[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-units-neonatal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-units-neonatal":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,69,112,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100550390","echography-guided-surfactant-therapy-esther-for-preterm-infants-with-respiratory-failure-100550390",false,"NCT06446453","Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure","Inclusion Criteria:\n\n* The infant's parent\u002Flegal guardian can understand and willingly sign a written informed consent document for this study\n* Birth gestational age between 27w0d-36w6d\n* Diagnosis of respiratory failure secondary to RDS requiring respiratory support with non-invasive positive pressure ventilation\n\nExclusion Criteria:\n\n* Unable to obtain lung ultrasound between 1-2 hours of life\n* Infants already intubated or received surfactant before the point of care lung ultrasound\n* Infants born with congenital cardiac disease, congenital lung disease, or congenital facial\u002Fairway malformations\n* Infants born with chromosomal abnormalities\n* Infants with APGARs ≤ 5 at 10 minutes of life\n* Infants requiring cardiopulmonary resuscitation or therapeutic hypothermia in the first 6 hours of life","ALL","0 Hours","2 Hours",{"count":19,"type":20},52,"ESTIMATED","INTERVENTIONAL",[23],"NA","Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management. POCUS can be used to diagnose the severity of neonatal respiratory distress syndrome (RDS) through a lung ultrasound score. Lung ultrasound scores have also been shown to predict if an infant is treated with an initial dose of surfactant. Therefore, using lung ultrasound scores to guide surfactant therapy for RDS will likely lead to earlier surfactant therapy and may improve short-term respiratory outcomes. This study will test this theory by comparing lung ultrasound score-guided surfactant therapy for premature infants with RDS with our current surfactant administration guidelines.",[26,27,28],"Respiratory Distress Syndrome, Newborn","Pulmonary Surfactants","Intensive Care Units, Neonatal","RECRUITING","2026-06-29",{"date":32,"type":33},"2026-07-01","ACTUAL",{"date":35,"type":33},"2024-06-25",{"date":37,"type":20},"2027-06",{"name":39,"class":40},"Connecticut Children's Medical Center","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":49,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100491946","multisite-inventory-of-neonatal-perinatal-interventions-mini-minimum-dataset-100491946","NCT05685745","Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset","Inclusion Criteria:\n\n* All local births with gestational ages of 22 weeks 0 days - 23 weeks 6 days, regardless of pregnancy outcome or neonatal intensive care (NICU) admission; AND\n* All outborn NICU admissions with gestational age at birth of 22 weeks 0 days - 23 weeks 6 days\n* Optional: Centers who desire to include data for NICU admissions of infants born \\\u003C22 weeks' gestation may also submit these data.","0 Years","1 Year",{"count":51,"type":20},5000,"OBSERVATIONAL","The goal of the Tiny Baby Collaborative Multicenter Inventory of Neonatal-Perinatal Interventions (MINI) minimum dataset is to serve as a registry detailing the outcomes and practices for all deliveries and infants admitted to intensive care at 22-23 weeks' gestation at participating hospitals.",[55,56,57,58,28],"Infant, Extremely Premature","Obstetric Labor, Premature","Premature Birth","Intensive Care, Neonatal","2026-04-28",{"date":61,"type":33},"2026-05-04",{"date":63,"type":33},"2019-01-01",{"date":65,"type":20},"2030-01-01",{"name":67,"class":40},"The University of Texas Health Science Center, Houston",51,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":15,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":80,"briefSummary":81,"conditions":82,"keywords":91,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":41},"100631599","heterologous-cord-blood-derived-red-blood-cell-for-transfusion-in-extremely-preterm-infants-100631599","NCT07502781","Heterologous Cord Blood-Derived Red Blood Cell for Transfusion in Extremely Preterm Infants","Multicenter, Randomized, Double-Blind Pilot Clinical Trial Evaluating the Impact of Transfusion With Heterologous Cord Blood-Derived Red Blood Cells Versus Adult Red Blood Cells in Extremely Premature Infants","Inclusion Criteria:\n\n* Signed informed consent obtained from parents or legal guardians.\n* Gestational age at birth \\\u003C 28 weeks or birth weight \\\u003C 1000 g.\n* Admission to one of the participating neonatal intensive care units (NICUs) in the Barcelona area.\n\nExclusion Criteria:\n\n* Prior red blood cell transfusion during the fetal or neonatal period.\n* Maternal-fetal immunization (e.g., isoimmunization).\n* Fetal hydrops.\n* Major congenital malformations.\n* Congenital infections.\n* Immediate need for blood before randomization (e.g., hemorrhagic shock, consumptive coagulopathy).\n* Participation in another clinical trial that could interfere with the primary outcome.","23 Weeks","28 Weeks",{"count":79,"type":20},176,[23],"Anemia is a condition in which there are not enough red blood cells to carry oxygen throughout the body. It is very common in extremely preterm infants (born before 28 weeks of pregnancy), and many of these babies require red blood cell transfusions during their hospital stay.\n\nCurrently, transfusions are given using red blood cells donated by adults. An alternative option is to use red blood cells collected from umbilical cord blood, which may be more similar to a newborn's own blood. This approach has been used in some neonatal units with encouraging results and no reported safety concerns.\n\nThis study aims to determine whether transfusion with umbilical cord blood improves clinical outcomes and reduces potential side effects compared to standard adult donor blood transfusion in extremely preterm infants. We hypothesize that umbilical cord blood transfusion will be at least as safe as adult donor blood and may provide clinical benefits.\n\nAbout 115 extremely preterm infants admitted to neonatal units in Catalonia will participate. If parents agree, their baby will be randomly assigned to receive either compatible umbilical cord blood or compatible adult donor blood if a transfusion becomes necessary. Babies will only receive a transfusion if they clinically need one. If cord blood is not available at the time of transfusion, the baby will receive compatible adult donor blood regardless of the assigned group.\n\nTo evaluate the response to treatment, small blood samples will be collected at birth, at one month of life, and 24 hours after any transfusion. These samples are taken at the same times as routine blood tests, so participation does not require additional needle sticks. The amount of blood collected is minimal (about 0.2 mL per sample).\n\nIn addition, a painless and non-invasive sensor will be placed on the baby's head for 24 hours to measure oxygen delivery to the brain. Urine samples will also be collected before and after transfusion to help assess how oxygen reaches body tissues.\n\nParticipation will continue until the baby reaches 36 weeks of postmenstrual age or is discharged from the hospital, whichever comes first.",[83,84,85,86,87,88,89,90,28],"Extremely Premature Infant","Anemia Neonatal","Blood Transfusion","Umbilical Cord Blood","Fetal Hemoglobin","Bronchopulmonary Dysplasia (BPD)","Retinopathy of Prematurity (ROP)","Death; Neonatal",[92,93,94,95,96,97,98,99,100,101],"Cord blood red blod cell transfusion","Umbilical cord blood transfusion","Extremely preterm infants","Neonatal anemia","Fetal hemoglobin","Adult donor red blood cells","Bronchopulmonary dysplasia","Retinopathy of prematurity","Oxygen delivery","Days requiring oxygen supplementation","NOT_YET_RECRUITING","2026-03-27",{"date":105,"type":33},"2026-03-31",{"date":107,"type":20},"2027-01",{"date":109,"type":20},"2029-12",{"name":111,"class":40},"Hospital Clinic of Barcelona",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":21,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":137},"100620998","effectiveness-of-family-integrated-newborn-care-to-improve-outcomes-for-preterm-and-low-birth-weight-neonates-100620998","NCT07364903","Effectiveness of Family-Integrated Newborn Care to Improve Outcomes for Preterm and Low-birth-weight Neonates","Effectiveness of Implementing Family-Integrated Newborn Care to Improve Outcomes for Preterm and Low-birth-weight Neonates in Resource-limited Settings; Quasi-experimental Design","FINC","Inclusion Criteria:\n\n* All neonates aged 0-28 days admitted to level-2 NCUs in the neonatal care unit, including Kangaroo Mother care ward or mothers' side ward, with conditions that require hospital stay at 48 hours; and\n* accompanied by at least one parent (preferably a mother) dedicated to spending up to 8 hours per day with the infant\n\nExclusion Criteria:\n\n* Neonates with major congenital anomalies\n* Infants with no family member to accompany the infant, or who do not consent to spend up to 8 hours per day in the NCU\n* Families with confirmed physical and\u002For mental problems limiting their capability to communicate and to engage, or those who leave against medical advice",{"count":121,"type":20},1020,[23],"The goal of this quasi-experimental study is to learn if integrating family in newborn care units as a key partner can improve the outcomes of preterm and low-birth-weight neonates. The main question\\[s\\] that the study aims to answer:\n\n• Does the implementation of the FINC intervention impact the neonatal outcomes for preterm and low-birth weight neonates in NCUs in resource-limited settings of Tigray, Northern Ethiopia? Researchers will compare the Length of hospital stay among preterm and low-birth-weight neonates admitted to hospitals included in the intervention groups and compared to the neonates admitted to hospitals in the control group.\n\nIn the intervention groups, family of preterm and low-birth-weight neonates will be trained, mentored, and integrated into the care targeted to their neonates.",[125,126,28,127],"Family Involvement\u002FEmpowerment","Family-centered Care","Family Integrated Newborn Care","2026-01-18",{"date":130,"type":33},"2026-01-23",{"date":132,"type":33},"2025-12-16",{"date":134,"type":20},"2026-06-16",{"name":136,"class":40},"Laerdal Foundation",2,{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":15,"minAge":145,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":149,"conditions":150,"keywords":161,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":137},"100601977","heterogeneity-index-in-neonatologist-performed-lung-ultrasound-in-neonates-receiving-respiratory-support---a-pilot-study-100601977","NCT07117513","Heterogeneity Index in Neonatologist-performed Lung Ultrasound in Neonates Receiving Respiratory Support - a Pilot Study","NPLUS HI","Inclusion Criteria:\n\n* Preterm neonates born between 28+0 and 36+6 weeks of gestation and term-born neonates (\\> 37+0 weeks of gestation) admitted to the NICU\n* Presence of respiratory distress requiring respiratory support (invasive and non-invasive) at the timepoint of NPLUS 1.\n* Written informed consent obtained from the parents prior to the measurement.\n\nExclusion Criteria:\n\n* cardiopulmonary malformations\n* pleural effusion\n* pneumothorax","1 Hour","7 Days",{"count":148,"type":20},40,"Lung ultrasound is an increasingly valuable diagnostic tool in neonatal intensive care due to its safety and accessability.\n\nThis pilot study investigates whether a quantitative approach - the heterogeneity index, previously only used in fetal lung assessment - can enhance the diagnostic accuracy of neonatologist-performed lung ultrasound (NPLUS). The index will be calculated from raw ultrasound images of preterm and term neonates and compared with conventional lung ultrasound scores to evaluate its clinical relevance.",[28,151,152,153,154,155,156,157,158,159,160],"Infant, Newborn","Infant, Premature","Point-of-Care Systems","Ultrasonography","Lung Ultrasound","Lung Ultrasound Score","Image Interpretation, Computer Assisted","Reproducibility of Results","Respiratory Distress Neonatal","Respiratory Support",[162,155,156,163,164,165,166,167,168,169,170],"Neonatologist-Performed Lung Ultrasound","Quantitative Lung Ultrasound","Neonatal Intensive Care Unit","Observer Variability in Imaging","Ultrasound Artifact Interpretation","Respiratory Distress Syndrome in Neonates","respiratory support","preterm neonate","newborn","2025-08-05",{"date":173,"type":33},"2025-08-12",{"date":175,"type":20},"2025-08-15",{"date":177,"type":20},"2026-08-01",{"name":179,"class":40},"Medical University of Graz"]