastric varices or other conditions predisposing to hemorrhage.",{"count":55,"type":19},26,[22],"The aim of this study was to investigate the effects of different oxygen therapy modalities (including nasal cannula oxygen, mask oxygen and high-flow nasal cannula oxygen) on the correlation between Nasal Pressure and Esophageal Pressure by means of a prospective physiological study, to assess the dynamic changes of nasal pressure and esophageal pressure and their underlying mechanisms under different conditions of oxygen therapy, to analyse the effects of oxygen therapy parameters on the relationship between the two, and to explore the feasibility of nasal pressure as a non-invasive monitoring indicator, in order to replaceor supplement esophageal manometry in clinical practice, especially in patients with respiratory distress and instability.Meanwhile, this study will also evaluate the effects of different oxygen therapy modalities on patients' respiratory mechanics and comfort, provide a scientific basis for the clinical selection of individualised oxygen therapy regimens, and ultimately provide new physiological evidence for the management of oxygen therapy in patients with acute respiratory failure in the intensive care unit (ICU) and outside the ICU, promote the development of non-invasive monitoring technology, and improve the clinical prognosis and therapeutic experience of patients.",[59,25],"Critical Care",[61,31,62,63],"Esophageal pressure","oxygen treatments","Nasal Pressure","2025-05-20",{"date":66,"type":38},"2025-05-22",{"date":64,"type":38},{"date":69,"type":19},"2025-12-30",{"name":71,"class":45},"Jian-Xin Zhou"]