[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-unit-sedation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-unit-sedation":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100611369","a-comparative-study-of-eleveld-and-schnider-pharmacokinetic-models-for-target-controlled-infusion-of-propofol-in-sedation-of-mechanically-ventilated-icu-patients-100611369",false,"NCT07239687","A Comparative Study of Eleveld and Schnider Pharmacokinetic Models for Target-Controlled Infusion of Propofol in Sedation of Mechanically Ventilated ICU Patients","Comparison of Eleveld and Schnider Models for Target-Controlled Infusion of Propofol in Intensive Care Unit Sedation","Inclusion Criteria:\n\nAge over 18 years,\n\nClassified as ASA (American Society of Anesthesiologists physical status) class I-IV,\n\nBeing monitored in the Anesthesiology and Reanimation Intensive Care Unit of Hacettepe University Faculty of Medicine Hospital,\n\nAvailability of necessary data (medical history, laboratory results, etc.) for analysis,\n\nHemodynamic stability -\n\nExclusion Criteria:Patients who refused to participate in the study or did not provide legal consent,\n\nPatients with an ASA (American Society of Anesthesiologists physical status) classification greater than IV,\n\nTransition to an alternative sedation method during the study,\n\nContraindication to propofol infusion (e.g., propofol anaphylaxis, lipid metabolism disorders),\n\nPatients whose sedation level could not be clinically assessed due to neurological or neurodegenerative diseases,\n\nPatients expected to require sedation for more than 72 hours (to reduce the risk of propofol infusion syndrome)\n\n\\-","ALL","18 Years",{"count":19,"type":20},84,"ESTIMATED","1 Day","OBSERVATIONAL","This prospective observational study aims to compare the clinical performance of two target-controlled infusion (TCI) models, Eleveld and Schnider, for propofol sedation in mechanically ventilated intensive care unit (ICU) patients. The study evaluates sedation depth, hemodynamic stability, and recovery profiles using the Bispectral Index (BIS) and Riker Sedation-Agitation Scale. Secondary outcomes include awakening time, total propofol dose, and incidence of delirium after sedation withdrawal. The findings may help identify the most reliable pharmacokinetic model for safe and effective ICU sedation.",[25,26,27],"Intensive Care Unit Sedation","Sedation","Target Controlled Infusion of Propofol",[29],"Propofol, Target-Controlled Infusion, Eleveld Model, Schnider Model, ICU, Sedation, BIS, Riker Scale","RECRUITING","2025-11-16",{"date":33,"type":34},"2025-11-20","ACTUAL",{"date":36,"type":34},"2025-02-01",{"date":38,"type":20},"2026-01-01",{"name":40,"class":41},"Hacettepe University","OTHER"]