[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-unit-icu\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-unit-icu":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,48,78,115,145,176,201,223,257,289],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100562590","phase-3-canadian-critical-care-comparative-effectiveness-platform-100562590",false,"NCT06605144","Canadian Critical Care Comparative Effectiveness Platform","Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en Soins Critiques (CEPEC)","CEPEC","VASOPRESSOR DOMAIN There is no minimum age limit in the Vasopressor Domain.\n\nInclusion criteria:\n\n1. Ongoing vasopressor infusion to treat hypotension, or would be used to treat clinician-defined hypotension as part of usual care;\n2. MAP \\\u003C75 mmHg at any point;\n3. Patient expected to be in the ICU for \\>24 hours.\n\nExclusion criteria:\n\n1. Treating team does not have equipoise for at least two contiguous MAP target ranges in the CEPEC Vasopressor Domain;\n2. Acute traumatic brain injury (within 7 days or ongoing active treatment for elevated intracranial pressure);\n3. Acute subarachnoid hemorrhage (within 21 days);\n4. Acute spinal cord injury (within 7 days of injury or ongoing vasopressor therapy for suspected spinal cord ischemia);\n5. Lung, heart, liver, kidney transplant recipient (within 7 days);\n6. Patient expected to become an organ donor (Donor Neurologic Death - DND or Donation After Circulatory Death - DCD);\n7. More than 24 hours since meeting inclusion criteria in the ICU;\n8. Previously randomized into the CEPEC Vasopressor Domain or a confounding trial.\n\nPLATELET DOMAIN\n\nInclusion criteria:\n\n1. Adult patients (age ≥18 years) admitted to the ICU;\n2. Latest platelet count in this hospital admission \\\u003C50×109\u002FL;\n3. Planned to undergo a specified low-moderate bleeding risk invasive procedure.\n\nExclusion criteria:\n\n1. Ongoing major hemorrhage requiring blood products and\u002For surgical\u002F radiological intervention;\n2. Intracranial hemorrhage within prior 72 hours;\n3. Contraindications to platelet transfusion (e.g. thrombotic microangiopathies, heparin-induced thrombocytopenia, recent history of immune thrombocytopaenia, congenital platelet function defects);\n4. Known advance decision of refusing blood\u002Fblood component transfusions;\n5. Acute promyelocytic leukemia (APML);\n6. Death perceived as imminent or admission for palliation;\n7. Previously randomized into the CEPEC Platelet Domain or the T4P Trial;\n8. Fulfilled all the inclusion criteria and none of the exclusion criteria ≥72 hours.\n\nNUTRITION DOMAIN\n\nInclusion criteria:\n\n1. Critically ill patients ≥18 years of age;\n2. Are invasively mechanically ventilated (including endotracheal tube or tracheostomy);\n3. Orogastric\u002Fnasogastric tube in place; or have an in dwelling percutaneous gastric tube (with confirmed placement);\n4. Treating team has started or has the intention of providing enteral nutrition.\n\nExclusion criteria:\n\n1. Patients who have had gastrointestinal (GI) surgery; in the last 3 months and deemed not ready to receive possible bolus nutrition;\n2. Bowel obstruction or ischemia; active;\n3. Has a post-pyloric small bowel feeding tube;\n4. Active GI bleeding;\n5. Patient who is chronically receiving enteral nutrition.","ALL","18 Years",{"count":20,"type":21},5500,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","The Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC) is an international multi-centered randomized adaptive platform clinical trial. CEPEC will evaluate supportive care interventions that are used routinely in intensive care units throughout the world.",[27,28,29,30],"Intensive Care Unit ICU","Vasopressor","Platelet","Nutrition",[32,33,28,29,34],"ICU","Adaptive platform trial","Enteral nutrition","RECRUITING","2026-06-25",{"date":38,"type":39},"2026-06-30","ACTUAL",{"date":41,"type":39},"2025-03-23",{"date":43,"type":21},"2030-06-30",{"name":45,"class":46},"Université de Sherbrooke","OTHER",9,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100640902","impact-on-prognosis-of-increased-sleep-quality-obtained-by-personalized-night-time-nursing-care-in-critically-ill-patients-100640902","NCT07606495","Impact on Prognosis of Increased Sleep Quality Obtained by Personalized Night-time Nursing Care in Critically Ill Patients","Impact Sur le Pronostic en réanimation d'Une Augmentation du Sommeil Par Soins Nocturnes personnalisés : Essai Clinique randomisé Multicentrique","MEDICOSLEEP","Inclusion Criteria:\n\n* Patients aged 18 years or older admitted to an intensive care unit\n* Conscious patients with a Richmond Agitation-Sedation Scale (RASS) score between -2 and +1\n* Patients without continuous sedation, regardless of ventilatory support\n* No indication for urgent intubation (\\\u003C12 hours)\n* Informed consent from the relatives or the patient himself\n\nExclusion Criteria:\n\n* Brain tumor or neuropsychiatric disorders affecting sleep\n* Amission for stroke or epilepsy\n* Administration of sleep-modifying medication within 24 hours prior to randomization\n* Patients with skin lesions around the central right and left areas preclunding the placement of the electrodes\n* Patients with expected ICU length of stay less than 48 hours\n* Patients with limitation or withdrawal of life-sustaining therapies\n* Patients already included in the study during a previous hospitalization\n* Patients under law protection (guardianship, conservatorship, or judicial protective measures)\n* People under protection (minors, persons deprived of liberty by a judicial or administrative decision, patients in emergency situations)",{"count":57,"type":21},460,[59],"NA","Sleep disturbances are common among intensive care unit (ICU) patients and have been associated with difficult weaning from invasive mechanical ventilation, with an increased risk of endotracheal intubation. Other studies have reported associations between sleep disturbances and prolonged ICU length of stay or the occurrence of delirium. Among the factors contributing to sleep impairment, nighttime care interventions have been identified as a major cause. The management of sleep disorders in the ICU remains complex and often disappointing, and no pharmacological treatment is currently formally recommended. Very recently, a considerable improvement of sleep quantity (+50%) and quality (doubling of deep sleep quantity) has been reported by reorganizing nighttime nursing care according to patients' sleep cycles, using a sleep monitoring medical device.\n\nThe objective of this study is to quantify the impact of a better sleep on prognosis. Sleep will be improved using sleep-guided nursing care during nighttime thanks to a real-time sleep monitor (Sleepscan°).\n\nThe primary endpoint is the proportion of patients requiring invasive mechanical ventilation or who have died at day 7 after inclusion. The main secondary outcomes include the duration of ICU stay, the number of delirium free-days, the score at a discomfort scale, the score at a post-traumatic stress disorder scale at ICU discharge. Intensive care unit-related costs will be assessed.\n\nA multi-sites, prospective, randomized, open-label, superiority trial with two parallel arms will be conducted.\n\nAwake and conscious patients without continuous sedation, regardless of ventilatory support, with no indication for urgent intubation (\\\u003C12 hours) and with an expected ICU length of stay greater than 48 hours will be included.\n\nThe intervention will consist of sleep-guided nighttime nursing care using the Sleepscan monitor from 7:00 p.m. to 7:00 a.m., every night until ICU discharge or day 7. Sleep-guided nursing care consist in postponing non urgent care (such as temperature measurement…) and avoiding entering the room when patients are asleep. Otherwise, when patients are awake, instructions are to go for all care, to cluster and anticipate nursing care and perform comfort care.\n\nIn the control group, sleep will also be recorded using the same device but the tablet will not display the patient's sleep (or awake) status, and nighttime nursing care will be performed according to usual practice and independently of patients' sleep cycles.\n\nBased on our preliminary data and previous studies, it has been estimated that 230 patients per group will be required to detect a reduction in the proportion of patients intubated or deceased at day 7 from 20% in the control group to 10% in the intervention group.\n\nThe intention-to-treat analysis population will include all randomized patients.\n\nDemonstrating an improvement in patient prognosis through enhanced sleep quality would represent a major advancement for intensive care medicine. Reducing the need for invasive mechanical ventilation may lead to shorter ICU stays, lower mortality, fewer post-ICU complications, and reduced hospital costs. Demonstrating an improvement in patient prognosis through enhanced sleep quality would represent a major advancement for intensive care medicine. Reducing the need for invasive mechanical ventilation and the incidence of delirium may lead to shorter ICU stays, lower mortality, fewer post-ICU complications, and reduced hospital costs.",[62,63,64],"Intensive Care Unit (ICU)","Sleep Disruption","Sleep Monitoring",[66,67],"night-time nurse care","sleep promotion","NOT_YET_RECRUITING","2026-05-26",{"date":71,"type":39},"2026-05-29",{"date":73,"type":21},"2026-09",{"date":75,"type":21},"2028-06",{"name":77,"class":46},"Poitiers University Hospital",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":97,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":114},"100637070","virtual-reality-for-recovery-after-intensive-care-pics-100637070","NCT07585500","Virtual Reality for Recovery After Intensive Care (PICS)","Virtual Reality Intervention for Post-Intensive Care Syndrome (PICS): A Protocol for a Pilot Randomized Controlled Trial for Cognitive, Physical and Psychological Outcomes","VR4ICU","Inclusion Criteria:\n\n* Adult patients, 18 years or older\n* Patients in the Intensive Care Unit\n* Ventilated patients must be in the post-extubation period\n* The patient has a projected remaining hospital stay of at least 4 days (assessed by the clinical team)\n* The patient has RASS score between -1 and +1\n* The patient has the ability to move both arms, even if with difficulties, as assessed by the clinical team, to be able to interact with the software\n* The patient can maintain a stable sitting position (30° to 60°)\n* The patient is able to communicate (speech, gesturing, or writing)\n* The patient can communicate and understand Portuguese\n* The patient or a legal representative provided informed consent\n\nExclusion Criteria:\n\n* Severe cognitive and neurodegenerative diseases: mental illness requiring institutionalization; acquired or congenital intellectual disability; known severe brain injuries (e.g., stroke with significant residual deficits); moderate to severe Traumatic Brain Injury (TBI) (defined by the duration of loss of consciousness\u002Fpost-traumatic amnesia or documented residual deficits); diagnosed neurodegenerative diseases (e.g., Parkinson's disease with severe movement impairment, Huntington's disease, severe Alzheimer's disease, or dementia of any etiology that prevents autonomy in daily life at baseline)\n* The patient uses neuromuscular blocking agents\n* The patient has a positive CAM-ICU result at the time of initial screening\n* The patient has active psychotic disorders or suicidal ideation\n* The patient has documented epilepsy or history of seizures\n* The patient has a \"Do Not Resuscitate\" (DNR) order, is on life support with exclusive focus on comfort, or has an unexpected survival predicted to be less than 24 hours\n* The patient has intoxication by an active substance or withdrawal syndrome requiring ongoing medical management that prevents safe and meaningful participation or accurate cognitive assessment\n* Patients with immobility or severe motor limitations in the upper limbs, fine motor skills, or cervical region\n* The patient has open wounds on the head or face that may affect the comfortable\u002Fsafe use of VR glasses, cause discomfort, or present a hygiene risk\n* The patient has uncorrected blindness or deafness that prevents the safe\u002Feffective use of VR\u002Ftablet devices.\n* Patients are participating in another rehabilitation study with interventions\n* Patients with a scheduled surgery where the ICU stay is expected to be less than 24 hours\n* Patients in need of respiratory support",{"count":87,"type":21},51,[59],"The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU). The study focuses on people who needed a breathing machine or stayed in the ICU for several days and are at risk for memory or \"brain fog\" issues.\n\nThe main questions it aims to answer are:\n\n* Does using VR improve a participant's memory, attention, and thinking skills after an ICU stay?\n* Does the \"immersive\" feel of a VR headset work better to improve these skills than using a handheld tablet?\n\nResearchers will compare three groups to see how different types of care affect the brain:\n\n* VR-Rehab: Participants use a VR headset to play brain-training games.\n* Tablet-Rehab: Participants use a handheld tablet to play the same brain-training games.\n* Standard Care: Participants receive the usual hospital care without digital brain games.\n\nParticipants will:\n\n* Play brain-training games for 12 minutes every day for up to one week while in the hospital.\n* Complete memory and thinking tests with a researcher at the start of the study and again after two weeks.\n* Answer follow-up questions about their memory and thinking skills for 6 months after leaving the hospital.",[91,92,93,94,95,96,62],"Post-Intensive Care Syndrome (PICS)","Critical Illness Recovery","Rehabilitation After Critical Illness","Rehabilitation Exercise of ICU Patients","Cognitive Impairment","Critical Illness",[91,95,96,98,99,100,62,101,102,103,104],"Virtual Reality (VR)","Digital Health","Rehabilitation","Critical Care","ICU Survivors","Pilot Study","Randomized Controlled Trial","2026-05-08",{"date":107,"type":39},"2026-05-13",{"date":109,"type":39},"2025-12-06",{"date":111,"type":21},"2026-06",{"name":113,"class":46},"University of Minho",1,{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":17,"minAge":123,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":114},"100638191","cally-index-frailty-and-sofa-2-for-mortality-prediction-in-geriatric-icu-patients-100638191","NCT07579728","CALLY Index, Frailty and SOFA-2 for Mortality Prediction in Geriatric ICU Patients","Prognostic Value of CALLY Index, Frailty and SOFA-2 Score for Mortality in Geriatric Intensive Care Patients: A Prospective Cohort Study","CALLY-FS","Inclusion Criteria:\n\n* Age ≥65 years\n* Admission to the intensive care unit\n* Availability of required clinical and laboratory data within the first 24 hours of ICU admission\n\nExclusion Criteria:\n\n* Death within the first 24 hours after ICU admission\n* Missing key clinical or laboratory data\n* Terminal malignancy receiving palliative care","65 Years",{"count":125,"type":21},100,"OBSERVATIONAL","This study aims to evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index, Clinical Frailty Scale (CFS), and SOFA-2 score in predicting mortality among geriatric intensive care unit (ICU) patients.\n\nThe primary outcome is ICU mortality. Secondary outcomes include 28-day mortality, ICU length of stay, duration of mechanical ventilation, need for renal replacement therapy, and vasopressor requirement.\n\nThe study also investigates whether the combined use of these parameters improves predictive performance compared to conventional scoring systems such as APACHE II.",[96,129,62],"Frailty",[131,132,133,134,135],"CALLY index","frailty","SOFA-2 score","ICU mortality","Geriatric patients","2026-05-06",{"date":138,"type":39},"2026-05-12",{"date":140,"type":39},"2026-04-30",{"date":142,"type":21},"2026-07-10",{"name":144,"class":46},"Istanbul University - Cerrahpasa",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":155,"briefSummary":156,"conditions":157,"keywords":160,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":114},"100606757","using-a-hypotension-prediction-index-to-prevent-low-blood-pressure-during-dialysis-in-icu-patients-100606757","NCT07179705","Using a Hypotension Prediction Index to Prevent Low Blood Pressure During Dialysis in ICU Patients","Hypotension Prediction Index Guided Prevention of Intradialytic Hypotension During Intermittent Renal Replacement Therapy in Intensive Care Units","HyPIR-ICU","Inclusion Criteria:\n\n* Adults \\>18 years old\n* Diagnosed with acute kidney injury (AKI) or end-stage kidney disease (ESKD)\n* Admitted to medical ICU\n* Scheduled for PIRRT\n* Have an indwelling arterial catheter\n\nExclusion Criteria:\n\n* Severe right heart dysfunction, significant valvular disease, arrhythmias, mechanical circulatory support, absence of arterial access, no UF prescription, palliative care, or expected ICU stay \\\u003C72 hours.",{"count":154,"type":21},46,[59],"This single-center, crossover randomized controlled trial (HyPIR-ICU) investigates whether a Hypotension Prediction Index (HPI)-guided management strategy can reduce intradialytic hypotension (IDH) during prolonged intermittent renal replacement therapy (PIRRT) in critically ill patients. All participants must have an indwelling arterial catheter for continuous hemodynamic monitoring.",[158,27,159],"Intradialytic Hypotension","Hemodialysis Patients",[161,162,163,164,165,166],"Hypotension Prediction Index (HPI)","Prolonged intermittent renal replacement therapy (PIRRT)","Slow-low efficiency dialysis","Intradialytic hypotension","Hemodynamic monitoring","Intensive Care Unit","2026-05-05",{"date":169,"type":39},"2026-05-07",{"date":171,"type":39},"2025-10-10",{"date":173,"type":21},"2026-12-31",{"name":175,"class":46},"Chulalongkorn University",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":185,"conditions":186,"keywords":188,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":200},"100584917","the-high-fidelity-hydraulic-coupling-upper-arm-cuff-assessment-of-limits-safety-and-effectiveness-hipulse-trial-100584917","NCT06895590","The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial","HIPULSE","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Indication for NIBP cuff\n* Indication for a radial arterial line\n* Subject or legal authorized representative is able to understand and speak the local language (also Spanish for US sites) to provide voluntary written informed consent prior to study procedures\n\nThe following stratification criteria must be met across the study sites and hence targeted enrollment may be required:\n\n* Age of every patient 18+; at least 30% \\> 65 years, 30% ≤ 65 years\n* At least 30% male, 30% female\n* Minimum number of subjects needed to test each size cuff (per ISO81060-2:2018\u002FAMD2:2024, based on limb circumference range):\n\n  * Adult Small (19-27 cm) = 165\\*\\[8\u002F(2\\*24)\\] = 28\n  * Adult (25-34 cm) = 165\\*\\[9\u002F(2\\*24)\\] = 31\n  * Adult Large Short (30-40 cm with severely conical arm) = 165\\*\\[10\u002F(2\\*24)\\] = 35\n  * Adult Large (32-43 cm) = 165\\*\\[11\u002F(2\\*24)\\] = 38\n* At least 40% of the subjects within each cuff size shall have a limb circumference that lies within the upper half of the specified range of use of the cuff\n* At least 40% of the subjects within each cuff size shall have a limb circumference within the lower half of the specified range of use of the cuff\n* At least 10% SBP measurements ≤ 100 mmHg\n* At least 10% SBP measurements ≥ 160 mmHg\n* At least 10% DBP measurements ≤ 70 mmHg\n* At least 10% DBP measurements ≥ 85 mmHg\n\nExclusion Criteria:\n\n* Emergency surgery\n* Surgeries in which both arms are tucked\n* Inability to place the Philips AMC appropriately due to subject anatomy or condition\n* Known pregnancy or lactating women (self-report)\n* Patients treated with an intra-aortic balloon pump\n* Aortic and mitral regurgitation (\\> 2nd degree), if known\n* Measurements taken in the lateral position\n* Pressure of the arterial line system, when tested at 100 mmHg with the VeriCal device, exceeds the +\u002F- 2 mmHg threshold\n* Currently participating in an investigational drug or another device study that clinically interferes with the study endpoints\n* Upper arm circumference \\\u003C 19 cm or \\> 43 cm\n* BMI \\> 45\n* If the average of 3 baseline NIBP lateral difference measurements for SBP is \\> 15 mmHg or for DBP is \\> 10 mmHg\n* At the PI's discretion, subject does not qualify to participate in the study for any reasons that are not mentioned above",{"count":184,"type":21},205,"The purpose of this study is to compare measurements of blood pressure (BP) and fluid responsiveness between the Philips AMC and invasive radial arterial line in surgical patients.",[187,62],"Non-cardiac Surgical",[189],"BP, FR, DBP, MAP, SBP, A-line","2026-02-24",{"date":192,"type":39},"2026-02-27",{"date":194,"type":39},"2025-10-02",{"date":196,"type":21},"2026-02",{"name":198,"class":199},"Philips Clinical & Medical Affairs Global","INDUSTRY",4,{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":22,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":114},"100610947","virtual-reality-use-for-icu-mobility-100610947","NCT07234201","Virtual Reality Use for ICU Mobility","Designing a Virtual Reality Intervention to Improve Physical and Psychological Health in Intensive Care Units","GAMERS","Inclusion Criteria:\n\n* English speaking\n* Adults age 18 or greater\n* ICU stay greater or equal to 3 days\n* Limited mobility\n\nExclusion Criteria:\n\n* Pregnancy\n* Special enteric contact isolation\n* Blindness\n* History of seizure or vertigo\n* Intubated and sedated\n* ICU delirium",{"count":210,"type":21},60,[59],"The purpose of this study is to explore if Virtual Reality (VR) helps patients in the Intensive Care Unit (ICU) move more and feel better.",[27],"2026-01-08",{"date":216,"type":39},"2026-01-12",{"date":218,"type":39},"2025-12-01",{"date":220,"type":21},"2027-11",{"name":222,"class":46},"Duke University",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":114},"100569296","the-effects-of-endotracheal-suctioning-on-pain-and-serum-markers-100569296","NCT06692400","The Effects of Endotracheal Suctioning on Pain and Serum Markers","The Impact of Endotracheal Suctioning on Pain, Hypoxia, and Oxidative Stress Biomarkers in Intubated Adult ICU Patients: A Controlled Trial","Inclusion Criteria:\n\n* Adults (aged 18 years and older)\n* Current diagnosis of flu, pneumonia, COVID, or sepsis\n* Intubated and receiving mechanical ventilation.\n* Have arterial lines placed\n* Require endotracheal suctioning as part of their care\n\nExclusion Criteria:\n\n* Patients receiving neuromuscular blocking agents\n* Contraindications for blood draws (hemoglobin levels below 8.0 g\u002FdL; Jehovah's Witness)",{"count":231,"type":21},110,[59],"The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress.\n\nThe main questions this study aims to answer are:\n\nDoes ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress.\n\nParticipants will:\n\nHave pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning.\n\nProvide demographic information (like age, gender, and diagnosis) from medical records.\n\nThis research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.",[27,235,96,236,237,238,239,240,241,242,243,244,245,246,247],"Intubation","Mechanical Ventilation","Pain Measurement","Pain, Procedural","Oxidative Stress","Hypoxia","Biomarkers \u002F Blood","Adult","Uric Acid","Sepsis","COVID","Influenza","Pneumonia","2025-05-19",{"date":250,"type":39},"2025-05-21",{"date":252,"type":39},"2025-01-30",{"date":254,"type":21},"2026-04",{"name":256,"class":46},"Loma Linda University",{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":261,"acronym":262,"eligibilityCriteria":263,"healthyVolunteers":264,"sex":17,"minAge":18,"maxAge":265,"enrollmentInfo":266,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":268,"conditions":269,"keywords":272,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":4},"100587669","expectations-and-experiences-with-virtual-reality-training-among-icu-physicians-and-nurses-100587669","NCT06931392","Expectations and Experiences With Virtual Reality Training Among ICU Physicians and Nurses","ExpertVR-ICU","Inclusion Criteria:\n\n* HCPs working in ICU.\n\nExclusion Criteria:\n\n* HCPs not working in ICU.",true,"100 Years",{"count":267,"type":21},200,"The goal of this observational study is to describe the expectations and experiences with virtual reality in physicians and nurses working in the European ICUs. The main questions it aims to answer are:\n\nWhat emotions and worries does the expected training with virtual reality evoke? What are the potential factors causing negative emotions and fear from expected training? What is the institutional approach to the online training approach regarding participation in working hours and covering the costs? How does the experience of training using virtual reality spread among the population of ICU physicians and nurses? Participants will fill out an electronic survey.",[270,271,27],"Virtual Reality","Education",[273,274,275,276,277,278,279],"virtual reality","education","intensive care unit","training","European survey","physicians","nurses","2025-04-23",{"date":282,"type":39},"2025-04-25",{"date":284,"type":21},"2025-06-01",{"date":286,"type":21},"2025-10-30",{"name":288,"class":46},"Brno University Hospital",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":265,"enrollmentInfo":297,"targetDuration":4,"studyType":126,"phases":4,"briefSummary":299,"conditions":300,"keywords":303,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":114},"100568634","ventilatory-settings-and-monitoring-variables-associated-with-weaning-failure-in-critically-ill-patients-100568634","NCT06683781","Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients","Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients: A Retrospective Study","WEAN-FAIL","Inclusion Criteria:\n\n* Over 18 years\n* MV for at least 48 hours, regardless of the cause of onset\n* Undergone at least one extubation, regardless of the outcome\n* At least one spontaneous breathing trial (SBT) during their ICU stay, regardless of the outcome\n\nExclusion Criteria:\n\n* MV records containing incorrect or inconsistent data\n* did not have adequate or continuous monitoring during the weaning process",{"count":298,"type":21},1077,"Mechanical ventilation (MV) is essential in managing acute respiratory failure. Its duration is a crucial aspect since both, unnecessary prolongation and premature withdrawal have deleterious effects on patient outcomes in the ICU. The process of weaning refers to the set of procedures and evaluations carried out to discontinue MV. Regardless of the definition used, within the population undergoing weaning, there is a group of patients who successfully pass the daily screening but fail the spontaneous breathing trial (SBT) or the separate attempt (SA). In Argentina, this figure is 39.5%, and 31.4% in patients with COVID-19. On the other hand, another group of patients successfully passes the SA, is extubated, but fails in post-extubation. This failure rate varies in the literature, ranging from approximately 10 to 20%. In our country, this figure is 16% in the general population and rises to 29.7% in COVID-19 patients. Additionally, this population is divided into those who cannot tolerate ventilation without an artificial airway due to upper airway patency issues (such as laryngeal edema), i.e., \"airway failure,\" and those who experience acute respiratory failure. In 2023, the WEAN SAFE study reported novel findings regarding variables associated with weaning failure. In multivariable analysis, it was found that the MV settings and monitoring variables at the time of the first SBT - respiratory rate, positive end-expiratory pressure (PEEP), dynamic airway pressure difference (peak pressure (Ppeak) minus PEEP) on the day of the SA - were associated with weaning failure. In this context, the investigators will conduct a retrospective cohort study, whose primary objective will be to assess which MV settings and monitoring variables are associated with weaning failure.\n\n\\*\\*Primary Objective\\*\\* To determine if there are any MV settings or monitoring variables that are associated with extubation failure.\n\n\\*\\*Secondary Objective\\*\\* To determine if there are any MV settings or monitoring variables that are associated with failure in the first SBT.",[236,301,302,27],"Weaning Failure","Weaning Failure of Mechanical Ventilation",[304,305],"weaning failure","mechanical ventilation","2025-03-12",{"date":308,"type":39},"2025-03-17",{"date":310,"type":39},"2024-12-01",{"date":312,"type":21},"2026-08-01",{"name":314,"class":46},"Hospital Italiano de Buenos Aires"]