[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-unit-delirium\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-unit-delirium":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,67,95,128],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100512323","prevention-of-delirium-in-icu-using-multimodal-interventions-100512323",false,"NCT05950958","Prevention of Delirium in ICU Using Multimodal Interventions","The Impact of Audio and Visual Intervention in Preventing ICU Delirium in Critically Ill Patients : A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients over 50 years who are expected to spend more than 24 hours in the intensive care unit\n\nExclusion Criteria:\n\n* Patients who developed delirium before entering the intensive care unit\n* Patients with cognitive impairment\n* Patients who have hearing or vision deficits, or have difficulty in communication\n* Patients who are expected to die within 24 hours or do not want life-sustaining treatment","ALL","50 Years",{"count":19,"type":20},196,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study was designed to evaluate the impact of non-pharmacological multimodal interventions including ongoing orientation, sensory correction, setting of familiar circumstance and promotion of sleep enviromnet for prevention of delirium in intensive care unit.",[26],"Intensive Care Unit Delirium",[28,29,30],"Delirium","Intensive Care Unit","Non-pharmacological intervention","RECRUITING","2026-05-30",{"date":34,"type":35},"2026-06-02","ACTUAL",{"date":37,"type":35},"2022-08-01",{"date":39,"type":20},"2028-07-31",{"name":41,"class":42},"Seoul National University Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":43},"100631098","virtual-reality-cognitive-intervention-for-critically-ill-delirium-survivors-vr-cog-100631098","NCT07496255","Virtual Reality Cognitive Intervention for Critically Ill Delirium Survivors (VR-Cog)","Inclusion Criteria:\n\n* Adults aged 50 years or older\n* English speaking\n* Admitted to the intensive care unit (ICU) with acute respiratory failure\u002Finvasive mechanical ventilation\n* Screening positive for delirium (using Richmond Agitation Sedation Scale and Confusion Assessment Method for the ICU)\n\nExclusion Criteria:\n\n* Acute neurologic injury such as stroke, traumatic brain injury, brain mass, intracranial hemorrhage, seizures, or central nervous system infection\n* Chronic cognitive or physical function deficit preventing participation in study interventions or assessments (determined by chart diagnoses and direct participant interview)\n* Chronic cognitive impairment (including mild cognitive impairment or dementia) identified by chart diagnosis, prescription of anti-dementia medications, or Informant Questionnaire on Cognitive Decline in the Elderly Score (IQCODE) \\>3.3 obtained from family caregiver\n* Severe, uncorrected vision or hearing impairment preventing participation in intervention or outcomes assessments\n* Admitted with acute alcohol or drug intoxication or withdrawal\n* Severe, uncontrolled psychiatric disorder (bipolar disorder or schizophrenia)\n* History of severe vertigo, motion-induced sickness, headaches, light sensitivity, seizures, or prior intolerance of virtual reality (VR)\n* Receiving comfort care measures or not expected to survive the hospitalization\n* Prisoners or patients unable to provide consent\n* Not expected to be discharged home from the hospital, or living more than 50 miles from the nearest recruitment site, or homeless",{"count":51,"type":20},100,[23],"The purpose of this study is to measure the feasibility, acceptability of virtual reality (VR) brain games and estimate their effect on memory, attention, and mood for ICU survivors. The VR program will be used at home through a headset and hand controls.",[26,55,56,57],"Intensive Care Acquired Cognitive Impairment","Post Intensive Care Unit Syndrome","Virtual Reality Cognitive Training","2026-04-15",{"date":60,"type":35},"2026-04-17",{"date":62,"type":35},"2026-03-19",{"date":64,"type":20},"2027-07-15",{"name":66,"class":42},"Indiana University",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":77,"phases":4,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":43},"100529339","automating-delirium-severity-in-the-icu-100529339","NCT06172491","Automating Delirium Severity in the ICU","Harnessing the Power of Technology to Transform Delirium Severity Measurement in the ICU","ADS-ICU","Inclusion Criteria: • Age \\>50;\n\n* Estimated length of stay \\>24 hours in ICU; and\n* Are not admitted for acute alcohol intoxication, drug (prescribed or illicit) overdose or withdrawal.\n\nExclusion Criteria:\n\n* Admitted for acute alcohol intoxication, drug (prescribed or illicit) overdose or withdrawal.\n* Admitted for acute neuronal injury\n* Unable to communicate with research team due to sensory deficits (aphasic, blind, deaf) or language (does not speak English)",{"count":76,"type":20},400,"OBSERVATIONAL","The goal of this observational study is to develop a passive digital marker (PDM) for delirium severity and examine its performance in comparison to validated delirium severity tools in ICU patients \\>50 years of age.\n\nThe main questions it aims to answer are:\n\n* Is the trained convolutional neural network able to reliably measure delirium severity.\n* Is the Passive Digital Marker able to accurately measure delirium severity\n* Is the Passive Digital Marker acceptable and usable by frontline ICU nurse clinicians, patients, and their identified proxies (i.e., caregivers).\n\nParticipants will:\n\n* Study participation involves a video camera recording you 24 hours per day while you are a patient in the Intensive Care Unit (ICU).\n* Study staff will visit you 4 times each day you are in the ICU. You will be asked questions each time they visit to train the digital marker and see differences between assessments and camera data.",[26,80,28],"Encephalopathy",[28,82,83,84,85],"Severity","Digital marker","Computer Vision","Artificial Intelligence","2026-04-02",{"date":88,"type":35},"2026-04-08",{"date":90,"type":35},"2023-01-15",{"date":92,"type":20},"2028-05-31",{"name":94,"class":42},"Mayo Clinic",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":103,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":77,"phases":4,"briefSummary":105,"conditions":106,"keywords":112,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":124,"leadSponsor":126,"locationsCount":43},"100573684","the-gut-microbiome---source-of-sepsis-and-novel-target-in-intensive-care-units-100573684","NCT06749483","The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?","The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units? Research on Human Tissue, Body Fluids, Neuropsychological Assessment and Brain Imaging","MS-ICU","Inclusion Criteria:\n\n* Age ≥ 18 years\n* One of the following criteria\n\n  1. Critically ill patients treated with meropenem or piperacillin\u002Ftazobactam started within the last 72 h\n  2. Critically ill patients without systemic antimicrobial therapy within the last 72 hours and an expected ICU length of stay of more than 3 days\n  3. Long-term survivors of sepsis, e.g. from pre-existing sepsis cohorts\n\nExclusion Criteria:\n\n* Inflammatory bowel disease\n* Major bowel resection\n* Selective decontamination of the oral and digestive tract\n* Oral vancomycin therapy\n* Immunocompromised patients\n* History of chemotherapy during the last 6 months.\n* Known travel history to countries to areas of high antimicrobial resistance (\\>5% according to the report of the European Centre for Disease Prevention and Control and all countries except USA and Canada) within the last 4 weeks\n* Acute neurological diseases (e.g., brain ischemia, hemorrhage, meningoencephalitis, tumor)\n* Manifest dementia, pre-existing psychiatric diseases (schizophrenia, psychosis)\n* Acute brain surgery\n* MRI contraindications: pacemakers, hearing aids, neurostimulation, insulin pumps, other potentially ferromagnetic implants, screws, clips, prostheses, metal splinters, etc., pregnancy, claustrophobia, extensive tattoos.","18 Years",{"count":51,"type":20},"Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis. The proposal aims to combine holistic approaches with emerging experimental technologies to investigate the complex interactions between the gut microbiota and its host and assess the impact of specific bacterial communities on longevity and stress responses. A strong focus of this study will also be placed on microbiome dysbiosis and secondary impacts on short- and long-term brain dysfunction using clinical, laboratory and imaging procedures.",[107,26,108,109,110,111],"Critical Illness","Neurocognitive Deficit","Microbiome,immune Function, Critically Ill","Infection in ICU","Sepsis",[113,114,115,116,117,118,119],"sepsis","broad-spectrum antibiotics","stool","neuropsychological assessment","delirium","neurocognitive impairment","microbiome","2024-12-27",{"date":122,"type":35},"2024-12-30",{"date":120,"type":35},{"date":125,"type":20},"2026-12-31",{"name":127,"class":42},"Jena University Hospital",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":16,"minAge":103,"maxAge":4,"enrollmentInfo":134,"targetDuration":4,"studyType":21,"phases":136,"briefSummary":138,"conditions":139,"keywords":140,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":43},"100504535","phase-3-dexmedetomidinine-in-the-prevention-of-postoperative-delirium-in-the-intensive-care-unit-after-cardiac-surgery-100504535","NCT05849597","Dexmedetomidinine in the Prevention of Postoperative Delirium in the Intensive Care Unit After Cardiac Surgery","Inclusion Criteria:\n\n* patients undergoing open heart surgery with the use of cardiopulmonary bypass (including coronary artery bypass grafting, valve repair\u002Freplacement, and combined)\n* left ventricular ejection fraction (LVEF) \\>40%.\n\nExclusion Criteria:\n\n* preoperative atrial fibrillation\n* previous history of interventionally treated arrhythmias\n* second and third degree atrioventricular block\n* bradycardia with heart rate ≤50\u002Fmin\n* pacemaker\n* renal or hepatic insufficiency\n* emergency procedures\n* history of serious mental illness, delirium, and severe dementia",{"count":135,"type":20},200,[137],"PHASE3","This is a prospective, randomized, single blinded, controlled clinical trial designed to compare the clinical effects of sedation with dexmedetomidine versus propofol in patients undergoing cardiac surgery.",[26],[141,142,143,144],"open heart surgery","sedation","dexmedetomidine","postoperative delirium","2024-12-03",{"date":147,"type":35},"2024-12-04",{"date":149,"type":35},"2022-03-01",{"date":151,"type":20},"2025-06",{"name":153,"class":42},"University of Novi Sad"]