[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"instability-ankle-ligaments-old-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:instability-ankle-ligaments-old-injury":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100439254","a-proprioceptive-training-program-using-an-uneven-terrain-treadmill-for-patients-with-ankle-instability-100439254",false,"NCT04999904","A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle Instability","ROCKY REHAB","Inclusion Criteria\n\n1. Aged 18-49.\n2. Score \\\u003C 24 on the Cumberland Ankle Instability Tool.\n3. Foot and Ankle Ability Measure Activities of Daily Living score ≤ 90 and Sports score ≤ 80 indicating substantial ankle-foot impairment and activity limitation.\n4. Able to attend treatment sessions for approximately a 6-week period.\n5. Passed most recent physical fitness test (Active duty only).\n6. Acute lateral ankle sprain specific inclusion criteria:\n\n   1. history of a first-time ankle sprain that resulted in activity limitation that lasted at least one day.\n   2. chronicity of 2-6 weeks prior to consent.\n7. Chronic ankle instability specific inclusion criteria:\n\n   1. history of at least one significant ankle sprain within the 12 months prior to enrollment that interrupted physical activity for 1+ days.\n   2. most recent ankle sprain in the past 2-12 weeks.\n   3. history of the previously injured ankle joint \"giving way\" and\u002For recurrent sprain and\u002For ''feelings of instability.''\n8. Individual is about to start care with physical therapy.\n\nExclusion Criteria\n\n1. Unable to walk at the point of study enrollment.\n2. Non-removable casting.\n3. History of previous surgeries to the musculoskeletal structures (i.e., bones, joint structures, nerves).\n4. History of fracture in either limb of the lower extremity requiring realignment.\n5. Acute injury to musculoskeletal structures of other joints of the lower extremity within the previous three months, which impacted joint integrity and function resulting in at least one interrupted day of physical activity.\n6. Pregnant.\n7. Self-reported disability due to neuromuscular impairment in the lower extremity, neurological or vestibular impairment that affected balance.\n8. Connective tissue disorder (e.g. Marfan Syndrome or Ehlers-Danlos syndrome).\n9. Anyone separating from the military within 12 months (other than normal military retirement), pending a medical evaluation board, discharge from the military for medical reasons, or pending or undergoing any litigation for an injury.","ALL","18 Years","49 Years",{"count":20,"type":21},312,"ESTIMATED","INTERVENTIONAL",[24],"NA","The ROCKY REHAB trial will provide a pragmatic approach to evaluate if incorporating a rocky, uneven terrain treadmill into the proprioceptive rehabilitation received during physical therapy can improve outcomes and reduce reinjury rates in patients with ankle instability.",[27,28],"Instability; Ankle (Ligaments) (Old Injury)","Sprain of Ankle",[30,31,32,33,34,35,36],"Acute Ankle Sprain","Chronic Ankle Instability","Proprioceptive Training","Uneven Treadmill","Reinjury","Rehabilitation","Service Members","RECRUITING","2025-07-15",{"date":40,"type":41},"2025-07-18","ACTUAL",{"date":43,"type":41},"2021-11-23",{"date":45,"type":21},"2026-09-30",{"name":47,"class":48},"Henry M. Jackson Foundation for the Advancement of Military Medicine","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100534875","bipedal-vs-unipedal-exercises-in-chronic-ankle-instability-100534875","NCT06244511","Bipedal vs. Unipedal Exercises in Chronic Ankle Instability","When to Start Bipedal Exercises in Chronic Ankle Instability?","Inclusion Criteria:\n\n* The documented unilateral ankle instability confirmed through clinical examinations (drawer test, talar tilt test) and MRI in cases requiring differential diagnosis.\n* A history of an initial ankle sprain occurring at least 6 months ago.\n* The presence of a recurrent sense of giving way that started at least 6 months ago and has been intermittently persistent.\n\nExclusion Criteria:\n\n* Presence of a history of previous surgery in the lower extremity.\n* Identification of organic and non-organic lesions such as cartilage injuries, periarticular tendon tears, and impingement syndromes.\n* The existence of a fracture accompanying instability in the foot-ankle.\n* Presence of congenital deformities in the foot-ankle.\n* Diagnosis of talus osteochondral lesion.\n* Diagnosis of ankle arthritis.\n* Presence of medial ligament lesion.\n* Existence of peripheral neuropathy.\n* Presence of additional rheumatological diseases.\n* Regular moderate-level exercise for at least 3 days a week in the last 6 months.","50 Years",{"count":58,"type":21},40,[24],"Ankle sprain is a commonly encountered condition in clinical practice, constituting approximately 15-30% of all musculoskeletal injuries. Long-term studies have demonstrated that up to 73% of patients experience at least one more ankle sprain following an acute ankle sprain. Inadequate treatment of acute ankle instability can lead to chronic ankle instability (CAI) in 30-70% of cases.\n\nTreatment approaches for CAI are classified into conservative and surgical methods. Typically, conservative treatment is initially employed to address proprioceptive deficits and static impairments. Passive, unidirectional treatments such as injections, electrotherapy, and ice, which do not target muscle strength, kinetic chain, tendon capacity, and cortical control, are reported to be insufficient or ineffective in treating CAI, relying solely on symptomatic relief. Therefore, therapeutic exercises are fundamental in CAI treatment, leading to positive developments in parameters such as strength, dynamic balance, functional status, quality of life, and injury risk. Among the most commonly used exercise approaches are proprioceptive and resistive exercises.\n\nUpon reviewing the literature, it is observed that bipedal exercises have been employed from the early stages of CAI. However, due to clinical symptoms such as pain, insecurity, and fear associated with loading the affected limb, patients tend to avoid putting weight on the affected limb, resulting in the frequent use of bipedal exercises in the early phases of rehabilitation.\n\nThe aim of this study is to comparatively examine the effectiveness of unipedal exercise interventions used in the early stages of rehabilitation for individuals with CAI in terms of pain, functional stability, fear avoidance, disease severity, functional performance, balance, and patient satisfaction, in comparison to bipedal exercise interventions.",[27],[63,64,65,35],"Proprioseptive exercise","Resistive exercise","Chronic ankle instability","2025-03-21",{"date":68,"type":41},"2025-03-24",{"date":70,"type":41},"2024-03-04",{"date":72,"type":21},"2026-07-01",{"name":74,"class":48},"Istanbul University - Cerrahpasa",1]