[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-unit-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-unit-syndrome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,67,95,127,156,185],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100549183","hemodynamic-impact-of-the-administration-of-paracetamol-in-patients-hospitalized-in-the-intensive-resuscitation-medicine-department-parea-100549183",false,"NCT06430697","Hemodynamic Impact of the Administration of PAracetamol in Patients Hospitalized in the Intensive Resuscitation Medicine Department [PAREA]","Prospective Study Evaluating the Hemodynamic Impact of PAracetamol Administration in Patients Hospitalized in the REAnimation Intensive Care Unit","PAREA","Inclusion Criteria:\n\nInclusion:\n\n* 18 years of age or older\n* Patient with arterial catheter\n* Indication of paracetamol's administration by the patient's attending practitioner.\n* No opposition to patient or support person participation in the study if the patient is unable to participate\n\nExclusionCriteria:\n\n* No Social Security Patient\n* Pregnant or nursing patient.\n* Patient with a legal protection measure\n* Hypersensitivity and\u002For allergy to paracetamol.\n* Contraindication to the use of paracetamol.\n* Patient opposition to health data collection.","ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","Paracetamol is commonly used in case of pain or fever. Few previously clinical studies has highlighted an arterial hypotension linked to intravenous administration of paracetamol. Currently, fewer data are available on the link of intravenous administration of paracetamol and effects on arterial tension. The aim of this study is to describe the frequency of occurrence of significative arterial hypotension within one hour following intravenous or per os administration of paracetamol . Other factors who can be associated to occurence of significative arterial hypotension will be also observe (for example age, weight, pain, vasopressor dosage or sedative...)",[27],"Intensive Care Unit Syndrome",[29,30,31],"Intensive Care Unit","PARACETAMOL","blood pressure","RECRUITING","2026-05-21",{"date":35,"type":36},"2026-05-26","ACTUAL",{"date":38,"type":36},"2025-02-03",{"date":40,"type":21},"2028-09",{"name":42,"class":43},"Centre Hospitalier Universitaire de Nice","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":44},"100625050","study-on-the-priorities-of-patients-admitted-to-intensive-care-100625050","NCT07417592","Study on the Priorities of Patients Admitted to Intensive Care","PRIOREA","Inclusion criteria for Patient:\n\n* Adult Patient\n* Estimated length of stay in intensive care exceeding 72 hours\n* No objection from the patient or the designated representative, if the patient is unable to consent to participate in the study\n\nInclusion criteria for Designated representative:\n\n* Adult Person\n* No objection to participate in the study\n\nInclusion criteria for Caregiver:\n\n• No objection to participate in the study\n\nExclusion criteria :\n\n* Patients under legal protection (guardianship, conservatorship)\n* Pregnant or breastfeeding women\n* Disagreement among the patient's relatives regarding the designated representative.",{"count":53,"type":21},100,"OBSERVATIONAL","The goal of this observational study is to learn about the priorities of patients admitted to intensive care units (ICUs) who have a life-threatening condition, as well as the priorities assumed by their designated relatives and healthcare professionals (nurses, nursing assistants, ICU physicians, and general practitioners).",[27],"NOT_YET_RECRUITING","2026-03-03",{"date":60,"type":36},"2026-03-05",{"date":62,"type":21},"2026-02-15",{"date":64,"type":21},"2027-11-14",{"name":66,"class":43},"University Hospital, Brest",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":44},"100501093","cerebral-perfusion-variation-during-blood-pressure-changes-in-icu-100501093","NCT05804773","Cerebral Perfusion Variation During Blood Pressure Changes in ICU","Cerebral Perfusion Variation During Blood Pressure Changes in ICU: Relationship Between Transcranial Doppler, Frontal EEG and Cerebral Oximetry: a Prospective Observational Study","DELTAPAMREA","Inclusion Criteria:\n\n* Adult patients (\\> 18 years old)\n* Requiring an intensive care unit admission\n* Informed patient who has expressed his\u002Fher non-opposition to participating in this research or, if applicable, trusted person\u002Frelative of patient unable to express his\u002Fher wishes\n\nExclusion Criteria:\n\n* Patients under 18 years of age.\n* Patient, or if applicable, trusted person \u002F close relative \u002F parent of patient unable to express his\u002Fher will, opposed to participation in the protocol\n* Pregnant woman\n* Patient under judicial protection\n* Patient not affiliated to a social health system",{"count":76,"type":21},92,"The risk associated with arterial hypotension during anesthesia for intensive care sedation has been demonstrated, but the threshold at which consequences for perfusion of one or more organs appear varies according to the mechanism of hypotension, associated abnormalities (HR, cardiac output and oxygen transport) and the patient's terrain.\n\nCurrently, a mean arterial pressure greater than 60 mm Hg (1) and a reduction of less than 30-50% from the value measured before sedation are commonly used to ensure good perfusion of all organs. In intensive care, it is recommended to maintain a MAP between 60 and 70 mmHg and a Cerebral Perfusion Pressure (CPP) \\> 50 mmHg for neurocompromised patients with Intra Cranial pressure (ICP) measure. Normally, cerebral blood flow is self-regulated, allowing adaptation of cerebral blood flow to oxygen requirements at different levels of high and low blood pressure. However, this protective mechanism may fail for a degree of hypotension that depends on several factors such as the age or vascular status of the patient.\n\nThe aim of the study is to measure non-invasively, easily and reliably the variations of cerebral perfusion in patients with or without cardiovascular risk factors during controlled variations performed during routine care to set the blood pressure level within the recommended safety standards during sedation in intensive care unit.\n\nWhat is the tolerable target BP level for a patient under continuous sedation in the ICU? Is there a simple and non-invasive way to measure the level of cerebral blood flow autoregulation and especially the adequacy of the brain's oxygen requirements?",[27],[80,81,82,83,84,85],"Cerebrovascular Autoregulation","neurovascular coupling","Individualized vs Standard Blood Pressure Management","Strategies","Multimodal monitoring","Monitoring Brain Oxygen Saturation","2026-02-17",{"date":88,"type":36},"2026-02-19",{"date":90,"type":36},"2023-07-09",{"date":92,"type":21},"2027-07",{"name":94,"class":43},"Assistance Publique - Hôpitaux de Paris",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":104,"conditions":105,"keywords":112,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":44},"100343574","recovery-from-icuaw-following-severe-respiratory-and-cardiac-failure-100343574","NCT03753412","Recovery From ICUAW Following Severe Respiratory and Cardiac Failure","Prospective Observational Study Regarding the Determinants of Functional Disability and Quality of Life in Patients Recovering From Severe Acute Cardiac or Respiratory Failure Considered for Mechanical Cardiorespiratory Support (CLEVERER)","CLEVERER","Inclusion Criteria:\n\n* Above the age of 18\n* Adults with severe cardio-respiratory failure requiring ECMO.\n* Adults who have had personal and professional consultees agree to enrol them in the trial.\n\nExclusion criteria:\n\n* Previous Stroke\n* Neuromuscular disease\n* Malignancy\n* Underlying neuromuscular disease\n* paediatrics",{"count":53,"type":21},"To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO). Additionally, to discover the effects of ICUAW on physical function and health-related quality of life (HRQoL) after critical illness. CLEVERER is a clinical observational pilot study.",[27,106,107,108,109,110,111],"Intensive Care Neuropathy","Intensive Care (ICU) Myopathy","Acute Respiratory Distress Syndrome","Cardiac Failure","Respiratory Failure","Critical Illness Myopathy",[113,114,115,116,117],"Extra Corporeal Membrane Oxygenation (ECMO)","Intensive Care Unit Acquired Weakness (ICUAW)","Critical Illness Polyneuromyopathy (CIPM)","Ultrasound (US)","Health Related Quality of Life (HRQoL)","2026-01-05",{"date":120,"type":36},"2026-01-07",{"date":122,"type":36},"2019-04-09",{"date":124,"type":21},"2026-09-26",{"name":126,"class":43},"Barts & The London NHS Trust",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":133,"sex":17,"minAge":18,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":137,"conditions":138,"keywords":143,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":44},"100548920","machine-learning-based-longitudinal-study-of-post-icu-syndrome-development-trajectory-in-critically-ill-patients-and-construction-of-clinical-early-warning-models-a-research-protocol-for-longitudinal-study-100548920","NCT06427265","Machine Learning-based Longitudinal Study of Post-ICU Syndrome Development Trajectory in Critically Ill Patients and Construction of Clinical Early Warning Models: a Research Protocol for Longitudinal Study","Inclusion Criteria patients :\n\n* Length of stay in ICU ≥24h;\n* Age ≥18 years old;\n* Conscious when leaving ICU, communicating with investigators without barriers;\n* Informed consent. Family members：\n* One family member ≥18 years of age was selected for each patient;\n* Assume the main role of caring for patients and medical decision-making;\n* No history of mental illness or other serious organic diseases;\n* Informed consent and voluntary participation in this study.\n\nExclusion Criteria patients :\n\n* Have been in ICU for more than 24h within 3 months before this admission;\n* Transferred to another ICU;\n* Cognitive impairment existed before ICU admission (BDRS \\> 4 points);\n* Severe hearing impairment, dysarthria, etc., which cannot be followed up;\n* Unable to complete the questionnaire survey due to serious illness.\n\nFamily members:\n\n* Family members refuse to participate in the study due to their own reasons;\n* Severe hearing and language impairment, unable to cooperate with researchers.",true,"100 Years",{"count":136,"type":21},840,"This project intends to track and evaluate whether post-ICU syndrome will occur 7 days, 1 month, 3 months and 6 months after ICU patients are transferred out of the ICU through a longitudinal study, apply the latent category growth model to identify different trajectory patterns of post-ICU syndrome in critically ill patients, and use modern machine learning models to build an early warning model of the trajectory patterns of post-ICU syndrome.",[27,139,140,141,142],"Prediction","Cognitive Impairment","Sleep Disorder","Memory Disorders",[144,145,146],"Post-icu syndrome","Prediction model","Development Trajectory","2025-05-26",{"date":149,"type":36},"2025-05-31",{"date":151,"type":36},"2023-12-01",{"date":153,"type":21},"2026-06-01",{"name":155,"class":43},"The Affiliated Hospital Of Guizhou Medical University",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":166,"briefSummary":167,"conditions":168,"keywords":170,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":44},"100573554","virtual-reality-to-reduce-the-anxiety-in-critically-ill-patient-100573554","NCT06747793","Virtual Reality to Reduce the Anxiety in Critically Ill Patient","Evaluation of the Use of Virtual Reality to Reduce Anxiety in Intensive Care Patients","VRAI","Inclusion Criteria:\n\n* Adult patient\n* Oral consent after free and informed information\n* Hospitalized in the multipurpose intensive care unit of Rangueil hospital with an estimated length of stay greater than 24 hours\n* Conscious (Glasgow Coma Scale \\> 8) and Richmond Agitation-Sedation Scale (RASS) sedation score between -1 and +1\n* Mechanically ventilated or not\n* Person affiliated to or beneficiary of a social security system.\n\nExclusion Criteria:\n\n* Patient under legal protection (guardianship or curatorship)\n* RASS \\\u003C -1 or \\> +1\n* Visual or hearing difficulties preventing the use of the VR headset\n* Severe psychiatric history (severe depression, psychosis, bipolarity), advanced dementia or mental retardation\n* Hemodynamic (Norepinephrine support \\> 0.5 gamma\u002Fkg\u002Fmin) and\u002For respiratory instability (invasive mechanical ventilation with FiO2 greater than 80%)\n* Presence of a malformation or cervical or facial trauma that does not allow the application of the VR headset\n* Pregnancy or breastfeeding",{"count":165,"type":21},128,[24],"Anxiety and discomfort generated by repeated medical cares and invasive procedures can induce cognitive disorders in critical illness survivors as post-traumatic stress disorder. For this reason, managing patients' anxiety is particularly important in the intensive care unit. Physicians have recently started using immersive virtual reality (VR), based on real-time interaction with an artificial 360° immersive world, as an adjunctive non-invasive and non-pharmacological anxiolysis technique. The purpose of this project is to assess the virtual reality stimulation to reduce anxiety in Intensive Care Unit (ICU) patients.",[169,27],"Anxiety",[171,172,173,174,175],"Intensive care unit","virtual reality","anxiety","depression","sleep quality","2025-01-24",{"date":178,"type":36},"2025-01-27",{"date":180,"type":21},"2025-02",{"date":182,"type":21},"2027-01",{"name":184,"class":43},"University Hospital, Toulouse",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":193,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":4},"100556303","ultrasound-of-the-quadriceps-femoris-compared-with-the-clinical-frailty-scale-100556303","NCT06523348","Ultrasound of the Quadriceps Femoris Compared With the Clinical Frailty Scale","Ultrasound of the Quadriceps Femoris for the Diagnosis of Frailty in the Intensive Care Unit, Compared With the Clinical Frailty Scale (CFS)","QUADRI-REA","Inclusion Criteria:\n\n* patient aged 65 or over\n* admitted to intensive care or the outpatient department for less than 24 hours\n* with an abdominal CT scan less than 30 days prior to admission OR who are scheduled for an scheduled for a routine abdomino-pelvic CT scan within the first 24 hours of admission\n\nExclusion Criteria:\n\n* Neuromuscular disease\n* Lower limb amputation\n* Paraplegia \\> 24 hours before admission\n* Clearly infected, burnt or lacerated ultrasound site.\n* Guardianship or curatorship\n* Opposition of the patient or his\u002Fher trusted support person or relative\n* Abdominal and pelvic CT scan not available in the previous month and not scheduled within the first 24 hours of treatment","65 Years",{"count":195,"type":21},70,"This is a single-centre prospective diagnostic study. When a patient is admitted to the inclusion centre, the clinician responsible for the patient checks the inclusion and exclusion criteria. The no objection from the patient (or their trusted support person or, failing that, a close if the patient is unable to give consent) is sought.The CFS scale is completed and recorded by the clinician in the observation observation notebook.The clinician performs a quadricipital muscle ultrasound, specifically for research purposes, with no changes to the therapeutic and its results are recorded in the observation notebook.\n\nobservation notebook.At 3 months after inclusion, information was collected from the medical records to identify secondary endpoints.\n\nTranslated with DeepL.com (free version)",[198,27],"Frailty","2024-07-25",{"date":201,"type":36},"2024-07-26",{"date":203,"type":21},"2024-08-01",{"date":205,"type":21},"2025-11-01",{"name":184,"class":43}]