[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-unit\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-unit":39},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,28,0,25,[9,54,85,115,139,165,207,235,258,287,314,342,366,395,423,445,466,506,527,552,580,603,633,655,671],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":40,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":50,"locationsCount":53},"100642312","risk-factors-of-atrial-fibrillation-after-cardiac-surgery-100642312",false,"NCT07625033","Risk Factors of Atrial Fibrillation After Cardiac Surgery","PFAS","Inclusion Criteria:\n\n* age \\>18\n* having undergone a scheduled cardiac surgery in the study center\n* having agreed to the reuse of their hospital care data\n\nExclusion Criteria:\n\n* Atrial fibrillation at the admission in hospital.","ALL","18 Years",{"count":20,"type":21},918,"ESTIMATED","OBSERVATIONAL","Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death. Preventing the occurrence of these arrhythmias is a major challenge. This study aims to investigate risk factors and protective factors regarding atrial fibrillation and other iatrogenic cardiac arrhythmias after cardiac surgery, particularly innovative anesthetic strategies such as stellar ganglion blockade which have been recently implemented in our center.",[25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"Cardiac Surgery","Peri Operative Medicine","Thoracic Surgery","Cardiopulmonary Bypass","Coronary Artery Bypass","Heart Valve Prosthesis Implantation","Aortic Valve Replacement","Perioperative Medicine","Preoperative Care","Intraoperative Care","Postoperative Care","Enhanced Recovery After Surgery","Anesthesia","Cardiac Anesthesia","Intensive Care Unit",[41],"Stellar Ganglion Blockade, SGB, cardiac surgery","NOT_YET_RECRUITING","2026-06-23",{"date":45,"type":46},"2026-06-25","ACTUAL",{"date":48,"type":21},"2026-07-01",{"date":48,"type":21},{"name":51,"class":52},"Centre Hospitalier Régional Metz-Thionville","OTHER",1,{"id":55,"slug":56,"hasResults":12,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":53},"100544452","continuous-veno-venous-hemodialysis-and-continuous-veno-venous-hemodiafiltration-on-urea-reduction-rate-in-intensive-care-patient-100544452","NCT06369064","Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patient","Comparison of the Effectiveness of Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patients With Acute Renal Injury : a Monocentric Controled Randomized Non Inferiority Open Labeled Study","CompEER","Inclusion criteria:\n\n* Adult patients hospitalized in ICU\n* Undergo RRT session because of AKI stage 3\n* At least one among criteria: pH \\\u003C 7,20 \u002F Blood urea \\> 30mM \u002F Fluid overload uncontrolled by with PaCO₂ \\\u003C 35 mmHg or mixed acidosis with PaCO₂ \\\u003C 50 mmHg.\n\n  * Oliguria lasting 72 hours or longer\n* Patients undergoing their first session of extracorporeal blood purification, initiated less than 12 hours prior to randomization\n* Patient having given free and informed consent, and having signed the consent form or patient included in an emergency situation\n* Patient affiliated with Social Security.\n\nExclusion criteria:\n\n* End-stage chronic kidney disease on dialysis\n* Intoxication with a dialyzable toxin (lithium\n* Criteria for emergency dialysis initiation: hyperkaliemia \\>6,5mM with electrocardiographic signs\n* Medical contraindication to regional citrate: severe liver failure\n* Medical contraindication to anticoagulation or heparin anticoagulation: heparin induced thrombopenia or uncontrolled bleeding\n* Pregnant women, parturient or breast-feeding patient",{"count":63,"type":21},80,"INTERVENTIONAL",[66],"NA","In patients requiring renal replacement therapy (RRT) in the intensive care unit (ICU), continuous techniques are predominantly using due to better hemodynamic tolerance. The most employed techniques in ICU are continuous venovenous hemodiafiltration (CVVHDF) and continuous venovenous hemodialysis (CVVHD).\n\nTo our knowledge, there are no prospective studies comparing the efficiency of these two techniques with the same dose of dialysis (and the same filter).\n\nIn the CompEER study, we aim to compare the efficiency of CVVHD and CVVHDF on urea reduction rate in intensive care patients with acute kidney injury.\n\nThe research hypothesis is that CVVHD citrate technique is as effective as CVVHDF heparin technique for urea reduction and provides prolonged and stable clearance, facilitating antibiotic management during RRT.",[69,70,39],"Acute Kidney Injury","Continuous Renal Replacement Therapy",[72,73,74],"continuous venovenous hemodiafiltration","continuous venovenous hemodialysis","urea reduction rate","RECRUITING","2026-05-15",{"date":78,"type":46},"2026-05-18",{"date":80,"type":46},"2024-07-03",{"date":82,"type":21},"2028-08-15",{"name":84,"class":52},"Centre Hospitalier Universitaire de Nīmes",{"id":86,"slug":87,"hasResults":12,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":64,"phases":94,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":53},"100361323","phase-3-evaluation-of-the-analgesia-by-serratus-plane-block-during-pleural-drainage-in-intensive-care-unit-100361323","NCT03984656","Evaluation of the Analgesia by Serratus Plane Block During Pleural Drainage in Intensive Care Unit.","SERRATUS","Inclusion Criteria:\n\n* patients over 18 years old.\n* non-intubated patient with spontaneous ventilation\n* free and informed consent of the patient,\n* affiliated to a social security scheme\n* hospitalized in ICU unit including surgical ICU, cardiothoracic and respiratory ICU or cardiothoracic and respiratory continuous care unit.\n* requiring pleural drainage gas or fluid\n* conscious patient, not sedated.\n\nExclusion Criteria:\n\n* patient under the age of 18 years old.\n* patient refusal\n* under curatorship or deprivation of liberty\n* pregnant, parturient or breastfeeding woman\n* contraindication to Lidocaine or Ropivacaine\n* coagulation disorders",{"count":93,"type":21},70,[95],"PHASE3","Pleural drainage under local anesthesia is a frequent practice in resuscitation, experienced as an unpleasant and painful event for patients. Pain management is an important issue for early rehabilitation, decrease hospitalisation's cost and shortening the length of stay in intensive care unit (ICU). A new type of locoregional anesthesia called Serratus plane block described by Blanco in 2013 showed a benefit in per and postoperative analgesia in thoracic surgery and carcinologic breast surgery, allowing a decrease in morphine use and an improvement of the patient's general satisfaction. Serratus plane block is a very effective technique in chest wall analgesia, easy and safe to perform, with few complications. No studies to date have evaluated this anesthetic practice in intensive care for pleural drainage. This technique could be used outside the operating room to improve the intensive care patients, who often have heavier pathologies and greater pain, such as patients with chest trauma or patients with cardiac or respiratory disease. The investigators would like to conduct a preliminary study of superiority in the CHU Amiens intensive care unit, to study the interest of the Serratus plane block in comparison with local anesthesia on the management of acute pain during pleural drainage.",[98,99,39],"Analgesia","Lidocaine",[101,102,103,104,105],"serratus plane block","analgesia","pleural drainage","lidocaine","intensive care unit","2026-05-12",{"date":108,"type":46},"2026-05-13",{"date":110,"type":46},"2019-06-04",{"date":112,"type":21},"2026-09-06",{"name":114,"class":52},"Centre Hospitalier Universitaire, Amiens",{"id":116,"slug":117,"hasResults":12,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":138},"100553096","asia-pediatric-intensive-care-epidemiology-and-outcomes-study-100553096","NCT06481644","Asia Pediatric Intensive Care Epidemiology and Outcomes Study","AsiaPedIC","Inclusion Criteria:\n\n* All patients admitted to the pediatric ICUs of participant hospitals\n\nExclusion Criteria:\n\n* No consent",{"count":123,"type":21},10000,"The overall objective of this study is to improve the standard of care of critically ill pediatric patients. The specific aims are to describe the clinical profile and outcomes of all admissions to Asian pediatric ICUs, determine the risk factors associated with poor outcomes, determine quality indicators for benchmarking ICU performance across sites and develop and train artificial intelligence algorithms to predict mortality, length of ICU stay and resource utilization.",[126,39,127],"Pediatrics","Critical Illness","2026-04-02",{"date":130,"type":46},"2026-04-08",{"date":132,"type":46},"2024-08-01",{"date":134,"type":21},"2027-12-31",{"name":136,"class":137},"KK Women's and Children's Hospital","OTHER_GOV",2,{"id":140,"slug":141,"hasResults":12,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":64,"phases":148,"briefSummary":149,"conditions":150,"keywords":151,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":53},"100529539","impact-of-an-alarm-management-protocol-on-noise-pollution-and-patient-safety-in-intensive-care-units-100529539","NCT06175091","Impact of an Alarm Management Protocol on Noise Pollution and Patient Safety in Intensive Care Units","REALARM","Inclusion Criteria:\n\n* Patient aged ≥ 18 years\n* Patient admitted to the intensive care unit of the ST-ETIENNE University Hospital\n* Patient affiliated or entitled to a social security system\n* Patient having received informed information about the study and having co-signed, with the investigator, a consent to participate in the study or, for patients who are unable to consent due to health condition, a trusted person\u002Ffamily member who has been informed about the study and has who has co-signed, with the investigator, a consent to participate\n\nExclusion Criteria:\n\n* Pregnant and nursing women\n* Persons of legal age under guardianship",{"count":147,"type":21},514,[66],"Resuscitation patients are monitored for various physiological parameters. When these parameters exceed abnormal thresholds, an audible alarm is triggered. Given the complexity of physiological situations and the number of monitored parameters, the number of alarms within an intensive care unit is significant. In the literature, the number ranges from 100 to 350 alarms per patient per day. Among these alarms, 74 to 99% are deemed irrelevant as they provide false or insignificant information. This study will enable to assess the efficacy of a restrictive protocol for managing alarms as a means of rationalizing their use.",[39],[152,153,154,155],"alarm fatigue","nursing staff","Resuscitation patients","restrictive alarm strategy","2026-03-09",{"date":158,"type":46},"2026-03-10",{"date":160,"type":46},"2024-02-08",{"date":162,"type":21},"2028-02-28",{"name":164,"class":52},"Centre Hospitalier Universitaire de Saint Etienne",{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":64,"phases":175,"briefSummary":177,"conditions":178,"keywords":189,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":206},"100537589","phase-2-intravenous-fish-oil-based-lipid-emulsion-to-enhance-recovery-in-high-risk-cardiac-surgery-patients-100537589","NCT06279793","Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients","Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients: a Phase II Multicenter Trial - A Randomized, Placebo-controlled Trial -","MODIFY CSX","Inclusion Criteria:\n\n1. Written informed consent prior to study participation\n2. Adult patients (≥ 18 years)\n3. Patients scheduled to undergo elective cardiac surgery with the use of CPB, who are defined as high risk based on having (i) one of the following surgical procedures: valvular heart surgery only, CABG, combined valve and CABG, multiple valve surgeries, combined cardiac procedures, aortic surgical procedures (aortic arch and\u002For descending aorta; aortic valve+ascending aorta) and (ii) at least one of the following additional risk factors: (a) a high perioperative risk profile, defined as predicted operative mortality of ≥8% (EuroSCORE II), (b) age ≥70, (c) Clinical Frailty Score 4 or more, (d) urgent surgery (defined as to be performed within 24-48 hours after admission), (e) left ventricular ejection fraction \\\u003C35%\n\nExclusion Criteria:\n\n1. Known hypersensitivity to fish oil\u002Ffish products or egg protein\n2. Pregnancy or lactation period\n3. Previous history of chronic atrial fibrillation, atrial flutter and\u002For atrial tachyarrhythmia\n4. Inability or unwillingness of individual to give written informed consent\n5. Not expected to survive an additional 48 hours from screening evaluation\n6. Lack of commitment to full, aggressive care (anticipated withholding or withdrawing treatments in the first week but isolated \"Do not Resuscitate\" \\[DNR\\] acceptable)\n7. Patients admitted with diabetic ketoacidosis or non-ketotic hyperosmolar coma\n8. Patients receiving extracorporeal mechanical assist device (e.g. ECLS, or IABP) or advanced heart failure therapies (e.g. TAH, VAD)\n9. Enrolment in anyinterventional trial within the last 30 days\n10. Already receiving FO-containing medical nutrition products\n11. Severe malnutrition (as defined by the BMI \\\u003C18.5)\n12. Severe liver dysfunction defined by Child Pugh Class C.\n13. Severe chronic kidney dysfunction defined by the National Kidney Foundation (NKF) stage 4 and 5 by using the glomerular filtration rate (GFR \\\u003C30ml\u002Fmin)\n14. Known severe coagulation disorder",{"count":174,"type":21},550,[176],"PHASE2","The MODIFY CSX study is a prospective, randomized, placebo-controlled trial conducted in heart centers in Germany and Italy.\n\nA total of 550 high-risk cardiac surgery patients will receive either 0.20 g fish oil\u002Fkg body weight (BW) + standard of care versus same volume of placebo (NaCl) + standard of care.",[39,179,180,28,181,182,183,184,185,186,187,188],"Coronary Artery Bypass Grafting (CABG)","High Risk Patients","Elective Cardiac Surgery","Valvular Heart Surgery","Multiple Valve Surgeries","Combined Cardiac Procedures","Aortic Surgical Procedures","Adult Patients ≥ 18 Years","Combined Valve and CABG","Combined Cardiac and Aortic Surgical Procedures",[105,190,191,192,193,194,195],"elective cardiac surgery","fish oil","medical nutrition therapy","atrial fibrillation","atrial flutter","atrial tachycardia","2026-02-19",{"date":198,"type":46},"2026-02-23",{"date":200,"type":46},"2024-02-15",{"date":202,"type":21},"2030-09",{"name":204,"class":205},"GCP-Service International West GmbH","INDUSTRY",10,{"id":208,"slug":209,"hasResults":12,"nctId":210,"briefTitle":211,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":12,"sex":17,"minAge":213,"maxAge":4,"enrollmentInfo":214,"targetDuration":4,"studyType":64,"phases":216,"briefSummary":217,"conditions":218,"keywords":221,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":53},"100598388","effects-of-two-different-eye-care-practices-on-eye-complications-in-mechanically-ventilated-intensive-care-patients-100598388","NCT07070843","Effects of Two Different Eye Care Practices on Eye Complications in Mechanically Ventilated Intensive Care Patients","Inclusion Criteria:\n\n* Age 18 years or older\n* Receiving mechanical ventilation\n* Glasgow Coma Scale (GCS) score \\\u003C 12\n* At least 24 hours have passed since ICU admission\n* Baseline Schirmer test result indicating tear production \\> 5 mm prior to study inclusion\n\nExclusion Criteria:\n\n* Diagnosed with brain death\n* Presence of facial or ocular trauma\n* Patients with head trauma\n* Patients who have undergone brain surgery\n* Patients diagnosed with an eye infection or chemosis\n\nWithdrawal Criteria:\n\n* Patient's death during the study period\n* Extubation of the patient before completion of the care period","18 Days",{"count":215,"type":21},156,[66],"This study was designed as a prospective, randomized controlled experimental study aiming to compare different approaches to eye care in intensive care patients receiving mechanical ventilation. In this study, patients receiving mechanical ventilation in the intensive care unit will be randomly assigned to four groups using a simple randomization method:\n\n1. Control Group: Standard Eye Care\n2. Intervention Group 1: Eye Care with Eye Care Kit\n3. Intervention Group 2: Eye Care According to Eye Care Protocol\n4. Intervention Group 3: Eye Care with Both Protocol and Eye Care Kit Research Hypotheses H1: Eye care provided using a care protocol is more effective in preventing the development of complications compared to standard eye care.\n\nH2: Eye care provided using an eye care kit is more effective in preventing the development of ocular complications compared to standard eye care.\n\nH3: The combined use of an eye care kit and a care protocol is more effective in preventing the development of ocular complications compared to using the care protocol alone.\n\nH4: The use of an eye care kit is more effective in preventing the development of ocular complications compared to the use of a care protocol.",[219,220,39],"Eye Care","Nursing Care",[222,223,224,225],"Critical care nursing","Eye infections","Intensive care units","Nursing care","2026-01-27",{"date":228,"type":46},"2026-01-29",{"date":230,"type":46},"2025-07-01",{"date":232,"type":21},"2026-10",{"name":234,"class":52},"Istanbul Saglik Bilimleri University",{"id":236,"slug":237,"hasResults":12,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":241,"eligibilityCriteria":242,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":245,"conditions":246,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":257},"100392621","covid-19---study-of-the-kinetics-of-the-immune-response-during-the-intensive-care-unit-stay-in-adult-patients-infected-with-sars-cov-2-multicentric-non-interventional-study-100392621","NCT04392401","COVID-19 - Study of the Kinetics of the Immune Response During the Intensive Care Unit Stay in Adult Patients Infected With SARS-CoV-2: Multicentric Non Interventional Study","Study of the Kinetics of the Immune Response During the Intensive Care Unit Stay in Adult Patients Infected With SARS-CoV-2: Multicentric Non Interventional Study","RICO","Inclusion Criteria:\n\n1. Man or woman aged 18 or over,\n2. Hospitalization in intensive care for Sars-Cov-2 pneumopathy,\n3. First hospitalization in intensive care unit,\n4. Positive diagnosis of SARS-CoV2 infection carried out by PCR or by another approved method in at least one respiratory sample,\n5. Sampling in the first 24 hours after admission to intensive care unit (D0 \u002F D1) feasible,\n6. Patient or next of kin who has been informed of the terms of the study and has not objected to participating.\n\nExclusion Criteria:\n\n1. Pregnant or lactating woman,\n2. Person placed under legal protection,",{"count":244,"type":21},200,"Infection with the SARS-CoV-2 coronavirus (COVID-19) has recently been identified as a pandemic due to the speed and global scale of its transmission. In Auvergne-Rhône-Alpes region (AURA), the epidemic began in February 2020 and the number of infected people is still important. Between 15 and 20% of COVID-19 patients develop an acute respiratory distress syndrome (ARDS) leading to their hospitalization in intensive care. Their clinical progression can be rapidly harmful with the development of severe ARDS associated with an increased risk of death.\n\nPreliminary data on the immune response of COVID-19 patients describe the induction of a moderate inflammatory response and the occurrence of major progressive lymphopenia over time associated with potential immunosuppression. Up to 50% of secondary infections are reported in deceased COVID-19 patients. However, no prospective study has exhaustively described the kinetics of the immune response of COVID-19 patients in intensive care.\n\nThe precise description of the immune response over time in adult patients with a proven infection with the SARS-CoV-2 virus and the study of the relation between this response and the increased risk of organ failure (severe ARDS), death or nosocomial infection will allow us to better understand the pathophysiology of the immune response induced by COVID-19 in order to (i) identify new therapeutic strategies targeting the host response in patients in intensive care (ii) to develop biological markers to stratify patients for future clinical trials evaluating these immunoadjuvant treatments in COVID-19.",[39,247],"SARS-Cov-2","2025-12-09",{"date":250,"type":46},"2025-12-17",{"date":252,"type":46},"2020-05-11",{"date":254,"type":21},"2026-04",{"name":256,"class":52},"Hospices Civils de Lyon",8,{"id":259,"slug":260,"hasResults":12,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":264,"eligibilityCriteria":265,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":266,"targetDuration":4,"studyType":64,"phases":268,"briefSummary":269,"conditions":270,"keywords":275,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":53},"100579905","effect-of-a-virtual-reality-program-on-patient-comfort-in-the-surgical-intensive-care-unit-100579905","NCT06830369","Effect of a Virtual Reality Program on Patient Comfort in the Surgical Intensive Care Unit","Effect of a Virtual Reality Program on Patient Comfort in the Surgical Intensive Care Unit of a French University Hospital: Study Protocol for a Monocentric, Prospective, Superiority, Randomized Controlled Trial, With Blinded End-point (PROBE), ZION Study","ZION","Inclusion Criteria:\n\n* Patients over 18 years old\n* scheduled for a major surgery (cardiothoracic surgery or a major abdominal surgery)\n* Written informed consent from patient.\n* Admitted in a surgical ICU for a postoperative care for at least 48 hours.\n* Absence of delirium at inclusion (RASS and CAM-ICU scale)\n\nExclusion Criteria:\n\n* Missing informed consent\n* Patient strictly under 18 years old\n* Inclusion in other study within the last 30 days\n* Pregnancy\n* Emergency hospitalization\n* Progressive sepsis\n* Patient transferred from another intensive care unit\n* Short-term life-threatening condition\n* Active psychiatric illness requiring antidepressant, antipsychotic or anxiolytic treatment\n* Mechanical ventilation \\> 48 hours\n* Patient known to have cognitive disorders.\n* Unbalanced epilepsy\n* Visual problems (absence of binocular vision, blindness) and\u002For auditory problems (deafness) preventing the use of virtual reality\n* Pregnant or breast-feeding women\n* Patients under guardianship or deprived of their liberty\n* Patients not registered with the national social security system",{"count":267,"type":21},194,[66],"Admission to a surgical intensive care unit (ICU) following major surgery is associated with a number of discomforts, not only related to the disease itself, but also to the care provided or the ICU environment itself (lights, sounds, pain, sleep deprivation, thirst...). This discomfort is real, and can be associated with psychological consequences. The investigators hypothesized that the use of immersive virtual reality (IVR) with HypnoVR® is feasible and can help reduce discomfort in intensive care.The ZION trial is a prospective, monocentric trial, randomizing 194 patients admitted in a surgical intensive care unit after a major surgery. The inclusion criterion are patients admitted in a surgical intensive care for at least 48 hours following major surgery (cardiac, thoracic or major abdominal surgery). Patients will be allocated to the intervention group (n=97) or the control group (n=97). In the intervention group, patients will receive IVR using HypnoVR®, twice a day, during the ICU stay (2 to 5 days). In the control group, postoperative care will be conducted according to standard cares without IVR. The primary endpoint will be the 18-items IPREA questionnaire on the day of ICU discharge. The secondary endpoints will include intensity of discomfort symptoms (anxiety, pain, dyspnea, thirst and sleep deprivation), incidence of delirium, cumulative morphine consumption at ICU discharge, length of ICU stay, and anxiety or depression at 1 month after discharge from intensive care and patient experience of device use.",[271,272,273,39,274],"Immersive Virtual Reality","Discomfort","IPREA","Delirium",[276,277,273,105,278],"Immersive virtual reality","discomfort","delirium","2025-11-17",{"date":281,"type":46},"2025-11-18",{"date":283,"type":46},"2025-09-12",{"date":285,"type":21},"2027-10",{"name":114,"class":52},{"id":288,"slug":289,"hasResults":12,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":294,"enrollmentInfo":295,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":297,"conditions":298,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":53},"100608381","neutrophils-to-lymphocytes-and-platelets-ratio-procalcitonin-and-total-leucocytic-count-as-indicators-of-prognostic-outcome-in-septic-patients-in-the-intensive-care-unit-100608381","NCT07200817","Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.","Comparison Between Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.","Inclusion Criteria:\n\n* Age from 18 to 70 years old.\n* Both sexes.\n* Septic patients (under the third international consensus definitions of sepsis and septic shock).\n\nExclusion Criteria:\n\n* Pregnancy\n* Malignancy\n* On immunosuppressive therapy\n* Hematological Disorders\n* Major Trauma\n* Major Burns\n* Child-Pugh Class C Liver Cirrhosis\n* On Hemodialysis","70 Years",{"count":296,"type":21},290,"This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.",[299,300,301,302,303,304,39],"Neutrophils to Lymphocytes","Platelets","Procalcitonin","Total Leucocytic Count","Prognostic Outcome","Septic Patients","2025-09-23",{"date":307,"type":46},"2025-10-01",{"date":309,"type":46},"2024-09-20",{"date":311,"type":21},"2026-03-19",{"name":313,"class":52},"Ain Shams University",{"id":315,"slug":316,"hasResults":12,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":320,"eligibilityCriteria":321,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":322,"enrollmentInfo":323,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":325,"conditions":326,"keywords":328,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":341},"100538864","normative-values-for-peripheral-muscle-strength-in-critical-patients-and-healthy-individuals-100538864","NCT06296381","Normative Values for Peripheral Muscle Strength in Critical Patients and Healthy Individuals","Analysis of Peripheral Muscle Strength Measurement Methods in Healthy Individuals and Critical Patients: A Health Technology Assessment","HHD-ICU","Inclusion Criteria:\n\n* Healthy individuals of both sexes\n* Patients and volunteers aged between 18 and 90 years old (youth\u002Fadults\u002Felderly).\n* Patients admitted to the ICU.\n* No recent muscle injuries of both limbs for a past 6-months.\n\nExclusion Criteria:\n\nPatients and volunteers \\\u003C 20 years and \\> 90 years\n\nHealthy individuals\n\n* Unable to follow command completely\n* Severe osteoporosis or neuromuscular disease leading to decreased muscle strength\n* Presence of opened or infectious wound\n* Presence of pain in evaluating muscle groups\n\nPatients in ICU\n\n* Unable to follow command completely\n* Acute stroke\n* Hip fracture, unstable cervical spine or pathological fracture\n* Recent surgery involving the upper airways, chest, abdomen, or limbs\n* Presence of opened or infectious wound\n* Presence of pain in evaluating muscle groups","90 Years",{"count":324,"type":21},180,"Muscle strength is an important indicator of overall health and is a factor that has been associated with increased mortality in critical patients. Its measurement must be reliable and reproducible to ensure a quality outcome for clinical applicability. Recently, the use of digital handheld dynamometers in intensive care has gained support; however, analysis becomes challenging due to the absence of standardized reference equations for the Brazilian population. The aim of this study is to develop reference equations for the Brazilian population and define specific cutoff points for men, women, healthy individuals, and critical patients.",[39,327],"Muscle Strength",[329,330,331],"Healthy Volunteers","Critically ill","Peripheral muscle","2025-09-13",{"date":334,"type":46},"2025-09-18",{"date":336,"type":46},"2024-03-01",{"date":338,"type":21},"2028-12-30",{"name":340,"class":52},"University of Pernambuco",4,{"id":343,"slug":344,"hasResults":12,"nctId":345,"briefTitle":346,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":348,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":349,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":351,"conditions":352,"keywords":354,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":53},"100558883","effect-of-albumin-replacement-on-oxygen-delivery-in-sepsis-patients-100558883","NCT06556914","Effect of Albumin Replacement on Oxygen Delivery in Sepsis Patients","Inclusion Criteria:\n\n* Followed up with a diagnosis of sepsis,\n* over 18 years old\n* Patients who were diagnosed with hypo-albuminemia after more than 4L\u002Fday fluid resuscitation and underwent albumin replacement\n\nExclusion Criteria:\n\n* Consent is not given by the patient or his\u002Fher guardian,\n* The initial cause of shock was hypovolemic, cardiogenic or obstructive shock.\n* Pregnancy or suspected pregnancy\n* Peripheral limb or severe organ ischemia with peripheral artery disease\n* Cardiac functions cannot be evaluated optimally by transthoracic echocardiography\n* Patients who died within the first 24 hours after intensive care admission",true,{"count":350,"type":21},45,"Fluid resuscitation is a critical component of sepsis treatment. Research has shown that intravenous (IV) fluid therapy in sepsis positively impacts cardiac output and thereby oxygen (O2) delivery through a complex interaction of central venous pressure, right atrial pressure, venous resistance, ventricular compliance, cardiac contractility, and systemic vascular resistance. The 2021 sepsis prevention guidelines recommend balanced crystalloids as first-line therapy. However, no studies in the literature have evaluated the effect of albumin on O2 delivery. In our study, the investigators aim to assess the impact of albumin replacement on O2 delivery in sepsis patients in the intensive care unit.",[353,39],"Sepsis",[355,353,356],"oxygen delivery","albumin deficiency","2025-06-30",{"date":359,"type":46},"2025-07-03",{"date":361,"type":46},"2024-11-15",{"date":363,"type":21},"2025-10-15",{"name":365,"class":52},"Samsun University",{"id":367,"slug":368,"hasResults":12,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":372,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":374,"targetDuration":376,"studyType":22,"phases":4,"briefSummary":377,"conditions":378,"keywords":380,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":53},"100561011","calibration-of-esophageal-balloon-catheter-in-spontaneous-and-mandatory-mechanical-ventilation-100561011","NCT06584604","Calibration of Esophageal Balloon Catheter in Spontaneous and Mandatory Mechanical Ventilation","Calibration of Esophageal Balloon Catheter in Spontaneous and Mandatory Mechanical Ventilation (PESCA)","PESCA","Inclusion Criteria:\n\n* 18 years or older.\n* Mechanically ventilated in spontaneous mode.\n* Sedated (Richmond Agitation Sedation Scale (RASS) between -3 and -5).\n* Pes catheter in situ according to the protocol used in the LUMC (Insertion of a Pes catheter is mandatory if it is suspected that te patient will be ventilated for more than 24 hrs.).\n\nExclusion Criteria:\n\n* Medical condition that excludes the placement of a Pes catheter.\n* Allergic reaction against rocuronium in the past.\n* Pregnant.\n* RASS \\> -3",{"count":375,"type":21},40,"1 Day","Calibration of the esophageal balloon catheter (Pes catheter) is important for the right measurement of the esophageal pressure (Pes) and subsequent interpretation of the derived transpulmonary pressures during mechanical ventilation. Both relative changes and absolute values of Pes can be affected by inappropriate filling of the esophageal balloon and by the elastance of the esophagus wall. Therefore one should calibrate the balloon to determine the best filling pressure. Calibration of the Pes catheter has only been validated in mandatory ventilation but not in support modes in which the patient triggers the ventilator and is supported by the mechanical ventilator. Because the forces in the thoracic cage behave differently in comparison with a controlled mode, it is to be expected that the calibration process in a support mode yields different filling volumes in comparison with the calibration process in a controlled mode. This would lead to a more reliable filling volume in support mechanical ventilation and a more reliable derivation of transpulmonary pressure and therefore to a better treatment of patients.",[39,379,127],"Mechanical Ventilation",[381,382,383,384,385],"Esophageal Pressure","Esophageal Balloon Catheter","Transpulmonary Pressure","Mandatory Ventilation","Support Ventilation","2025-04-17",{"date":388,"type":46},"2025-04-22",{"date":390,"type":46},"2024-12-29",{"date":392,"type":21},"2027-01",{"name":394,"class":52},"Leiden University Medical Center",{"id":396,"slug":397,"hasResults":12,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":402,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":404,"conditions":405,"keywords":412,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":53},"100459360","analysis-of-the-evolution-of-mortality-in-an-intensive-care-unit-100459360","NCT05261607","Analysis of the Evolution of Mortality in an Intensive Care Unit","Epidemiological Analysis of the Evolution of the Case-mix and Mortality in the Intensive Care Unit of Hospital Universitario De Getafe (1991-2026)","Inclusion Criteria:\n\n• Patients admitted to intensive care unit\n\nExclusion Criteria:\n\n• None",{"count":403,"type":21},25000,"The intensive care units is of the main components of modern healthcare systems. Formally, its aim is to offer the critically ill health care fit to their needs; ensuring that this health care is appropriate, sustainable, ethical and respectful of their autonomy. Intensive medicine is a cross-sectional specialty that encompasses a broad spectrum of pathologies in their most severe condition, and specifically has as its foundation the practice of comprehensive care of the patient with organ dysfunction and susceptible to recovery. Although critically ill patients are a heterogeneous population, they have in common the need for a high level of care, often requiring the use of high technology, specific procedures for the support of organ dysfunction and the collaboration of other medical and surgical specialties for their management and treatment.\n\nSince their origins in the late 1950s, intensive care units have been adapting to the changes arising from the best scientific evidence. In the late 1990s and early 2000s, there were some successful clinical trials published that had tested alternative management strategies in the ICU.\n\nMechanical ventilation is an intervention that defines the critical care specialty. Between 1970 and the 1990s, the management focused on normalizing arterial blood gas with aggressive mechanical ventilation. Over the ensuing decades, it became apparent that performing positive pressure ventilation worsened lung injury. The pivotal moment in the mechanical ventilation story would be the low versus high tidal volume trial. This trial shifted the focus away from normalizing gas exchange to reducing harm with mechanical ventilation. Further, it paved way for further trials testing ventilation interventions (PEEP strategy, prone position ventilation) and nonventilation interventions (neuromuscular blockade, corticosteroids, inhaled nitric oxide, extracorporeal gas exchange) in critically ill patients.\n\nThat evidence-based intensive care medicine has undoubtedly had an influence on the outcome of critically ill patients, in general, and, particularly, of patients requiring mechanical ventilation. Temporal changes in mortality over the time have been scarcely reported for patients admitted to intensive care unit.\n\nObjective of this study is to estimate the changes over the time in several outcomes in the patients admitted to an 18-beds medical-surgical intensive care unit from 1991 (year of start of activity) to 2026",[39,406,407,408,409,410,411],"Mortality","Epidemiology","Respiration, Artificial","Sepsis Syndrome","Respiratory Failure","Neurologic Disorder",[224,413,406],"Outcome","2025-03-11",{"date":416,"type":46},"2025-03-13",{"date":418,"type":46},"1991-07-01",{"date":420,"type":21},"2026-10-31",{"name":422,"class":52},"Hospital Universitario Getafe",{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":430,"enrollmentInfo":431,"targetDuration":4,"studyType":64,"phases":433,"briefSummary":434,"conditions":435,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":443,"locationsCount":53},"100582980","phase-3-role-of-non-selective-beta-adrenergic-blocker-in-severe-tbi-100582980","NCT06870370","Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI","Role of Non-Selective Beta-Adrenergic Blocker in Severe Traumatic Brain Injury","Inclusion Criteria:\n\n* Patients aged between 18and 65 years old\n* Patients who have Severe traumatic brain injury\n* Glascow outcome scale ≤ 8\n\nExclusion Criteria:\n\n* Patients have pre-existing heart disease.\n* If there are contraindications to β blocker.\n* penetrating traumatic brain injury.\n* pre-injury brain dysfunction.\n* β-blocker or α2-agonist use before trauma.","65 Years",{"count":432,"type":21},60,[95],"The role of nonselective beta adrenergic blocker as antistress agent in severe traumatic brain injury",[436,437,39,406],"Traumatic Brain Injury (TBI) Patients","Intracranial Pressure","2025-03-06",{"date":414,"type":46},{"date":441,"type":21},"2025-09-20",{"date":441,"type":21},{"name":444,"class":52},"Tanta University",{"id":446,"slug":447,"hasResults":12,"nctId":448,"briefTitle":449,"officialTitle":450,"acronym":4,"eligibilityCriteria":451,"healthyVolunteers":12,"sex":17,"minAge":452,"maxAge":453,"enrollmentInfo":454,"targetDuration":4,"studyType":64,"phases":456,"briefSummary":457,"conditions":458,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":461,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":465,"locationsCount":53},"100582375","open-surgical-modified-seldingers-and-us-techniques-for-jugular-central-line-insertion-in-infants-100582375","NCT06862492","Open Surgical, Modified Seldinger's and US Techniques for Jugular Central Line Insertion in Infants","Comparing Open Surgical, Modified Seldinger's and Ultrasound Guided Techniques for Jugular Central Line Insertion in Infants","Inclusion Criteria:\n\n\\- 1-patients needed Central venous catheterization insertion in the internal jugular vein for medical or surgical causes.\n\n2- patients with age ranging from birth till two years\n\nExclusion Criteria:\n\n* 1- femoral or subclavian Central venous catheterization insertion. 2- patients with thrombosed internal jugular vein . 3- patients with previous Central venous catheterization insertion. 4- those with malignant conditions","1 Hour","18 Months",{"count":455,"type":21},35,[66],"The aim of this study was to compare the three approaches: open technique, modified Seldinger's technique and closed ultrasound-guided Central venous catheterization insertion for central line insertion in infancy as regards safety, success of cannulation, technique time, and preservation of the patency of the internal jugular vein.",[459,39,460],"Infants","Central Venous Catheterization",{"date":414,"type":46},{"date":463,"type":21},"2025-08-21",{"date":463,"type":21},{"name":444,"class":52},{"id":467,"slug":468,"hasResults":12,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":472,"eligibilityCriteria":473,"healthyVolunteers":12,"sex":17,"minAge":376,"maxAge":18,"enrollmentInfo":474,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":476,"conditions":477,"keywords":483,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":53},"100473975","validation-of-vital-signs-recording-with-vt-patch-connected-devices-in-children-100473975","NCT05451875","Validation of Vital Signs Recording With VT-Patch Connected Devices in Children","Validation of Vital Signs Recording With VT-Patch® Connected Devices in Children","VT","Inclusion Criteria:\n\n* PICU monitoring for the next 24 hours\n\nExclusion Criteria:\n\n* Recent cardiac or thoracic surgery\n* Thoracic skin lesion that contraindicates the VT patch\n* No parental consent\n* Intermittent presence of one study observer in the patient room considered inappropriate by the physician or the nurse in charge because of the child's medical condition",{"count":475,"type":21},48,": Patient readmission to PICU is a major point of concern for physicians because, although being a rare event, it has been strongly associated with more morbidity and death. Patient monitoring once they have left the PICU is drastically modified, and small connected devices could be an option to early identify patients at risk of PICU readmission. Such devices have been manufactured for the recording of vital signs in adults, but they do not exist for children.\n\nBesides, studies have recently shown that devices that use optical sensors may be less accurate in individuals with dark skin pigmentation since dark skin tones impose a limitation on optical biometric sensing. The wearable and medical device industry has not sufficiently addressed this issue yet. This is one of the main challenges that need to be addressed in this area to make sure the connected devices using this technology will work with all different skin colours including very dark skin.",[478,479,480,39,481,482],"Vital Signs","Oxygen Saturation","Children","Heart Rate","Respiratory Rate",[484,485,486,487,488,489,490,491,492,480,493,494,495,496],"Vital signs","SPO2","ECG","Continuous","Skin temperature","Heart rate","VitalTracer","Wearable","All-in-one","PICU","Different Skin Color","Dark skin color","Monk Scale","2025-03-05",{"date":499,"type":46},"2025-03-10",{"date":501,"type":46},"2025-02-03",{"date":503,"type":21},"2025-12-31",{"name":505,"class":205},"VitalTracer Ltd.",{"id":507,"slug":508,"hasResults":12,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":513,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":515,"conditions":516,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":518,"lastUpdatePostDateStruct":519,"startDateStruct":521,"completionDateStruct":523,"leadSponsor":525,"locationsCount":53},"100542299","the-application-of-contrast-enhanced-ultrasound-in-acute-kidney-injury-in-icu-100542299","NCT06341062","The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU","The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in Intensive Care Unit","Inclusion Criteria:\n\n* Age \\>18 years old;\n* AKI was diagnosed \\\u003C 24 hours after first admission to intensive care unit (ICU) and the expected length of stay in ICU ≥48 hours;\n* Meet Kidney Disease Improving Global Outcomes (KDIGO) 2012 diagnostic criteria for acute kidney injury;\n* Contrast-enhanced ultrasound was performed within 24 hours after diagnosis of acute kidney injury (AKI).\n\nExclusion Criteria:\n\n* Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment;\n* Kidney transplantation or renal malignancy;\n* Terminal stage of malignant tumor;\n* Pregnancy;\n* Renal artery stenosis or renal vein thrombosis;\n* Allergy to contrast agent SonoVue(BraccoSpA, Milan, Italy) or its components, or the presence of severe cardiopulmonary insufficiency (e.g., right-to-left shunt heart disease or pulmonary systolic blood pressure \\>90mmHg).",{"count":514,"type":21},44,"The goal of this study is to quantitatively assess renal microcirculation changes by contrast-enhanced ultrasound and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore its predictive value in renal function recovery in patients with critical acute kidney injury. The main questions it aims to answer are:\n\n1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation.\n2. To explore the relationship between renal microcirculation and systemic hemodynamics.\n3. To explore the value of renal microflow changes quantitatively evaluated by contrast-enhanced ultrasound in predicting renal function recovery.",[39,69,517],"Ultrasound","2025-02-13",{"date":520,"type":46},"2025-02-17",{"date":522,"type":46},"2024-04-15",{"date":524,"type":21},"2026-06-30",{"name":526,"class":52},"Peking University Third Hospital",{"id":528,"slug":529,"hasResults":12,"nctId":530,"briefTitle":531,"officialTitle":532,"acronym":533,"eligibilityCriteria":534,"healthyVolunteers":348,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":535,"targetDuration":4,"studyType":64,"phases":537,"briefSummary":538,"conditions":539,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":543,"lastUpdatePostDateStruct":544,"startDateStruct":546,"completionDateStruct":548,"leadSponsor":550,"locationsCount":4},"100575616","effects-of-nonpharmacological-interventions-in-sleep-quality-anxiety-and-delirium-for-patients-of-adult-intensive-care-units-100575616","NCT06774599","Effects of Nonpharmacological Interventions in Sleep Quality, Anxiety, and Delirium for Patients of Adult Intensive Care Units","Effects of Nonpharmacological Interventions in Sleep Quality, Anxiety, and Delirium for Patients of Adult Intensive Care Units: a Randomized Controlled Trial","Sleep","Inclusion Criteria:\n\n* Conscious and able to speak or write (GCS ≥ 11)\n* Hemodynamically stable\n* Normal hearing and able to communicate in a low voice\n* Stay in ICU for more than 24 hours\n* Aged over 18 years.\n\nExclusion Criteria:\n\n* Pre-existing insomnia diagnosis with long-term reliance on sleep medication,\n* Sleep-related medical history such as sleep apnea\n* Shift work prior to hospitalization\n* Diagnosis of alcohol abuse or schizophrenia\n* End-of-life or terminal conditions\n* Allergy to essential oils\n* Exclusion of dementia",{"count":536,"type":21},154,[66],"This study will investigate the effect of nonpharmacological intervention in sleep quality, anxiety and delirium among adult ICU patients.",[39,540,541,542,274],"Critical Care","Sleep Quality","Anxiety","2025-01-12",{"date":545,"type":46},"2025-01-14",{"date":547,"type":21},"2025-03-14",{"date":549,"type":21},"2025-10-09",{"name":551,"class":52},"Chiayi Christian Hospital",{"id":553,"slug":554,"hasResults":12,"nctId":555,"briefTitle":556,"officialTitle":557,"acronym":558,"eligibilityCriteria":559,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":560,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":562,"conditions":563,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":570,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":579},"100523843","patient-reported-outcome-and-patient-reported-experience-after-status-epilepticus-100523843","NCT06100978","Patient-reported Outcome and Patient-reported Experience After Status Epilepticus","Patient-reported Outcomes in Status Epilepticus Requiring Intensive Care Unit Management. A Multicenter Longitudinal Cohort Study","POSEIDON2","Inclusion Criteria:\n\n* Adults 18 years old or older\n* Patients previously included in the ICTAL registry (Status Epilepticus cohort NCT03457831)\n* Survivors after ICU management for Status Epilepticus More than 3 months and less than 5 years after ICU discharge\n\nExclusion Criteria:\n\n* Legal guardianship\n* Opposition to participate\n* Unread and unwritten French language\n* Patient not affiliated to a Social Security system",{"count":561,"type":21},145,"Status epilepticus (SE) is a common life-threatening neurological emergency in which prolonged or multiple closely spaced seizures can result in long-term impairments. SE remains associated with considerable mortality and morbidity, with little progress over the last three decades. The proportion of patients who die in the hospital is about 20% overall and 40% in patients with refractory SE. Morbidity is more difficult to evaluate, as adverse effects of SE are often difficult to differentiate from those attributed to the cause of SE. Our experience suggests that nearly 50% of patients may experience long-term functional impairments. The precise description of the consequences of these functional impairments and their impact on quality of life after SE requiring intensive care management has been little studied. Indeed, if cognitive, physical and mental impairments are now identified in the populations of patients who required intensive care under the term postresuscitation syndrome (PICS), neuronal lesions consecutive to the SE itselfor to its cause could be responsible for these different functional alterations.\n\nThus, the following have been described: (i) cognitive disorders in the areas of attention, executive functions and verbal fluency, visual and working memory disorders, but also spatio-temporal disorders; (ii) physical disorders such as the so-called post-resuscitation polyneuromyopathy; and (iii) mental disorders such as anxiety disorders, depressive states or those related to post-traumatic stress.\n\nAssessment and characterization of patient-reported outcomes is essential to complement the holistic assessment of clinically relevant outcomes from the patient's perspective. The POSEIDON study was a cross-sectional collection of PROs and HR-QOL components, and associated with patient functional outcomes, in those who required ICU management for status epilepticus. We propose here to continue the description of potential alterations after a subsequent ME, namely a longitudinal study (POSEIDON 2) which will also include the evaluation of patient-reported experience (PREMS) and the measurement of family burden.",[564,565,566,567,39,568,569],"Patient Reported Outcomes","Patient Satisfaction","Long Term Outcomes","Status Epilepticus","Burden","Relatives","2024-11-04",{"date":572,"type":46},"2024-11-05",{"date":574,"type":46},"2024-05-25",{"date":576,"type":21},"2026-07",{"name":578,"class":52},"Versailles Hospital",13,{"id":581,"slug":582,"hasResults":12,"nctId":583,"briefTitle":584,"officialTitle":585,"acronym":586,"eligibilityCriteria":587,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":588,"targetDuration":589,"studyType":22,"phases":4,"briefSummary":590,"conditions":591,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":598,"completionDateStruct":600,"leadSponsor":602,"locationsCount":138},"100546168","oxygen-consumption-vo2-effort-and-weaning-in-the-mechanically-ventilated-patient-in-the-intensive-care-unit-icu-100546168","NCT06391424","Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU)","Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU): EXTUBATE Study","EXTUBATE","Inclusion Criteria:\n\n* Age above 18 years\n* \\> 24 hours mechanically ventilated\n* Eligible for a spontaneous breathing trial according to the clinical team\n* Regular SBT (\"Regulier SBT\") according to the Leiden University Medical Center (LUMC) protocol\n* Hemodynamically stable\n* Esophageal Catheter in situ\n\nExclusion Criteria:\n\n* Severe chronic obstructive pulmonary disease (COPD) (Gold class IV) if it results in a non regular SBT according to the LUMC protocol.\n* Heart failure (LVEF \\\u003C30%) if it results in a non regular SBT according to the LUMC protocol\n* Known pregnancy",{"count":432,"type":21},"2 Days","In patients who are mechanically ventilated for more than 72 hours weaning failure is a common issue. The Spontaneous breathing trial (SBT) is often done to assess if the patient can be extubated with a high chance of success. However, re-intubation rates are between 15 - 20 % after a successful SBT. The rapid shallow breathing index (RSBI) is an important parameter used in an SBT. Because the high incidence of extubation failure (re-intubation within 48 hours) a search for a better parameter than the RSBI is warranted. Using the measured end-tidal oxygen (etO2) of mechanically ventilated patients it is possible to calculate the VO2, which is a measure of patient effort. The VO2 is a parameter with the potential to predict weaning success or failure, together with other parameters of patient effort like the work of breathing (WOB), pressure time product (PTP) and esophageal pressure swings, reflecting muscle strength of the diaphragm. Therefore, the investigators want to investigate if these parameters are associated with an SBT success or failure.",[127,39,592,593,379,594],"Oxygen Consumption","Weaning Failure","Spontaneous Breathing Trial","2024-09-02",{"date":597,"type":46},"2024-09-19",{"date":599,"type":46},"2024-01-01",{"date":601,"type":21},"2026-01",{"name":394,"class":52},{"id":604,"slug":605,"hasResults":12,"nctId":606,"briefTitle":607,"officialTitle":608,"acronym":609,"eligibilityCriteria":610,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":611,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":613,"conditions":614,"keywords":617,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":53},"100551955","prediction-of-undesired-obstruction-in-external-ventricular-drains-100551955","NCT06466811","Prediction of Undesired Obstruction in External Ventricular Drains.","Identification of Patients at Risk of Undesired Obstruction in External Ventricular Drain: Development of a Score Based on the Extent of Intra-ventricular Hemorrhage. A Single-Center, Prospective Observational Study.","EVD-OBS","Inclusion Criteria :\n\nPatient older than 18 years old,\n\n* admitted to the ICU,\n* with first EVD inserted for less than 12 hours,\n* and brain imaging (CT or MRI) available in the timespan \"24 hours before to 24 hours after\" the EVD insertion.\n\nExclusion Criteria :\n\n* EVD intentionally occluded immediately after its insertion,\n* purulent cerebrospinal fluid\n* Pregnant or breast-feeding patient\n* Moribund patient or patient with decision of withholding or withdrawing life-sustaining treatment within the 12 hours\n* Patient with no health insurance\n* Patient under guardianship",{"count":612,"type":21},640,"Acute obstructive hydrocephalus often complicates intraventricular hemorrhage (IVH). The insertion of an external ventricular drain (EVD) is typically necessary in order to alleviate intracranial pressure by draining excess fluid. However, dysfunction of the EVD whether due to malposition or obstruction, can exacerbate hydrocephalus in an already compromised brain. EVD dysfunction must therefore be promptly detected and treated.\n\nConsequently, identifying high-risk patients and closely monitoring them is imperative. While IVH is known to increase the risk of obstruction in the natural cerebrospinal fluid outflow tract, its association with ventricular drain obstruction remains unproven.",[39,615,616],"Intraventricular Hemorrhage","External Ventricular Drain",[618,619,620,621,622,623],"Intensive care unit","External ventricular drain","Neuromeningeal infection","Obstruction","Intraventricular hemorrhage","Functional outcome","2024-07-11",{"date":626,"type":46},"2024-07-12",{"date":628,"type":46},"2024-07-04",{"date":630,"type":21},"2026-12-01",{"name":632,"class":52},"Nantes University Hospital",{"id":634,"slug":635,"hasResults":12,"nctId":636,"briefTitle":637,"officialTitle":637,"acronym":638,"eligibilityCriteria":639,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":640,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":642,"conditions":643,"keywords":645,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":648,"lastUpdatePostDateStruct":649,"startDateStruct":651,"completionDateStruct":652,"leadSponsor":653,"locationsCount":53},"100551100","intra-hospital-transport-of-critically-ill-patients-in-intensive-care-unit-100551100","NCT06455696","Intra-Hospital Transport of Critically Ill Patients in Intensive Care Unit","TIGRHOU","Inclusion Criteria:\n\n* Patients aged over 18 years old\n* Hospitalized in ICU\n* Requiring an intra-hospital transport (e.g imagery, operating room, etc) by the ICU team\n* With a departure from ICU and arrival to ICU\n\nExclusion Criteria:\n\n* Person under guardianship\n* Protected Majors\n* Already included in the study\n* Transport for an ICU discharge in a medical or surgical ward\n* Transport with another team than the ICU team\n* Not affiliated to French social security",{"count":641,"type":21},645,"Intra-hospital transport is a frequent procedure in the ICU, involving patients with the highest severity scores. Although some studies estimate the rate of adverse events to be around 33% during intra-hospital transport, including 4% of serious adverse events, the epidemiological data available is small, heterogeneous, and probably subject to methodological bias.\n\nThe aim of this study observational prospective observatoinal study is to determine:\n\n* the different practices existing between ICUs (\"practice survey\")\n* the occurrence of adverse events during intra-hospital transport provided by intensive care units (epidemiological study)",[127,644,39],"Transportation Accidents",[646,647,618],"Intra-hospital transport","Critical ill patients","2024-06-07",{"date":650,"type":46},"2024-06-12",{"date":599,"type":46},{"date":357,"type":21},{"name":654,"class":52},"French Society for Intensive Care",{"id":656,"slug":657,"hasResults":12,"nctId":658,"briefTitle":659,"officialTitle":660,"acronym":4,"eligibilityCriteria":661,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":662,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":663,"conditions":664,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":665,"lastUpdatePostDateStruct":666,"startDateStruct":668,"completionDateStruct":669,"leadSponsor":670,"locationsCount":4},"100543268","the-diagnostic-value-of-contrast-enhanced-ultrasound-in-acute-kidney-injury-in-icu-100543268","NCT06353659","The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU","The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in Intensive Care Unit","Inclusion Criteria:\n\n* Age\\>18 years old\n* First admission to ICU \\\u003C 24h after admission and expected ICU stay ≥48 hours\n* Acute kidney injury risk factors (KDIGO 2012)\n* Contrast-enhanced ultrasound\n\nExclusion Criteria:\n\n* Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment\n* Kidney transplantation or renal malignancy\n* Terminal stage of malignant tumor\n* Pregnancy\n* Renal artery stenosis or renal vein thrombosis\n* The quality of CEUS images is poor, and quantitative analysis cannot be performed",{"count":432,"type":21},"The goal of this observational study is to quantitatively assess the renal microcirculation changes by contrast-enhanced ultrasound (CEUS) and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore the diagnostic value of CEUS in critically ill acute kidney injury.",[39,69,517],"2024-04-07",{"date":667,"type":46},"2024-04-09",{"date":522,"type":21},{"date":524,"type":21},{"name":526,"class":52},{"id":672,"slug":673,"hasResults":12,"nctId":674,"briefTitle":675,"officialTitle":675,"acronym":676,"eligibilityCriteria":677,"healthyVolunteers":348,"sex":17,"minAge":18,"maxAge":678,"enrollmentInfo":679,"targetDuration":4,"studyType":64,"phases":681,"briefSummary":682,"conditions":683,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":691,"lastUpdatePostDateStruct":692,"startDateStruct":694,"completionDateStruct":696,"leadSponsor":698,"locationsCount":53},"100461399","efficacy-of-the-use-of-diaries-in-intensive-care-units-100461399","NCT05288140","Efficacy of the Use of Diaries in Intensive Care Units","QUADERN","Inclusion Criteria:\n\n* admitted intensive care unit\n* sedated and mechanically ventilated for 24hours\n* signed consent\n* not language barrier\n* willingness to attend follow-up visits\n\nExclusion Criteria:\n\n* verbal manifestation of psychiatric, mental or cognitive antecedents\n* who do not coluntarily agree to participate","100 Years",{"count":680,"type":21},240,[66],"Randomized clinical trial that aims to evaluate the impact of the use of a diary in patients and relatives of patients admitted to an ICU in relation to usual practice in terms of health-related quality of life, the post-traumatic stress and anxiety\u002Fdepression at 2, 6 and 12 months after ICU discharge.",[684,39,685,686,687,688,542,689,690],"Diary (Blank Journal)","Patient","Family","PICS","Stress","Depression","Quality of Life","2024-03-26",{"date":693,"type":46},"2024-03-27",{"date":695,"type":46},"2022-01-01",{"date":697,"type":21},"2026-12-31",{"name":699,"class":52},"University of Barcelona"]