[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-icu\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-icu":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,47,75,106,134,160,199,232,254,280,303,323,353,379,402],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100598875","effects-of-permissive-lung-protective-ventilation-on-outcome-in-critically-ill-invasively-ventilated-patients-100598875",false,"NCT07077174","Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients","Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients (PERMISS) - a Feasibility and Safety Pilot Study for a Randomized Clinical Trial","PERMISS pilot","Inclusion Criteria:\n\n* admission to one of the participating ICUs;\n* intubated and receiving invasive ventilation with an expected duration of ventilation of at least 24 hours.\n\nExclusion Criteria:\n\n* age below 18 years;\n* receiving invasive ventilation \\> 1 hour in the ICU, or receiving invasive ventilation \\> 6 hours directly preceding the current ICU admission (i.e., in the operating room or in the emergency department);\n* receiving or planned to receive veno-venous, veno-arterial or arterio-venous extracorporeal membrane oxygenation (ECMO);\n* having COPD GOLD III and IV;\n* contra-indication for hypercapnia, such as ongoing cardiac ischemia (as defined in the guideline of the European Society of Cardiology), or having suspected or confirmed increased intracranial pressure due to brain injury, judged by the attending physician;\n* any neurologic diagnosis that can prolong duration of mechanical ventilation, e.g., Guillain-Barré syndrome, high spinal cord lesion or amyotrophic lateral sclerosis, multiple sclerosis, or myasthenia gravis;\n* suspected or confirmed pregnancy;\n* participation in another interventional trial using similar endpoints;\n* previously randomized in this study;\n* no informed consent; or\n* admitted for terminal care","ALL","18 Years",{"count":20,"type":21},56,"ESTIMATED","INTERVENTIONAL",[24],"NA","RATIONALE Lung-protective ventilation using a lower respiratory rate (RR) is an appealing strategy to reduce ventilation intensity, which may require permissive hypercapnia. However, the feasibility and safety of this so-called 'permissive lung-protective ventilation' must be investigated, before conducting a large randomized clinical trial to evaluate its effectiveness on patient-centered outcomes.\n\nOBJECTIVE To study the feasibility and safety of permissive lung-protective ventilation in adult critically ill patients receiving invasive ventilation for acute hypoxemic respiratory failure, and to inform the design of a future randomized clinical trial in this patient population.\n\nHYPOTHESIS Permissive lung-protective ventilation is a feasible and safe ventilation strategy.\n\nSTUDY DESIGN Multicenter, randomized clinical pilot trial. STUDY POPULATION Critically ill patients, aged \\> 18 years, intubated for acute hypoxemic respiratory failure, and expected to receive ventilation for \\> 24 hours.\n\nMETHODS Patients are randomized to permissive lung-protective ventilation wherein RR is stepwise reduced, or to conventional lung-protective ventilation.\n\nOUTCOME MEASURES The primary endpoint is feasibility, assessed by the difference in respiratory rate (RR) between the two groups, from the start of mechanical ventilation until first extubation. Secondary endpoints include protocol compliance and feasibility of collecting data, and safety, assessed by the occurrence of unacceptable hypercapnia and hypoxemia and the incidence of ventilator-associated complications SAMPLE SIZE To estimate the appropriate sample size for this pilot study, we considered the primary feasibility endpoint of detecting a difference in the respiratory rate (RR). Assuming an expected mean difference in RR of 7.5, based on previous studies \\[1, 2\\], with an SD of 10, a power of 90% and an alpha of 0.05, with a drop-out rate estimated at 10%, a two-tailed t-test was used. The required sample size is 84 patients (42 patients per group).\n\nNATURE AND EXTENT OF THE BURDEN AND RISKS ASSOCIATED WITH PARTICIPATION, BENEFIT AND GROUP RELATEDNESS Ventilation with a lower RR may require permissive hypercapnia, which, when kept within safe limits, is safe. In current daily practice, there is no guidance in setting RR; consequently, RR varies widely across patients and is often set high. This pilot study compares two forms of lung-protective ventilation, both considered standard care in current ICU practice. The control group receives conventional ventilation with low tidal volumes and high RR to maintain normal PaCO₂ and pH. The intervention group, permissive ventilation, uses a lower RR to reduce mechanical power, accepting mild hypercapnia and acidosis. Permissive ventilation is most often reserved for patients with severe lung conditions, where ventilator settings are more complex and ventilation intensity is high. In these patients, permissive ventilation is considered safe, and may even be beneficial. We aim to evaluate this strategy more broadly in critically ill patients. The collection of demographic, ventilation and outcome data causes no harm to patients. Blood is drawn for arterial blood gas analysis, but this is also part of standard care.",[27,28],"Mechanical Ventilation","Intensive Care (ICU)",[30,31,32,33],"mechanical ventilation","intensive care unit","mechanical power","respiratory rate","RECRUITING","2026-06-19",{"date":37,"type":38},"2026-06-23","ACTUAL",{"date":40,"type":38},"2025-08-31",{"date":42,"type":21},"2026-08-31",{"name":44,"class":45},"Reinier de Graaf Groep","OTHER",5,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100643650","intensive-care-outcome-prediction-using-admission-carbohydrate-deficient-transferrin-100643650","NCT07632716","Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin","IMPACT - Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin A Prospective Single-center Cohort Study","IMPACT","Inclusion Criteria:\n\n* all patients ≥ 18 admitted to the Department of Emergency Medicine and subsequently transferred to an in-house intensive care unit (ICU)\n\nExclusion Criteria:\n\n* Patients transferred to other hospital departments prior to completion of intensive care\n* Patients admitted directly to the ICU without passing the ED\n* Patients admitted to intermediate care units\n* Patients with pre-existing or newly diagnosed hepatic cirrhosis\n* Patients with known or obvious pregnancy will be excluded.\n* Patients with no vascular access",{"count":56,"type":21},800,"OBSERVATIONAL","The goal of this observational study is to learn whether hazardous alcohol consumption, measured objectively by carbohydrate-deficient transferrin (CDT) levels at intensive care unit (ICU) admission, is associated with worse outcomes in critically ill patients. The main question it aims to answer is:\n\nDo elevated CDT levels at ICU admission predict increased short-term mortality and adverse clinical outcomes in adult non-traumatic ICU patients? Participants admitted to the intensive care unit via the emergency department will have CDT levels measured as part of the study. Researchers will then collect and analyze clinical data, including mortality, duration of mechanical ventilation, delirium, ICU length of stay, renal replacement therapy, and ICU readmission rates, during hospitalization and follow-up.",[28,60,61],"Critical Illness","Alcohol Misuse",[63,60,64],"Alcohol-Related Disorders","Intensive Care Units","NOT_YET_RECRUITING","2026-06-02",{"date":68,"type":38},"2026-06-08",{"date":70,"type":21},"2026-06",{"date":72,"type":21},"2028-07",{"name":74,"class":45},"Medical University of Vienna",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":86,"conditions":87,"keywords":93,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":105},"100612143","factor-associated-with-mortality-in-the-icu-100612143","NCT07249749","Factor Associated With Mortality in the ICU","Factors Associated With Mortality in the Intensive Care Unit From the Orinoco Region. An Observational Trial","ICUMortal","Inclusion Criteria:\n\n* All adult patients older than 18 admitted to the intensive care unit during the study period.\n\nExclusion Criteria:\n\n* Patients admitted for intermediate care (low therapeutic intervention with a TISS \\[Therapeutic Intervention Scoring System\\] - 28 score below 20 points). Patients derived to other institutions.","100 Years",{"count":85,"type":21},1000,"ICU mortality indicates the severity of disease, healthcare quality, and the efficacy of interventions. The severity scores are tools to predict the risk of mortality in the ICU, and the APACHE II score is frequently used for this purpose. However, studies validating the score in Colombia are limited. There is uncertainty about the precision and discrimination capacity of the APACHE II score in a population that varies from the original, with varying diseases, and in a different timeline. The investigators determined to evaluate: 1. Evaluate the rate of mortality in the ICU by type of disease and type of admission. 2. The factors associated with mortality. 3. Validate the performance of the APACHE II score as a predictor of mortality.",[88,28,89,90,91,92],"Critically Ill","Intensive Care Medicine","Mortality","Mortality Prediction","Mortality in Intensive Care Units",[88,94,90,95],"Intensive Care Unit","Colombia","2026-05-25",{"date":98,"type":38},"2026-05-27",{"date":100,"type":38},"2026-01-10",{"date":102,"type":21},"2028-12-21",{"name":104,"class":45},"Hospital Departamental de Villavicencio",1,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":105},"100637848","evaluate-the-performance-of-the-dexcom-g7-continuous-glucose-monitoring-cgm-system-in-critically-ill-patients-undergoing-major-abdominal-surgery-and-solid-organ-transplantation-which-require-blood-glucose-monitoring-for-intensive-insulin-therapy-100637848","NCT07611721","Evaluate the Performance of the Dexcom G7 Continuous Glucose Monitoring (CGM) System in Critically Ill Patients Undergoing Major Abdominal Surgery and Solid Organ Transplantation Which Require Blood Glucose Monitoring for Intensive Insulin Therapy.","Determining the Reliability and Accuracy of the Dexcom G7 Continuous Glucose Monitoring System in the ICU","DREAM-ICU","Inclusion Criteria:\n\n* Age 18 years or over\n* Intensive care unit admission\n* Requiring blood glucose monitoring for insulin therapy\n\nExclusion Criteria:\n\n* High-dose ascorbic acid or acetaminophen \\> 4g\u002Fday\n* Physical or mental health condition precluding continuous wear of the continuous glucose monitor, as judged by the physician",{"count":115,"type":21},62,[24],"Main objective:\n\nThe goal is to to determine the accuracy of Dexcom G7 Continuous glucose monitor system in critically ill patients, undergoing major abdominal surgery and solid organ transplantation, in the intensive care unit.\n\nOn admission to the intensive care unit or at the end of surgery, two Dexcom G7 sensors are placed in the infraclavicular position.\n\nSensor number 1 will be blinded and will only be active when paired with the receiver, without the ability to monitor glucose levels.\n\nSensor number 2 is used for continuous glucose monitoring and can be used to adjust the insulin dose.\n\nPatients will wear the continuous glucose monitoring sensor for a maximum of 10 days, including the time spent in the intensive care unit and the immediate care unit. The study will not interfere with any usual care clinical workflows.\n\nCalibration is only performed on an unblinded sensor. The reference method for calibration is the glucose from the blood glucose meter.\n\nCalibrate on the first day of monitoring: 4 times a day after approximately 6 hours, or if the blood glucose reading from the blood glucose meter is not within the estimated error range of the continuous glucose monitor (difference greater than 1,5mmol\u002FL).\n\nCalibration on days 2 and 3 of monitoring: once in the morning, or when the meter's glucose reading is not within the estimated error range of the continuous glucose monitoring (difference greater than 1,5mmol\u002FL) On subsequent days when the blood glucose meter reading is not within the estimated error range of continuous glucose monitoring (difference greater than 1,5mmol\u002FL).\n\nHypothesis:\n\n* Ho: No difference in mean absolute relative difference (MARD) between calibrated and non-calibrated sensors.\n* Ha: Calibrated sensors have lower mean absolute relative difference (δ = 4%, SD = 5%).\n\nFurther objectives:\n\nTo evaluate further aspects regarding the Dexcom G7 continuous glucose monitor system's performance in the intensive care unit (ICU), particularly in terms of sensitivity and specificity to detect hypo- and hyperglycaemic events, data availability, device deficiencies and safety.\n\nTo identify predictive factors of the accuracy of the Dexcom G7 continuous glucose monitor system in critically ill patients in the ICU.",[119,28,120,121,122,123],"CGM","Liver Transplant Surgery","Solid Organ Transplantation","Major Abdominal Surgeries","Diabetes (Insulin-requiring, Type 1 or Type 2)","2026-05-20",{"date":126,"type":38},"2026-05-28",{"date":128,"type":38},"2026-01-14",{"date":130,"type":21},"2027-04",{"name":132,"class":133},"Institute for Clinical and Experimental Medicine","OTHER_GOV",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":22,"phases":144,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":155,"leadSponsor":157,"locationsCount":159},"100607056","impact-of-infusion-line-change-frequency-on-infectious-complications-related-to-central-venous-catheters-in-the-icu---a-randomized-controlled-trial-100607056","NCT07183592","Impact of Infusion Line Change Frequency on Infectious Complications Related to Central Venous Catheters in the ICU - A Randomized Controlled Trial","Impact of Infusion Line Change Frequency on Infectious Complications Related to Central Venous Catheters in the Intensive Care Unit ICU","TANDOORI","Inclusion criteria\n\n* Adult patient\n* Any ICU patient with a central venous catheter (inserted by venipuncture) in place for less than 72 hours and with an expected dwell time of at least 7 days\n* Patient affiliated with or covered by a social security system\n* Patient who has given verbal consent or written consent from a third party or in the event that the patient is unable to give consent.\n\nExclusion Criteria\n\n* Patient with a documented bloodstream infection at the time of inclusion\n* Patient whose central venous catheter has been in place for more than 72 hours\n* Patient with suspected catheter-related infection\n* Patient whose study catheter was inserted using a guidewire exchange\n* Patient previously enrolled in the study during the same ICU stay\n* Patient whose condition, according to the clinician, does not allow safe placement of a central venous catheter, such as:\n\n  * Allergy to catheter material\n  * Confirmed deep vein thrombosis at the time of insertion\n  * Inflammatory skin disorder at the insertion site\n* Patient admitted for extensive burns\n* Inadequate understanding of the French language\n* Pregnant, breastfeeding, or postpartum woman\n* Person deprived of liberty by judicial or administrative decision\n* Person receiving involuntary psychiatric care\n* Person under legal guardianship or other legal protection measure",{"count":143,"type":21},2830,[24],"In the intensive care unit, patients' care and secure drugs administration require a central venous catheter. These invasive devices can lead to complications, particularly infections. Most preventive recommendations focus on catheter insertion, line handling, and dressings. Few recommendations adress catheter dwell time, which is certainly the main source of infection. Part of the prevention strategy is the regular and systematic replacement of infusion sets , as they may become contaminated during use, mainly through the hands of healthcare professionals. Prolonged use increases the risk of infection. Infusion lines changes involve disconnecting the old sets, discarding infusion devices containing drug residues, and replacing them with new sterile devices.\n\nCurrent international guidelines recommend replacing these sets every 4 days, and the Center for Disease Control and Prevention recommends not exceeding 7 days. Replacing these devices requires the time of qualified nurses, numerous sterile medical devices, and medications. In addition to the intended effect on infection prevention, the procedure has impacts on workload and costs.\n\nThe objective of the study is to demonstrate that changing infusion set every 7 days does not increase the rate of central venous catheters related infections compared with changing infusion set every 4 days.",[28,147,148,149,150],"Central Venous Catheter Related Infections","Critical Care Nursing","Catheter-associated Bloodstream Infections (CLABSI)","Nursing Workload","2026-05-12",{"date":153,"type":38},"2026-05-13",{"date":151,"type":38},{"date":156,"type":21},"2028-12",{"name":158,"class":133},"University Hospital, Angers",27,{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":22,"phases":170,"briefSummary":171,"conditions":172,"keywords":180,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":105},"100640195","feasibility-of-protocolised-analgosedation-in-ecmo-100640195","NCT07580781","Feasibility of Protocolised Analgosedation in ECMO","Feasibility of a Cluster Randomised Control Trial Evaluating a Co-designed Analgosedation Protocol in Extracorporeal Membrane Oxygenation (ECMO) Patients","ECMO-SED","Inclusion Criteria:\n\n* Aged 18 years and older\n* Receiving IV continuous infusions of analgosedation medication\n* Receiving ECMO treatment\n\nExclusion Criteria:\n\n* There will be no exclusion criteria as analgosedation management is routine for all adult ECMO patients.",{"count":169,"type":21},60,[24],"Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable. ECMO is a life support machine that provides oxygen and removes waste gases (carbon dioxide) in very sick patients with severe heart or lung failure. About 300-400 patients per year receive ECMO in the UK. These patients are younger and generally more healthy compared to other critically ill patients. However patients that survive ECMO have long-term health problems. These include anxiety, memory problems, withdrawal from medicines, and mobility issues. These problems issues could all be related to the type and amount of sedation given.\n\nA sedation protocol is a way of guiding healthcare professionals how much sedation is given to patients in ICU. Too much sedation can cause confusion, hallucinations, excessive sleepiness, and longer time in hospital. Too little sedation can cause pain, distress, and also a longer time in hospital. Using a sedation protocol in non-ECMO patients has been shown to reduce these complications.\n\nHowever, there are no protocols for giving sedation to ECMO patients in research papers. Investigators know healthcare staff find it difficult to manage sedation, and higher amounts of sedation is given to ECMO patients.\n\nAims:\n\nTo see whether it is possible to run a trial that compares using a sedation protocol against usual care.\n\nDesign\u002Fmethods:\n\nThirty to 60 ECMO patients will be chosen and will be put into one of two groups. One group will receive usual care, and the other will receive care using the sedation protocol. The investigators will collect information from both groups to find out if the study design works and how many patients agree to take part.\n\nPatient and public involvement\u002Fengagement:\n\nThe investigators received feedback from patients and family member participants which helped to design this proposal, the lay summary and what to measure in a trial. They will advise how the investigators should review study findings, and support sharing of results to the public.\n\nImpact\u002Fdissemination:\n\nThe investigators will share findings through social media, patient charities, research papers and conferences.",[28,173,174,175,176,177,178,179],"Respiratory Distress Syndrome (RDS)","Sedation and Analgesia","Extracorporeal Membrane Oxygenation","Sedation for Mechanical Ventilation","Cardiogenic Shock","Opioid Analgesia","Analgesia",[181,182,183,184,185,30,186,187,94,188,189,190],"extracorporeal membrane oxygenation","sedation","opioid","sedative","analgosedation","ECMO","ICU","Critical Care","sedation protocol","analgesia","2026-05-05",{"date":151,"type":38},{"date":194,"type":21},"2026-09-01",{"date":196,"type":21},"2027-08-31",{"name":198,"class":45},"Guy's and St Thomas' NHS Foundation Trust",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":22,"phases":209,"briefSummary":210,"conditions":211,"keywords":216,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":46},"100613517","early-antibiotics-adaptation-in-severe-pneumoniathe-early-adapt-study-100613517","NCT07267624","EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)","EARLY Antibiotics aDaptation in Ventilator-Acquired-Pneumonia Treatment After Implementation of a Broad-Panel Respiratory Multiplex PCR Test: A Multicenter Randomized Control Trial Conducted In Swiss Intensive Care Units. The EARLY ADAPT Study.","EARLY ADAPT","Inclusion Criteria:\n\n* Adult patients (≥ 18 years old)\n* Hospitalized in intensive care with invasive mechanical ventilation ≥ 48 hours\n* Administration of antimicrobial therapy for suspected VAP at the time of inclusion.\n* Expected survival \\> 96 hours.\n\nExclusion Criteria:\n\n* Enrollment prior to the current trial\n* Participation in an interventional study on the management of AMR that has a direct impact on antibiotic therapy practices.",{"count":208,"type":21},170,[24],"The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed ventilator-associated pneumonia, compared to standard diagnostic methods.\n\nAs secondary objectives, the investigators will study antibiotic management and overall antibiotic consumption, as well as escalation or de-escalation events. The investigators will study the potential clinical impact of using multiplex PCR to see if the length of stay in the intensive care unit is reduced, as well as the duration of mechanical ventilation.",[212,213,214,215,28],"VAP - Ventilator Associated Pneumonia","Antibiotic","Antibiotic Stewardship","Antibiotic Prescribing for Acute Respiratory-tract Infections",[217,218,219,220,221,222],"ventilator Associated Pneumonia (VAP)","antibiotic","PCR multiplex","intensive care","broad spectrum antibiotic","stewardship","2026-04-28",{"date":225,"type":38},"2026-04-29",{"date":227,"type":21},"2026-06-05",{"date":229,"type":21},"2028-06-30",{"name":231,"class":45},"University Hospital, Geneva",{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":22,"phases":242,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":5},"100633656","protein-provision-in-critical-illness--2-100633656","NCT07529522","PRotEin Provision in Critical IllneSs -2","The Impact of Low Versus Standard Enteral Protein Provision on Health-related Quality of Life Following Intensive Care Admission: a Randomised Controlled, Multicentre, Parallel Group Trial in Mechanically Ventilated, Critically Ill Patients","PRECISe-2","Inclusion Criteria:\n\n* Adult (≥ 18 years-old) patient\n* Admission to the ICU\n* Invasive, mechanical ventilation initiated within 72 hours following ICU admission, or mechanically ventilated upon arrival to the ICU\n* Expected ICU stay on mechanical ventilation of ≥ 3 days after randomisation\n\nExclusion Criteria:\n\n* Expected contra-indication for enteral nutrition for at least one week, at the discretion of the treating physician, such as a bowel discontinuity that cannot be solved within one week\n* Moribund (expected to die within 48 hours) or withholding of treatment (DNR code 3)\n* Previous inclusion in the PRECISe-2 trial\n* Transfer from another ICU with an ICU stay longer than 3 days",{"count":241,"type":21},1026,[24],"When patients survive a life-threatening condition in the intensive care unit (ICU), they often face a prolonged recovery process marked by persistent health issues that significantly reduce their quality of life. Muscle weakness is the most defining feature of this post-intensive care syndrome. This weakness, along with the associated decline in quality of life, presents major challenges for patients, their families, and the healthcare system, including the high costs of long-term care.\n\nUntil recently, it was believed that providing additional nutrition-particularly protein-during the early phase of a critical illness could help prevent muscle loss and promote recovery. However, the recent PRECISe study showed that administering a high amount of protein (target: 2 g\u002Fkg per day) via feeding tube actually worsened outcomes: patients who received high-protein nutrition during the acute phase reported a lower quality of life over the six months following ICU admission and were discharged from the hospital later.\n\nThese findings from the PRECISe study have renewed attention on the amount of protein administered to critically ill patients. Current European ICU nutrition guidelines (1.3 g\u002Fkg per day) recommend a higher protein intake than the daily recommended amount for healthy individuals (0.8 g\u002Fkg per day). However, in critically ill patients, protein metabolism may be impaired, potentially leading to the accumulation of toxic protein breakdown products and hindering recovery, ultimately resulting in a lower quality of life.\n\nReducing protein intake below the level recommended for healthy individuals during the acute phase of a life-threatening illness-while maintaining total energy intake (calories)-may be beneficial for long-term recovery and rehabilitation.\n\nThe PRECISe-2 study investigates whether patients who receive less protein (0.6-0.8 g\u002Fkg per day) but sufficient energy during the early phase of their critical illness feel better and experience a higher quality of life in the long term compared to those who receive the standard amount of protein (1.3 g\u002Fkg per day).",[60,28],"2026-04-20",{"date":247,"type":38},"2026-04-23",{"date":249,"type":21},"2026-05",{"date":251,"type":21},"2029-07",{"name":253,"class":45},"Ziekenhuis Oost-Limburg",{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":261,"enrollmentInfo":262,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":268,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":105},"100628892","turkish-validity-and-reliability-of-the-behavioral-indicators-of-pain-scaleescid-100628892","NCT07467551","Turkish Validity and Reliability of the Behavioral Indicators of Pain Scale(ESCID)","Reliability and Validity of the Turkish Version of the Behavioral Indicators of Pain Scale in Mechanically Ventilated Intensive Care Unit Patients","Inclusion Criteria:\n\n* Individuals aged 18 years and older\n* Patients who are intubated, receiving mechanical ventilation, and unable to establish verbal communication (Glasgow Coma Scale score \\\u003C14)\n* Patients who have been hospitalized in the intensive care unit for at least 24 hours\n\nExclusion Criteria:\n\n* Presence of postoperative complications\n* Hemodynamic instability\n* History of diagnosed cognitive or psychiatric disorders\n* History of epilepsy or use of neuromuscular blocking agents\n* History of spinal cord injury affecting motor function of all four extremities\n* Individuals with a Richmond Agitation-Sedation Scale (RASS) score of -5 (unresponsive)\n* Cases with suspected brain death","85 Years",{"count":263,"type":21},50,[24],"A significant proportion of patients hospitalized in intensive care units (ICUs) require mechanical ventilation, and the treatments applied during this process may cause pain. Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Although it is associated with delirium and agitation, pain is often an overlooked symptom in ICU patients, and a large proportion of mechanically ventilated patients continue to experience moderate to severe pain. The most common type of pain in critically ill patients is nociceptive pain, which may result from invasive procedures such as tracheal intubation, catheter insertion, aspiration, wound care, and patient repositioning. Additionally, the noisy and unfamiliar ICU environment and patients' inability to express themselves may further increase the perception of pain.\n\nRegular assessment of pain is associated with many positive outcomes, including more effective pain management, appropriate use of analgesic and sedative medications, and shorter duration of mechanical ventilation and ICU stay. Although self-reporting of pain is considered the gold standard, many patients receiving mechanical ventilation are unable to communicate their pain. Therefore, various behavioral pain assessment scales are used to evaluate pain in ICU patients. One of these tools is the Behavioral Indicators of Pain Scale (Escala de Conductas Indicadoras de Dolor - ESCID), which was developed to assess pain in critically ill adult patients receiving mechanical ventilation who are unable to communicate. However, a Turkish version of this scale has not yet been developed. Therefore, the aim of this study is to translate the ESCID scale into Turkish, perform its cultural adaptation, and test the validity and reliability of the Turkish version.",[27,267,28],"Pain Perception",[30,220,269,270],"intubation","pain","2026-03-13",{"date":273,"type":38},"2026-03-16",{"date":275,"type":38},"2026-03-01",{"date":277,"type":21},"2027-07-01",{"name":279,"class":45},"Saglik Bilimleri Universitesi",{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":287,"targetDuration":4,"studyType":22,"phases":288,"briefSummary":289,"conditions":290,"keywords":292,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":4},"100622513","pharmacokinetic-profiles-of-subcutaneous-enoxaparin-for-thromboprophylaxis-in-critically-ill-patients-with-renal-failure-treated-or-not-with-continuous-veno-veinous-hemofiltration-100622513","NCT07384598","Pharmacokinetic Profiles of Subcutaneous Enoxaparin for Thromboprophylaxis in Critically Ill Patients With Renal Failure Treated or Not With Continuous Veno-veinous Hemofiltration.","AKI-ENOXA","Inclusion Criteria:\n\n* Age \\> 18 year old\n* Hospitalized in the ICU.\n* Equiped with an arterial line.\n* Indication for thromboprophylaxis with a daily prophylactic dose of enoxaparin.\n* Additionnally:\n\n  * For cohort 1: severe renal failure (KDIGO stage ≥2) without CVVH AND SOFA score ≥4.\n  * For cohort 2: severe renal failure (KDIGO stage ≥2) with CVVH AND sequential organ failure assessment (SOFA) score ≥4.\n  * For cohort 3: no renal failure (creatinine clearance \\> 60 ml\u002Fmin)\n\nExclusion Criteria:\n\n* Platelet count \\\u003C 50 000\u002Fμl.\n* CHILD PUGH stage C cirrhosis.\n* Known coagulation disorder.\n* Patient treated in the last 3 days with direct oral anticoagulants.\n* Patient treated in the last 24h with LMWH before enrollment.\n* High bleeding risk with contra indication for standard dose of LMWH prophylaxis, as per investigator judgment\n* Indication for therapeutic anticoagulation (including CVVH with systemic heparin anticoagulation).\n* Body weight \\\u003C 50 kg or \\> 120 kg.\n* Evidence of recovery of renal function before enrollment, based on investigator judgement.",{"count":169,"type":21},[24],"Thromboprophylaxis is recommended for critically ill patients without contraindications and is usually achieved by the subcutaneous daily administration of a low dose of low molecular weight heparin (LMWH). The efficacy of this measure can be assessed by measuring the anticoagulation level obtained in the blood by dosing the anti-Xa activity. However, multiple studies have shown that anti-Xa activities in critically ill patients in the intensive care unit (ICU) are much lower, and below the desired range, than their ward counterparts.\n\nLMWH elimination depends on kidney function and reduced dosing is recommended for patients with renal failure, treated or not with renal replacement therapy (continuous veno-venous hemofiltration (CVVH)). However, some scarce data suggest that even critically ill patients with renal failure treated with reduced or even with standard doses of LMWH, also have lower anti-Xa activities (below the desired range). If confirmed, this finding may suggest that reduced or even standard dosing of LMWH for thromboprophylaxis in critically ill patients with renal failure should be replaced by another dosing regimen or another route of administration. Therefore, this study aims to better characterize the pharmacokinetic profiles of LMWH after administration of a prophylactic dose of enoxaparin daily in patients with renal failure treated or not with CVVH, and to compare them to patients with no renal failure.",[291,60,28],"Thromboprophylaxis",[293],"thromboprophylaxis","2026-01-29",{"date":296,"type":38},"2026-02-03",{"date":298,"type":21},"2026-02-01",{"date":300,"type":21},"2027-12-31",{"name":302,"class":45},"Clinique Saint Pierre Ottignies",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":310,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":311,"conditions":312,"keywords":313,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":4},"100621858","ultrasound-vs-chest-x-ray-for-ng-tube-placement-in-icu-100621858","NCT07376083","Ultrasound vs Chest X-ray for NG Tube Placement in ICU","Comparison of the Diagnostic Accuracy of Bedside Gastric Ultrasonography and Chest Radiography for Verification of Nasogastric Feeding Tube Placement in Intensive Care Unit Patients: A Prospective Observational Study","Inclusion Criteria:\n\nAge ≥ 18 years\n\nClinical indication for nasogastric tube placement\n\nWritten informed consent obtained from the patient or a legally authorized representative\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n\nAge \\\u003C 18 years\n\nPregnancy\n\nContraindications to nasogastric tube placement, including:\n\nFacial trauma\n\nBasilar skull fracture\n\nEsophageal obstruction\n\nRecent upper gastrointestinal surgery\n\nPresence of wounds, burns, or surgical dressings in the epigastric region that preclude adequate ultrasonographic evaluation",{"count":208,"type":21},"his study evaluates the diagnostic accuracy of bedside gastric ultrasonography for confirmation of nasogastric tube placement in intensive care unit patients, using chest radiography as the reference standard. Sensitivity and specificity of bedside ultrasonography will be calculated to assess its performance in this clinical setting.",[28],[314],"Nasogastric Tube Placement, Point-of-Care Ultrasonography, Diagnostic Accuracy Chest X-ray , Intensive Care Unit","2026-01-21",{"date":294,"type":38},{"date":318,"type":21},"2026-01",{"date":320,"type":21},"2026-07",{"name":322,"class":45},"Tepecik Training and Research Hospital",{"id":324,"slug":325,"hasResults":11,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":330,"targetDuration":4,"studyType":22,"phases":332,"briefSummary":333,"conditions":334,"keywords":338,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":351,"locationsCount":4},"100615362","synchrony-optimized-non-invasive-ventilation-education-program-and-icu-patients-100615362","NCT07291622","Synchrony-Optimized Non-Invasive Ventilation Education Program and ICU Patients","Effect of a Synchrony-Optimized Non-Invasive Ventilation Education Program on Intensive Care Unit Patients' Outcomes: A Randomized Clinical Trial Protocol","Inclusion Criteria:\n\n* Adult patients over 18 years of age\n* Admitted to the ICU for at least 24 hours\n* Anticipated to be hospitalized for more than one week\n* Receiving NIV treatment for any underlying condition\n* Capable of learning\n* Proficient in the Persian language\n\nExclusion Criteria:\n\n* Patients with Richmond Agitation-Sedation Scale (RASS) scores of +4 or -5\n* Patients with cognitive disorders\n* Patients with neurological disorders\n* Patients with anxiety disorders\n* Patients whose condition deteriorates, making continued cooperation impossible\n* Patients unable to participate in educational sessions",{"count":331,"type":21},92,[24],"The aim of this clinical trial is to find out whether a synchrony-optimized education program for non-invasive ventilation (NIV) can help ICU patients use their ventilator more effectively and improve their comfort, symptoms, and psychological well-being.\n\nResearchers want to answer these main questions:\n\nCan a structured two-session NIV education program help patients use their ventilator more regularly and for longer periods?\n\nDoes this type of training reduce anxiety, depression, and respiratory symptoms?\n\nCan synchrony training improve patients' comfort and reduce NIV-related problems such as mask leaks or sleep disturbances?\n\nIs this program more effective than the routine ICU education normally provided?\n\nWhat Will Happen in the Study\n\nAdults (18+) who are receiving NIV in the ICU will participate in this study.\n\nParticipants will be randomly assigned to one of two groups:\n\nIntervention Group: Will receive the SYNC-NIV education program, consisting of:\n\nOne hands-on session (20-40 minutes) teaching patients how to synchronize their breathing with the ventilator\n\nOne supplementary session (45-60 minutes) covering mask management, preventing complications, reducing leaks, breathing exercises, equipment care, and alarm handling\n\nAn educational booklet for continued support\n\nControl Group: Will receive the standard ICU education normally provided about the ICU environment, general care, communication, and monitoring.\n\nAll participants will be evaluated at three times:\n\nbefore the intervention, the day after the program ends, and one week later.",[335,336,28,337],"Ventilator Associated Events","Asynchrony, Patient-Ventilator","Noninvasive Ventilation",[339,340,341,342,343,344],"Non-Invasive Ventilation","Patient-Ventilator Synchrony","Intensive Care Unit (ICU)","Anxiety and Depression","Randomized Clinical Trial","Patient Comfort","2025-12-17",{"date":347,"type":38},"2025-12-24",{"date":349,"type":21},"2025-12-19",{"date":100,"type":21},{"name":352,"class":45},"Shahid Beheshti University of Medical Sciences",{"id":354,"slug":355,"hasResults":11,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":359,"eligibilityCriteria":360,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":363,"conditions":364,"keywords":367,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":105},"100605030","an-international-survey-on-the-use-of-niv-outside-the-icu-100605030","NCT07157215","An International Survey on the Use of NIV Outside the ICU","An International Survey on the Use of NIV Outside the ICU (NIV-Safety Study)","NIV-SAFETY","Inclusion criteria Physicians, Nursing Officers, and Respiratory therapists dealing with adult patients with acute and chronic respiratory failure.\n\nExclusion Criteria Physicians and Respiratory therapists who refuse to give consent.",{"count":362,"type":21},400,"Non-invasive ventilation (NIV) is a way to support breathing using a mask or helmet instead of a breathing tube, and it is proven to reduce the need for intubation, save lives, shorten hospital stays, and lower costs. While NIV has long been used in intensive care units, it is now increasingly applied in emergency rooms, hospital wards, and long-term care facilities. However, global data on how it is used outside ICUs-such as which patients receive it, how well it works, and what barriers exist-is lacking. The NIV-Safety Study is a worldwide survey of doctors, nurses, and respiratory therapists to understand current practices, outcomes, and challenges of NIV use beyond the ICU. The findings aim to guide safer, more effective, and standardized use of NIV across different healthcare settings.",[365,28,366],"Non-invasive Ventilation","Safety",[368,369,187],"NIV","SAFETY","2025-09-28",{"date":372,"type":38},"2025-09-30",{"date":374,"type":38},"2025-09-16",{"date":376,"type":21},"2026-03-15",{"name":378,"class":133},"Dr. Ram Manohar Lohia Hospital",{"id":380,"slug":381,"hasResults":11,"nctId":382,"briefTitle":383,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":385,"targetDuration":387,"studyType":57,"phases":4,"briefSummary":388,"conditions":389,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":105},"100608674","medical-anthropology-and-migrants-in-precarious-situations-cared-for-in-intensive-and-post-intensive-care-units-100608674","NCT07204626","Medical Anthropology and Migrants in Precarious Situations, Cared for in Intensive and Post-intensive Care Units","Inclusion Criteria:\n\nFor patients:\n\nMale and female migrants (born outside of France and its territories, regardless of date of arrival, length of residence, or acquired nationality)\n\nAged 18 years or older\n\nLiving in or transiting through France\n\nWith or without residence permits or legal documentation\n\nHospitalized in ICUs and receiving care in post-ICU rehabilitation units (SRPR)\n\nProviding consent to participate in the study\n\nHaving good proficiency in French, Spanish, or Italian, or, if not, benefiting from professional interpretation (ISM) or cultural mediation ensuring effective communication\n\nHaving a psychological and neurological state compatible with providing informed consent and taking part in an interview\n\nFor healthcare professionals and associative actors:\n\nBeing a healthcare, social work, or associative professional\n\nInvolved in the medical, psycho-social, and\u002For legal support and care of migrant patients admitted to ICUs and SRPR\n\nProviding consent to participate in the study\n\nExclusion Criteria:\n\nFor patients:\n\nBeing born in France\n\nBeing a minor (\\\u003C18 years old)\n\nBeing under guardianship or curatorship\n\nHaving a neurological state incompatible with providing informed consent and taking part in an interview\n\nFor healthcare professionals and associative actors:\n\nNot being involved in the care of migrant patients admitted to ICUs and SRPR",{"count":386,"type":21},100,"8 Months","Analyze the experience (perception, interpretation and incorporation - embodiment) that migrant people with low socio-economic status\u002Fprecarity have of their own health conditions for which they have come to be hospitalized in the Intensive Care Unit (ICU) and Post-Resuscitation Rehabilitation Care (PRRC).",[390,391,28,392],"Anthropology","Immigrant","Precariousness","2025-09-24",{"date":395,"type":38},"2025-10-02",{"date":397,"type":21},"2025-10-15",{"date":399,"type":21},"2026-07-15",{"name":401,"class":45},"Centre Hospitalier de Saint-Denis",{"id":403,"slug":404,"hasResults":11,"nctId":405,"briefTitle":406,"officialTitle":406,"acronym":4,"eligibilityCriteria":407,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":408,"targetDuration":4,"studyType":22,"phases":410,"briefSummary":411,"conditions":412,"keywords":415,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":105},"100600066","effectiveness-of-an-educational-intervention-of-spirituality-in-nursing-professionals-working-in-critical-health-care-settings-to-promote-spiritual-self-care-100600066","NCT07092657","Effectiveness of an Educational Intervention of Spirituality in Nursing Professionals Working in Critical Health Care Settings to Promote Spiritual Self-care.","Inclusion Criteria:\n\n* Work in a critical unit of the institutions where the study will be carried out.\n* Have a minimum experience of 6 continuous months in critical care contexts.\n* Have a score of 35-45 points (moderate) and 10-30 points (low).\n\nExclusion Criteria:\n\n* Nursing professional who fails to complete full participation in the study (pre- test, nursing intervention and post-test).",{"count":409,"type":21},68,[24],"This study will evaluate the effect of an educational intervention of spirituality in nursing professionals acting in critical care contexts to favor spiritual self-care, compared with the conventional care group. The educational intervention adopts Pamela Reed's theory of the transcendence of the self as a theoretical reference, which facilitates the understanding of the phenomenon of spirituality by adopting an integral approach focused on personal growth. To determine the effect of the intervention, the Spiritual Perspective Scale (SPS) developed by Reed will be applied.",[413,414,28],"Spirituality","Nursing",[413,416,417],"Critical care nursing","Nursing care","2025-07-25",{"date":420,"type":38},"2025-07-30",{"date":422,"type":21},"2025-07",{"date":424,"type":21},"2026-02",{"name":426,"class":45},"Universidad de Antioquia"]