[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-icu-myopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-icu-myopathy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100347976","metabolomics-study-on-postoperative-intensive-care-acquired-muscle-weakness-100347976",false,"NCT03810768","Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness","Metabolomics Pilot Study on Postoperative Intensive Care Acquired Muscle Weakness (MIRACLE-I Study)","MIRACLE I","Inclusion Criteria:\n\n* invasive mechanically ventilated critically ill patient with expected intensive care unit stay \\> 3 days\n* postoperative patient\n* ≥ 18 years old\n* American Society of Anesthesiology (ASA) classification ≥ III\n\nExclusion Criteria:\n\n* moribund patient\n* non-curative care (comfort care)","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","OBSERVATIONAL","In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.\n\nAim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.",[25,26,27,28,29,30,31],"Metabolomics","Critical Care","Critical Illness","Critical Illness Myopathy","Critical Illness Polyneuropathy","Intensive Care (ICU) Myopathy","Muscle Weakness",[33,34,35],"pilot trial","muscle biopsy","blood metabolome","RECRUITING","2026-02-28",{"date":39,"type":40},"2026-03-03","ACTUAL",{"date":42,"type":40},"2022-09-02",{"date":44,"type":21},"2026-12-31",{"name":46,"class":47},"Technical University of Munich","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100455523","diaphragm-atrophy-and-dysfunction-in-mechanical-ventilation-100455523","NCT05211661","Diaphragm Atrophy and Dysfunction in Mechanical Ventilation","Development of Diaphragm Atrophy, Dysfunction and Inhibited Cortical Control in Mechanical Ventilation","DAM","Inclusion Criteria:\n\n* Initiation of invasive mechanical ventilation in the Intensive Care Unit within 48 hours.\n* Expected duration of invasive mechanical ventilation of at least 5 days.\n\nExclusion Criteria:\n\n* Body-mass-index (BMI) \\>40\n* Expected absence of active participation of the patient in study-related measurements after extubation\n* Alcohol or drug abuse\n* Non MRI compatible implant in the body\n* Slipped disc\n* Epilepsy\n* Patients in an interdependence or with an employment contract with the principal investigator, Co-PI or his deputy.","75 Years",{"count":58,"type":21},15,"The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.\n\nThrough measurements made even after mechanical ventilation (MV) it could be clarified to what extent patients recover from VIDD.\n\nPaired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex.\n\nAgainst that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).",[61,62,63,30],"Diaphragm Issues","Mechanical Ventilation Complication","Respiratory Failure","2026-02-04",{"date":66,"type":40},"2026-02-09",{"date":68,"type":40},"2022-10-10",{"date":70,"type":21},"2028-06-01",{"name":72,"class":47},"RWTH Aachen University",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":73},"100343574","recovery-from-icuaw-following-severe-respiratory-and-cardiac-failure-100343574","NCT03753412","Recovery From ICUAW Following Severe Respiratory and Cardiac Failure","Prospective Observational Study Regarding the Determinants of Functional Disability and Quality of Life in Patients Recovering From Severe Acute Cardiac or Respiratory Failure Considered for Mechanical Cardiorespiratory Support (CLEVERER)","CLEVERER","Inclusion Criteria:\n\n* Above the age of 18\n* Adults with severe cardio-respiratory failure requiring ECMO.\n* Adults who have had personal and professional consultees agree to enrol them in the trial.\n\nExclusion criteria:\n\n* Previous Stroke\n* Neuromuscular disease\n* Malignancy\n* Underlying neuromuscular disease\n* paediatrics",{"count":83,"type":21},100,"To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO). Additionally, to discover the effects of ICUAW on physical function and health-related quality of life (HRQoL) after critical illness. CLEVERER is a clinical observational pilot study.",[86,87,30,88,89,63,28],"Intensive Care Unit Syndrome","Intensive Care Neuropathy","Acute Respiratory Distress Syndrome","Cardiac Failure",[91,92,93,94,95],"Extra Corporeal Membrane Oxygenation (ECMO)","Intensive Care Unit Acquired Weakness (ICUAW)","Critical Illness Polyneuromyopathy (CIPM)","Ultrasound (US)","Health Related Quality of Life (HRQoL)","2026-01-05",{"date":98,"type":40},"2026-01-07",{"date":100,"type":40},"2019-04-09",{"date":102,"type":21},"2026-09-26",{"name":104,"class":47},"Barts & The London NHS Trust"]