[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-units-pediatric\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-units-pediatric":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100505906","phase-3-advancing-brain-outcomes-in-pediatric-critically-ill-patients-sedated-with-volatile-anesthestic-agents-100505906",false,"NCT05867472","Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents","Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents: A Pilot Multicentre Randomized Controlled Trial","ABOVE","Inclusion Criteria:\n\n1. Pediatric patients age from 1 month to less than 18 years who need sedation to tolerate mechanical ventilation and will remain ventilated for ≥ 24 hours\n2. Receiving IV sedation by infusion or bolus for ≤72h to aid mechanical ventilation (but will be recruited as early as possible)\n\nExclusion Criteria:\n\n1. Current use of inhaled prostacyclin (high viscosity of prostacyclin impairs vaporizer device) or continuous salbutamol nebulization (impairs gas analyzer function)\n2. Family history or personal history of malignant hyperthermia (MH)\n3. Allergy to isoflurane, sevoflurane or other volatile inhaled anesthetic gas\n4. Metabolic, mitochondrial or myopathy disease e.g., Duchenne muscular dystrophy (volatiles may trigger malignant hyperthermia like reaction)\n5. Moribund with expected survival \\\u003C 24h\n6. Known pregnancy or lactation\n7. Suspected or evidence of high intracranial pressure (ICP)\n8. Not a 'closed ventilator circuit' with potential for gas leak (e.g. uncuffed ETT, bronchopleural fistula, tracheal\u002Ftrachea-esophageal fistulas, or other sources of \"gas leak\" from patient circuit that cannot be removed)\n9. Prior enrollment in the ABOVE trial","ALL","1 Month","18 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","The goal of a pilot study is to test a study plan to see if it is appropriate for a larger study. This study plan is looking at whether the use of inhaled sedatives (medications that help people be calm and sleep) can reduce delirium (extreme confusion) in children who need a ventilator (breathing machine) compared to IV or oral sedatives.\n\nThe main question\\[s\\] it aims to answer are:\n\n* Will people join the study? (recruitment)\n* Will participants finish the study?\n* Will healthcare teams accept the study procedures?\n\nParticipants will be randomized to receive study treatment (inhaled sedation) or standard of care (IV sedation). They will be monitored daily for up to 28 days. They will complete memory, thinking and behaviour tasks after 9-12 months.",[28,29,30],"Intensive Care Units, Pediatric","Anesthetics, Inhalation","Mechanically Ventilated, Critically Ill Children","RECRUITING","2026-02-02",{"date":34,"type":35},"2026-02-04","ACTUAL",{"date":37,"type":35},"2023-10-10",{"date":39,"type":22},"2026-12",{"name":41,"class":42},"Sunnybrook Health Sciences Centre","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":19,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":47,"conditions":54,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100597530","high-flow-nasal-cannula-vs-niv-after-extubation-in-children-undergoing-heart-surgery-100597530","NCT07059689","High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery","High Flow Nasal Cannula vs. Non-Invasive Ventilation in Post-Extubation Pediatric Cardiac Surgery Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients under 18 years of age.\n* Post-cardiac surgery patients in the CICU of Cipto Mangunkusumo National General Hospital\n* Patients at high risk of extubation failure (e.g., young age, open sternotomy, mechanical ventilation \\>48 hours).\n* Patients who pass the extubation readiness test and spontaneous breathing trial.\n\nExclusion Criteria:\n\n* Diaphragmatic paralysis.\n* Decreased consciousness.\n* Neuromuscular disease.\n* Pneumothorax without drainage.\n* Airway obstruction.\n* Patients with a tracheostomy.\n* Unplanned extubation.\n* Patient received PEEP (Positive End-Expiratory Pressure) \\>7 prior to extubation",{"count":51,"type":22},114,[53],"NA",[55,28,56,57],"Heart Defects, Congenital","Respiration, Artificial","Extubation","2025-07-07",{"date":60,"type":35},"2025-07-11",{"date":62,"type":35},"2025-06-05",{"date":64,"type":22},"2025-12",{"name":66,"class":42},"Indonesia University",1,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":67},"100496260","cardiac-output-measurement-in-pediatric-intensive-care-unit-by-metabolic-monitor-fick-method-pedia-fick-icu-100496260","NCT05741918","Cardiac Output Measurement in Pediatric Intensive Care Unit by Metabolic Monitor (Fick Method) (PEDIA-FICK-ICU)","Cardiac Output Measurement in Pediatric Intensive Care Unit by Metabolic Monitor (Fick Method) : Prospective Feasibility Study","PEDIA-FICK-ICU","Inclusion Criteria:\n\n* Patient under 18 years old\n* Patient over 10 kg\n* Patient requiring intubation or intubated with a cuffed tube\n* Patient requiring a central venous line in superior vena cava territory\n\nExclusion Criteria:\n\n* Mechanical ventilation with leak\n* Bad echogenicity preventing echocardiography\n* Absence of written informed consent\n* Patient not affiliated to French Health Insurance or not covered by public health insurance\n* Patient with a legal protection","28 Days","17 Years",{"count":79,"type":22},20,[53],"Cardiac output measurement is one of the most frequently used haemodynamic parameter used for intensive care unit (ICU) patients. In pediatric ICU, it is often measured with echocardiography that is a non-invasive method but is operator dependant and can't provide continuous monitoring.\n\nThe goal of this clinical trial is to evaluate the feasibility of cardiac output measurement by Fick's method, non-invasive and allowing continuous monitoring, in comparison to echocardiography in pediatric intensive care unit.",[28],[84,85,86,87],"Cardiac output","Oxygen Consumption (VO2)","Fick","Pediatric Intensive Care Unit","2024-08-23",{"date":90,"type":35},"2024-08-26",{"date":92,"type":35},"2023-08-20",{"date":94,"type":22},"2025-09",{"name":96,"class":42},"University Hospital, Montpellier"]