[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"insufficient-keratinized-gingiva\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:insufficient-keratinized-gingiva":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100640454","reharvested-free-gingival-grafts-3d-shrinkage-and-histological-changes-100640454",false,"NCT07617987","Reharvested Free Gingival Grafts: 3D Shrinkage and Histological Changes","Three-Dimensional Assessment of Graft Shrinkage in Relation to Histological Alterations in Reharvested Free Gingival Grafts From the Same Palatal Donor Site","Inclusion Criteria:\n\n* Individuals aged between 18 and 65 years,\n* Absence of any systemic disease that may adversely affect periodontal health and wound healing,\n* Non-smokers,\n* Periodontally healthy individuals,\n* Mean plaque index (PI) score \\\u003C1 following non-surgical periodontal therapy (NSPT),\n* No use of antibiotics or anti-inflammatory drugs within the last 3 months,\n* Not being pregnant or breastfeeding,\n* Willingness to participate in the study by signing the informed consent form.\n\nExclusion Criteria:\n\n* Presence of any systemic disease contraindicating surgical procedures,\n* Use of medications or supplements affecting bleeding or wound healing,\n* Presence of uncontrolled diabetes mellitus (HbA1c \\>7),\n* Pregnancy or breastfeeding,\n* History of chemotherapy or radiotherapy within the last 6 months,\n* History of antibiotic use within the last 3 months,\n* Palatal mucosal thickness \\\u003C3 mm or presence of palatal torus,\n* Presence of deep and narrow (U-shaped) or shallow palatal vaults interfering with palatal measurements,\n* Non-compliance with treatment or follow-up protocols.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},20,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to evaluate the dimensional stability of free gingival grafts (FGG) and to investigate the relationship between graft shrinkage (GS) and the histological and biochemical characteristics of grafts reharvested from the same palatal donor site. The primary objective is to investigate the relationship between histological alterations in grafts reharvested from the same donor site and graft shrinkage at the recipient site.\n\nThis study is designed as a split-mouth study in which FGGs are applied to contralateral recipient sites within the same patient. Each participant will receive two grafts: an initial graft harvested from the palatal donor site and a second graft reharvested from the same donor site 63 days after the initial procedure.\n\nGraft dimensional changes will be evaluated using three-dimensional digital measurements. Intraoral digital scans will be obtained at baseline, immediately after surgery, and at 1 and 3 months postoperatively. GS will be assessed through superimposition of digital models.\n\nIn addition, histological, histomorphometric, and immunohistochemical analyses will be performed on tissue samples obtained from the donor site to evaluate collagen characteristics and epithelial structure. Furthermore, protein expression levels of specific markers, including collagen type I, collagen type III, and alpha-smooth muscle actin (α-SMA), will be assessed. Early wound healing at the recipient site will be evaluated using the Landry healing index at postoperative days 7, 14, and 28. In addition, biological mediators, including transforming growth factor beta 1 (TGF-β1), vascular endothelial growth factor A (VEGF-A), and platelet-derived growth factor (PDGF), will be analyzed in wound exudate samples obtained from the recipient site to biochemically assess the early healing process.",[26],"Insufficient Keratinized Gingiva",[28],"free gingival graft","NOT_YET_RECRUITING","2026-05-25",{"date":32,"type":33},"2026-06-01","ACTUAL",{"date":35,"type":22},"2026-06-15",{"date":37,"type":22},"2027-09-15",{"name":39,"class":40},"Biruni University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":41},"100546765","three-dimensional-changes-in-free-gingival-grafts-around-dental-implants-100546765","NCT06399198","Three-dimensional Changes in Free Gingival Grafts Around Dental Implants","Evaluation of the Three-dimensional Changes in Free Gingival Grafts Around Dental Implants","Inclusion Criteria:\n\n* Periodontal and peri-implant tissue health\n* Good oral hygiene (plaque accumulation \\\u003C20%)\n* Either around the functioning implant or in patients scheduled for second-stage surgery following implant surgery \\\u003C2 mm keratinized gingiva on the vestibular side of the implant\n* No systemic disease and medication use that may affect soft tissue healing.\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Systemic disease that is a contraindication to the surgical procedure,\n* Uncontrolled diabetes (HbA1c \\> 7),\n* Being pregnant or breastfeeding,\n* Autoimmune and\u002For inflammatory diseases of the oral cavity,\n* Active periodontal disease,\n* Incorrectly positioned implants",{"count":50,"type":22},32,"INTERVENTIONAL",[53],"NA","The purpose of this study is to evaluate the stability of the free gingival graft dimensions around dental implants and to compare three-dimensional changes according to smoking status. Its primary goal is to provide an answer to:\n\nIs this grafting procedure stable around dental implants? Are there any differences in tissue stability between smoker and non-smoker patients?\n\nOur study consists of 2 groups:\n\nThe first group includes smoker patients who need free gingival grafts around their dental implants (n=16).\n\nThe second group includes non-smoker patients who need free gingival grafts around their dental implants (n=16).\n\nClinical measurements will be recorded at the baseline, 1st month, 3rd month, and 6th month of the study. An intraoral digital scanner will be used to measure the dimension changes of the graft at the baseline, after the surgery, 1st month, 3rd month, and 6th month of the study. Wound healing will be evaluated on postoperative days 10, 1 month, 3 months, and 6 months. Visual Analog Scale will be used to measure postoperative pain, and the number of painkillers taken will be recorded.",[26],"RECRUITING","2024-11-25",{"date":59,"type":33},"2024-11-27",{"date":61,"type":33},"2024-11-10",{"date":63,"type":22},"2025-07-10",{"name":39,"class":40}]