[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inspiratory-muscle-training\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inspiratory-muscle-training":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,46,75,104,130,157,189,221,250,276,301],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100644698","inspiratory-muscle-training-in-individuals-with-multiple-sclerosis-100644698",false,"NCT07672535","Inspiratory Muscle Training in Individuals With Multiple Sclerosis","Comparison of the Effects of High-Intensity and Low-Intensity Inspiratory Muscle Training in Individuals With Multiple Sclerosis","Inclusion Criteria:\n\n* Diagnosis of multiple sclerosis (MS) according to the 2024 McDonald criteria\n* Expanded Disability Status Scale (EDSS) score ≥2 and \\\u003C6\n* Age between 18 and 65 years\n* Mini-Mental State Examination (MMSE) score \\>24\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Experiencing an MS relapse within the past three months\n* Presence of chronic cardiac or pulmonary diseases that may affect respiratory muscle strength and function, such as COPD, asthma, interstitial lung disease, or heart failure\n* Presence of pulmonary infection\n* Presence of orthopedic problems\n* Presence of psychiatric disorders\n* Pregnancy","ALL","18 Years","65 Years",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, characterized by inflammation, demyelination, and axonal degeneration, and primarily affects young adults. Muscle weakness, sensory disturbances, spasticity, pain, visual impairment, ataxia, fatigue, cognitive dysfunction, and respiratory complications are among the most commonly reported symptoms in individuals with MS. Although inspiratory muscle training has been shown to have beneficial effects in individuals with MS, the effects of different inspiratory muscle training intensities on respiratory muscle strength and pulmonary function have not been sufficiently investigated.\n\nThe primary aim of this study is to investigate the effectiveness and clinical feasibility of high-intensity interval inspiratory muscle training in individuals with MS. The secondary aim is to compare the effects of high-intensity interval inspiratory muscle training, low-intensity inspiratory muscle training, and conventional rehabilitation on respiratory muscle strength, pulmonary function, cough effectiveness, exercise capacity, lower extremity functional muscle strength, balance, fatigue, dysphagia severity, sleep quality, and quality of life in individuals with MS.\n\nParticipants will be randomly assigned to one of three groups: a high-intensity interval inspiratory muscle training group, a low-intensity inspiratory muscle training group, or a conventional rehabilitation group. All three groups will receive conventional rehabilitation, while the inspiratory muscle training groups will additionally receive their respective inspiratory muscle training programs. This study aims to be the first randomized controlled trial to evaluate the effects of high-intensity interval inspiratory muscle training in individuals with MS.",[27,28],"Multiple Sclerosis","Inspiratory Muscle Training",[30,31,32,33],"multiple sclerosis","inspiratory muscle training","respiratory muscle training","respiratory muscle strength","NOT_YET_RECRUITING","2026-06-26",{"date":37,"type":38},"2026-06-29","ACTUAL",{"date":40,"type":21},"2026-08",{"date":42,"type":21},"2028-01",{"name":44,"class":45},"Istanbul University - Cerrahpasa","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100640906","feasibility-and-effects-of-inspiratory-muscle-training-combined-with-blood-flow-restriction-for-frail-older-adults-100640906","NCT07573995","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults","Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Community-dwelling adults aged 65 years and older who are classified as at least \"vulnerable\" using the Clinical Frailty Scale (score ≥4).\n* Participants must have no cognitive impairment and be able to follow commands, as assessed by the Mini-Mental State Examination (MMSE).\n\nExclusion Criteria:\n\n* (1) are unable to participate in exercise (e.g., due to severe musculoskeletal disorders)\n* (2) have high-risk factors for exercise, such as uncontrolled hypertension (\\>150 mmHg systolic blood pressure (SBP) \u002F \\>90 mmHg diastolic blood pressure (DBP), coagulation disorders, and deep venous thrombosis\n* (3) have hematological disorders or are using hematology related-medications\n* (4) have significant comorbidities, including a history of stroke, diabetes with severe complications, or cardiovascular diseases\n* (5) chronic lung conditions (e.g., obstructive pulmonary disease, asthma), and\n* (6) have participated in a structured exercise training program within the past 3 months at a frequency exceeding three sessions per week.",{"count":54,"type":21},30,[24],"This randomized controlled trial study aims to evaluate the feasibility and preliminary efficacy of a combined inspiratory muscle training (IMT) and blood flow restriction (BFR) intervention in frail older adults. Outcomes of interest include feasibility, physical function, respiratory muscle strength, handgrip strength, five-times sit-to-stand performance, body composition, frailty level, fall efficacy, blood pressure, and adverse events.",[58,59,60,28],"Frailty Syndrome","Older Adults","Blood Flow Restriction (BFR) Training Effects",[62,63,64,31],"frailty","older adults","blood flow restriction","2026-05-01",{"date":67,"type":38},"2026-05-07",{"date":69,"type":21},"2026-05",{"date":71,"type":21},"2026-10",{"name":73,"class":45},"Taipei Medical University",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100544588","inspiratory-muscle-training-in-lung-transplant-candidates-100544588","NCT06370832","Inspiratory Muscle Training in Lung Transplant Candidates","Inspiratory Muscle Training in Lung Transplant Candidates and Implications on Early Post-Transplant Outcomes: A Pilot and Feasibility Multicenter Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult participants (≥ 18 years of age)\n* Lung Transplant Candidates\n* Participating in outpatient pulmonary rehabilitation (standard of care)\n* Diagnosis of Interstitial Lung Disease or Chronic Obstructive Pulmonary Disease\n\nExclusion Criteria:\n\n* Respiratory exacerbation within the last 1 month\n* Neurologic or musculoskeletal conditions that may interfere with IMT or functional assessments (i.e. history of stroke, severe arthritis of hands)\n* Insufficient English fluency to provide informed consent or to follow study protocols\n* Any evidence of pneumothorax on recent imaging (\\\u003C 6 months)\n* Present ruptures of eardrums or infections leading to fluid behind ear drum\n* Marked left or right ventricular end-diastolic volume and pressure overload on right heart catheterization or echocardiogram\n* Severe osteoporosis with history of rib fractures\n* Cardiac pacemaker or other electronic or magnetic body implant\n* Individuals listed as rapidly deteriorating or inpatient at the time of eligibility assessment\n* Individuals awaiting a re-transplant\n* Inability of the patient to connect to the internet",{"count":83,"type":21},90,[24],"Recovery after lung transplantation (LTx) may be complicated by prolonged mechanical ventilation (MV) and protracted intensive care unit (ICU) stay leading to immobilization and impaired health-related quality of life (HRQoL). In the critical care setting, diaphragm atrophy and weakness have been associated with difficulty weaning from MV, increased risk for readmission to hospital or ICU, and increased mortality. Increasing respiratory muscle strength by inspiratory muscle training (IMT) as part of pre-rehabilitation mitigates respiratory muscle dysfunction peri-operatively and may reduce the risk of post-operative complications. However, IMT is not widely used prior to LTx and the benefits of pre-operative IMT on post-transplant outcomes in LTx candidates have not been studied. Objectives: (1) To evaluate the feasibility of a multicenter randomized clinical trial of IMT in LTx candidates in terms of recruitment rate, retention, program adherence, and outcome ascertainment; (2) To establish the change in pre-transplant dyspnea perception, diaphragm structure and function, health related quality of life (HRQoL) and post-transplant intensive care unit (ICU), hospital and post-transplant 3-month outcomes with IMT relative to usual care group; and (3) To characterize the effect of pre-transplant IMT on peri-transplant diaphragm myofibrillar cross-sectional area (CSA), oxidative capacity, inflammatory markers and post-transplant diaphragm muscle thickness and function (UHN TGH site).",[28],[88,89,90,91,92],"Lung transplant candidates","Exercise training","Prehabilitation","Chronic Obstructive Pulmonary Disease","Interstitial Lung Disease","RECRUITING","2026-03-25",{"date":96,"type":38},"2026-03-30",{"date":98,"type":38},"2024-08-06",{"date":100,"type":21},"2027-09-30",{"name":102,"class":45},"University Health Network, Toronto",4,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":112,"sex":16,"minAge":113,"maxAge":17,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":74},"100630912","land--and-water-based-inspiratory-muscle-training-in-young-swimmers-100630912","NCT07493837","Land- and Water-based Inspiratory Muscle Training in Young Swimmers","Effects of Inspiratory Muscle Training on Performance in Young Swimmers: a Comparison of Land- and Water-based Applications","IMT","Inclusion Criteria:\n\nYoung competitive swimmers aged between 13 and 18 years.\n\nRegular participation in swimming training for at least 2 years.\n\nParticipation in routine training consisting of approximately 20 hours\u002Fweek of pool training and 8 hours\u002Fweek of land training.\n\nBeing medically fit to participate in swimming training and inspiratory muscle training.\n\n\\-\n\nExclusion Criteria:\n\nPresence of any acute or chronic respiratory, cardiovascular, neurological, or musculoskeletal disorder that may affect exercise performance or respiratory function.\n\nCurrent upper or lower respiratory tract infection at the time of assessment or intervention.\n\nUse of medication that may affect respiratory or exercise performance.",true,"13 Years",{"count":54,"type":21},[24],"The aim of this study is to investigate the effects of four weeks of land- and water-based inspiratory muscle training (IMT) on performance and selected physiological variables in young swimmers. A total of 30 competitive swimmers (22 males and 8 females), who have been training regularly for at least two years, will be voluntarily recruited and assigned to three groups: Land + IMT, Swimming + IMT, and Water + IMT. To compare the effects of different training protocols and evaluate their specific contributions to performance, participants will undergo assessments before the intervention and after the completion of the four-week training period. These assessments will include anthropometric measurements, pulmonary function tests, respiratory muscle strength, 100- and 200-meter freestyle swimming performance, stroke rate and stroke efficiency, as well as cardiopulmonary capacity.\n\nPrevious studies investigating the effects of inspiratory muscle training in swimmers have generally applied the intervention in land-based settings and reported positive physical and physiological adaptations. However, to the best of our knowledge, no previous study has examined the effects of IMT performed in the water in swimmers. This novel approach is expected to better simulate the actual breathing demands encountered during swimming, thereby improving respiratory control, promoting a more efficient breathing rhythm during competition, and enhancing swimming performance.",[118,28],"Sport Performance",[120,31,121],"Young swimmers","swimming performance","2026-03-21",{"date":94,"type":38},{"date":125,"type":21},"2026-03-01",{"date":127,"type":21},"2026-07-01",{"name":129,"class":45},"Ondokuz Mayıs University",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":144,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":153,"leadSponsor":155,"locationsCount":74},"100629025","high-intensity-progressive-inspiratory-muscle-training-in-class-iii-obesity-and-obstructive-sleep-apnea-100629025","NCT07469280","High-Intensity Progressive Inspiratory Muscle Training in Class III Obesity and Obstructive Sleep Apnea","High-Intensity Progressive Inspiratory Muscle Training in Class III Obesity and Obstructive Sleep Apnea: Study Protocol for a Prospective Nonconcurrent Multiple-Baseline Single-Case Experimental Design With Stability-Based Phase Transition","Inclusion Criteria: -Adults (≥18 years).\n\n* Of both genders.\n* Class III obesity (BMI \\> 40 kg\u002Fm²).\n* Diagnosis of OSA.\n* Without neurological conditions that would prevent them from responding to the study assessments.\n\nExclusion Criteria:\n\n* Systemic diseases (pulmonary, cardiac or renal).\n* Are using medications that may affect muscle performance.\n* Are currently using CPAP therapy.\n* Conditions that could compromise adherence to the study protocol.",{"count":138,"type":21},10,[24],"The purpose of this study is to evaluate the feasibility and effects of a 12-week high-intensity progressive Inspiratory Muscle Training (IMT) program in individuals with Class III obesity (BMI ≥ 40 kg\u002Fm²) and obstructive sleep apnea (OSA). Using a single-case experimental design (SCED) with multiple baselines, the study will investigate whether this respiratory intervention can reduce the severity of sleep apnea, as measured by the Apnea-Hypopnea Index (AHI), and improve inspiratory muscle strength and sleep quality. Participants will perform daily training sessions using a resistive loading device (POWERbreathe), with intensity progressing from 40% to 90% of their maximum inspiratory pressure.",[142,143,28],"Obesity, Class III","Sleep Apnea, Obstructive",[145,146,147,148],"Class III obesity","Inspiratory muscle training","Obstructive sleep apnea","Single-case experimental design","2026-03-18",{"date":151,"type":38},"2026-03-23",{"date":65,"type":21},{"date":154,"type":21},"2027-12-01",{"name":156,"class":45},"University of the State of Santa Catarina",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":168,"briefSummary":169,"conditions":170,"keywords":175,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":74},"100621011","the-primrose-trial-100621011","NCT07365072","The PRIMROSE Trial","A Randomised Controlled Trial to Evaluate the Impact of Thoracic PRehabilitation With Inspiratory Muscle tRaining cOmpared to Standard prEhabilitation in People With Lung Cancer for Surgical Treatment . The PRIMROSE Trial","PRIMROSE","Inclusion Criteria: Adults with lung cancer with surgically resectable disease who are referred for pre-treatment optimization with Prehab, from the lung cancer Multi-Disciplinary Teams (MDTs).\n\nThe referral criteria for Prehab is below:\n\n* ≥1 Medical Research Council (MRC) dyspnoea score\n* ≥1 World Health Organization (WHO) performance status (PS)\n* Age ≥ 70 years\n* Frailty index \\>3\n* Borderline or poor pulmonary function (forced expiratory volume in one second (FEV1) \\\u003C 50% or diffusion capacity for carbon monoxide (DLCO) \\\u003C50%)\n* Sedentary people despite having adequate FEV1 or DLCO\n* People who are eligible for surgical procedures, including endobronchial excision of tumour, or lobectomy, segmental resection, pneumonectomy or wedge resection, either via a minimally invasive approach or a standard thoracotomy approach\n\nAdditionally:\n\n* Participants will be included in the trial if they are capable of providing verbal and written consent for Prehab, and written consent for undergoing a surgical procedure for lung cancer\n* People over 18 years of age\n* All people will be considered regardless of their baseline respiratory muscle strength\n\nExclusion Criteria: Inclusion criteria not met\n\n* People diagnosed with other cancers namely, metastatic lung cancer, mesothelioma, sarcoma, mediastinal tumours, or benign diseases\n* People who decline Prehab\n* People who do not consent to Prehab, and do not attend Prehab. People who do not consent to surgery\n* People with a high cardiovascular risk for Prehab and awaiting investigations or interventions (including unstable angina and syncope)\n* People with a serious concomitant disorder that would compromise safety during Prehab\n* People with an abdominal hernia or recent abdominal surgery\n* People with a history of spontaneous pneumothorax and\u002For evidence of large bullae on radiological imaging\n* People with an inability to understand written and\u002For spoken English (only if carers are able to translate)\n* People with a perforated ear drum\n* People with worsening heart failure signs and symptoms after IMT\n* People with pulmonary hypertension\n* People who have suffered from or likely to suffer from costochondritis\n* If a participant was involved in a similar study, with potential to cause bias or conflict of interest then they will be excluded","90 Years",{"count":167,"type":21},100,[24],"Smoking is a major cause for developing lung cancer. People diagnosed with lung cancer, may be offered surgery which offers a complete cure. Smoking also damages the lungs and compromises a person's lung function, resulting in shortness of breath. Breathlessness limits the ability to carry out daily physical activities and exercise and makes people vulnerable to developing post procedure complications and even death. Some people with surgically treatable lung cancer have a poor ability to exercise and compromised lung function and are not fit for surgery. They will instead be referred for radiation therapy, chemotherapy or palliative care. Surgery is the preferred treatment option.\n\nThe pulmonary rehabilitation program (Prehab) improves fitness levels. In addition, it improves the level of breathlessness, exercise capacity and vulnerability of people with lung cancer, with the aim of making them fit for safe surgery. By adding a breathing training device to the Prehab program, the investigators aim to further improve participants fitness for surgery, lower their risk of developing complications and the time spent in hospital after the procedure. The breathing training device is called an inspiratory muscle training device. The hand-held device helps to train and strengthen the breathing muscles, which are then able to work more effectively. After the procedure, participants may be able to breathe and exercise more easily reducing their risk of developing complications and improving outcomes.\n\nThe study will compare two groups of people with lung cancer having surgical removal of part of the lung, at a specialist hospital . One group will receive standard Prehab and inspiratory muscle training with the device prior to the procedure; patients in the second group with receive standard Prehab prior to the procedure. Participants will be followed up for twelve months.",[171,172,28,90,173,174],"Cancer","Lung Resection","Respiratory Complications","Length of Hospital Stay",[146,171,176,90,177,178,179],"Lung resection","Lung surgery","Randomised control trial","length of hospital stay","2026-01-28",{"date":182,"type":38},"2026-01-30",{"date":184,"type":38},"2025-05-01",{"date":186,"type":21},"2027-05-01",{"name":188,"class":45},"Swansea Bay University Health Board",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":112,"sex":16,"minAge":17,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":206,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":74},"100617609","the-effect-of-exercise-training-on-lncrna-expression-in-rheumatoid-arthritis-100617609","NCT07320846","The Effect of Exercise Training on lncRNA Expression in Rheumatoid Arthritis","Investigation of the Effects of Standard Rehabilitation Program and Inspiratory Muscle Training on lncRNA HOTAIR Expression in Patients With Rheumatoid Arthritis","Inclusion Criteria:\n\n* Diagnosed with RA according to the ACR\u002FEULAR 2010 classification criteria\n* Duration of diagnosis greater than 2 years\n* Disease activity with a DAS28 score below 5.1\n* Voluntary participation in the study\n* Presence of lung involvement\n\nExclusion Criteria:\n\n* Having orthopedic deformities that may affect the treatment program\n* Pregnancy\n* Uncontrolled diabetes or heart disease\n* Participation in a rehabilitation program within the last 6 months\n* Body Mass Index (BMI) \\> 30\n* Patients with severe organ failure\n* Recent acute coronary syndrome\n* Presence of active infection","75 Years",{"count":198,"type":21},39,[24],"The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in in patients with rheumatoid arthritis-associated interstitial lung disease. The main questions it aims to answer are:\n\n* Does respiratory muscle strengthening exercise added to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have additional benefits on rehabilitation outcome measures such as exercise capacity, shortness of breath, and muscle strength?\n* Does the gain obtained with respiratory muscle strengthening iin patients with rheumatoid arthritis-associated interstitial lung disease increase the quality of life of patients and have a positive effect on their psychological state?\n* Does respiratory rehabilitation applied to iin patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes?\n* Does respiratory muscle strengthening training applied in addition to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes?\n* Participants will be included in two different respiratory rehabilitation programs with and without respiratory muscle training, and pre- and post- treatment rehabilitation criteria and genetic changes will be compared.",[202,203,92,204,28,205],"Exercise","Pulmonary Rehabilitation","Long Noncoding RNA","Rheumatoid Arthritis",[31,207,208,209,210,211],"long noncoding RNA","exercise","pulmonary rehabilitation","Interstitial lung disease","rheumatoid arthritis","2025-12-27",{"date":214,"type":38},"2026-01-06",{"date":216,"type":38},"2024-05-18",{"date":218,"type":21},"2026-03-12",{"name":220,"class":45},"Saglik Bilimleri Universitesi",{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":112,"sex":16,"minAge":17,"maxAge":228,"enrollmentInfo":229,"targetDuration":4,"studyType":22,"phases":231,"briefSummary":232,"conditions":233,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":74},"100609605","effects-of-breathing-training-and-nitrate-on-exercise-at-simulated-altitude-100609605","NCT07216755","Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude","Impact of Respiratory Muscle Training and Nitrate Therapy on Exercise Tolerance in Simulated Altitude","Inclusion Criteria:\n\n* Healthy adults between 18 and 40 years old.\n\nRecreationally active (performing ≥3 hours of structured physical activity per week).\n\nNon-smokers for at least the past 6 months.\n\nFree from any known cardiovascular, pulmonary, metabolic, or neuromuscular disease as determined by health screening questionnaire and medical history.\n\nAble to perform cycle ergometer exercise to volitional fatigue.\n\nWilling to abstain from high-nitrate foods and supplements (e.g., beets, spinach, arugula) for 48 hours prior to each testing session.\n\nAble and willing to provide written informed consent and comply with all study procedures.\n\nExclusion Criteria:\n\n* Diagnosis of or history of heart disease, hypertension, diabetes, or chronic respiratory disorders (e.g., asthma, COPD).\n\nCurrent use of medications or supplements known to affect cardiovascular, metabolic, or respiratory function (e.g., beta-blockers, nitrates, stimulants).\n\nSmoking, vaping, or tobacco use within the past 6 months.\n\nKnown allergy or intolerance to beetroot products or nitrates.\n\nParticipation in another interventional research study within the past 30 days.\n\nPregnant or breastfeeding women.\n\nAny orthopedic or musculoskeletal limitation preventing safe exercise testing.\n\nFailure to meet inclusion criteria or inability to complete familiarization and baseline testing.","40 Years",{"count":230,"type":21},80,[24],"This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory systems, which may limit endurance performance. By combining RMT-designed to strengthen the muscles involved in breathing-with nitrate therapy, which enhances nitric oxide availability and vascular function, this study aims to determine whether these interventions independently or synergistically improve oxygen delivery, reduce physiological strain, and enhance exercise performance. The findings will help identify non-pharmacological strategies to improve physical performance and tolerance to hypoxia in both clinical and operational environments.",[234,235,236,237,238,239,240,28],"Healthy Adults","Mechanical Ventilation Dependence","Hypoxia","Exercise Training","Exercise Intolerance","Dietary Supplement","Nitrate Supplementation","2025-10-13",{"date":243,"type":38},"2025-10-15",{"date":245,"type":38},"2025-09-01",{"date":247,"type":21},"2028-08-31",{"name":249,"class":45},"Embry-Riddle Aeronautical University",{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":254,"acronym":255,"eligibilityCriteria":256,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":22,"phases":259,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":4},"100605338","implementation-of-new-exercise-protocols-in-cardiac-rehabilitation-100605338","NCT07161219","Implementation of New Exercise Protocols in Cardiac Rehabilitation.","REVACARD","Inclusion Criteria:\n\n\\- Patient meeting the conditions of the permanent life support agreement following hospitalization for a cardiac condition such as: acute myocardial infarction; coronary surgery; therapeutic percutaneous endovascular intervention on the coronary arteries, under medical imaging guidance; therapeutic percutaneous endovascular intervention on the heart, under medical imaging guidance; surgery for congenital or acquired heart malformation; surgery for valvular lesion; heart transplantation; resistant angina (to be specified by detailed history, medical history, and technical examinations, justifying multidisciplinary care); cardiomyopathy with left ventricular dysfunction (to be specified by detailed history, medical history, and technical examinations, justifying multidisciplinary care).\n\n* Patient aged between 18 and 80 years.\n* Patient capable of giving informed consent.\n* Patient registered for permanent life support at the CuSL.\n* Patient capable of understanding instructions in French. - Patient with prior medical consent and clinically stable.\n\nExclusion Criteria:\n\n* \\- Minor (\\\u003C18 years old).\n* Pregnant woman.\n* Patient unable to provide informed consent.\n* Patient with cognitive, neurological, or orthopedic limitations.\n* Patient with mobility or musculoskeletal difficulties incompatible with physical activity.\n* Clinical instability.","80 Years",{"count":230,"type":21},[24],"* Primary Objective: To evaluate the effects of complementary exercise protocols in cardiac rehabilitation (CR), such as inspiratory muscle training (IMT), by assessing inspiratory muscle strength.\n* Secondary Objectives: To assess functional capacity, quality of life (QoL), and pulmonary function.",[262,263,28],"Heart Diseases","Cardiac Disease",[265,266],"heart failure","inspiratory muscles training","2025-09-18",{"date":269,"type":38},"2025-09-23",{"date":271,"type":21},"2025-12-01",{"date":273,"type":21},"2029-12-31",{"name":275,"class":45},"Cliniques universitaires Saint-Luc- Université Catholique de Louvain",{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":282,"targetDuration":4,"studyType":22,"phases":284,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":74},"100597665","effects-of-different-inspiratory-muscle-training-protocols-in-hematopoietic-stem-cell-transplant-recipients-100597665","NCT07061444","Effects of Different Inspiratory Muscle Training Protocols in Hematopoietic Stem Cell Transplant Recipients","Inclusion Criteria:\n\n* Planned haematopoietic stem cell transplantation in the adult bone marrow transplant unit\n* Between the ages of 18-65\n* Under standard medical treatment, including immunosuppressives, antibiotics and other medications\n* Ability to walk, co-operate and be clinically stable\n* No history of orthopaedic, neurological, cardiac disorders\n\nExclusion Criteria:\n\n* Cognitive disorders\n* Have orthopaedic or neurological diseases that may affect the assessment of physical fitness tests\n* Having comorbidities such as asthma, COPD\n* Conditions in which exercise training is contraindicated, such as acute bleeding, haemoglobin value \\\u003C5 g\u002Fdl, platelet count ≤10000 mm3, high fever (body temperature \\>38◦C), severe pain, confusion, dizziness, nausea and vomiting\n* Patients with pneumonia or any acute infection\n\n  -≥ 3 consecutive sessions of interruption of the exercise group subjects' attendance to the training protocol\n* Loss of willingness to participate in the research during the research process\n* Development of clinical haemodynamic instability in patients",{"count":283,"type":21},45,[24],"Introduction: After haematopoietic stem cell transplantation (HSCT), patients often experience complications such as respiratory difficulties, fatigue and decreased quality of life.\n\nThe aim of the study was to compare the effectiveness of different inspiratory muscle training (IMT) protocols on respiratory muscle strength and endurance, dyspnoea, maximal exercise capacity, diaphragmatic function, respiratory function parameters, peripheral muscle strength, fatigue, quality of life, oxidative stress parameters, muscle biomarkers and inflammatory biomarkers in HSCT recipients during the transplantation process.\n\nMethod: The study will include patients between 18-65 years of age, who are able to walk and understand the instructions, who do not have orthopedic, neurological or cardiac disorders and who will undergo haematopoietic stem cell transplantation. Patients with cognitive impairments; orthopedic or neurological diseases that may affect the evaluation of physical fitness tests; patients with comorbidities such as asthma, COPD will not be included in the study. In cases where the exercise group subjects' attendance to the training protocol is interrupted for 3 sessions or more consecutively, the voluntariness to participate in the research is lost during the research process, and clinical haemodynamic instability develops in the subjects, the participant will be excluded from the study. Patients in whom exercise training is contraindicated such as acute bleeding, haemoglobin value \\\u003C5 g\u002Fdl, platelet count ≤10000 mm3, high fever (body temperature \\>38◦C), severe pain, confusion, dizziness, nausea and vomiting will not be included in the exercise.\n\nIt is planned as a prospective, randomised controlled and single blinded study. Triple blinding could not be performed due to the executive's evaluation and implementation of the study protocol. Patients included in the study will be randomly divided into 3 study groups of 15 people each. Stratified randomisation technique will be used. A total of 45 haematopoietic stem cell transplant patients will be included in the study. Patients will be evaluated 3 times: before exercise therapy (pre-HSCT), before and after starting the preparatory regime and after exercise therapy (post-HSCT). Primary assessment measures are dyspnoea, maximal exercise capacity, respiratory muscle strength and endurance, diaphragmatic respiration, oxidative stress parameters, inflammatory markers, muscle biomarkers, pulmonary function test. Secondary assessment measures were peripheral muscle strength, fatigue, depression, and quality of life.\n\nThe research arms consisted of a total of 45(15;15;15) people in 3 groups: 'standard inspiratory muscle training group', 'functional respiratory muscle training group' and 'control group' with 15 people in each group. All patients in the control and research groups will receive inspiratory muscle training for a total of 30 minutes twice a day, every weekday during the transplantation period, starting at the end of the session in which their initial assessment was made. Functional respiratory muscle training group will perform functional exercises simultaneously with inspiratory muscle training 3 days a week (Monday-Wednesday-Friday or Tuesday-Thursday-Saturday). All exercises will be supervised by a physiotherapist.\n\nThe most important originality of this study is that it is the first study to investigate the effects of functional respiratory muscle training on respiratory parameters, diaphragm function, peripheral muscle strength, maximum oxygen consumption, dyspnoea, fatigue, depression and quality of life in HSCT recipients. It is the first randomised controlled study to demonstrate the effect of inspiratory muscle training on diaphragmatic function in HSCT recipients and it is one of the rare studies in which exercise capacity will be evaluated by cardiopulmonary exercise test. It is also the first study to examine the relationship between inspiratory muscle training and muscle biomarkers and oxidative stress parameters in HSCT recipients.\n\nH0: There is no difference in the effectiveness of different inspiratory muscle training protocols on maximal exercise capacity, respiratory muscle strength, respiratory muscle endurance, diaphragmatic function, oxidative stress parameters, muscle biomarkers, inflammatory biomarkers, dyspnoea, peripheral muscle strength, quality of life, fatigue, depression in haematopoietic stem cell transplant recipients.\n\nH1: There is a difference in the effectiveness of different inspiratory muscle training protocols on maximal exercise capacity, respiratory muscle strength, respiratory muscle endurance, diaphragmatic function, oxidative stress parameters, muscle biomarkers, inflammatory biomarkers, dyspnoea, peripheral muscle strength, quality of life, fatigue, depression in haematopoietic stem cell transplant recipients.",[287,203,28],"Hematopoietic Stem Cell Transplantation (HSCT)",[31,209,289,290,291],"hematopoietic stem cell transplantation","respiratory therapy","respiratory muscle","2025-07-02",{"date":294,"type":38},"2025-07-11",{"date":296,"type":21},"2025-08-02",{"date":298,"type":21},"2026-09-02",{"name":300,"class":45},"Ceren Derya Gültekin",{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":11,"sex":16,"minAge":228,"maxAge":257,"enrollmentInfo":308,"targetDuration":4,"studyType":310,"phases":4,"briefSummary":311,"conditions":312,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":323,"locationsCount":4},"100583516","inspiratory-and-trunk-muscle-activity-during-imt-on-stable-and-unstable-surfaces-in-stroke-patients-100583516","NCT06877338","Inspiratory and Trunk Muscle Activity During IMT on Stable and Unstable Surfaces in Stroke Patients","Inspiratory and Trunk Muscle Activity During Inspiratory Muscle Training on Stable and Unstable Surfaces in People After Stroke","Inclusion Criteria:\n\n* Age ≥ 40 years and \\\u003C 80 years\n* Breathing spontaneously\n* Clinically diagnosed with ischemic and\u002For hemorrhagic stroke\n* Stroke duration from onset between 1 and 12 months\n* No thoracic or abdominal surgery in the past 6 months\n* No cognitive impairment (Montreal Cognitive Assessment (MoCA) score ≥ 26)\n* Able to understand and follow verbal instructions\n* No facial palsy or only mild facial palsy without limitation of labial occlusion\n* Able to complete all loaded breathing tests on both stable and unstable surfaces included in this study\n\nExclusion Criteria:\n\n* Acute myocardial infarction or acute heart failure\n* Acute pain in any part of the body\n* History of chronic respiratory illness or positive clinical signs of impaired respiratory function (such as shortness of breath, hypoxemia, chronic cough, and sputum retention)\n* Presence of a nasal feeding tube, tracheal tube, or any condition that prevents the measurement or implementation of the study procedures",{"count":309,"type":21},24,"OBSERVATIONAL","This study aims to investigate the differences in muscle recruitment of the diaphragm (assessed using ultrasound), the sternocleidomastoid (SCM) and trunk muscles (both measured via surface electromyography (sEMG)), during loaded breathing training performed on both stable and unstable surfaces. The goal is to understand the interaction between the inspiratory and trunk muscles during Inspiratory muscle training (IMT) across these two surface conditions.",[313,28,314,315,316],"Stroke","Diaphragm","Sternocleidomastoid Muscles","Trunk Muscle Activity","2025-03-11",{"date":319,"type":38},"2025-03-14",{"date":321,"type":21},"2025-03-15",{"date":243,"type":21},{"name":324,"class":45},"Hong Kong Metropolitan University"]