[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,43,68,94,120,152,175,218,234,259,292,322],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100558304","kinetics-of-inf--production-in-intensive-care-patients-100558304",false,"NCT06549374","Kinetics of INF-γ Production in Intensive Care Patients","Kinetics of INF-γ Production in Intensive Care Patients-Monitoring of INF-γ in Intensive Care","IGREY","Inclusion Criteria:\n\n* Aged 18 years or older\n* Patients admitted to intensive care after severe trauma, or presenting with acute respiratory distress, or undergoing cardiac, vascular, or digestive surgery with planned postoperative intensive care. Exclusion Criteria\n\nExclusion Criteria:\n\n* Expressed opposition from the patient, a relative (if applicable), or their legal representative (guardian, curator)\n* Pregnant woman\n* Hemoglobin less than 7g\u002Fdl at inclusion","ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","OBSERVATIONAL","Most patients admitted to intensive care after severe trauma, high-risk surgery, or acute respiratory distress are frequently characterized by significant initial inflammation accompanied by a compensatory anti-inflammatory response, which can lead to profound post-aggressive immunosuppression. This immunosuppression is associated with an increased risk of nosocomial infections, viral reactivations, prolonged ICU stays, and ultimately, increased mortality. Consequently, immunostimulation with agents such as interferon gamma (IFN-γ) has been proposed as a means to restore immune defense in the most severe patients. However, in a recent study conducted on mechanically ventilated patients with acute organ failure, treatment with interferon gamma-1b compared to placebo did not significantly reduce the incidence of nosocomial pneumonia or 28-day mortality and was even associated with an increase in severe side effects, leading to the premature termination of the trial. These results, along with previous studies, suggest that for IFN-γ to be effective, it must be targeted at patients who have reached the immunosuppressive phase. In the absence of evident clinical signs, the use of biomarkers could guide clinicians in identifying the appropriate patients and the optimal timing for this therapy.\n\nIn a recent monocentric study, they evaluated a new automated IFN-γ assay on a cohort of 22 septic patients to monitor T lymphocyte functionality independently of antigen. As expected, the results showed a marked decrease in IFN-γ release, which correlated with altered classical cellular parameters (CD8+ T cells, mHLA-DR). Since the test is performed using whole blood, requires no technician intervention, and provides results within four hours, this project propose to characterize the evolution of the immune status of a large cohort of ICU patients, including those with severe trauma, high-risk surgery, or acute respiratory distress syndrome.",[25],"Intensive Care",[27,28,29],"INF-γ","Inflammation","immunostimulation","RECRUITING","2026-05-18",{"date":33,"type":34},"2026-05-19","ACTUAL",{"date":36,"type":34},"2025-04-24",{"date":38,"type":21},"2026-10-24",{"name":40,"class":41},"Assistance Publique - Hôpitaux de Paris","OTHER",7,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100557044","predictive-algorithms-for-critical-rehabilitation-outcomes-100557044","NCT06532994","Predictive Algorithms for Critical Rehabilitation Outcomes","Development and Validation of a Prediction Algorithms to Estimate the Clinical Effect of Early Rehabilitation on ICU Survivors Received Mechanical Ventilation in the ICU","Inclusion Criteria:\n\n1. Age older than 18 years;\n2. Received mechanical ventilation, including endotracheal intubation and tracheostomy, during ICU admission;\n3. Met the rehabilitation intervention indications outlined in the \"Chinese Expert Consensus on Neurocritical Rehabilitation\" during ICU admission and underwent corresponding early rehabilitation interventions, including but not limited to arousal therapy for consciousness disorders, early active\u002Fpassive mobilization, comprehensive pulmonary rehabilitation, etc.;\n4. No mortality events occurred during ICU admission;\n5. Informed consent form signed by family members or the patient.\n\nExclusion Criteria:\n\n1. Pediatric patients under 18 years of age;\n2. Hospitalized patients in the ICU who did not receive mechanical ventilation;\n3. Patients in the ICU who did not undergo early rehabilitation interventions;\n4. mortality events occurred during ICU admission;\n5. Patients transferred out of the ICU due to treatment abandonment by family members;\n6. Family refusal to sign the informed consent form or patient refusal to sign the informed consent form when conscious and competent.","90 Years",{"count":52,"type":21},250,"An increasing amount of evidence from evidence-based medicine indicates that early rehabilitation intervention for patients receiving mechanical ventilation is safe and feasible, and can promote functional recovery and reduce hospital stay. However, the conscious state, respiratory function, and daily living activities of these patients after being discharged from the ICU vary greatly, and some patients do not show obvious benefits. How to identify which patients may have benefit from early rehabilitation is a key issue that needs to be addressed in critical care rehabilitation. This study aims to investigate the clinical data related to the disease of the ICU survivors who received mechanical ventilation as the research object, by collecting their clinical data when receiving early rehabilitation intervention, and constructing a clinical prediction model for the efficacy of early rehabilitation intervention in the ICU through the selection of optimal regression equation or machine learning algorithm. The application of this model can effectively determine whether ICU inpatients need early rehabilitation intervention, thereby reducing complication rates and improving their quality of life.",[25,55,56,57],"Mechanical Ventilation","Rehabilitation","Algorithms","2026-04-15",{"date":60,"type":34},"2026-04-21",{"date":62,"type":34},"2024-08-01",{"date":64,"type":21},"2026-12-30",{"name":66,"class":41},"Wuhan University",1,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":93},"100564381","development-and-validation-of-a-mouth-assessment-tool-for-orally-intubated-patients-in-intensive-care-unit-100564381","NCT06628440","Development and Validation of a Mouth Assessment Tool for Orally Intubated Patients in Intensive Care Unit)","MAT","Inclusion Criteria:\n\n* Person aged 18 or over\n* Person hospitalized in an adult intensive care unit for medical, surgical, polyvalent or burns specialties.\n* Person undergoing oro-tracheal intubation.\n* Person affiliated with or benefiting from a social security scheme.\n* Free and informed oral consent of the patient or his\u002Fher legal representative\n\nExclusion Criteria:\n\n* Person undergoing Limitation or Cessation of Active Therapeutics\n* Person wearing a multi-attachment fixed dental appliance (braces, multi-rings, brackets bonded to teeth)\n* Person with oral damage making it impossible to measure one of the items on the oral cavity assessment tool (e.g.: removal of the tongue, etc.).\n* Patient under protective supervision (safeguard of justice, curatorship, guardianship)\n* Refusal of patient or legal representative to participate",{"count":76,"type":21},500,"Oro-tracheal Intubation uses oro-pharyngeal lesions, impacting on the length and quality of the patient's hospital stay.\n\nThere are no oral status assessment tools specifically adapted to orally intubated patients.\n\nIt is therefore necessary to create a new tool for assessing the condition of the oral cavity, specific to oro-intubated patients in intensive care.\n\nThe aim of the protocol is to evaluate the metrological performance of the newly-developed tool for assessing the state of the oral cavity in adult orally intubated intensive care patients.",[25],[80,81,82,83],"intensive care","oral care","paramedical care","oro-tracheal intubation","2026-04-01",{"date":86,"type":34},"2026-04-07",{"date":88,"type":34},"2026-03-31",{"date":90,"type":21},"2028-10",{"name":92,"class":41},"University Hospital, Bordeaux",10,{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":67},"100552198","phase-2-evolution-of-the-initial-distribution-volume-of-glucose-in-the-severe-burned-adults-100552198","NCT06469970","Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults","INDICIA: Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults","INDICIA","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patients hospitalized with burns of at least 30% of body surface area\n\n  * By a thermal mechanism\n  * At the CHR Metz-Thionville burn center\n  * managed within the 8 hours post-burn\n* Patient affiliated to a social security scheme\n* Written consent obtained from the patient (or from the trusted person, family or relatives if the patient is unable to sign\u002Fexpress consent) or emergency inclusion if the patient is unable to express consent and neither the trusted support person nor any member of the family or relatives is present at the time of inclusion.\n\nExclusion Criteria:\n\n* Diabetic patients on insulin\n* Patient with a CONTRAINDICATION to GLUCOSE 30% PROAMP, solution for injection\n* Patients with pre-hospital cardiac arrest\n* extra corporeal circulation patient: Extra Corporeal Membranous Oxygenation (ECMO) or Extra Corporeal Life Support (ECLS) or CRRT (Continuous Renal Replacement Therapy)\n* patient without a central venous line or arterial catheter\n* Patient moribund or immediately subject to therapeutic limitation\n* Impossibility of trans-pulmonary thermodilution monitoring (vascular access difficulties)\n* Pregnant, parturient or breast-feeding women\n* Patient under guardianship, curatorship or safeguard of justice\n* Cognitive impairment or language barrier",{"count":103,"type":21},15,"INTERVENTIONAL",[106],"PHASE2","This is a prospective, observational, monocentric, phase II (exploratory) cohort study aiming to describe the evolutionary profile of the initial volume of glucose distribution (IDVG) during the first four days of management of severely burned patient.",[109,25,110],"Burns","Emergencies","2026-03-10",{"date":113,"type":34},"2026-03-12",{"date":115,"type":34},"2024-11-28",{"date":117,"type":21},"2027-03-28",{"name":119,"class":41},"Centre Hospitalier Régional Metz-Thionville",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":104,"phases":131,"briefSummary":133,"conditions":134,"keywords":138,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":67},"100577981","lung-recruitment-during-chest-physiotherapy-in-mechanically-ventilated-patients-100577981","NCT06805357","Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients","Evaluation of Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients","RECRUTKI","Inclusion Criteria:\n\n* Patient under assisted ventilation (in V-ACV or PSV) triggering all ventilator cycles\n* Patient deemed \" secretive \": requiring ≥ 2 tracheal aspirations every 3 hours\n* Patient (or relative) who has given consent to participate in the research\n* Patient covered by social security\n\nExclusion Criteria:\n\n* Age under 18 years\n* Legal guardian required\n* Recent cardiac and\u002For thoracic and\u002For abdominal surgery (\\\u003C 3 months)\n* Rib fracture(s)\n* Pneumothorax and\u002For presence of a chest drain\n* Recent neurosurgery (\\\u003C 3 months) and\u002For proven or suspected increased intracranial pressure (ICP)\n* Hemodynamic instability defined as: noradrenaline ≥ 1mg\u002Fh, adrenaline ≥ 0.5 mg\u002Fh, dobutamine ≥ 5γ\u002Fkg\u002Fmin.\n* Respiratory instability defined as: PEEP \\> 10 cmH2O and\u002For PaO2\u002FFiO2 \\\u003C 150 mm Hg\n* Pregnancy\n* Hemoptysis\n* Sever skin lesions (e.g., burns, Lyell's syndrome)\n* Patient under foreign health insurance","100 Years",{"count":130,"type":21},40,[132],"NA","In intensive care, respiratory physiotherapy is an integral part of the daily care of patients under invasive mechanical ventilation. Its goals are to improve the clearance of bronchial secretions to allow for the resolution of atelectasis and alveolar recruitment, thereby enhancing respiratory mechanics and gas exchange. The most widespread technique in France is external expiratory compression of the chest.\n\nThe effectiveness of this technique depends on the selection of patients (it seems to be more effective in patients with higher secretion levels) and on the practical implementation of the technique (favoring brief and vigorous compressions at the beginning of expiration). However, the effect of the artificial ventilator settings, particularly the ventilatory mode used during the respiratory physiotherapy session, has never been evaluated. The two most commonly used ventilatory modes worldwide are Volume Assist Control Ventilation (V-ACV) and pressure support ventilation (PSV). In this unit, respiratory physiotherapy under artificial ventilation is performed daily on patients with artificial ventilation with abundant secretions, regardless of the ventilatory mode.",[25,135,136,137],"Invasive Mechanical Ventilation","Chest Physiotherapy","Airway Clearance",[139,140,141,142,143,80],"ICU","Lung recruitment","Respiratory physiotherapy","Rib Cage Compressions (RCC)","mechanical ventilation","2026-01-14",{"date":146,"type":34},"2026-01-15",{"date":148,"type":34},"2024-07-23",{"date":150,"type":21},"2027-06-23",{"name":40,"class":41},{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":171,"leadSponsor":173,"locationsCount":67},"100595981","evolution-of-d-dimer-as-a-marker-of-bleeding-risk-on-ecmo-100595981","NCT07039513","EVOLUTION OF D-DIMER AS A MARKER OF BLEEDING RISK ON ECMO","ECMOstase2","Inclusion Criteria:\n\n* Male or female ≥ 18 years of age\n* Hospitalized patient in intensive care\n* Implementation of a VV or VA ECMO for less than 24 hours\n* Patient affiliated to a social protection health insurance scheme\n* Non-opposition by the patient or a relative in the event that the patient is not in a state to express his or her non-opposition or inclusion in an emergency procedure in the event that the patient is not in a state to express his or her non-opposition and no relative of the patient can be reached.\n\nExclusion Criteria:\n\n* Patient on veno-arterial ECMO after cardiac, cardiopulmonary surgery or after placement of a left or biventricular cardiac assist device\n* Congenital hemostasis disorder or anatomical abnormality predisposing to bleeding\n* Dying patient on the day of inclusion\n* Patient under judicial protection\n* Patient under guardianship or curatorship\n* Pregnancy\n* Breastfeeding",{"count":160,"type":21},100,"ECMO (extracorporeal membrane oxygenation) is a life-saving device, used in intensive care to treat severe respiratory or cardiac failure. However, it carries a high risk of serious life-threatening bleeding.\n\nBleeding complications have been attributed to coagulopathy triggered either by the underlying pathology or by the extracorporeal circuit itself, as well as excessive or inappropriate anticoagulation initiated to prevent thrombotic complications.\n\nThe objective of this cohort is to confirm the interest of the evolution of D-dimers as a prognostic marker of serious bleeding events in patients on veno-venous (VV) or veno-arterial (VA) ECMO, and to determine the threshold.",[163,164,165],"ECMO","Mplementation of a Veno-venous VV or Veno-arterial VA","INTENSIVE CARE","NOT_YET_RECRUITING","2025-11-27",{"date":169,"type":34},"2025-12-01",{"date":167,"type":21},{"date":172,"type":21},"2027-06-01",{"name":174,"class":41},"University Hospital, Strasbourg, France",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":104,"phases":185,"briefSummary":186,"conditions":187,"keywords":193,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":67},"100561711","hemodynamic-monitoring-and-fluid-responsiveness-in-venovenous-extracorporeal-membrane-oxygenation-vv-ecmo---hemodynamecmonitoring-vv-study-100561711","NCT06593717","Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - \"HemodynamECMOnitoring-VV Study\"","Validation of Techniques for Hemodynamic Monitoring and Prediction of Fluid Responsiveness in Patients Undergoing Venovenous Extracorporeal Membrane Oxygenation - A Prospective Diagnostic Accuracy Study (\"HemodynamECMOnitoring-VV Study\")","Inclusion Criteria:\n\n* Patient receiving VV-ECMO support\n* Age 18 - 75 years\n\nExclusion Criteria:\n\n* Pregnancy\n* Conditions not allowing for passive leg raising maneuvers, e.g. \"open abdomen\", known or suspected elevation of intracranial pressure, recent leg or spinal trauma or orthopedic conditions not permitting leg raising\n* Known ischemic or hemorrhagic stroke within 3 months prior to study enrollment.\n\nSuspicion of raised intracranial pressure is defined as pupil divergence (if not yet further clarified radiographically\u002Fneurologically\u002Fophthalmologically) or signs detected in routine computed tomography scans (compressed or elapsed basal cisterns or midline shift \\> 5 mm.","75 Years",{"count":184,"type":21},30,[132],"In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels. This allows the supply of oxygen-rich blood to the organs (brain, heart, lungs, kidneys, liver, intestines, etc.) to be maintained.\n\nContinuous monitoring of cardiac function and circulatory status (blood pressure, blood flow to organs) is very important in intensive care medicine in order to control the administration of circulation-supporting medication and infusions. Various devices are routinely used for this task. However, in the specific situation of ECMO treatment, the measurements of these devices could be affected due to the artificial circulation; outside the body.\n\nThe purpose of this study is therefore to test the accuracy of different methods of circulation monitoring during ECMO treatment.",[188,189,190,25,191,192],"ECMO Treatment","ARDS","Pneumonia","Hemodynamic Monitoring","Fluid Responsiveness",[194,195,189,196,197,191,192,198,199,200,201,202,203,204,205,206,207,208],"VV ECMO","Extracorporeal Membrane Oxygenation","Intensive Care Medicine","Critical Care Medicine","Passive Leg Raising","Pulse Contour Analysis","Transpulmonary Thermodilution","Bioreactance","Pulse Pressure Variation","End-expiratory Occlusion Test","End-inspiratory Occlusion Test","Cardiac Output","LVOT VTI","Stroke Volume","Vena Cava Ultrasound","2025-09-23",{"date":211,"type":34},"2025-09-29",{"date":213,"type":34},"2024-05-03",{"date":215,"type":21},"2027-01",{"name":217,"class":41},"Medical University of Vienna",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":182,"enrollmentInfo":225,"targetDuration":4,"studyType":104,"phases":226,"briefSummary":227,"conditions":228,"keywords":229,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":230,"startDateStruct":231,"completionDateStruct":232,"leadSponsor":233,"locationsCount":67},"100561714","hemodynamic-monitoring-and-fluid-responsiveness-in-venoarterial-extracorporeal-membrane-oxygenation-va-ecmo---hemodynamecmonitoring-va-study-100561714","NCT06593756","Hemodynamic Monitoring and Fluid Responsiveness in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) - \"HemodynamECMOnitoring-VA Study\"","Validation of Techniques for Hemodynamic Monitoring and Prediction of Fluid Responsiveness in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation - A Prospective Diagnostic Accuracy Study (\"HemodynamECMOnitoring-VA Study\")","Inclusion Criteria:\n\n* Patient receiving VA ECMO support\n* Age 18 - 75 years\n\nExclusion Criteria:\n\n* Pregnancy\n* Conditions not allowing for passive leg raising maneuvers, e.g. \"open abdomen\", known or suspected elevation of intracranial pressure, recent leg or spinal trauma or orthopedic conditions not permitting leg raising\n* Known ischemic or hemorrhagic stroke within 3 months prior to study enrollment.",{"count":184,"type":21},[132],"In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels. This allows the supply of oxygen-rich blood to the organs (brain, heart, lungs, kidneys, liver, intestines, etc.) to be maintained. Continuous monitoring of cardiac function and circulatory status (blood pressure, blood flow to organs) is very important in intensive care medicine in order to control the administration of circulation-supporting medication and infusions. Various devices are routinely used for this task. However, in the specific situation of ECMO treatment, the measurements of these devices could be affected due to the artificial circulation; outside the body. The purpose of this study is therefore to test the accuracy of different methods of circulation monitoring during ECMO treatment.",[188,189,190,25,191,192],[194,195,189,196,197,191,192,198,199,200,201,202,203,204,205,206,207,208],{"date":211,"type":34},{"date":213,"type":34},{"date":215,"type":21},{"name":217,"class":41},{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":241,"targetDuration":4,"studyType":104,"phases":243,"briefSummary":244,"conditions":245,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":67},"100571176","remimazolam-besylate-in-sedation-of-postcardioperative-patients-100571176","NCT06716840","Remimazolam Besylate in Sedation of Postcardioperative Patients","Remimazolam Besylate Versus Propofolfor Sedation of Postcardioperative Patients in Intensive Care Unit: a Prospective,Single-center,Randomized Non-inferior Trial","Inclusion Criteria:\n\n1. age ≥ 18 years ;\n2. admitted to the intensive care unit after cardiac surgery with techanical ventilation；\n3. expected to extubation within 48hours ；\n4. participant has given informed consent\n\nExclusion Criteria:\n\n1. pregnant or lactating women\n2. known or suspected hypersensitivity to the study drug\n3. history of impaired consciousness or psychiatric illness\n4. severe bradycardia with a heart rate of \\\u003C 50 beats per minute\n5. systolic blood pressure \\\u003C 90 mmHg with fluid resuscitation and vasopressor maintenance\n6. atrioventricular block（II or III degree）, Left ventricular ejection fraction(LVEF) \\\u003C30%\n7. participated in other clinical studies within 3 months",{"count":242,"type":21},120,[132],"Intensive care medicine is vital in managing patients after cardiac surgery with endotracheal intubation，in order to provide extensive monitoring to assure clinical stabilization. During this time of recovery, sedation is frequently employed. However, prolonged sedation risks negative sequelae.At present,propofol, benzodiazepines, and dexmedetomidine are typical drugs used for sedation of patients in intensive care unit.Each has its own advantages and disadvantages.The investigators try to find near-ideal agents for sedation,characterized by good sedative effect,minimal adverse effects and rapid awakening facilitating earlier extubation.Remimazolam appeared to be an effective and safe sedative for short term sedation. Study participants were predicated on age (\\> 18 years), admission following cardiac surgery, still mechanical ventilation within 48 hours,and prior informed consent.Participants were randomized to receive remimazolam besylate or propofol in a 1:1 ratio for sedation with a target sedation depth before extubation.Finally，the investigators will compare the sedation effect and safety between the 2 groups ，to prove if remimazolam is appropriate for sedation in patients after cardiac surgery in intensive care unit.",[246,247,248,55,25,249],"Remimazolam","Propofol","Sedation","Cardiac Surgery","2025-02-16",{"date":252,"type":34},"2025-02-18",{"date":254,"type":34},"2025-02-10",{"date":256,"type":21},"2025-05-31",{"name":258,"class":41},"First Affiliated Hospital of Zhejiang University",{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":263,"acronym":4,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":17,"minAge":265,"maxAge":4,"enrollmentInfo":266,"targetDuration":4,"studyType":104,"phases":268,"briefSummary":269,"conditions":270,"keywords":273,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":67},"100568756","the-cost-effectiveness-of-artificial-intelligence-acute-kidney-injury-prediction-auxiliary-software-acura-aki-100568756","NCT06685367","The Cost-effectiveness of Artificial Intelligence Acute Kidney Injury Prediction Auxiliary Software (Acura AKI)","Inclusion Criteria:\n\n* Over 20 years old\n* Admitted to adult ICU\n* Hospital stay of more than 30 hours\n\nExclusion Criteria:\n\n* Known to have acute kidney injury at enrollment\n* Currently undergoing hemodialysis treatment\n* No available blood or urine test data\n* Pregnant women\n* HIV-positive patients\n* Those who have not provided informed consent form\n* Regarded as unsuitable for inclusion in the trial by the researcher","20 Years",{"count":267,"type":21},3600,[132],"\"Huede\" AI Aided AKI Prediction Software, Acura AKI, uses machine learning algorithms to predict the risk of AKI within the next 24 hours and provide a ranking of feature importance. By using Acura AKI, physicians can assess the risk of AKI, focusing on high-risk patients to provide care decisions. This study will be conducted in a prospective randomized clinical trial in adult ICUs, implementing the Acura AKI system for predicting AKI. The study aims to determine whether early prediction and intervention using the Acura AKI system can improve the outcomes of critically ill patients with adverse kidney conditions. The study endpoint is to evaluate the cost-effectiveness of using Acura AKI, including the incidence of AKI, dialysis rates, mortality rates, length of hospital stay, and treatment costs.",[271,25,272],"Acute Kidney Injury","Renal Replacement Therapy",[271,274,275,276,277,278,279,280,272,281],"Intensive Care Units","Critical Ill","Prevention","Artificial Intelligence","Machine Learning","Clinical Decision Support System","Dialysis","Cost-effectiveness","2024-11-10",{"date":284,"type":34},"2024-11-12",{"date":286,"type":34},"2024-10-17",{"date":288,"type":21},"2025-09-15",{"name":290,"class":291},"Huede Healthtech Co., Ltd.","INDUSTRY",{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":297,"acronym":298,"eligibilityCriteria":299,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":300,"enrollmentInfo":301,"targetDuration":4,"studyType":104,"phases":303,"briefSummary":304,"conditions":305,"keywords":308,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":67},"100438106","interest-of-peripheral-venous-catheter-insertion-using-a-micro-guide-in-neonatology-100438106","NCT04984967","Interest of Peripheral Venous Catheter Insertion Using a Micro-guide in Neonatology","Comparison of Two Techniques of Peripheral Venous Catheterization in Newborns : Insertion on Micro-guide Versus Conventional Insertion, Without Micro-guide","EASYCATH","Inclusion Criteria:\n\n* Newborn admitted in the department of neonatal medicine and pediatric intensive care, at Montpellier University Hospital\n\nExclusion Criteria:\n\n* Term neonate \\> 28 days\n* Premature neonate \\> 41 weeks of corrected gestational age\n* Exclusive requirement for an umbilical venous catheter, in the context of neonatal resuscitation\n* Exclusive requirement for an epicutaneous-cava catheter, in the context of prolonged parenteral nutrition.","28 Days",{"count":302,"type":21},116,[132],"Peripheral venous catheterization represents the preferential option for term or preterm infant care in order to start drug treatment or hydration, or perform anesthesia.\n\nHowever, the peripheral venous access is associated in approximately 50% of cases with a failure of the insertion on the first attempt in an emergency context. Using a micro-guide may facilitate the peripheral venous catheterization in newborns, by guiding the catheter in the vein and, thereby reduce the risk of transfixion of the vascular lumen.",[306,307,25],"Newborns","Neonatology",[309,310,311,312],"Newborn infant","Intensive care","vascular access","Peripheral intravenous catheterization","2024-06-03",{"date":315,"type":34},"2024-06-04",{"date":317,"type":34},"2021-12-08",{"date":319,"type":21},"2025-03",{"name":321,"class":41},"University Hospital, Montpellier",{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":329,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":330,"targetDuration":4,"studyType":104,"phases":332,"briefSummary":333,"conditions":334,"keywords":4,"overallStatus":166,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":67},"100519915","d2-versus-d3-dissection-in-laparoscopic-right-hemicolectomy-100519915","NCT06049758","D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy","D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy In Right Cancer Colon Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients with right-side colon cancer (caecum, ascending, or hepatic flexure)\n* Diagnosed by CT entero-colonography\n* Diagnosed by colonoscopy\n* Diagnosed by biopsy.\n\nExclusion Criteria:\n\n* Emergency surgery (obstruction, perforation with generalized peritonitis),\n* Metastatic tumor diagnosed\n* ASA score of IV or higher\n* Need for more than one surgical procedure\n* Conversion to open surgery",true,{"count":331,"type":21},80,[132],"Evaluating the differences between D2 and D3 lymphadenectomy in laparoscopic right hemicolectomy in patients with right cancer colon post-operative outcome, intra-operative blood transfusion, post-operative ICU admission, anastomotic leakage, lymph node harvesting in the final specimen, and six months follow up and overall survival time after 5-years",[335,25,336,337,338,339],"Blood Loss","Anastomotic Leakage","Lymph Node Disease","Survival","Blood Transfusion","2023-09-19",{"date":342,"type":34},"2023-09-22",{"date":344,"type":21},"2024-01-02",{"date":346,"type":21},"2030-01-02",{"name":348,"class":349},"General Committee of Teaching Hospitals and Institutes, Egypt","OTHER_GOV"]