[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-units\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-units":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,52,83,105,131,164,198,222,246,274,295,315],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100642479","ventilation-modalities-during-transport-of-postoperative-critically-ill-patients-to-the-icu-100642479",false,"NCT07646249","VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU","VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU - A Multicenter Observational Study","VENTICRIT","Inclusion criteria\n\n* Intubated patients undergoing general anesthesia for non-cardiac surgery\n* Requirement for postoperative IMV\n* Age ≥18 years\n* Obtained informed consent Exclusion criteria\n* Patients undergoing cardiac surgery\n* Patients receiving preoperative mechanical ventilation prior to surgery.","ALL","18 Years",{"count":20,"type":21},800,"ESTIMATED","OBSERVATIONAL","Patients undergoing major non-cardiac surgery may require postoperative mechanical ventilation and transfer from the operating room to the intensive care unit (ICU). This intra-hospital transport phase is critical, as patients may experience changes in respiratory and hemodynamic status, including alterations in oxygenation, ventilation, blood pressure, and heart rate.\n\nDuring transport, ventilatory support may be provided using different strategies, including manual ventilation with a bag-valve device or mechanical ventilation with a portable ventilator. Although both approaches are commonly used in clinical practice, there is limited evidence comparing their effects on respiratory function, gas exchange, and overall physiological stability during and after transport.\n\nThis multicenter, prospective observational study aims to describe current clinical practices in ventilatory support during intra-hospital transport in adult patients undergoing non-cardiac surgery who require ICU admission. The study will also evaluate changes in vital signs, arterial blood gas parameters, and respiratory mechanics, as well as the occurrence of adverse events during transport and postoperative pulmonary complications within the first five days after surgery.\n\nNo additional interventions or procedures beyond standard clinical care will be performed. All data will be collected as part of routine clinical practice. The results of this study are expected to improve the understanding of ventilation management during transport and to identify safer and more effective strategies for critically ill postoperative patients.",[25,26,27,28,29,30],"Respiration, Artificial","Positive-Pressure Respiration","Postoperative Complications (Cardiopulmonary)","Postoperative Complications","Critical Illness","Intensive Care Units",[32,33,34,25,26,35,28,36,29,30,37,38,39],"Intra-hospital Transport","Mechanical Ventilation","Manual Ventilation","Postoperative Care","Postoperative Pulmonary Complications","Endotracheal Intubation","General Anesthesia","Non-Cardiac Surgery","NOT_YET_RECRUITING","2026-06-09",{"date":43,"type":44},"2026-06-12","ACTUAL",{"date":46,"type":21},"2026-07-01",{"date":48,"type":21},"2027-10-01",{"name":50,"class":51},"Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100643453","preventive-narrative-exposure-intervention-for-ptsd-in-icu-patients-after-cardiopulmonary-bypass-cardiac-surgery-100643453","NCT07632131","Preventive Narrative Exposure Intervention for PTSD in ICU Patients After Cardiopulmonary Bypass Cardiac Surgery","Effects of Preventive Narrative Exposure Intervention on Posttraumatic Stress Disorder Among ICU Patients After Cardiopulmonary Bypass Cardiac Surgery: A Randomized Controlled Trial","ICU-pNET","Inclusion Criteria:\n\n1. Aged 18 years or older.\n2. Scheduled to undergo cardiac surgery with cardiopulmonary bypass, with planned postoperative admission to the cardiac surgical intensive care unit and an expected ICU stay of more than 24 hours.\n3. The participant is able to communicate effectively, and the participant and family members are willing to cooperate with the study.\n4. Conscious before the first postoperative intervention, negative for delirium as assessed by the Confusion Assessment Method for the Intensive Care Unit, and able to understand and complete the intervention and related assessments.\n\nExclusion Criteria:\n\n1. Experienced severe traumatic events within the past year, such as diagnosis of a major disease unrelated to the current cardiac condition in the participant or an immediate family member, or death of an immediate family member or significant other.\n2. Currently receiving treatment for mental disorders, including pharmacological treatment or psychotherapy for conditions such as depressive disorder, anxiety disorder, bipolar disorder, or schizophrenia spectrum disorders.\n3. History of a clearly diagnosed severe mental disorder, or mental abnormalities caused by organic brain disease.",{"count":61,"type":21},100,"INTERVENTIONAL",[64],"NA","This clinical trial aims to evaluate whether an ICU-based preventive narrative exposure intervention can help prevent posttraumatic stress symptoms in adult patients after cardiac surgery with cardiopulmonary bypass.\n\nThe study will include adult patients who undergo cardiac surgery with cardiopulmonary bypass and are admitted to the cardiac surgical intensive care unit. Participants will be randomly assigned to either the intervention group or the control group.\n\nParticipants in the control group will receive routine care and routine psychological support. Participants in the intervention group will receive routine care plus an ICU-based preventive narrative exposure intervention supported by an ICU visitor book. The intervention includes preoperative education, review of ICU experiences, construction of a timeline, guided narration of stressful ICU-related events, and integration of the experience before discharge.\n\nThe ICU visitor book includes selected photos, family messages, and key recovery events. It is used to help patients better understand and organize their ICU experience.\n\nResearchers will compare the intervention group with the control group to see whether the intervention reduces posttraumatic stress symptoms. The primary outcome is posttraumatic stress symptoms at 1 month after discharge. Secondary outcomes include posttraumatic stress symptoms at 3 months after discharge, ICU memories, anxiety, depression, sleep quality, quality of life, and patient and family satisfaction with ICU care.\n\nThe findings may provide evidence for an early psychological nursing intervention to prevent posttraumatic stress disorder in ICU patients after cardiopulmonary bypass cardiac surgery.",[67,30,68],"Cardiopulmonary Bypass","Stress Disorders, Post-Traumatic",[67,70,71,68],"Intensive Care Unit","Narrative Exposure","RECRUITING","2026-06-03",{"date":75,"type":44},"2026-06-08",{"date":77,"type":44},"2026-06-02",{"date":79,"type":21},"2027-04-30",{"name":81,"class":51},"First Affiliated Hospital of Fujian Medical University",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":82},"100634687","prediction-of-postoperative-icu-requirement-in-oncologic-surgery-100634687","NCT07542925","Prediction of Postoperative ICU Requirement in Oncologic Surgery","Comparison of ASA, SORT, CACI, and P-POSSUM Scores for Predicting Postoperative Intensive Care Unit Requirement in Patients Undergoing Oncologic Surgery","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Patients scheduled for elective or emergency oncologic surgery.\n* Patients who are able to provide written informed consent.\n* Patients whose data will be analyzed for both planned and unplanned intensive care unit (ICU) admissions.\n\nExclusion Criteria:\n\n* Patients under 18 years of age.\n* Patients requiring continuous ICU follow-up due to a pre-existing critical illness prior to the current surgery.\n* Patients who do not provide consent to participate in the study.",{"count":91,"type":21},500,"This prospective observational cohort study aims to compare the performance of commonly used perioperative risk scoring systems in predicting postoperative intensive care unit (ICU) requirement among adult patients undergoing oncologic surgery. Accurate prediction of postoperative ICU admission is essential for optimizing patient safety and efficient allocation of limited critical care resources, particularly in high-risk oncologic surgical populations.\n\nA total of 500 adult patients scheduled for elective or emergency oncologic surgery will be prospectively enrolled at a single tertiary oncology center. Preoperative clinical and demographic data, intraoperative variables, and perioperative characteristics will be recorded using a standardized data collection form. Risk assessment will include the American Society of Anesthesiologists (ASA) Physical Status classification, Surgical Outcome Risk Tool (SORT), Age-adjusted Charlson Comorbidity Index (CACI), Portsmouth Physiological and Operative Severity Score for the enumeration of Mortality and morbidity (P-POSSUM), Eastern Cooperative Oncology Group (ECOG) performance status, Nutritional Risk Screening 2002 (NRS-2002), and preoperative serum albumin levels.\n\nThe primary outcome is the need for postoperative ICU admission within the first 24 hours after surgery. Secondary outcomes include unplanned ICU admission, duration of ICU stay, need for mechanical ventilation, hospital length of stay, and 30-day mortality. The predictive performance of each scoring system will be evaluated using receiver operating characteristic (ROC) analysis and multivariable logistic regression models.",[94,28,95,30],"Neoplasms","Perioperative\u002FPostoperative Complications","2026-04-18",{"date":98,"type":44},"2026-04-21",{"date":100,"type":44},"2025-12-15",{"date":102,"type":21},"2026-11-15",{"name":104,"class":51},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":62,"phases":114,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":82},"100624694","the-effect-of-pink-noise-and-the-quiet-night-intervention-on-sleep-parameters-in-intensive-care-unit-patients-a-single-center-randomized-controlled-trial-100624694","NCT07412964","The Effect of Pink Noise and the Quiet Night Intervention on Sleep Parameters in Intensive Care Unit Patients: A Single-Center Randomized Controlled Trial","The Effect of Pink-Brown Noise and the Quiet Time Intervention on Sleep Parameters in Intensive Care Unit Patients: A Single-Center, Randomized Controlled Trial","Inclusion Criteria:\n\n* Inclusion Criteria:\n* Adults aged 18 years and older\n* Patients admitted to the adult intensive care unit\n* Expected ICU stay of at least one night\n* Ability to tolerate non-invasive sleep-related interventions (earplugs, eye mask, or acoustic masking)\n* Informed consent obtained from the patient or legally authorized representative\n\nExclusion Criteria:\n\nExclusion Criteria:\n\n* Severe hearing impairment preventing use of acoustic interventions\n* Severe cognitive impairment or coma preventing sleep assessment\n* Use of continuous deep sedation\n* Diagnosed sleep disorders requiring pharmacological treatment\n* Skin conditions preventing use of wrist-worn actigraphy",{"count":113,"type":21},18,[64],"Sleep disruption is common in adult intensive care unit (ICU) patients and is often worsened by environmental noise and nighttime care activities. Poor sleep may negatively affect recovery and well-being.\n\nThis single-center, three-arm randomized controlled trial will evaluate the short-term effects of two non-pharmacological interventions-(1) pink-brown noise masking and (2) a quiet time intervention-on objective sleep parameters in adult ICU patients, compared with standard care.\n\nSleep outcomes will be measured using actigraphy-based wearable monitoring, including total sleep time, sleep efficiency, sleep onset latency, wake after sleep onset, and number of awakenings. Results are expected to support evidence-based nursing approaches to improve sleep in ICU patients.",[117,30],"Sleep Disturbance",[30,119,120,121,117],"Noise","Sound Masking","Actigraphy","2026-04-17",{"date":124,"type":44},"2026-04-22",{"date":126,"type":21},"2026-05",{"date":128,"type":21},"2027-01",{"name":130,"class":51},"Abant Izzet Baysal University",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":139,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":62,"phases":142,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":163},"100630057","virtual-reality-based-transitional-care-for-icu-survivors-100630057","NCT07482722","Virtual Reality-Based Transitional Care for ICU Survivors","Impact of a Virtual Reality-Based Transitional Care Program on Heart Rate Variability, Pain, Relocation Stress, and Unplanned ICU Readmission Among Adult ICU Survivors: A Randomized Controlled Trial","VRICU","Inclusion Criteria:\n\n* Age 20 years or older\n* Adult patients admitted to the intensive care unit (ICU)\n* Planned transfer from ICU to the general ward\n* Able to communicate and provide informed consent or have a legal representative provide consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment or delirium preventing participation\n* Severe visual or hearing impairment interfering with VR use\n* Hemodynamic instability requiring immediate life-saving intervention\n* Isolation precautions prohibiting device use\n* Participation in another interventional study that may affect outcomes","20 Years",{"count":141,"type":21},150,[64],"This study aims to evaluate the effectiveness of a virtual reality (VR)-based transitional care program for adult survivors of intensive care unit (ICU) care. ICU survivors frequently experience relocation stress, anxiety, pain, and physiological instability after transfer from the ICU to general wards, which may increase the risk of unplanned ICU readmission.\n\nParticipants will be randomly assigned to receive either standard transitional care or additional VR-based intervention sessions during their ICU stay. The VR intervention is designed to provide psychological support, environmental orientation, and stress reduction.\n\nPrimary outcomes include short-term physiological indicators within 48 hours after ICU transfer. Secondary outcomes include pain, relocation stress, and unplanned ICU readmission within 7 days.",[29,145,30],"Stress, Psychological",[147,148,149,150,151,152,153],"Virtual Reality","ICU Survivors","Relocation Stress","Heart Rate Variability","Transitional Care","Unplanned ICU Readmission","Randomized Controlled Trial","2026-03-16",{"date":156,"type":44},"2026-03-19",{"date":158,"type":21},"2026-03-09",{"date":160,"type":21},"2027-02",{"name":162,"class":51},"Mackay Memorial Hospital",2,{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":171,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":62,"phases":174,"briefSummary":175,"conditions":176,"keywords":181,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":82},"100620649","interprofessional-collaboration-in-the-cardiac-intensive-care-unit-cicu-an-action-research-training-project-100620649","NCT07360366","Interprofessional Collaboration in the Cardiac Intensive Care Unit (CICU): An Action-Research Training Project","COLLUTIC_25","Inclusion Criteria:\n\n* Healthcare professionals (physicians, nurses and healthcare assistants\u002FOSS) employed in the Cardiac Intensive Care Unit (UTIC) of the University Hospital of Parma.\n* Healthcare professionals who have completed the training pathway and are still working in the unit at the time of the six-month follow-up.\n* Medical and nursing students who have carried out or are carrying out a clinical placement within the UTIC.\n* Ability to use a computer or mobile device, essential for participating in the online training activities (e.g. Moodle, H5P).\n* Provision of written informed consent before initiation of any study procedure.\n\nExclusion Criteria:\n\n* Healthcare professionals who do not work in the cardiology setting or who are not employed in the UTIC of the AOU Parma.\n* Inability to participate in the training activities or assessment sessions for logistical, organisational or clinical reasons (e.g. planned prolonged absences during the study period).\n* Refusal or inability to provide informed consent.",true,{"count":173,"type":21},60,[64],"This study evaluates the impact of a structured interprofessional training program on daily collaboration within the Cardiac Intensive Care Unit (CICU\u002FUTIC) at the University Hospital of Parma. In high-intensity clinical settings, rapid and accurate coordination between physicians, nurses, and healthcare assistants is vital. Ineffective teamwork often leads to communication breakdowns, potentially compromising patient safety and care quality. This project investigates whether an interactive, scenario-based educational program can strengthen role clarity, communication, and shared decision-making.\n\nThe study seeks to determine if an active-learning program using interactive branching scenarios improves interprofessional collaboration more effectively than traditional methods. The researchers hypothesize that this simulation-based approach will significantly enhance professional outcomes, including self-efficacy, shared decision-making, and commitment to both the team and the profession.\n\nThe study utilizes a convenience sample (approx. 5 physicians, 30 nurses, 8 healthcare assistants, and 10 students). Eligible participants include staff and students currently or recently active in the Parma CICU who provide informed consent.\n\nThe intervention is delivered via a Moodle-based platform featuring case-based simulations. These scenarios replicate complex clinical pathways, such as:\n\nCath-lab and Electrophysiology procedures.\n\nHeart failure management.\n\nTAVI (Transcatheter Aortic Valve Implantation) preparation.\n\nAs participants navigate these scenarios, they must make critical decisions and receive immediate feedback designed to reinforce collaborative best practices.\n\nData Collection and Timeline\n\nData is gathered at three intervals: T0 (Baseline), T1 (Post-training), and T2 (6-month follow-up). Validated questionnaires measure:\n\nAttitudes toward physician-nurse collaboration.\n\nPerceived daily collaboration and decision-making satisfaction.\n\nProfessional commitment and work-related self-efficacy.\n\nThe training phase spans six months, with a subsequent six-month follow-up, totaling a 24-month project duration.\n\nEthics and Privacy Risks are minimal, primarily involving the time required for participation. The primary benefit is the development of skills that foster safer, more coordinated patient care. Privacy is strictly maintained through pseudo-anonymization, with data access restricted to the research team.",[177,178,179,30,180],"Interprofessional Relations","Interprofessional Education","Attitude of Health Personnel","Critical Care",[177,182,183,184,30,185,180,186,187,188],"Interdisciplinary Communication","Health Personnel Attitudes","Nurse-Physician Relations","Coronary Care Units","Patient Care Team","Education, Interprofessional","Clinical Decision-Making","2026-01-14",{"date":191,"type":44},"2026-01-22",{"date":193,"type":21},"2026-02-15",{"date":195,"type":21},"2028-02-15",{"name":197,"class":51},"Azienda Ospedaliero-Universitaria di Parma",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":82},"100607785","clinical-and-biological-signs-of-dapagliflozin-overdose-in-icu-patients-with-metformin-poisoning-100607785","NCT07193069","Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Admission to an intensive care unit (ICU) due to acute drug poisoning\n* Documented exposure to either:\n* Metformin alone\n* Metformin in combination with dapagliflozin\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* No exposure to metformin\n* Exposure to dapagliflozin without metformin",{"count":205,"type":21},50,"This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both metformin and dapagliflozin, another diabetes drug. The goal is to find clinical or laboratory signs that could help doctors quickly recognize a dapagliflozin overdose in this context, which could improve treatment and patient outcomes.",[208,209,210,211,212,30],"Drug Overdose","Metformin","Dapagliflozin","Lactic Acidosis","Diabetic Ketoacidosis","2025-09-24",{"date":215,"type":44},"2025-09-25",{"date":217,"type":44},"2025-04-11",{"date":219,"type":21},"2026-04-11",{"name":221,"class":51},"Centre Hospitalier de Saint-Denis",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":62,"phases":232,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":82},"100401476","rapid-response-teams---how-and-who-100401476","NCT04507737","Rapid Response Teams - How and Who?","Rapid Response Teams - How and Who? A Randomized Controlled Trial Examining the Composition of the RRT in a General Hospital","RRT-Comp","Inclusion Criteria:\n\n* Admitted to any general ward of the hospital AND\n* Aged ≥ 18 years AND\n* In need of RRT attention\n\nExclusion Criteria:\n\n* Age \\\u003C 18\n* Admitted to the delivery ward\n* Admitted to any ward in the anesthetic department\n\n  * ICU\n  * High Dependency Unit\n  * Post Operation Department\n  * Operating Theatre\n  * Same Day Admissions - Surgery Ward\n* Not admitted at the time of call\n\n  * Evaluation track in Emergency department (prior to being seen by a doctor)\n  * Out-Patient departments\n  * X-ray department\n* Any patient who cannot be randomized at the time of call",{"count":231,"type":21},1500,[64],"This will be an investigator initiated One-sided blinded Randomized Clinical Trial.\n\nThe study will examine the composition of the Rapid Response Team (RRT). the investigators will examine to see if a Critical Care Outreach Team (CCOT) consisting of an ICU-Nurse and a general ward physician and nurse are non-inferior to a Medical Emergency Team (MET) consisting of an ICU-Doctor and ICU Nurse as well as a general ward physician and nurse. The randomization will be done using an Analogue randomization sequence using sealed opaque envelopes with central randomization.The experimental intervention will be the CCOT. The statistical analyses will be done on the primary outcomes in the intention to treat population and on the secondary outcomes on an per-protocol basis exempting those with protocol violations.",[235,236,30],"Hospital Rapid Response Team","Early Warning Score","2025-09-11",{"date":239,"type":44},"2025-09-17",{"date":241,"type":44},"2021-09-01",{"date":243,"type":21},"2026-01-31",{"name":245,"class":51},"Nordsjaellands Hospital",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":62,"phases":255,"briefSummary":256,"conditions":257,"keywords":263,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":273},"100552080","dexmedetomidine-esketamine-combination-for-sedation-and-analgesia-in-icu-patients-100552080","NCT06468436","Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients","Effect of Dexmedetomidine-Esketamine Combination for Sedation and Analgesia on Delirium in ICU Patients With Mechanical Ventilation: A Multicenter Randomized Trial","Inclusion Criteria:\n\n1. Aged ≥18 years;\n2. Receiving invasive or non-invasive mechanical ventilation in the ICU, with an expected duration ≥24 hours;\n3. Require sedation as judged by ICU physicians.\n\nExclusion Criteria:\n\n1. Pregnant or lactating women;\n2. History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis;\n3. Unable to communicate due to coma, severe dementia, or language barrier prior to invasive\u002Fnon-invasive mechanical ventilation;\n4. After stroke, hypoxic encephalopathy, traumatic brain injury, or neurosurgery;\n5. Comorbid with hyperthyroidism or pheochromocytoma;\n6. Left ventricular ejection fraction \\\u003C30%, sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C50 bpm), second-degree or higher atrioventricular block without a pacemaker, or systolic blood pressure \\\u003C90 mmHg despite use of vasopressors;\n7. Severe liver dysfunction (Child-Pugh Class C), severe renal dysfunction (requiring dialysis), or expected survival ≤24 hours;\n8. Allergy to dexmedetomidine and\u002For esketamine, or any other conditions that are considered unsuitable for study participation.",{"count":254,"type":21},1508,[64],"Patients with mechanical ventilation in the intensive care unit (ICU) often develop anxiety and agitation, sleep distuebances, and delirium. Delirium occurrence is associated with worse early and long-term outcomes. Dexmedetomidine and ketamine are recommended for sedation and analgesia in ICU patients, but each may induce side effects. The sedative effects of dexmedetomidine can help mitigate the psychiatric side effects of esketamine. Recent studies showed that dexmedetomidine-esketamine combination improved analgesia and sleep quality without increasing psychiatric side effects. This trial is designed to test the hypothesis that dexmedetomidine-esketamine combination for sedation and analgesia in ICU patients with mechanical ventilation may reduce delirium and improve respiratory recovery.",[258,30,259,260,261,262],"Aged","Ventilators, Mechanical","Dexmedetomidine","Esketamine","Delirium",[258,30,259,260,261,262],"2025-07-28",{"date":266,"type":44},"2025-07-31",{"date":268,"type":21},"2025-11",{"date":270,"type":21},"2030-12-01",{"name":272,"class":51},"Peking University First Hospital",3,{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":62,"phases":281,"briefSummary":282,"conditions":283,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":82},"100596949","non-invasive-blood-pressure-monitoring-in-icu-patients-using-the-dare-device-100596949","NCT07052123","Non-Invasive Blood Pressure Monitoring in ICU Patients Using the DARE Device","Inclusion Criteria:\n\n* Adult patients (male or female), aged 18 years or older\n* Admitted to intensive care unit (ICU) or critical care with an expected hospital stay longer than 2 days\n* Equipped with an arterial catheter for invasive blood pressure monitoring\n* Equipped with a urinary catheter for invasive core body temperature monitoring\n\nExclusion Criteria:\n\n* Patients under 18 years old (minors)\n* Known skin allergy to adhesives or silicone, or skin condition preventing adhesive use\n* History of extensive skin pathology (e.g., Lyell syndrome)\n* Patients with therapeutic limitations\n* Patients with active implanted medical devices (e.g., pacemaker, defibrillator)\n* Pregnant or breastfeeding women\n* Patients not affiliated with the French social security system\n* Patients or their legal representatives refusing consent, or unable to understand information and give informed consent\n* Patients under legal guardianship, curatorship, or deprived of liberty",{"count":163,"type":21},[64],"This study tests a new non-invasive device called DARE to monitor blood pressure in patients in intensive care. It compares the device's readings to standard invasive methods and also looks at how well it measures other vital signs like temperature, oxygen levels, and heart rhythm. The goal is to improve patient safety and comfort while helping doctors detect problems earlier.",[284,285,30,29,286],"Hemodynamics","Blood Pressure Monitoring","Monitoring, Physiologic","2025-06-26",{"date":289,"type":44},"2025-07-04",{"date":291,"type":44},"2025-03-24",{"date":293,"type":21},"2028-03-24",{"name":221,"class":51},{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":301,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":303,"conditions":304,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":309,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":82},"100596986","antibiotic-treatment-for-pneumonia-caused-by-stenotrophomonas-maltophilia-in-icu-patients-100596986","NCT07052604","Antibiotic Treatment for Pneumonia Caused by Stenotrophomonas Maltophilia in ICU Patients","Inclusion Criteria:\n\n* Adult patients (age ≥ 18 years)\n* Hospitalized in Medical Intensive Care Unit between January 1, 2018, and December 31, 2023\n* Intubated and mechanically ventilated\n* Diagnosed with ventilator-associated pneumonia caused by Stenotrophomonas maltophilia\n\nExclusion Criteria:\n\n* Patients under 18 years old\n* Patients who refuse the use of their data for research purposes",{"count":302,"type":21},300,"This study looks at how different antibiotic treatments affect patients in intensive care who have pneumonia caused by the bacteria Stenotrophomonas maltophilia. It compares using one antibiotic versus two antibiotics, and treatment lengths of 7 days versus 14 days, to see which approach helps patients survive better. The study also examines how resistant the bacteria are to antibiotics and how often the pneumonia comes back.",[305,306,30,307,308],"Pneumonia, Ventilator-Associated","Stenotrophomonas Maltophilia","Anti-Bacterial Agents","Drug Resistance, Bacterial",{"date":289,"type":44},{"date":311,"type":44},"2023-12-15",{"date":313,"type":21},"2025-09-15",{"name":221,"class":51},{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":321,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":62,"phases":325,"briefSummary":326,"conditions":327,"keywords":331,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":82},"100489986","effect-of-collaborative-requesting-on-dcd-refusal-rates-randomized-controlled-trial-100489986","NCT05660252","Effect of Collaborative Requesting on DCD Refusal Rates: Randomized Controlled Trial","Collaborative Approach to Identifying Organ Donation Consent by Relatives of Potential Cardiocirculatory Arrest Donors (Maastricht Category 3): A Randomized Controlled Open-Label Trial","PRODON","Inclusion Criteria:\n\n* Patient 18 years or more Patients in the ICU for whom a decision to withdraw life-sustaining treatments (WLST) has been made and for whom the cessation of circulatory and respiratory functions is anticipated to occur within a time frame that will enable organ recovery\n* Patient's relative 18 years or more Has consented to participate in the trial Has had at least one conversation with the clinical team before study inclusion Has good knowledge of spoken French\n\nExclusion Criteria:\n\n* None",{"count":324,"type":21},548,[64],"The most common reason for not obtaining donation after brain death (DBD) or donation after controlled circulatory death (DCD) in France is refusal of consent by the relatives. Many observational studies suggest that consent rates may increase when the request is made by specially trained and highly experienced professionals. One technique that may maximize the consent rate is collaborative requesting made jointly by the physician in charge of the patient and an organ procurement coordinator (OPC).\n\nAlthough the general principles are the same for DCD as for DBD, several differences and specificities exist. First, withdrawal of life-sustaining treatments (WLST) decisions should be entirely independent from organ-donation considerations, in order to eliminate potential conflicts of interest. However, separating conversations about WLST and donation may not always be possible. Potential DCD situations often occur after an extended ICU stay with the development of close ties between families and staff. The ICU physician may therefore feel that suggesting donation during the WLST conversation serves the family-ICU staff relationship.\n\nAn unblinded multicenter randomized controlled trial tested the null hypothesis of no difference in organ-donation consent rates between collaborative requesting (clinical team and OPC together) vs. the clinical team only (routine requesting). The potential donors met criteria for brain-stem death or had impending brain-stem death; none were candidates for DCD. Collaborative requesting did not increase the consent rate.\n\nThe PRODON study will test whether collaborative requesting by the ICU team and OPC decreases the rate of DCD refusal by families compared to routine requesting by the ICU team only.",[328,329,330,30],"Organ Donation","Required Organ Donation Request","Professional Family Relations",[332,333,334,335,336],"Donation request","Organ donation","Consent for organ donation","Health care professionals","Randomized controlled trial","2022-12-21",{"date":339,"type":44},"2022-12-22",{"date":341,"type":44},"2022-06-16",{"date":343,"type":21},"2026-06-16",{"name":345,"class":51},"Nantes University Hospital"]