[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intercostal-nerve-block\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intercostal-nerve-block":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,74,102,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100582290","cryo-nerve-block-trial-100582290",false,"NCT06861387","Cryo Nerve Block Trial","A Randomized Controlled Trial Studying the Effect of Additional Intercostal Cryo-analgesia (ICCA) to Standard Postoperative Pain Management in Patients Undergoing Minimally Invasive Lung Surgery","Inclusion Criteria:\n\n1. Patients are at least 18 years or older.\n2. Patients are electively scheduled to undergo minimally invasive (i.e., VATS or RATS) anatomical lung (i.e., pneumonectomy, (bi)lobectomy, or segmentectomy) resection for benign or malignant disease.\n3. Proficient understanding of the consequences of enrolment by the patients.\n4. Written informed consent by the patient.\n\nExclusion Criteria:\n\n1. Patients with reported intolerance or hypersensitivity to the anaesthetic drug used for ICNB.\n2. Patients chronically using opioids for reasons not related to the operation (i.e., more than 3 months).\n3. Patients with liver failure inhibiting the systematic use of acetaminophen (i.e., paracetamol)\n4. Patients with connective tissue disease.\n5. Patients with comorbidities or history contra-indicating ICCA.\n6. Patients who are pregnant.\n7. Participation in other clinical trial(s) that may interfere with the current trial.","ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","INTERVENTIONAL",[23],"NA","Background:\n\nMinimally invasive lung surgery, such as video-assisted thoracoscopic surgery (VATS) or robot-assisted thoracoscopic surgery (RATS), has become more common for lung resections because it leads to faster recovery, less pain, and shorter hospital stays. However, pain after surgery remains a major issue. Current guidelines suggest using a combination of pain management strategies to reduce the use of opioids and their side effects. Intercostal cryo-analgesia (ICCA), a technique that uses cold to reduce nerve activity, may help lower pain and opioid use after surgery. However, there is limited research on ICCA, with most studies having small sample sizes and lacking randomized controlled trials. More research is needed to compare ICCA with standard pain management in patients undergoing minimally invasive lung surgery.\n\nObjective:\n\nThe goal of this study is to determine whether ICCA improves recovery compared to standard pain management after minimally invasive lung surgery. The investigators aim to measure recovery time and quality using the Quality of Recovery-15 (QoR-15) questionnaire. The investigators expect that ICCA will result in better recovery, less pain, reduced opioid use, and shorter hospital stays, without increasing the risk of nerve damage or other complications.\n\nStudy Design:\n\nThis will be a single-center, blinded, randomized controlled trial, along with an observational registry.\n\nStudy Population:\n\nThe study will include adults who are undergoing elective minimally invasive lung resections.\n\nIntervention:\n\nPatients in the intervention group will receive ICCA in addition to standard pain management after surgery. ICCA will be administered by the surgeon before closing the wound, targeting the intercostal nerves between ribs 3 and 7.\n\nMain Study Parameters\u002FEndpoints:\n\nThe primary outcome will be recovery time, measured using the QoR-15 questionnaire. The QoR-15 assesses overall recovery after surgery across several domains, with a score of 118 or higher indicating good recovery. The questionnaire is a reliable and valid tool for measuring postoperative recovery.\n\nRisks and Benefits:\n\nThis trial will examine the effects of adding ICCA to the standard pain management protocol. Potential risks include numbness or nerve damage, neuropathic pain (pain caused by nerve injury), or complications such as bleeding (hematoma) or lung collapse (pneumothorax) at the treatment site. The potential benefits of ICCA include improved recovery, reduced opioid use, less pain, shorter hospital stays, and fewer respiratory complications after surgery.",[26,27,28],"Intercostal Nerve Block","Cryo Analgesia","Minimally Invasive Lung Surgery",[30,31,32,33],"cryo analgesia","intercostal nerve block","minimally invasive lung surgery","pain management","RECRUITING","2026-06-25",{"date":37,"type":38},"2026-06-26","ACTUAL",{"date":40,"type":20},"2026-09-01",{"date":42,"type":20},"2029-12-12",{"name":44,"class":45},"St. Antonius Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":71,"locationsCount":46},"100637381","analgesic-efficiency-of-sipspb-vs-icnb-in-vats-surgery-100637381","NCT07577908","Analgesic Efficiency of SIPSPB vs ICNB in VATS Surgery","Comparison Of The Analgesic Effectiveness Of Ultrasonography-Guided Serratus Posterıor Superior Intercostal Plane (SPSIP) Block And Intercostal Nerve (ICN) Block In Video-Assisted Thoracoscopic Surgery Patients","Inclusion Criteria:\n\n* Aged 18-80 years,\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients who have provided informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients who refuse to participate in the study by not signing the informed consent\n* Patients classified as ASA \\> 3, according to the system established by the American Society of Anesthesiologists\n* Patients unable to understand the use of the NPR Scale or the PCA device that will be used for postoperative analgesia\n* Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia\n* Patients with allergies to analgesic and\u002For anesthetic drugs\n* Infection at the block injection site\n* Patients whose surgical procedure is intraoperatively converted to an open pulmonary resection","80 Years",{"count":56,"type":20},80,"OBSERVATIONAL","This study aims to evaluate the effectiveness of Serratus Posterior Superior Intercostal Plane (SPSIP) block compared to Intercostal Nerve (ICN) block in terms of postoperative pain control, reduction of opioid analgesic consumption, minimization of postoperative respiratory complications, and increase patient satisfaction (using a 5-point Likert scale) in patients undergoing video-assisted thoracoscopic surgery (VATS).",[26,60,61,62],"Serratus Posterior Superior Intercostal Plane Block","Post-operative Pain Management","VATS",[64,31,62],"Serratus posterior superior intercostal plane block","2026-05-18",{"date":67,"type":38},"2026-05-20",{"date":65,"type":38},{"date":70,"type":20},"2026-08-01",{"name":72,"class":73},"Kocaeli City Hospital","OTHER_GOV",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100634131","ultrasound-guided-erector-spinae-plane-block-versus-thoracoscopically-guided-intercostal-nerve-block-in-video-assisted-thoracoscopic-surgery-100634131","NCT07535697","Ultrasound-Guided Erector Spinae Plane Block Versus Thoracoscopically-Guided Intercostal Nerve Block in Video-Assisted Thoracoscopic Surgery","Prospective, Randomized Comparative Study of an Anesthesiological, Ultrasound-Guided \"Erector Spinae Plane Block\" (ESPB) Versus a Surgical, Thoracoscopically-Guided \"Intercostal Nerve Block\" (ICNB) in \"Video-Assisted Thoracoscopic\" (VATS) Procedures, Evaluating Postoperative Analgesic Consumption, Postoperative Pain Perception, and Duration of the Procedure","Inclusion Criteria:\n\n* Provision of written informed consent\n* Adults (≥ 18 years of age)\n* Elective video-assisted thoracoscopic surgery (VATS) for pulmonary resection (e.g., lobectomy, segmentectomy, wedge resection)\n\nExclusion Criteria:\n\n* Lack of informed consent\n* Language barrier\n* Pregnancy or breastfeeding\n* Known allergy to local anesthetics used in the study\n* Infection at the injection site(s)\n* History of complex chest wall surgery\n* Revision surgery with a prior operation within the last 6 months\n* Intraoperative conversion to open thoracotomy\n* Chronic pain syndrome\n* Fibromyalgia\n* Chronic opioid use\n* Chronic alcohol abuse\n* Chronic substance abuse (e.g., THC, amphetamines, cocaine)\n* History of psychiatric disorders (e.g., depression, schizophrenia)\n* Impaired consciousness, cognition, or ability to communicate\n* Known coagulopathy (including platelet count \\\u003C 80,000\u002FµL or prolonged PTT\u002FaPTT \\>1.5× the upper limit of normal)\n* Ongoing therapeutic anticoagulation",true,{"count":83,"type":20},72,[23],"Effective postoperative pain management is essential after thoracic surgery. Insufficient pain control may impair breathing and coughing, increasing the risk of pulmonary complications such as collapsed lungs (atelectasis) or pneumonia.\n\nAlthough minimally invasive lung surgery (video-assisted thoracoscopic surgery, VATS) is less painful than open surgery, people can still have significant pain after the operation.\n\nThe goal of this randomized comparative study is to compare two commonly used regional anesthesia techniques for pain control after VATS in adults.\n\nResearchers will compare an ultrasound-guided erector spinae plane block (ESPB), performed by anesthesiologists, to a thoracoscopically-guided intercostal nerve block (ICNB), performed by surgeons.\n\nParticipants will:\n\n* Undergo elective VATS lung resection surgery\n* Receive either ESPB or ICNB, according to random assignment\n* Have the received amount of analgesics recorded during the first 24 hours\n* Have their pain levels assessed at predefined time points after surgery\n\nThe main questions this study aims to answer are:\n\n* Does ESPB result in similar analgesic consumption in the first 24 hours after surgery?\n* Does ESPB provide similar postoperative pain relief compared to ICNB?\n* Is the time needed to perform ESPB similar to ICNB?",[87,88,89,26],"Regional Anesthesia","Video-assisted Thoracoscopic Surgery (VATS)","Erector Spinae Plane Block",[87,88,89,91,26,92],"ESPB","ICNB","2026-04-27",{"date":95,"type":38},"2026-05-01",{"date":97,"type":20},"2026-05-04",{"date":99,"type":20},"2027-05-03",{"name":101,"class":45},"Sana Klinikum Offenbach",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":46},"100633899","effect-of-early-versus-late-surgical-intercostal-block-on-postoperative-pain-relief-following-video-assisted-thoracic-surgery-vats-100633899","NCT07532681","Effect of Early Versus Late Surgical Intercostal Block on Postoperative Pain Relief Following Video-Assisted Thoracic Surgery (VATS)","Effect of Early Versus Late Surgical Intercostal Block on Postoperative Pain Relief Following Video-Assisted Thoracic Surgery (VATS): a Randomised, Double-blind Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled for single-port or two-port video-assisted thoracoscopic surgery (VATS).\n* ASA classification 1 to 3\n* Able to understand the study, describe their pain and provide valid informed consent\n\nExclusion Criteria:\n\n* Neurological or psychiatric conditions that compromise the reliable assessment of pain(dementia, cognitive impairment, severe communication disorders)\n* Chronic opioid use or regular use (\\> 3 months) of strong analgesics for chronic pain\n* History of allergy or known hypersensitivity to local anaesthetics\n* Coagulopathy or anticoagulant therapy precluding the safe performance of an intercostal block\n* Local infection at the injection site or active systemic infection\n* Bilateral thoracic surgery or intraoperative conversion to thoracotomy\n* Second surgery at the same site.\n* Current pregnancy or breastfeeding\n* Inability to understand postoperative instructions or a language barrier preventing a validated assessment of pain\n* Simultaneous participation in another clinical trial involving analgesia or thoracic surgery\n* Refusal to participate or withdrawal of consent at any time",{"count":110,"type":20},140,[23],"Video-assisted thoracoscopic surgery (VATS) is associated with significant postoperative pain despite lower morbidity compared with thoracotomy. Adequate pain management is essential within Enhanced Recovery After Surgery (ERAS) pathways to preserve respiratory function and facilitate postoperative recovery. Surgical intercostal block performed under direct vision is a simple and effective regional analgesic technique commonly used following VATS. However, the optimal timing of intercostal block administration during surgery remains uncertain.\n\nThis prospective randomized double-blind study will compare surgical intercostal block performed at the beginning versus the end of the surgical procedure. The study aims to evaluate the effect of block timing on postoperative pain intensity and postoperative opioid consumption. The results may help optimize multimodal analgesic strategies in patients undergoing thoracic surgery.",[114,26],"Video Assisted Thoracic Surgery (VATS)",[62,26,116],"Pain","NOT_YET_RECRUITING","2026-04-09",{"date":120,"type":38},"2026-04-16",{"date":122,"type":20},"2026-04-01",{"date":124,"type":20},"2027-09-30",{"name":126,"class":45},"Erasme University Hospital",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":135,"minAge":17,"maxAge":54,"enrollmentInfo":136,"targetDuration":4,"studyType":21,"phases":137,"briefSummary":138,"conditions":139,"keywords":144,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":4},"100599049","eit-evaluation-of-pulmonary-ventilation-with-different-ropivacaine-concentrations-in-intercostal-nerve-blockade-100599049","NCT07079436","EIT Evaluation of Pulmonary Ventilation With Different Ropivacaine Concentrations in Intercostal Nerve Blockade","Electrical Impedance Tomography (EIT) to Evaluate the Effect of Different Concentrations of Ropivacaine on Pulmonary Ventilation Function During Intercostal Nerve Blockade","EIT","Inclusion Criteria:\n\n* Patients scheduled for elective breast quadrantectomy;\n* Aged 18-80 years;\n* American Society of Anesthesiologists (ASA) physical status I-II;\n* Body mass index (BMI) \\\u003C35 kg\u002Fm².\n\nExclusion Criteria:\n\n* Contraindications for nerve block: infection at the puncture site, local anesthetic allergy, coagulation dysfunction or bleeding risk;\n* Patients with unilateral diaphragmatic paralysis;\n* Patients with severe ventilatory or gas exchange dysfunction;\n* Complicated with acute or chronic pulmonary and bronchial diseases, sleep apnea syndrome;\n* Mental disorders;\n* Patients who refuse to participate;\n* Patients whom the researchers consider unsuitable for the clinical trial, with reasons to be specified.","FEMALE",{"count":83,"type":20},[23],"This study aims to find out how different strengths of the anesthetic drug ropivacaine affect lung breathing function when used in intercostal nerve block (a type of local anesthesia) for breast quadrantectomy surgery. Researchers will use a non-invasive imaging technique called electrical impedance tomography (EIT) to monitor lung ventilation in real time.\n\nWhy is this study being done? Intercostal nerve block is a common anesthesia method for breast surgeries, but the ideal strength of ropivacaine that balances effective pain relief with safety for lung function is not fully clear. EIT can help measure how each drug strength affects breathing by showing changes in lung airflow.\n\nWhat will happen in the study? Participants: 72 adults scheduled for breast quadrantectomy, aged 18-80, will be randomly assigned to receive one of three ropivacaine strengths (0.25%, 0.375%, or 0.5%) during intercostal nerve block.\n\nProcedures: After anesthesia, EIT will monitor lung ventilation before and after the block. Researchers will measure:\n\nHow much each lung side contributes to breathing during quiet and deep breaths. How quickly the anesthesia works, pain levels during surgery, and any side effects (like difficulty breathing or allergic reactions).\n\nWho can join? Adults having elective breast quadrantectomy. ASA physical status I-II (generally healthy to mildly ill). BMI \\\u003C35 kg\u002Fm². No history of nerve block allergies, breathing problems, or certain lung diseases.\n\nWhat are the possible benefits? The study may help doctors choose the best ropivacaine strength to ensure good pain control while minimizing risks to lung function, especially for same-day surgery patients.\n\nWhat are the risks? Potential risks include rare side effects from the anesthetic (like allergic reactions or low blood pressure) or temporary breathing changes, which will be closely monitored.\n\nHow is the study designed? This is a double-blind, randomized trial (neither patients nor doctors know which drug strength is used) at Fudan University Shanghai Cancer Center.",[26,140,141,142,143],"Pulmonary Ventilation","Anesthesia, Local","Breast Neoplasms","Surgical Procedures, Operative",[145,26,146,147,148,142],"Ropivacaine","Pulmonary Ventilation Function","Electrical Impedance Tomography","Anesthetic Concentration","2025-07-22",{"date":151,"type":38},"2025-07-23",{"date":153,"type":20},"2025-08-10",{"date":155,"type":20},"2025-12-31",{"name":157,"class":45},"Fudan University"]