[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"interdental-papillae-reconstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:interdental-papillae-reconstruction":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100593906","phase-1-clinical-evaluation-of-photobiomodulated-hyaluronic-acid-therapy-for-interdental-papillary-loss-minimal-invasive-blind-split-mouth-technique-100593906",false,"NCT07012525","Clinical Evaluation of Photobiomodulated Hyaluronic Acid Therapy for Interdental Papillary Loss: Minimal Invasive Blind Split Mouth Technique","Inclusion Criteria:\n\n* Adults aged 20 to 40 years\n* Presence of at least two non-adjacent interdental papilla defects (Class I, Norland \\& Tarnow classification) in the maxillary anterior region\n* Healthy periodontal status, with:\n* Probing depth ≤ 3 mm\n* No gingival recession\n* No tooth mobility (Score 0)\n* No interdental bone loss on radiographs\n* Non-smokers\n* No previous orthodontic treatment\n* Free from gingival or dental surface alterations (e.g., abfraction, irregularities, or overcontouring)\n* Systemically healthy (no systemic diseases or conditions affecting healing or immune function)\n* Willing and able to comply with study procedures and follow-up visits\n* Provided written informed consent after explanation of study procedures\n\nExclusion Criteria:\n\n* Candidates will be excluded if they meet any of the following:\n* Systemic diseases or medications known to affect soft tissue healing (e.g., diabetes, immunosuppressants)\n* Pregnancy or lactation\n* History of periodontal surgery in the study area\n* Known allergy or hypersensitivity to hyaluronic acid or local anesthetics\n* Current use of anti-inflammatory drugs, anticoagulants, or antibiotics that could affect healing\n* Poor oral hygiene or non-compliance during pre-treatment phase\n* Participation in another clinical trial within the last 3 months",true,"ALL","20 Years","40 Years",{"count":20,"type":21},14,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","The goal of this clinical trial is to evaluate the effectiveness of a minimally invasive therapy combining photobiomodulation (PBMT) with injectable dermal filler (hyaluronic acid) in adult patients (ages 20-40) with interdental papillary loss (Norland \\& Tarnow Class I) in the maxillary anterior region.\n\nThe main questions it aims to answer are:\n\nDoes PBMT enhance the regenerative effect of hyaluronic acid filler in restoring the interdental papilla? Is the combined therapy superior to dermal filler alone in achieving long-term aesthetic and clinical stability?\n\nResearchers will compare:\n\nGroup I (control) - hyaluronic acid filler alone vs. Group II (experimental) - PBMT applied before and after hyaluronic acid filler to see if PBMT contributes to better papilla height, width, and volume restoration over 12 months.\n\nParticipants will:\n\nUndergo standard periodontal cleaning and education 4 weeks before treatment Receive local anesthesia and dermal filler injections in both quadrants (split-mouth design)\n\nHave PBMT applied in one quadrant only (Group II) Be followed up at regular intervals (1 week to 12 months) for clinical measurements and digital image analysis of papilla dimensions This study introduces a non-surgical, patient-friendly technique that may enhance soft tissue regeneration in esthetic areas, offering a potential breakthrough in managing interdental papillary loss.",[28],"Interdental Papillae Reconstruction","NOT_YET_RECRUITING","2025-08-18",{"date":32,"type":33},"2025-08-22","ACTUAL",{"date":35,"type":21},"2025-09-15",{"date":37,"type":21},"2026-12-30",{"name":39,"class":40},"Dar Al Uloom University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":15,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100584436","a-modern-non-surgical-method-for-treating-papillary-deficiencies-is-the-use-of-hyaluronic-acid-which-have-demonstrated-encouraging-outcome-subperiosteal-hyaluronic-acid-injection-overlay-technique-with-the-idea-of-merging-hyaluronic-acid-injection-with-surgical-intervention-to-reconstruct-idp-100584436","NCT06889311","A Modern, Non-surgical Method for Treating Papillary Deficiencies is the Use of Hyaluronic Acid, Which Have Demonstrated Encouraging Outcome. Subperiosteal Hyaluronic Acid Injection Overlay Technique with the Idea of Merging Hyaluronic Acid Injection with Surgical Intervention to Reconstruct Idp","Evaluation of Subperiosteal Hyaluronic Acid Injection Overlay Technique Compared to Tunneling with Connective Tissue Graft in Management of Interdental Papillary Defects: a Randomized Clinical Trial","Inclusion Criteria:\n\n\\- 1. Patients aged over 18 years. 2. Class I papillary recession according to the Nordland and Tarnow classification system. (Nordland and Tarnow 1998) 3. Patients free from any systemic conditions that may affect healing. (Hamadeh et al. 2024).\n\n4\\. The distance between the contact point to alveolar crest between 5 to 7 mm. 5. Presence of the adjacent teeth. 6. Compliant patients with good oral hygiene.\n\nExclusion Criteria:\n\n\\- 1. Smokers. 2. Pregnant females. 3. Patients with active periodontal disease. 4. Patients who has spacing or crowding between the teeth to be treated. 5. Abnormal tooth shape or adjacent teeth with caries. 6. Presence of proximal restoration or orthodontic appliances or fixed prosthesis.\n\n7\\. Patients with poor oral hygiene according to plaque index score of 2.0 to 3.0 evaluated according to the criteria of Silness and Loe.","18 Years",{"count":51,"type":21},38,[53],"NA","The interdental papilla is a crucial part of an esthetic smile, its loss results in gingival black triangles giving unpleasant appearance which directly affect patient self-esteem (Lee et al. 2016). The presence of interdental papilla is of great concern for the clinician and the patient. Gingival black triangles are considered to be the most disliked esthetic issue. As well open embrasures can cause food impaction and phonetic problems (Prato et al. 2004).\n\nThe treatment of black triangles is challenging in modern dentistry. The treatment options are surgical and non-surgical. Surgical treatments are invasive and do not always give a predictable result due to limited blood supply of the papilla (Mansouri 2013).\n\nHowever, no technique has been set up as a gold standard treatment for gingival black triangles, although, connective tissue graft surgical techniques are the most common used approaches for treatment of black triangles (RahimiRad 2018).\n\nA modern, non-surgical method for treating papillary deficiencies is the use of hyaluronic acid, which have demonstrated encouraging outcome (Ni et al. 2021). Subperiosteal hyaluronic acid injection overlay technique was proposed by Spano et al, (2020) with the idea of merging hyaluronic acid injection with simple surgical intervention to reconstruct the lost interdental papilla. As far as we know, there is no present studies comparing hyaluronic acid overlay technique with connective tissue graft in treatment of interdental papilla deficiencies.",[28,56],"Hyaluronic Acid",[58],"Hyaluronic acid, Interdental papilla, Black triangle","2025-03-17",{"date":61,"type":33},"2025-03-21",{"date":63,"type":21},"2025-07",{"date":65,"type":21},"2027-07",{"name":67,"class":40},"Cairo University"]